{"id":"https://openalex.org/W2163036365","doi":"https://doi.org/10.1109/tbme.2011.2107553","title":"Challenges and Opportunities for Next-Generation Intracortically Based Neural Prostheses","display_name":"Challenges and Opportunities for Next-Generation Intracortically Based Neural Prostheses","publication_year":2011,"publication_date":"2011-01-21","ids":{"openalex":"https://openalex.org/W2163036365","doi":"https://doi.org/10.1109/tbme.2011.2107553","mag":"2163036365","pmid":"https://pubmed.ncbi.nlm.nih.gov/21257365"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2011.2107553","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2011.2107553","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044960129","display_name":"Vikash Gilja","orcid":"https://orcid.org/0000-0002-0619-2686"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"V Gilja","raw_affiliation_strings":["Department of Computer Science and SINTN, Stanford University, Stanford, CA 94305, USA. gilja@stanford.edu","Department of Computer Science and SINTN, University of Stanford, Stanford, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and SINTN, Stanford University, Stanford, CA 94305, USA. gilja@stanford.edu","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Computer Science and SINTN, University of Stanford, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034110217","display_name":"Cindy A Chestek","orcid":null},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C A Chestek","raw_affiliation_strings":["Department of Electrical Engineering and SINTN, University of Stanford, Stanford, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and SINTN, University of Stanford, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017967974","display_name":"Ilka Diester","orcid":"https://orcid.org/0000-0001-9362-0986"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I Diester","raw_affiliation_strings":["Department of Bioengineering, University of Stanford, Stanford, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Stanford, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009856256","display_name":"Jaimie M. Henderson","orcid":"https://orcid.org/0000-0002-3276-2267"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J M Henderson","raw_affiliation_strings":["Departments of Neurosurgery and Neurology & Neurological Sciences, University of Stanford, Stanford, CA, USA"],"affiliations":[{"raw_affiliation_string":"Departments of Neurosurgery and Neurology & Neurological Sciences, University of Stanford, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014360828","display_name":"Karl Deisseroth","orcid":"https://orcid.org/0000-0001-9440-3967"},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Deisseroth","raw_affiliation_strings":["Departments of Bioengineering and Psychiatry & Behavioral Sciences, University of Stanford, Stanford, CA, USA","Howard Hughes Medical Institute, Chevy Chase, MD, USA"],"affiliations":[{"raw_affiliation_string":"Departments of Bioengineering and Psychiatry & Behavioral Sciences, University of Stanford, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Chevy Chase, MD, USA","institution_ids":["https://openalex.org/I1344073410"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004430663","display_name":"Krishna V. Shenoy","orcid":"https://orcid.org/0000-0003-1534-9240"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K V Shenoy","raw_affiliation_strings":["University of Stanford, Stanford, CA, USA"],"affiliations":[{"raw_affiliation_string":"University of Stanford, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5044960129"],"corresponding_institution_ids":["https://openalex.org/I97018004"],"apc_list":null,"apc_paid":null,"fwci":9.3418,"has_fulltext":false,"cited_by_count":152,"citation_normalized_percentile":{"value":0.98718436,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"58","issue":"7","first_page":"1891","last_page":"1899"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10502","display_name":"Advanced Memory and Neural Computing","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neural-prosthesis","display_name":"Neural Prosthesis","score":0.7618528604507446},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5685482025146484},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.5636648535728455},{"id":"https://openalex.org/keywords/neuroprosthetics","display_name":"Neuroprosthetics","score":0.4988119602203369},{"id":"https://openalex.org/keywords/brain\u2013computer-interface","display_name":"Brain\u2013computer interface","score":0.48171287775039673},{"id":"https://openalex.org/keywords/somatosensory-system","display_name":"Somatosensory system","score":0.4134931266307831},{"id":"https://openalex.org/keywords/physical-medicine-and-rehabilitation","display_name":"Physical medicine and rehabilitation","score":0.4042145907878876},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.400884747505188},{"id":"https://openalex.org/keywords/human\u2013computer-interaction","display_name":"Human\u2013computer interaction","score":0.3806541860103607},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3678203225135803},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.216354638338089},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.20909801125526428},{"id":"https://openalex.org/keywords/electroencephalography","display_name":"Electroencephalography","score":0.13036638498306274},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.12096452713012695}],"concepts":[{"id":"https://openalex.org/C2908765479","wikidata":"https://www.wikidata.org/wiki/Q1431093","display_name":"Neural Prosthesis","level":2,"score":0.7618528604507446},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5685482025146484},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.5636648535728455},{"id":"https://openalex.org/C197525751","wikidata":"https://www.wikidata.org/wiki/Q1431093","display_name":"Neuroprosthetics","level":2,"score":0.4988119602203369},{"id":"https://openalex.org/C173201364","wikidata":"https://www.wikidata.org/wiki/Q897410","display_name":"Brain\u2013computer interface","level":3,"score":0.48171287775039673},{"id":"https://openalex.org/C172497186","wikidata":"https://www.wikidata.org/wiki/Q328835","display_name":"Somatosensory system","level":2,"score":0.4134931266307831},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.4042145907878876},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.400884747505188},{"id":"https://openalex.org/C107457646","wikidata":"https://www.wikidata.org/wiki/Q207434","display_name":"Human\u2013computer interaction","level":1,"score":0.3806541860103607},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3678203225135803},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.216354638338089},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20909801125526428},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.13036638498306274},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12096452713012695},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008328","descriptor_name":"Man-Machine Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008328","descriptor_name":"Man-Machine Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008328","descriptor_name":"Man-Machine Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008328","descriptor_name":"Man-Machine Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058117","descriptor_name":"Neural Prostheses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058117","descriptor_name":"Neural Prostheses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058117","descriptor_name":"Neural Prostheses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058117","descriptor_name":"Neural Prostheses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1109/tbme.2011.2107553","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2011.2107553","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:21257365","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21257365","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null},{"id":"pmh:oai:europepmc.org:2157821","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3150197","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Quality Education","score":0.5099999904632568,"id":"https://metadata.un.org/sdg/4"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":91,"referenced_works":["https://openalex.org/W1527400574","https://openalex.org/W1966679339","https://openalex.org/W1973468287","https://openalex.org/W1975792056","https://openalex.org/W1986848074","https://openalex.org/W1989927577","https://openalex.org/W1991326578","https://openalex.org/W1994636909","https://openalex.org/W2000186054","https://openalex.org/W2006304614","https://openalex.org/W2006837676","https://openalex.org/W2009534332","https://openalex.org/W2009664245","https://openalex.org/W2012924135","https://openalex.org/W2020748969","https://openalex.org/W2023042493","https://openalex.org/W2023295798","https://openalex.org/W2025310166","https://openalex.org/W2030845253","https://openalex.org/W2037547604","https://openalex.org/W2039621768","https://openalex.org/W2041248708","https://openalex.org/W2041602825","https://openalex.org/W2047347093","https://openalex.org/W2048272660","https://openalex.org/W2048314955","https://openalex.org/W2049341022","https://openalex.org/W2052109162","https://openalex.org/W2056918894","https://openalex.org/W2057584021","https://openalex.org/W2062159891","https://openalex.org/W2062842385","https://openalex.org/W2063210874","https://openalex.org/W2065646999","https://openalex.org/W2065833894","https://openalex.org/W2080865257","https://openalex.org/W2081218172","https://openalex.org/W2083932518","https://openalex.org/W2088469166","https://openalex.org/W2089916944","https://openalex.org/W2090175454","https://openalex.org/W2092109065","https://openalex.org/W2095913976","https://openalex.org/W2098373948","https://openalex.org/W2102286276","https://openalex.org/W2104137141","https://openalex.org/W2105102432","https://openalex.org/W2105469435","https://openalex.org/W2106465336","https://openalex.org/W2108846059","https://openalex.org/W2109458355","https://openalex.org/W2111186480","https://openalex.org/W2111685939","https://openalex.org/W2112938540","https://openalex.org/W2114004602","https://openalex.org/W2117151438","https://openalex.org/W2128188461","https://openalex.org/W2128675085","https://openalex.org/W2131644089","https://openalex.org/W2134973295","https://openalex.org/W2135762586","https://openalex.org/W2137011456","https://openalex.org/W2144284928","https://openalex.org/W2148824675","https://openalex.org/W2152315848","https://openalex.org/W2153156720","https://openalex.org/W2153636199","https://openalex.org/W2155790994","https://openalex.org/W2158496664","https://openalex.org/W2160414975","https://openalex.org/W2164546307","https://openalex.org/W2165376801","https://openalex.org/W2165449323","https://openalex.org/W2167095271","https://openalex.org/W2167716858","https://openalex.org/W2168197053","https://openalex.org/W2168905284","https://openalex.org/W2171077154","https://openalex.org/W2171431653","https://openalex.org/W2171746059","https://openalex.org/W2203848466","https://openalex.org/W2328544710","https://openalex.org/W2497715227","https://openalex.org/W2538064501","https://openalex.org/W2610186576","https://openalex.org/W2616371433","https://openalex.org/W2789500754","https://openalex.org/W4237805535","https://openalex.org/W4253453051","https://openalex.org/W4285719527","https://openalex.org/W6986207403"],"related_works":["https://openalex.org/W2037377756","https://openalex.org/W2103494817","https://openalex.org/W2032806855","https://openalex.org/W4386177096","https://openalex.org/W3185527278","https://openalex.org/W4255609005","https://openalex.org/W2082255253","https://openalex.org/W4242484341","https://openalex.org/W2188944156","https://openalex.org/W2077293880"],"abstract_inverted_index":{"Neural":[0],"prosthetic":[1,22],"systems":[2,87],"aim":[3],"to":[4],"help":[5,147],"disabled":[6,151],"patients":[7],"by":[8],"translating":[9],"neural":[10,139],"signals":[11,17],"from":[12,38],"the":[13,47,83],"brain":[14],"into":[15,88],"control":[16],"for":[18,55,124],"guiding":[19],"computer":[20],"cursors,":[21],"arms,":[23],"and":[24,34,50,65,103,111,116,146],"other":[25],"assistive":[26],"devices.":[27],"Intracortical":[28],"electrode":[29],"arrays":[30],"measure":[31],"action":[32],"potentials":[33,37],"local":[35],"field":[36],"individual":[39],"neurons,":[40,45],"or":[41,134],"small":[42],"populations":[43],"of":[44,85,99,150],"in":[46],"motor":[48],"cortices":[49],"can":[51,131],"provide":[52],"considerable":[53],"information":[54],"controlling":[56],"prostheses.":[57],"Despite":[58],"several":[59],"compelling":[60],"proof-of-concept":[61],"laboratory":[62],"animal":[63],"experiments":[64],"an":[66],"initial":[67],"human":[68],"clinical":[69,90,144],"trial,":[70],"at":[71],"least":[72],"three":[73],"key":[74],"challenges":[75,130],"remain":[76],"which,":[77],"if":[78],"left":[79],"unaddressed,":[80],"may":[81,141],"hamper":[82],"translation":[84],"these":[86,94,126,129],"widespread":[89],"use.":[91],"We":[92,118],"review":[93],"challenges:":[95],"achieving":[96,106],"able-bodied":[97,113],"levels":[98],"performance":[100],"across":[101,104,108],"tasks":[102],"environments,":[105],"robustness":[107],"multiple":[109],"decades,":[110],"restoring":[112],"quality":[114],"proprioception":[115],"somatosensation.":[117],"also":[119],"describe":[120],"some":[121],"emerging":[122],"opportunities":[123],"meeting":[125],"challenges.":[127],"If":[128],"be":[132],"largely":[133],"fully":[135],"met,":[136],"intracortically":[137],"based":[138],"prostheses":[140],"achieve":[142],"true":[143],"viability":[145],"increasing":[148],"numbers":[149],"patients.":[152]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":24},{"year":2012,"cited_by_count":12}],"updated_date":"2026-02-27T16:54:17.756197","created_date":"2025-10-10T00:00:00"}