{"id":"https://openalex.org/W2161093026","doi":"https://doi.org/10.1109/tbme.2011.2128869","title":"Quantifying Fluid Infusions and Tissue Expansion in Brain","display_name":"Quantifying Fluid Infusions and Tissue Expansion in Brain","publication_year":2011,"publication_date":"2011-03-17","ids":{"openalex":"https://openalex.org/W2161093026","doi":"https://doi.org/10.1109/tbme.2011.2128869","mag":"2161093026","pmid":"https://pubmed.ncbi.nlm.nih.gov/21421430"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2011.2128869","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2011.2128869","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030815730","display_name":"Martin Brady","orcid":"https://orcid.org/0000-0002-1484-5683"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"M. Brady","raw_affiliation_strings":["L.L.C., Baltimore, MD, USA"],"affiliations":[{"raw_affiliation_string":"L.L.C., Baltimore, MD, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003352663","display_name":"Raghu Raghavan","orcid":"https://orcid.org/0000-0002-4576-1132"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Raghavan","raw_affiliation_strings":["L.L.C., Baltimore, MD, USA"],"affiliations":[{"raw_affiliation_string":"L.L.C., Baltimore, MD, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100716621","display_name":"Zhijian Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhi-Jian Chen","raw_affiliation_strings":["Department of Neurosurgery, Virginia Commonwealth University, Richmond, VA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Virginia Commonwealth University, Richmond, VA, USA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049344071","display_name":"William C. Broaddus","orcid":"https://orcid.org/0000-0001-9614-8162"},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. C. Broaddus","raw_affiliation_strings":["Department of Neurosurgery, Virginia Commonwealth University, Richmond, VA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Virginia Commonwealth University, Richmond, VA, USA","institution_ids":["https://openalex.org/I184840846"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5030815730"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5416,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.88765886,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"58","issue":"8","first_page":"2228","last_page":"2237"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/white-matter","display_name":"White matter","score":0.7367092370986938},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"Cerebrospinal fluid","score":0.66888427734375},{"id":"https://openalex.org/keywords/parenchyma","display_name":"Parenchyma","score":0.6464778184890747},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.6034020185470581},{"id":"https://openalex.org/keywords/interstitial-fluid","display_name":"Interstitial fluid","score":0.5785602331161499},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5175228118896484},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.5078127980232239},{"id":"https://openalex.org/keywords/brain-tissue","display_name":"Brain tissue","score":0.4732937216758728},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.4451074004173279},{"id":"https://openalex.org/keywords/blood\u2013brain-barrier","display_name":"Blood\u2013brain barrier","score":0.43626317381858826},{"id":"https://openalex.org/keywords/tissue-fluid","display_name":"Tissue fluid","score":0.4100847542285919},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.33048027753829956},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"Central nervous system","score":0.25875598192214966},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.21082422137260437},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.10572001338005066}],"concepts":[{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.7367092370986938},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.66888427734375},{"id":"https://openalex.org/C196822366","wikidata":"https://www.wikidata.org/wiki/Q270524","display_name":"Parenchyma","level":2,"score":0.6464778184890747},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.6034020185470581},{"id":"https://openalex.org/C2779822359","wikidata":"https://www.wikidata.org/wiki/Q2914458","display_name":"Interstitial fluid","level":2,"score":0.5785602331161499},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5175228118896484},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5078127980232239},{"id":"https://openalex.org/C2986936838","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Brain tissue","level":2,"score":0.4732937216758728},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4451074004173279},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.43626317381858826},{"id":"https://openalex.org/C2908754555","wikidata":"https://www.wikidata.org/wiki/Q2914458","display_name":"Tissue fluid","level":2,"score":0.4100847542285919},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.33048027753829956},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.25875598192214966},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.21082422137260437},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10572001338005066}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002555","descriptor_name":"Cerebrospinal Fluid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002555","descriptor_name":"Cerebrospinal Fluid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002555","descriptor_name":"Cerebrospinal Fluid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012212","descriptor_name":"Rheology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012212","descriptor_name":"Rheology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012212","descriptor_name":"Rheology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019786","descriptor_name":"Gadolinium DTPA","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019786","descriptor_name":"Gadolinium DTPA","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019786","descriptor_name":"Gadolinium DTPA","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019786","descriptor_name":"Gadolinium DTPA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019786","descriptor_name":"Gadolinium DTPA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019786","descriptor_name":"Gadolinium DTPA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D057967","descriptor_name":"Infusions, Intraventricular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057967","descriptor_name":"Infusions, Intraventricular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057967","descriptor_name":"Infusions, Intraventricular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tbme.2011.2128869","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2011.2128869","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:21421430","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21421430","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W336737080","https://openalex.org/W1552826555","https://openalex.org/W1660607775","https://openalex.org/W1955027235","https://openalex.org/W1978506065","https://openalex.org/W1980441719","https://openalex.org/W1980877573","https://openalex.org/W1993685077","https://openalex.org/W1996001296","https://openalex.org/W2011139878","https://openalex.org/W2011840283","https://openalex.org/W2017839807","https://openalex.org/W2019190989","https://openalex.org/W2026812901","https://openalex.org/W2030003406","https://openalex.org/W2059864970","https://openalex.org/W2074779696","https://openalex.org/W2083113845","https://openalex.org/W2103550847","https://openalex.org/W2107155103","https://openalex.org/W2135062838","https://openalex.org/W2145945239","https://openalex.org/W2149452746","https://openalex.org/W2176801482","https://openalex.org/W2181569653","https://openalex.org/W2182857445","https://openalex.org/W2280420202","https://openalex.org/W6685599984","https://openalex.org/W6695026058"],"related_works":["https://openalex.org/W157263847","https://openalex.org/W4361801081","https://openalex.org/W226440774","https://openalex.org/W2018884571","https://openalex.org/W2065616581","https://openalex.org/W2411505909","https://openalex.org/W2058400590","https://openalex.org/W2090298599","https://openalex.org/W146746983","https://openalex.org/W3200325581"],"abstract_inverted_index":{"The":[0],"technique":[1],"of":[2,8,30,37,47,51,67,79,87,113,116,120,128,141,169,183],"direct":[3],"infusions":[4,46,91],"into":[5,33,59,92],"brain":[6,42,93,129],"tissue":[7],"therapeutic":[9],"molecules":[10,40],"that":[11,160,176],"would":[12],"otherwise":[13],"not":[14],"adequately":[15],"cross":[16],"the":[17,35,52,76,80,111,114,117,121,167,170],"blood\u2013brain":[18],"barrier":[19],"(BBB)":[20],"continues":[21],"to":[22,73,83],"be":[23,178],"used":[24],"in":[25,41,124],"clinical":[26],"trials.":[27],"As":[28],"part":[29],"our":[31],"research":[32],"understanding":[34],"transport":[36],"fluids":[38],"and":[39,82,98,173],"tissue,":[43],"we":[44,106],"performed":[45],"a":[48,148],"saline":[49],"solution":[50],"magnetic":[53],"resonance":[54],"(MR)":[55],"marker":[56],"Gadodiamide":[57],"(Omniscan)":[58],"porcine":[60],"brains.":[61],"We":[62,133,153],"use":[63],"quantitative":[64,181],"concentration":[65],"measurements":[66],"contrast":[68],"reagents":[69],"from":[70,99],"MR":[71],"images":[72],"both":[74],"measure":[75],"distribution":[77],"profile":[78],"infusate":[81],"elucidate":[84],"important":[85],"determinants":[86,159],"fluid":[88,142,172],"flow":[89],"during":[90,104,130],"parenchyma.":[94],"Based":[95],"on":[96,157],"this,":[97],"other":[100,158],"MRI":[101],"data":[102],"collected":[103],"infusion,":[105],"give":[107],"preliminary":[108],"results":[109],"for":[110,151],"quantification":[112],"expansion":[115],"volume":[118],"fraction":[119],"interstitium":[122],"particularly":[123],"white":[125,145],"matter":[126,146],"regions":[127],"infusion-induced":[131],"edema.":[132],"claim":[134],"this":[135],"expansion,":[136],"rather":[137],"than":[138],"an":[139],"anisotropy":[140],"conductivity,":[143],"makes":[144],"tracts":[147],"preferred":[149],"pathway":[150],"flow.":[152],"also":[154],"comment":[155],"briefly":[156],"are":[161],"currently":[162],"being":[163],"pursued":[164],"such":[165],"as":[166],"influence":[168],"cerebrospinal":[171],"perivascular":[174],"spaces":[175],"may":[177],"elucidated":[179],"with":[180],"tracking":[182],"tracer,":[184],"but":[185],"which":[186],"need":[187],"further":[188],"studies":[189]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}