{"id":"https://openalex.org/W2143714033","doi":"https://doi.org/10.1109/tbme.2009.2014738","title":"Integrated Model of Endothelial NO Regulation and Systemic Circulation for the Comparison Between Pulsatile and Continuous Perfusion","display_name":"Integrated Model of Endothelial NO Regulation and Systemic Circulation for the Comparison Between Pulsatile and Continuous Perfusion","publication_year":2009,"publication_date":"2009-02-26","ids":{"openalex":"https://openalex.org/W2143714033","doi":"https://doi.org/10.1109/tbme.2009.2014738","mag":"2143714033","pmid":"https://pubmed.ncbi.nlm.nih.gov/19237340"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2009.2014738","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2009.2014738","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043740841","display_name":"Ettore Lanzarone","orcid":"https://orcid.org/0000-0001-8816-9086"},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ettore Lanzarone","raw_affiliation_strings":["Laboratory of Biological Structures Mechanics, Politecnico di Milano, 20133 Milan, Italy. ettore.lanzarone@polimi.it","Lab. of Biol. Struct. Mech., Politec. di Milano, Milan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biological Structures Mechanics, Politecnico di Milano, 20133 Milan, Italy. ettore.lanzarone@polimi.it","institution_ids":["https://openalex.org/I93860229"]},{"raw_affiliation_string":"Lab. of Biol. Struct. Mech., Politec. di Milano, Milan","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076543057","display_name":"Giustina Casagrande","orcid":"https://orcid.org/0000-0002-5852-8903"},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giustina Casagrande","raw_affiliation_strings":["Politecnico di Milano, Laboratory of Biological Structures Mechanics, Milan, Italy","Lab. of Biol. Struct. Mech., Politec. di Milano, Milan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Politecnico di Milano, Laboratory of Biological Structures Mechanics, Milan, Italy","institution_ids":["https://openalex.org/I93860229"]},{"raw_affiliation_string":"Lab. of Biol. Struct. Mech., Politec. di Milano, Milan","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103520137","display_name":"Roberto Fumero","orcid":null},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberto Fumero","raw_affiliation_strings":["Politecnico di Milano, Laboratory of Biological Structures Mechanics, Milan, Italy","Lab. of Biol. Struct. Mech., Politec. di Milano, Milan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Politecnico di Milano, Laboratory of Biological Structures Mechanics, Milan, Italy","institution_ids":["https://openalex.org/I93860229"]},{"raw_affiliation_string":"Lab. of Biol. Struct. Mech., Politec. di Milano, Milan","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018961824","display_name":"Maria Laura Costantino","orcid":"https://orcid.org/0000-0001-6974-2692"},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Laura Costantino","raw_affiliation_strings":["Politecnico di Milano, Laboratory of Biological Structures Mechanics, Milan, Italy","Lab. of Biol. Struct. Mech., Politec. di Milano, Milan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Politecnico di Milano, Laboratory of Biological Structures Mechanics, Milan, Italy","institution_ids":["https://openalex.org/I93860229"]},{"raw_affiliation_string":"Lab. of Biol. Struct. Mech., Politec. di Milano, Milan","institution_ids":["https://openalex.org/I93860229"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I93860229"],"apc_list":null,"apc_paid":null,"fwci":0.7079,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.72866114,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"56","issue":"5","first_page":"1331","last_page":"1340"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.9912999868392944,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10675","display_name":"Mechanical Circulatory Support Devices","score":0.9908999800682068,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulsatile-flow","display_name":"Pulsatile flow","score":0.9220457673072815},{"id":"https://openalex.org/keywords/perfusion","display_name":"Perfusion","score":0.6936275959014893},{"id":"https://openalex.org/keywords/endothelium","display_name":"Endothelium","score":0.5240737795829773},{"id":"https://openalex.org/keywords/constriction","display_name":"Constriction","score":0.5119673013687134},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.41355395317077637},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.4088508188724518},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.377747118473053},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3320658206939697},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.32144564390182495}],"concepts":[{"id":"https://openalex.org/C79191276","wikidata":"https://www.wikidata.org/wiki/Q7259620","display_name":"Pulsatile flow","level":2,"score":0.9220457673072815},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.6936275959014893},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.5240737795829773},{"id":"https://openalex.org/C174940676","wikidata":"https://www.wikidata.org/wiki/Q495626","display_name":"Constriction","level":2,"score":0.5119673013687134},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.41355395317077637},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4088508188724518},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.377747118473053},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3320658206939697},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32144564390182495}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002315","descriptor_name":"Cardiopulmonary Bypass","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002315","descriptor_name":"Cardiopulmonary Bypass","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002315","descriptor_name":"Cardiopulmonary Bypass","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002320","descriptor_name":"Cardiovascular Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002320","descriptor_name":"Cardiovascular Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002320","descriptor_name":"Cardiovascular Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011673","descriptor_name":"Pulsatile Flow","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011673","descriptor_name":"Pulsatile Flow","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011673","descriptor_name":"Pulsatile Flow","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052250","descriptor_name":"Nitric Oxide Synthase Type III","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052250","descriptor_name":"Nitric Oxide Synthase Type III","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052250","descriptor_name":"Nitric Oxide Synthase Type III","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055119","descriptor_name":"Elastic Modulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055119","descriptor_name":"Elastic Modulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055119","descriptor_name":"Elastic Modulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1109/tbme.2009.2014738","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2009.2014738","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:19237340","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19237340","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null},{"id":"pmh:oai:aisberg.unibg.it:10446/170353","is_oa":false,"landing_page_url":"http://hdl.handle.net/10446/170353","pdf_url":null,"source":{"id":"https://openalex.org/S4377196347","display_name":"Aisberg (University of Bergamo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I11039511","host_organization_name":"University of Bergamo","host_organization_lineage":["https://openalex.org/I11039511"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:re.public.polimi.it:11311/554895","is_oa":false,"landing_page_url":"http://hdl.handle.net/11311/554895","pdf_url":null,"source":{"id":"https://openalex.org/S4306400312","display_name":"Virtual Community of Pathological Anatomy (University of Castilla La Mancha)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I79189158","host_organization_name":"University of Castilla-La Mancha","host_organization_lineage":["https://openalex.org/I79189158"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/1","display_name":"No poverty","score":0.44999998807907104}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W23664147","https://openalex.org/W1604362023","https://openalex.org/W1966344476","https://openalex.org/W1968141837","https://openalex.org/W1990044304","https://openalex.org/W1996728375","https://openalex.org/W2002387264","https://openalex.org/W2006184287","https://openalex.org/W2010100459","https://openalex.org/W2014830922","https://openalex.org/W2024856205","https://openalex.org/W2028364766","https://openalex.org/W2054649187","https://openalex.org/W2059107906","https://openalex.org/W2068125806","https://openalex.org/W2070284330","https://openalex.org/W2078496953","https://openalex.org/W2081160920","https://openalex.org/W2081913215","https://openalex.org/W2091181219","https://openalex.org/W2094475932","https://openalex.org/W2104846745","https://openalex.org/W2112837796","https://openalex.org/W2127604369","https://openalex.org/W2127963035","https://openalex.org/W2128635269","https://openalex.org/W2132440861","https://openalex.org/W2140143190","https://openalex.org/W2148037731","https://openalex.org/W2162140829","https://openalex.org/W2177270915","https://openalex.org/W2273250957","https://openalex.org/W2324235425","https://openalex.org/W2341645605","https://openalex.org/W2357389099","https://openalex.org/W2400880132","https://openalex.org/W2413006301","https://openalex.org/W2419243513","https://openalex.org/W2461168023","https://openalex.org/W2756815368","https://openalex.org/W4214833830","https://openalex.org/W4231323928","https://openalex.org/W4234704331","https://openalex.org/W6600919360","https://openalex.org/W6679015770","https://openalex.org/W6704451951","https://openalex.org/W6715244415","https://openalex.org/W6716994877","https://openalex.org/W6744618709"],"related_works":["https://openalex.org/W2070116989","https://openalex.org/W1982466137","https://openalex.org/W111119222","https://openalex.org/W4386383647","https://openalex.org/W2068076496","https://openalex.org/W2082724546","https://openalex.org/W2085955295","https://openalex.org/W4387369608","https://openalex.org/W2376275270","https://openalex.org/W1976370882"],"abstract_inverted_index":{"Many":[0],"experimental":[1,74,169],"studies":[2],"concerning":[3,40],"nitric":[4],"oxide":[5],"(NO)":[6],"release":[7,113],"from":[8,114,175],"endothelium":[9,116],"and":[10,50,71,78,93,108,203],"its":[11],"vasodilative":[12],"action":[13],"are":[14],"available":[15,39],"in":[16,67,142,155,194],"the":[17,32,41,48,63,68,85,103,115,131,147,156,168,171,176,195],"literature,":[18],"but":[19],"no":[20],"analytical":[21],"description":[22],"or":[23,135,139],"modeling":[24,36],"of":[25,62,84,89,150,158,197,200],"these":[26,58],"phenomena":[27],"can":[28],"be":[29],"found.":[30],"On":[31],"contrary,":[33],"a":[34,60,81,151,179],"large":[35,90],"literature":[37],"is":[38,117],"other":[42],"cardiovascular":[43],"control":[44,65],"mechanisms,":[45],"such":[46],"as":[47],"myogenic":[49],"metabolic":[51],"control.":[52],"In":[53],"order":[54,143],"to":[55,129,144,162,167,188],"analytically":[56],"describe":[57],"phenomena,":[59],"model":[61,83,99,125,177],"endothelial":[64,97],"(defined":[66],"Laplace":[69],"domain":[70],"based":[72,101],"on":[73,102],"data)":[75],"was":[76,100,126],"implemented":[77],"integrated":[79],"with":[80,160,186],"lumped-parameter":[82],"systemic":[86],"circulation,":[87],"consisting":[88],"artery":[91],"segments":[92],"peripheral":[94],"networks.":[95],"The":[96,123],"regulation":[98],"hypothesis":[104],"proposed":[105],"by":[106,119],"Kuchan":[107],"Frangos,":[109],"considering":[110],"that":[111],"NO":[112],"generated":[118],"two":[120],"parallel":[121],"paths.":[122],"whole":[124],"then":[127],"applied":[128],"study":[130],"different":[132,198],"vascular":[133,181],"constriction":[134,182],"dilation":[136],"under":[137,183],"continuous":[138,159,184],"pulsatile":[140,163],"perfusion,":[141],"better":[145],"understand":[146],"clinical":[148],"evidences":[149],"poor":[152],"organ":[153],"perfusion":[154,185],"presence":[157,196],"respect":[161,187],"cardiopulmonary":[164],"bypass.":[165],"According":[166],"evidences,":[170],"main":[172],"results":[173],"obtained":[174],"revealed":[178],"widespread":[180],"pulsatile.":[189],"This":[190],"result":[191],"remains":[192],"constant":[193],"conditions":[199],"blood":[201],"parameters":[202],"flow":[204],"waveform.":[205]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}