{"id":"https://openalex.org/W2156422447","doi":"https://doi.org/10.1109/tbme.2010.2095852","title":"Textureless Macula Swelling Detection With Multiple Retinal Fundus Images","display_name":"Textureless Macula Swelling Detection With Multiple Retinal Fundus Images","publication_year":2010,"publication_date":"2010-12-09","ids":{"openalex":"https://openalex.org/W2156422447","doi":"https://doi.org/10.1109/tbme.2010.2095852","mag":"2156422447","pmid":"https://pubmed.ncbi.nlm.nih.gov/21118759"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2010.2095852","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2010.2095852","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026804774","display_name":"Luca Giancardo","orcid":"https://orcid.org/0000-0002-4862-2277"},"institutions":[{"id":"https://openalex.org/I177064439","display_name":"Universit\u00e9 de Bourgogne","ror":"https://ror.org/03k1bsr36","country_code":"FR","type":"education","lineage":["https://openalex.org/I177064439"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Luca Giancardo","raw_affiliation_strings":["Le2i, University of Burgundy, France","Universite de Bourgogne, Dijon, Bourgogne, FR"],"affiliations":[{"raw_affiliation_string":"Le2i, University of Burgundy, France","institution_ids":["https://openalex.org/I177064439"]},{"raw_affiliation_string":"Universite de Bourgogne, Dijon, Bourgogne, FR","institution_ids":["https://openalex.org/I177064439"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079375904","display_name":"Fabrice M\u00e9riaudeau","orcid":"https://orcid.org/0000-0002-8656-9913"},"institutions":[{"id":"https://openalex.org/I177064439","display_name":"Universit\u00e9 de Bourgogne","ror":"https://ror.org/03k1bsr36","country_code":"FR","type":"education","lineage":["https://openalex.org/I177064439"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fabrice Meriaudeau","raw_affiliation_strings":["Le2i, University of Burgundy, France"],"affiliations":[{"raw_affiliation_string":"Le2i, University of Burgundy, France","institution_ids":["https://openalex.org/I177064439"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004617550","display_name":"Thomas P. Karnowski","orcid":"https://orcid.org/0000-0002-0376-4917"},"institutions":[{"id":"https://openalex.org/I1289243028","display_name":"Oak Ridge National Laboratory","ror":"https://ror.org/01qz5mb56","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289243028","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I4210159294"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas P. Karnowski","raw_affiliation_strings":["Oak Ridge National Laboratory , Oak Ridge, TN, USA"],"affiliations":[{"raw_affiliation_string":"Oak Ridge National Laboratory , Oak Ridge, TN, USA","institution_ids":["https://openalex.org/I1289243028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049719212","display_name":"Kenneth W. Tobin","orcid":"https://orcid.org/0000-0003-3577-9520"},"institutions":[{"id":"https://openalex.org/I1289243028","display_name":"Oak Ridge National Laboratory","ror":"https://ror.org/01qz5mb56","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289243028","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I4210159294"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth W. Tobin","raw_affiliation_strings":["Oak Ridge National Laboratory , Oak Ridge, TN, USA"],"affiliations":[{"raw_affiliation_string":"Oak Ridge National Laboratory , Oak Ridge, TN, USA","institution_ids":["https://openalex.org/I1289243028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022937331","display_name":"Enrico Grisan","orcid":"https://orcid.org/0000-0002-7365-5652"},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Enrico Grisan","raw_affiliation_strings":["BioImLab, University of Padua , Italy","BiomIn Laboratory, University of Padua, Italy"],"affiliations":[{"raw_affiliation_string":"BioImLab, University of Padua , Italy","institution_ids":["https://openalex.org/I138689650"]},{"raw_affiliation_string":"BiomIn Laboratory, University of Padua, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070940574","display_name":"Paolo Favaro","orcid":"https://orcid.org/0000-0003-3546-8247"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paolo Favaro","raw_affiliation_strings":["Heriott-Watt University, Edinburgh , EH14, U.K"],"affiliations":[{"raw_affiliation_string":"Heriott-Watt University, Edinburgh , EH14, U.K","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110261303","display_name":"Alfredo Ruggeri","orcid":null},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alfredo Ruggeri","raw_affiliation_strings":["BioImLab, University of Padua , Italy","BiomIn Laboratory, University of Padua, Italy"],"affiliations":[{"raw_affiliation_string":"BioImLab, University of Padua , Italy","institution_ids":["https://openalex.org/I138689650"]},{"raw_affiliation_string":"BiomIn Laboratory, University of Padua, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091627951","display_name":"Edward Chaum","orcid":"https://orcid.org/0000-0003-3542-8376"},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward Chaum","raw_affiliation_strings":["University of Tennessee Health Science Center, Memphis, USA"],"affiliations":[{"raw_affiliation_string":"University of Tennessee Health Science Center, Memphis, USA","institution_ids":["https://openalex.org/I160606119"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5026804774"],"corresponding_institution_ids":["https://openalex.org/I177064439"],"apc_list":null,"apc_paid":null,"fwci":2.1799,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.87032751,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"58","issue":"3","first_page":"795","last_page":"799"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12599","display_name":"Retinal and Optic Conditions","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.7692427635192871},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.739177405834198},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.7205055952072144},{"id":"https://openalex.org/keywords/fundus","display_name":"Fundus (uterus)","score":0.6982886791229248},{"id":"https://openalex.org/keywords/preprocessor","display_name":"Preprocessor","score":0.6238787174224854},{"id":"https://openalex.org/keywords/retinal","display_name":"Retinal","score":0.5557125806808472},{"id":"https://openalex.org/keywords/ophthalmology","display_name":"Ophthalmology","score":0.19967353343963623},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.15288656949996948}],"concepts":[{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.7692427635192871},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.739177405834198},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.7205055952072144},{"id":"https://openalex.org/C2776391266","wikidata":"https://www.wikidata.org/wiki/Q9612","display_name":"Fundus (uterus)","level":2,"score":0.6982886791229248},{"id":"https://openalex.org/C34736171","wikidata":"https://www.wikidata.org/wiki/Q918333","display_name":"Preprocessor","level":2,"score":0.6238787174224854},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.5557125806808472},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.19967353343963623},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15288656949996948}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005654","descriptor_name":"Fundus Oculi","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005654","descriptor_name":"Fundus Oculi","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005654","descriptor_name":"Fundus Oculi","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008266","descriptor_name":"Macula Lutea","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008266","descriptor_name":"Macula Lutea","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008266","descriptor_name":"Macula Lutea","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009887","descriptor_name":"Ophthalmoscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009887","descriptor_name":"Ophthalmoscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009887","descriptor_name":"Ophthalmoscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017216","descriptor_name":"Telemedicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017216","descriptor_name":"Telemedicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017216","descriptor_name":"Telemedicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019095","descriptor_name":"Point-of-Care Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019095","descriptor_name":"Point-of-Care Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019095","descriptor_name":"Point-of-Care Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1109/tbme.2010.2095852","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2010.2095852","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:21118759","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21118759","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null},{"id":"pmh:oai:www.research.unipd.it:11577/2449321","is_oa":false,"landing_page_url":"http://hdl.handle.net/11577/2449321","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6399999856948853,"id":"https://metadata.un.org/sdg/9","display_name":"Industry, innovation and infrastructure"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1500191525","https://openalex.org/W1565206031","https://openalex.org/W1641973618","https://openalex.org/W1677409904","https://openalex.org/W1992989752","https://openalex.org/W2032988656","https://openalex.org/W2038473515","https://openalex.org/W2093183007","https://openalex.org/W2102303023","https://openalex.org/W2103820732","https://openalex.org/W2104223983","https://openalex.org/W2119605622","https://openalex.org/W2125524382","https://openalex.org/W2136539671","https://openalex.org/W2142501586","https://openalex.org/W2146881125","https://openalex.org/W2146898399","https://openalex.org/W2157840858","https://openalex.org/W2490698652","https://openalex.org/W6675468141"],"related_works":["https://openalex.org/W2755342338","https://openalex.org/W2058170566","https://openalex.org/W2036807459","https://openalex.org/W2775347418","https://openalex.org/W1969923398","https://openalex.org/W2166024367","https://openalex.org/W2772917594","https://openalex.org/W3116076068","https://openalex.org/W2229312674","https://openalex.org/W2079911747"],"abstract_inverted_index":{"Retinal":[0],"fundus":[1,7,59,97],"images":[2,60,173,194],"acquired":[3],"with":[4,41,87,95,220],"nonmydriatic":[5],"digital":[6],"cameras":[8,35],"are":[9,112,156,187],"versatile":[10],"tools":[11],"for":[12,44,170],"the":[13,21,63,66,71,108,124,142,146,150,172,184,205,218,221],"diagnosis":[14,117],"of":[15,20,23,25,65,76,118,126,145,183,192,198,212],"various":[16],"retinal":[17],"diseases.":[18],"Because":[19],"ease":[22],"use":[24],"newer":[26],"camera":[27],"models":[28],"and":[29,73,91,148,174,195,215],"their":[30],"relatively":[31],"low":[32],"cost,":[33],"these":[34],"can":[36],"be":[37],"employed":[38],"by":[39,79],"operators":[40],"limited":[42],"training":[43],"telemedicine":[45],"or":[46],"point-of-care":[47],"(PoC)":[48],"applications.":[49],"We":[50,99],"propose":[51],"a":[52,88,137,163,179,209],"novel":[53],"technique":[54,129,139],"that":[55],"uses":[56],"uncalibrated":[57],"multiple-view":[58],"to":[61,93,104,177,207,216],"analyze":[62],"swelling":[64,211],"macula.":[67,185],"This":[68,82],"innovation":[69],"enables":[70],"detection":[72],"quantitative":[74],"measurement":[75],"swollen":[77,222],"areas":[78],"remote":[80],"ophthalmologists.":[81],"capability":[83],"is":[84,131,168],"not":[85],"available":[86,154],"single":[89],"image":[90],"prone":[92],"error":[94],"stereo":[96],"cameras.":[98],"also":[100],"present":[101],"automatic":[102],"algorithms":[103],"measure":[105],"features":[106],"from":[107],"reconstructed":[109],"image,":[110],"which":[111],"useful":[113],"in":[114],"PoC":[115],"automated":[116],"early":[119],"macular":[120],"edema,":[121],"e.g.,":[122],"before":[123],"appearance":[125],"exudation.":[127],"The":[128],"presented":[130,188],"divided":[132],"into":[133],"three":[134,190],"parts:":[135],"first,":[136],"preprocessing":[138],"simultaneously":[140],"enhances":[141],"dark":[143],"microstructures":[144],"macula":[147],"equalizes":[149],"image;":[151],"second,":[152],"all":[153,171],"views":[155],"registered":[157],"using":[158],"nonmorphological":[159],"sparse":[160],"features;":[161],"finally,":[162],"dense":[164],"pyramidal":[165],"optical":[166],"flow":[167],"calculated":[169],"statistically":[175],"combined":[176],"build":[178],"naive":[180],"height":[181],"map":[182],"Results":[186],"on":[189],"sets":[191,197],"synthetic":[193],"two":[196],"real-world":[199],"images.":[200],"These":[201],"preliminary":[202],"tests":[203],"show":[204],"ability":[206],"infer":[208],"minimum":[210],"300":[213],"\u03bcm":[214],"correlate":[217],"reconstruction":[219],"location.":[223]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}