{"id":"https://openalex.org/W2111452665","doi":"https://doi.org/10.1109/tbme.2008.2002109","title":"A Computational Model of FGF-2 Binding and HSPG Regulation Under Flow","display_name":"A Computational Model of FGF-2 Binding and HSPG Regulation Under Flow","publication_year":2009,"publication_date":"2009-03-09","ids":{"openalex":"https://openalex.org/W2111452665","doi":"https://doi.org/10.1109/tbme.2008.2002109","mag":"2111452665","pmid":"https://pubmed.ncbi.nlm.nih.gov/19272950"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2008.2002109","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2008.2002109","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2729807","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011969636","display_name":"Wensheng Shen","orcid":"https://orcid.org/0000-0002-1854-4474"},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I4210112962","display_name":"York University","ror":"https://ror.org/022jz8688","country_code":"US","type":"education","lineage":["https://openalex.org/I4210112962"]},{"id":"https://openalex.org/I4864440","display_name":"SUNY Brockport","ror":"https://ror.org/0306aeb62","country_code":"US","type":"education","lineage":["https://openalex.org/I4864440"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wensheng Shen","raw_affiliation_strings":["Department of Computational Science, State University of New York College at Brockport, Brockport, NY 14420, USA. wshen@brockport.edu","Coll. at Brockport, Dept. of Comput. Sci., State Univ. of New York, Brockport, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computational Science, State University of New York College at Brockport, Brockport, NY 14420, USA. wshen@brockport.edu","institution_ids":["https://openalex.org/I4864440","https://openalex.org/I4210112962"]},{"raw_affiliation_string":"Coll. at Brockport, Dept. of Comput. Sci., State Univ. of New York, Brockport, NY, USA","institution_ids":["https://openalex.org/I1327163397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071898642","display_name":"Changjiang Zhang","orcid":"https://orcid.org/0000-0002-2170-3878"},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Changjiang Zhang","raw_affiliation_strings":["Department of Computer Science, University of Kentucky, Lexington, KY, USA","Dept. of Comput. Sci., Univ. of Kentucky, Lexington, KY, USA#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Kentucky, Lexington, KY, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Dept. of Comput. Sci., Univ. of Kentucky, Lexington, KY, USA#TAB#","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033319049","display_name":"Michael Fannon","orcid":null},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.W. Fannon","raw_affiliation_strings":["Department of Ophthamology and Visual Science, University of Kentucky, Lexington, KY, USA","[Department of Ophthamology and Visual Science, University of Kentucky, Lexington, KY, USA]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthamology and Visual Science, University of Kentucky, Lexington, KY, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"[Department of Ophthamology and Visual Science, University of Kentucky, Lexington, KY, USA]","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042236151","display_name":"Kimberly Forsten\u2010Williams","orcid":null},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Forsten-Williams","raw_affiliation_strings":["Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA","Department of Chemical Engineering Virginia Polytechnic Institute and State University Blacksburg VA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"Department of Chemical Engineering Virginia Polytechnic Institute and State University Blacksburg VA USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100433119","display_name":"Jun Zhang","orcid":"https://orcid.org/0000-0002-1826-6099"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2324,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.78767263,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"56","issue":"9","first_page":"2147","last_page":"2155"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.516014575958252},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.47420433163642883},{"id":"https://openalex.org/keywords/flow","display_name":"Flow (mathematics)","score":0.45957422256469727},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.41144615411758423},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4002847671508789},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.393629252910614},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.25060105323791504},{"id":"https://openalex.org/keywords/mechanics","display_name":"Mechanics","score":0.2213699221611023},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.19677677750587463}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.516014575958252},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.47420433163642883},{"id":"https://openalex.org/C38349280","wikidata":"https://www.wikidata.org/wiki/Q1434290","display_name":"Flow (mathematics)","level":2,"score":0.45957422256469727},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41144615411758423},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4002847671508789},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.393629252910614},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25060105323791504},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.2213699221611023},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.19677677750587463}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012212","descriptor_name":"Rheology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012212","descriptor_name":"Rheology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012212","descriptor_name":"Rheology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012212","descriptor_name":"Rheology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017468","descriptor_name":"Receptors, Fibroblast Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017468","descriptor_name":"Receptors, Fibroblast Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017468","descriptor_name":"Receptors, Fibroblast Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017468","descriptor_name":"Receptors, Fibroblast Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019149","descriptor_name":"Bioreactors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019149","descriptor_name":"Bioreactors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019149","descriptor_name":"Bioreactors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019149","descriptor_name":"Bioreactors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019812","descriptor_name":"Heparan Sulfate Proteoglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019812","descriptor_name":"Heparan Sulfate Proteoglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019812","descriptor_name":"Heparan Sulfate Proteoglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019812","descriptor_name":"Heparan Sulfate Proteoglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/tbme.2008.2002109","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2008.2002109","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:19272950","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19272950","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:2729807","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2729807","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans Biomed Eng","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2729807","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2729807","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans Biomed Eng","raw_type":"Text"},"sustainable_development_goals":[{"score":0.5400000214576721,"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W61761228","https://openalex.org/W126059566","https://openalex.org/W1581983308","https://openalex.org/W1943173994","https://openalex.org/W1968512837","https://openalex.org/W1974489896","https://openalex.org/W1977909615","https://openalex.org/W1977913288","https://openalex.org/W1985804036","https://openalex.org/W1985811499","https://openalex.org/W1995464852","https://openalex.org/W1996605326","https://openalex.org/W2025145489","https://openalex.org/W2031315926","https://openalex.org/W2038785086","https://openalex.org/W2070584222","https://openalex.org/W2075161553","https://openalex.org/W2097097666","https://openalex.org/W2099897830","https://openalex.org/W2102771902","https://openalex.org/W2124192278","https://openalex.org/W2135070789","https://openalex.org/W2138321569","https://openalex.org/W2150936201","https://openalex.org/W2159041180","https://openalex.org/W2166085065","https://openalex.org/W2744008313","https://openalex.org/W4297978922","https://openalex.org/W6640822977"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W2078814861","https://openalex.org/W2527526854","https://openalex.org/W2062208111","https://openalex.org/W1976181487","https://openalex.org/W1986764834"],"abstract_inverted_index":{"A":[0],"novel":[1],"convection-diffusion-reaction":[2],"model":[3,33,115,145],"is":[4,59,77],"developed":[5],"to":[6,13,123,151],"simulate":[7],"fibroblast":[8],"growth":[9,118,140,159],"factor":[10,119,160],"(FGF-2)":[11],"binding":[12,122],"cell":[14],"surface":[15],"receptors":[16,124],"(FGFRs)":[17],"and":[18,45,61,97,108,121,162],"heparan":[19,129],"sulfate":[20],"proteoglycans":[21],"(HSPGs)":[22],"under":[23],"flow":[24,104,137,157],"conditions":[25],"within":[26,165],"a":[27,36,46,64,80,148],"cylindrical-shaped":[28],"vessel":[29],"or":[30],"capillary.":[31],"The":[32,55,74,90],"consists":[34],"of":[35,38,48,93,128,136,155],"set":[37,47],"coupled":[39,49],"nonlinear":[40,50],"partial":[41],"differential":[42,52],"equations":[43,53],"(PDEs)":[44],"ordinary":[51],"(ODEs).":[54],"time-dependent":[56],"PDE":[57],"system":[58,76],"discretized":[60],"solved":[62,78],"by":[63,79],"second-order":[65],"implicit":[66],"Euler":[67],"scheme":[68],"using":[69,85],"the":[70,114,126,134,153,166],"finite":[71],"volume":[72],"method.":[73],"ODE":[75,82],"stiff":[81],"solver":[83],"VODE":[84],"backward":[86],"differencing":[87],"formulation":[88],"(BDF).":[89],"transient":[91],"solution":[92],"FGF-2,":[94],"FGFR,":[95],"HSPG,":[96],"their":[98],"bound":[99],"complexes":[100],"for":[101],"three":[102],"different":[103],"rates":[105],"are":[106],"computed":[107],"presented.":[109],"Simulation":[110],"results":[111],"indicate":[112],"that":[113],"can":[116],"predict":[117],"transport":[120],"with/without":[125],"presence":[127],"sulfate,":[130],"as":[131,133],"well":[132],"effect":[135],"rate":[138],"on":[139,158],"factor-receptor":[141],"binding.":[142],"Our":[143],"computational":[144],"may":[146],"provide":[147],"useful":[149],"means":[150],"investigate":[152],"impact":[154],"fluid":[156],"dynamics,":[161],"ultimately,":[163],"signaling":[164],"circulation.":[167]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
