{"id":"https://openalex.org/W2067814190","doi":"https://doi.org/10.1109/tbme.2010.2077292","title":"Effects of the Antiarrhythmic Drug Dofetilide on Transmural Dispersion of Repolarization in Ventriculum. A Computer Modeling Study","display_name":"Effects of the Antiarrhythmic Drug Dofetilide on Transmural Dispersion of Repolarization in Ventriculum. A Computer Modeling Study","publication_year":2010,"publication_date":"2010-09-20","ids":{"openalex":"https://openalex.org/W2067814190","doi":"https://doi.org/10.1109/tbme.2010.2077292","mag":"2067814190","pmid":"https://pubmed.ncbi.nlm.nih.gov/20851784"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2010.2077292","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2010.2077292","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://zenodo.org/record/3435023","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063676325","display_name":"Javier S\u00e1iz","orcid":"https://orcid.org/0000-0002-9850-0825"},"institutions":[{"id":"https://openalex.org/I60053951","display_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","ror":"https://ror.org/01460j859","country_code":"ES","type":"education","lineage":["https://openalex.org/I60053951"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Javier Saiz","raw_affiliation_strings":["Institute for Research in Bioengineering and Human Oriented Technology, Universidad Polit\u00e9cnica de Valencia, Valencia 46022, Spain. jsaiz@gbio.i3bh.es","Inst. for Res. in Bioeng. & Human Oriented Technol., Univ. Politec. de Valencia, Valencia, Spain"],"affiliations":[{"raw_affiliation_string":"Institute for Research in Bioengineering and Human Oriented Technology, Universidad Polit\u00e9cnica de Valencia, Valencia 46022, Spain. jsaiz@gbio.i3bh.es","institution_ids":["https://openalex.org/I60053951"]},{"raw_affiliation_string":"Inst. for Res. in Bioeng. & Human Oriented Technol., Univ. Politec. de Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I60053951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067152818","display_name":"Julio Gomis-Tena","orcid":"https://orcid.org/0000-0002-1309-2368"},"institutions":[{"id":"https://openalex.org/I60053951","display_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","ror":"https://ror.org/01460j859","country_code":"ES","type":"education","lineage":["https://openalex.org/I60053951"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Julio Gomis-Tena","raw_affiliation_strings":["Department of Electronic Engineering, Institute for Research in Bioengineering and Human Oriented Technology, Universidad Polit\u00e9cnica de Valencia, Valencia, Spain","Dept. of Electron. Eng., Univ. Politec. de Valencia, Valencia, Spain"],"affiliations":[{"raw_affiliation_string":"Department of Electronic Engineering, Institute for Research in Bioengineering and Human Oriented Technology, Universidad Polit\u00e9cnica de Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I60053951"]},{"raw_affiliation_string":"Dept. of Electron. Eng., Univ. Politec. de Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I60053951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111894654","display_name":"Marta Monserrat","orcid":null},"institutions":[{"id":"https://openalex.org/I60053951","display_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","ror":"https://ror.org/01460j859","country_code":"ES","type":"education","lineage":["https://openalex.org/I60053951"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marta Monserrat","raw_affiliation_strings":["Department of Electronic Engineering, Institute for Research in Bioengineering and Human Oriented Technology, Universidad Polit\u00e9cnica de Valencia, Valencia, Spain","Dept. of Electron. Eng., Univ. Politec. de Valencia, Valencia, Spain"],"affiliations":[{"raw_affiliation_string":"Department of Electronic Engineering, Institute for Research in Bioengineering and Human Oriented Technology, Universidad Polit\u00e9cnica de Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I60053951"]},{"raw_affiliation_string":"Dept. of Electron. Eng., Univ. Politec. de Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I60053951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070750789","display_name":"J.M. Ferrero","orcid":"https://orcid.org/0000-0003-4200-9225"},"institutions":[{"id":"https://openalex.org/I60053951","display_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","ror":"https://ror.org/01460j859","country_code":"ES","type":"education","lineage":["https://openalex.org/I60053951"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jose M Ferrero","raw_affiliation_strings":["Department of Electronic Engineering, Institute for Research in Bioengineering and Human Oriented Technology, Universidad Polit\u00e9cnica de Valencia, Valencia, Spain","Dept. of Electron. Eng., Univ. Politec. de Valencia, Valencia, Spain"],"affiliations":[{"raw_affiliation_string":"Department of Electronic Engineering, Institute for Research in Bioengineering and Human Oriented Technology, Universidad Polit\u00e9cnica de Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I60053951"]},{"raw_affiliation_string":"Dept. of Electron. Eng., Univ. Politec. de Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I60053951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001198057","display_name":"Karen Cardona","orcid":null},"institutions":[{"id":"https://openalex.org/I60053951","display_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","ror":"https://ror.org/01460j859","country_code":"ES","type":"education","lineage":["https://openalex.org/I60053951"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Karen Cardona","raw_affiliation_strings":["Department of Electronic Engineering, Institute for Research in Bioengineering and Human Oriented Technology, Universidad Polit\u00e9cnica de Valencia, Valencia, Spain","Dept. of Electron. Eng., Univ. Politec. de Valencia, Valencia, Spain"],"affiliations":[{"raw_affiliation_string":"Department of Electronic Engineering, Institute for Research in Bioengineering and Human Oriented Technology, Universidad Polit\u00e9cnica de Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I60053951"]},{"raw_affiliation_string":"Dept. of Electron. Eng., Univ. Politec. de Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I60053951"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082717926","display_name":"J. Chorro","orcid":null},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Javier Chorro","raw_affiliation_strings":["Universidad de Valencia, Valencia, Spain","Univ. de Valencia, Valencia, Spain"],"affiliations":[{"raw_affiliation_string":"Universidad de Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I16097986"]},{"raw_affiliation_string":"Univ. de Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I16097986"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5063676325"],"corresponding_institution_ids":["https://openalex.org/I60053951"],"apc_list":null,"apc_paid":null,"fwci":2.10253669,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.86628325,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"58","issue":"1","first_page":"43","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11434","display_name":"Electrochemical Analysis and Applications","score":0.9557999968528748,"subfield":{"id":"https://openalex.org/subfields/1603","display_name":"Electrochemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dofetilide","display_name":"Dofetilide","score":0.974941611289978},{"id":"https://openalex.org/keywords/repolarization","display_name":"Repolarization","score":0.6796913146972656},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.48288893699645996},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.4510287344455719},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.33661893010139465},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.27657777070999146},{"id":"https://openalex.org/keywords/qt-interval","display_name":"QT interval","score":0.2361544370651245},{"id":"https://openalex.org/keywords/electrophysiology","display_name":"Electrophysiology","score":0.17620432376861572}],"concepts":[{"id":"https://openalex.org/C2777796741","wikidata":"https://www.wikidata.org/wiki/Q3712521","display_name":"Dofetilide","level":3,"score":0.974941611289978},{"id":"https://openalex.org/C146403970","wikidata":"https://www.wikidata.org/wiki/Q205729","display_name":"Repolarization","level":3,"score":0.6796913146972656},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.48288893699645996},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4510287344455719},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33661893010139465},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27657777070999146},{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.2361544370651245},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.17620432376861572}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000889","descriptor_name":"Anti-Arrhythmia Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000889","descriptor_name":"Anti-Arrhythmia Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000889","descriptor_name":"Anti-Arrhythmia Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010627","descriptor_name":"Phenethylamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010627","descriptor_name":"Phenethylamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010627","descriptor_name":"Phenethylamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/tbme.2010.2077292","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2010.2077292","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:20851784","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20851784","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null},{"id":"pmh:oai:zenodo.org:3435023","is_oa":true,"landing_page_url":"https://zenodo.org/record/3435023","pdf_url":null,"source":null,"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:zenodo.org:3435023","is_oa":true,"landing_page_url":"https://zenodo.org/record/3435023","pdf_url":null,"source":null,"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W136206523","https://openalex.org/W1530248218","https://openalex.org/W1926137227","https://openalex.org/W1963579302","https://openalex.org/W1970058620","https://openalex.org/W1974250840","https://openalex.org/W1975151540","https://openalex.org/W1980538198","https://openalex.org/W1982019406","https://openalex.org/W1984313043","https://openalex.org/W1988498011","https://openalex.org/W1990068148","https://openalex.org/W2007448071","https://openalex.org/W2013157031","https://openalex.org/W2015595803","https://openalex.org/W2026247776","https://openalex.org/W2036038468","https://openalex.org/W2038131479","https://openalex.org/W2040003245","https://openalex.org/W2041110681","https://openalex.org/W2054839336","https://openalex.org/W2056757939","https://openalex.org/W2061424979","https://openalex.org/W2066195045","https://openalex.org/W2067647989","https://openalex.org/W2069187704","https://openalex.org/W2081672353","https://openalex.org/W2087070363","https://openalex.org/W2088576259","https://openalex.org/W2107658445","https://openalex.org/W2110170894","https://openalex.org/W2121217634","https://openalex.org/W2124912765","https://openalex.org/W2126997063","https://openalex.org/W2136653489","https://openalex.org/W2151631583","https://openalex.org/W2158801730","https://openalex.org/W2163863644","https://openalex.org/W2164412463","https://openalex.org/W2168806904","https://openalex.org/W2410308392"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W3183948672","https://openalex.org/W2948807893","https://openalex.org/W2778153218","https://openalex.org/W1531601525","https://openalex.org/W2155400405","https://openalex.org/W2097888163","https://openalex.org/W2087239677","https://openalex.org/W2159015025","https://openalex.org/W1950232442"],"abstract_inverted_index":{"Dofetilide":[0],"is":[1,76],"a":[2,97,132],"class-III":[3],"drug":[4],"that":[5,21,46,60,126,168],"inhibits":[6],"the":[7,11,22,53,61,79,84,116,161,172,178,197],"rapid":[8],"component":[9],"of":[10,25,73,81,99,105,120,136,146,158,175,199],"delayed":[12],"potassium":[13],"current":[14],"(":[15],"I(Kr)).":[16],"Experimental":[17],"studies":[18,58],"have":[19],"shown":[20],"different":[23,36,162],"layers":[24],"ventricular":[26,90,100,121,179],"muscle":[27],"present":[28],"differences":[29],"in":[30,52,56,68,88,96,129,139,177],"action":[31,85],"potential":[32],"duration":[33],"(APD)":[34],"and":[35,92,113,144],"responses":[37],"to":[38,49,77],"class":[39],"III":[40],"agents.":[41],"It":[42],"has":[43,110],"been":[44,111],"suggested":[45],"it":[47],"contributes":[48],"APD":[50,66,94,176],"heterogeneity":[51],"ventricles.":[54],"However,":[55,192],"vivo":[57],"suggest":[59],"strong":[62,189],"cellular":[63],"coupling":[64,204],"reduces":[65],"dispersion":[67,95,157],"intact":[69],"heart.":[70],"The":[71,164],"aim":[72],"this":[74],"paper":[75],"study":[78],"effect":[80],"dofetilide":[82,106,127,170],"on":[83,93,108],"potentials":[86],"(APs)":[87],"isolated":[89],"cells":[91,131],"strand":[98],"tissue.":[101],"A":[102],"mathematical":[103],"model":[104,119],"effects":[107],"I(Kr)":[109,137],"developed":[112],"incorporated":[114],"into":[115],"Luo--Rudy":[117],"dynamic":[118],"AP.":[122],"Our":[123],"results":[124,165],"show":[125],"induces":[128],"midmyocardium":[130],"faster":[133],"time-course":[134],"inhibition":[135],"than":[138],"endocardial":[140],"or":[141],"epicardial":[142],"cells,":[143],"periods":[145],"instability":[147],"with":[148],"beat-to-beat":[149],"APs":[150],"variability.":[151],"This":[152],"behavior":[153],"could":[154],"favor":[155],"temporal":[156],"repolarization":[159,194],"between":[160],"cells.":[163],"also":[166],"indicate":[167],"although":[169],"increases,":[171],"transmural":[173],"gradient":[174],"wall,":[180],"early":[181],"afterdepolarizations":[182],"(EADs)":[183],"did":[184],"not":[185],"appear":[186],"even":[187,201],"under":[188,202],"uncoupling":[190],"conditions.":[191,205],"reduced":[193],"reserve":[195],"favors":[196],"induction":[198],"EADs,":[200],"normal":[203]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-02-05T00:54:17.221276","created_date":"2025-10-10T00:00:00"}