{"id":"https://openalex.org/W2113933145","doi":"https://doi.org/10.1109/tbme.2010.2060338","title":"An Integrative Approach for In Silico Glioma Research","display_name":"An Integrative Approach for In Silico Glioma Research","publication_year":2010,"publication_date":"2010-07-26","ids":{"openalex":"https://openalex.org/W2113933145","doi":"https://doi.org/10.1109/tbme.2010.2060338","mag":"2113933145","pmid":"https://pubmed.ncbi.nlm.nih.gov/20656651"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2010.2060338","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2010.2060338","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034820084","display_name":"Lee Cooper","orcid":"https://orcid.org/0000-0002-3504-4965"},"institutions":[{"id":"https://openalex.org/I4210164546","display_name":"Comprehensive Clinical Research","ror":"https://ror.org/05mezvj34","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210164546"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lee A D Cooper","raw_affiliation_strings":["Center for Comprehensive Informatics, Atlanta, GA 30322, USA. lee.cooper@emory.edu","Emory University, Atlanta, GA, USA","Center for Comprehensive Informatics, Atlanta, GA, USA"],"affiliations":[{"raw_affiliation_string":"Center for Comprehensive Informatics, Atlanta, GA 30322, USA. lee.cooper@emory.edu","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Center for Comprehensive Informatics, Atlanta, GA, USA","institution_ids":["https://openalex.org/I4210164546"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066949209","display_name":"Jun Kong","orcid":"https://orcid.org/0000-0001-8757-8339"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Kong","raw_affiliation_strings":["Emory University, Atlanta, GA, USA"],"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073937900","display_name":"David A. Gutman","orcid":"https://orcid.org/0000-0002-1386-8701"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A Gutman","raw_affiliation_strings":["Emory University, Atlanta, GA, USA"],"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100704639","display_name":"Fusheng Wang","orcid":"https://orcid.org/0000-0002-9369-9361"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fusheng Wang","raw_affiliation_strings":["Emory University, Atlanta, GA, USA"],"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112812132","display_name":"Sharath R. Cholleti","orcid":null},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharath R Cholleti","raw_affiliation_strings":["Emory University, Atlanta, GA, USA"],"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105460573","display_name":"Tony Pan","orcid":"https://orcid.org/0000-0001-7945-6534"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tony C Pan","raw_affiliation_strings":["Emory University, Atlanta, GA, USA"],"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005946388","display_name":"Patrick Widener","orcid":"https://orcid.org/0000-0002-5882-0816"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick M Widener","raw_affiliation_strings":["Emory University, Atlanta, GA, USA"],"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079763100","display_name":"Ashish Sharma","orcid":"https://orcid.org/0000-0002-1011-6504"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashish Sharma","raw_affiliation_strings":["Emory University, Atlanta, GA, USA"],"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069699492","display_name":"Tom Mikkelsen","orcid":"https://orcid.org/0000-0001-6285-2442"},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tom Mikkelsen","raw_affiliation_strings":["Department of Neurology and Neurosurgery, Henry Ford Hospital, Detroit, MI, USA"],"affiliations":[{"raw_affiliation_string":"Department of Neurology and Neurosurgery, Henry Ford Hospital, Detroit, MI, USA","institution_ids":["https://openalex.org/I2803043754"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023589639","display_name":"Adam E. Flanders","orcid":"https://orcid.org/0000-0002-4679-0787"},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam E Flanders","raw_affiliation_strings":["Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004965117","display_name":"Daniel L. Rubin","orcid":"https://orcid.org/0000-0001-5057-4369"},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel L Rubin","raw_affiliation_strings":["Stanford University Medical Center, Stanford, CA, USA"],"affiliations":[{"raw_affiliation_string":"Stanford University Medical Center, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004","https://openalex.org/I4210137306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078040311","display_name":"Erwin G. Van Meir","orcid":"https://orcid.org/0000-0003-2444-7707"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erwin G Van Meir","raw_affiliation_strings":["Emory University, Atlanta, GA, USA"],"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037383891","display_name":"Tahsin Kur\u00e7","orcid":"https://orcid.org/0000-0001-9237-4306"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tahsin M Kurc","raw_affiliation_strings":["Emory University, Atlanta, GA, USA"],"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056719621","display_name":"Carlos S. Moreno","orcid":"https://orcid.org/0000-0002-5582-0028"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos S Moreno","raw_affiliation_strings":["Emory University, Atlanta, GA, USA"],"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078484855","display_name":"Daniel J. Brat","orcid":"https://orcid.org/0000-0002-0633-6563"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J Brat","raw_affiliation_strings":["Emory University, Atlanta, GA, USA"],"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105466808","display_name":"Joel H. Saltz","orcid":null},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel H Saltz","raw_affiliation_strings":["Emory University, Atlanta, GA, USA"],"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":16,"corresponding_author_ids":["https://openalex.org/A5034820084"],"corresponding_institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4210164546"],"apc_list":null,"apc_paid":null,"fwci":10.1952,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.97892104,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"57","issue":"10","first_page":"2617","last_page":"2621"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9889000058174133,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.8794354200363159},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"Glioblastoma","score":0.5969673991203308},{"id":"https://openalex.org/keywords/glioma","display_name":"Glioma","score":0.5942134857177734},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.560431182384491},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4588620662689209},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.4233446419239044},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3597603440284729},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.34010863304138184},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.3248092532157898},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.11334598064422607},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.09092068672180176}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.8794354200363159},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.5969673991203308},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.5942134857177734},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.560431182384491},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4588620662689209},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4233446419239044},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3597603440284729},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34010863304138184},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3248092532157898},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11334598064422607},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09092068672180176},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/tbme.2010.2060338","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2010.2060338","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:20656651","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20656651","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null},{"id":"pmh:oai:europepmc.org:2295495","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3289150","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1515242458","https://openalex.org/W1984643873","https://openalex.org/W2025183726","https://openalex.org/W2028201091","https://openalex.org/W2046796218","https://openalex.org/W2142160388","https://openalex.org/W2157667905","https://openalex.org/W2161289668","https://openalex.org/W2320804136","https://openalex.org/W3149760511"],"related_works":["https://openalex.org/W2912862995","https://openalex.org/W3129816939","https://openalex.org/W2101501829","https://openalex.org/W2985427592","https://openalex.org/W2003194288","https://openalex.org/W2060263731","https://openalex.org/W391093122","https://openalex.org/W4361305867","https://openalex.org/W2234322404","https://openalex.org/W1521239975"],"abstract_inverted_index":{"The":[0,21,97],"integration":[1],"of":[2,14,48,72,81,94,103],"imaging":[3],"and":[4,52,59,91,106],"genomic":[5,92],"data":[6,33],"is":[7,85],"critical":[8],"to":[9,29],"forming":[10],"a":[11,26],"better":[12],"understanding":[13],"disease.":[15],"Large":[16],"public":[17],"datasets,":[18],"such":[19],"as":[20],"Cancer":[22],"Genome":[23],"Atlas,":[24],"present":[25,68],"unique":[27],"opportunity":[28],"integrate":[30],"these":[31],"complementary":[32],"types":[34],"for":[35,109],"in":[36,110],"silico":[37,111],"scientific":[38],"research.":[39,112],"In":[40],"this":[41],"letter,":[42],"we":[43],"focus":[44],"on":[45],"the":[46,54,78,101],"aspect":[47],"pathology":[49],"image":[50,62],"analysis":[51,80],"illustrate":[53],"challenges":[55],"associated":[56],"with":[57,64,87],"analyzing":[58],"integrating":[60],"large-scale":[61],"datasets":[63],"molecular":[65,107],"characterizations.":[66],"We":[67],"an":[69],"example":[70],"study":[71],"diffuse":[73],"glioma":[74],"brain":[75],"tumors,":[76],"where":[77],"morphometric":[79,105],"81":[82],"million":[83],"nuclei":[84],"integrated":[86],"clinically":[88],"relevant":[89],"transcriptomic":[90],"characterizations":[93,108],"glioblastoma":[95],"tumors.":[96],"preliminary":[98],"results":[99],"demonstrate":[100],"potential":[102],"combining":[104]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":13}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}
