{"id":"https://openalex.org/W4388820050","doi":"https://doi.org/10.1109/tbdata.2023.3334673","title":"AMDECDA: Attention Mechanism Combined With Data Ensemble Strategy for Predicting CircRNA-Disease Association","display_name":"AMDECDA: Attention Mechanism Combined With Data Ensemble Strategy for Predicting CircRNA-Disease Association","publication_year":2023,"publication_date":"2023-11-20","ids":{"openalex":"https://openalex.org/W4388820050","doi":"https://doi.org/10.1109/tbdata.2023.3334673"},"language":"en","primary_location":{"id":"doi:10.1109/tbdata.2023.3334673","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbdata.2023.3334673","pdf_url":null,"source":{"id":"https://openalex.org/S2491400915","display_name":"IEEE Transactions on Big Data","issn_l":"2332-7790","issn":["2332-7790","2372-2096"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320439","host_organization_name":"IEEE Computer Society","host_organization_lineage":["https://openalex.org/P4310320439","https://openalex.org/P4310319808"],"host_organization_lineage_names":["IEEE Computer Society","Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Big Data","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100436059","display_name":"Lei Wang","orcid":"https://orcid.org/0000-0003-0184-307X"},"institutions":[{"id":"https://openalex.org/I25757504","display_name":"China University of Mining and Technology","ror":"https://ror.org/01xt2dr21","country_code":"CN","type":"education","lineage":["https://openalex.org/I25757504"]},{"id":"https://openalex.org/I4210165264","display_name":"Guangxi Academy of Sciences","ror":"https://ror.org/054x1kd82","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210165264"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Wang","raw_affiliation_strings":["School of Computer Science and Technology, China University of Mining and Technology, Xuzhou, China","Guangxi Academy of Sciences, Nanning, Chinaf"],"raw_orcid":"https://orcid.org/0000-0003-0184-307X","affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, China University of Mining and Technology, Xuzhou, China","institution_ids":["https://openalex.org/I25757504"]},{"raw_affiliation_string":"Guangxi Academy of Sciences, Nanning, Chinaf","institution_ids":["https://openalex.org/I4210165264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101604712","display_name":"Leon Wong","orcid":"https://orcid.org/0000-0002-6864-991X"},"institutions":[{"id":"https://openalex.org/I4210152380","display_name":"Shenzhen Technology University","ror":"https://ror.org/04qzpec27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210152380"]},{"id":"https://openalex.org/I4210159676","display_name":"Zaozhuang University","ror":"https://ror.org/05x21tp94","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210159676"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Leon Wong","raw_affiliation_strings":["College of Big Data and Internet, Shenzhen Technology University, Shenzhen, China","School of Information Science and Engineering, Zaozhuang University, Zaozhuang, China"],"raw_orcid":"https://orcid.org/0000-0002-6864-991X","affiliations":[{"raw_affiliation_string":"College of Big Data and Internet, Shenzhen Technology University, Shenzhen, China","institution_ids":["https://openalex.org/I4210152380"]},{"raw_affiliation_string":"School of Information Science and Engineering, Zaozhuang University, Zaozhuang, China","institution_ids":["https://openalex.org/I4210159676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019805735","display_name":"Zhu\u2010Hong You","orcid":"https://orcid.org/0000-0003-1266-2696"},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhu-Hong You","raw_affiliation_strings":["School of Computer Science, Northwestern Polytechnical University, Xi'an, China"],"raw_orcid":"https://orcid.org/0000-0003-1266-2696","affiliations":[{"raw_affiliation_string":"School of Computer Science, Northwestern Polytechnical University, Xi'an, China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060381913","display_name":"De-Shuang Huang","orcid":"https://orcid.org/0000-0002-6759-2691"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4394709157","display_name":"Eastern Institute of Technology, Ningbo","ror":"https://ror.org/036mbz113","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709157"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"De-Shuang Huang","raw_affiliation_strings":["Eastern Institute for Advanced Study, Eastern Institute of Technology, Ningbo, Zhejiang, China","Institute of Machine Learning and Systems Biology, School of Electronics and Information Engineering, Tongji University, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0002-6759-2691","affiliations":[{"raw_affiliation_string":"Eastern Institute for Advanced Study, Eastern Institute of Technology, Ningbo, Zhejiang, China","institution_ids":["https://openalex.org/I4394709157"]},{"raw_affiliation_string":"Institute of Machine Learning and Systems Biology, School of Electronics and Information Engineering, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.9959,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.96745947,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"10","issue":"4","first_page":"320","last_page":"329"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7900223135948181},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.5926472544670105},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4639458656311035},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4424525201320648},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.43426239490509033},{"id":"https://openalex.org/keywords/benchmark","display_name":"Benchmark (surveying)","score":0.4312407970428467},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.40045303106307983},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.11079418659210205}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7900223135948181},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5926472544670105},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4639458656311035},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4424525201320648},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.43426239490509033},{"id":"https://openalex.org/C185798385","wikidata":"https://www.wikidata.org/wiki/Q1161707","display_name":"Benchmark (surveying)","level":2,"score":0.4312407970428467},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.40045303106307983},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11079418659210205},{"id":"https://openalex.org/C13280743","wikidata":"https://www.wikidata.org/wiki/Q131089","display_name":"Geodesy","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/tbdata.2023.3334673","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbdata.2023.3334673","pdf_url":null,"source":{"id":"https://openalex.org/S2491400915","display_name":"IEEE Transactions on Big Data","issn_l":"2332-7790","issn":["2332-7790","2372-2096"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320439","host_organization_name":"IEEE Computer Society","host_organization_lineage":["https://openalex.org/P4310320439","https://openalex.org/P4310319808"],"host_organization_lineage_names":["IEEE Computer Society","Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Big Data","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3588239447","display_name":null,"funder_award_id":"61702444","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4306865477","display_name":null,"funder_award_id":"ZR2022LZL003","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"},{"id":"https://openalex.org/G7911954467","display_name":null,"funder_award_id":"62172355","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324174","display_name":"Natural Science Foundation of Shandong Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W2018780815","https://openalex.org/W2029838682","https://openalex.org/W2141222510","https://openalex.org/W2323385078","https://openalex.org/W2617446819","https://openalex.org/W2800766678","https://openalex.org/W2802780709","https://openalex.org/W2807602500","https://openalex.org/W2898991725","https://openalex.org/W2906953716","https://openalex.org/W2909637325","https://openalex.org/W2919182022","https://openalex.org/W2940511651","https://openalex.org/W2948996631","https://openalex.org/W2949259826","https://openalex.org/W2951739649","https://openalex.org/W2953428282","https://openalex.org/W2980767508","https://openalex.org/W2981316968","https://openalex.org/W2991743543","https://openalex.org/W3006715646","https://openalex.org/W3014454282","https://openalex.org/W3014858999","https://openalex.org/W3016565860","https://openalex.org/W3025043200","https://openalex.org/W3026308742","https://openalex.org/W3085038881","https://openalex.org/W3092486253","https://openalex.org/W3093030756","https://openalex.org/W3106430627","https://openalex.org/W3117187745","https://openalex.org/W3119572516","https://openalex.org/W3138507232","https://openalex.org/W3141142801","https://openalex.org/W3142426520","https://openalex.org/W3156969875","https://openalex.org/W3158198533","https://openalex.org/W3163629447","https://openalex.org/W3174376470","https://openalex.org/W3179782236","https://openalex.org/W3189024187","https://openalex.org/W3198879735","https://openalex.org/W4205478771","https://openalex.org/W4210852391","https://openalex.org/W4213277551","https://openalex.org/W4225873739","https://openalex.org/W4286373989","https://openalex.org/W4292263641","https://openalex.org/W4294990936","https://openalex.org/W4296394114","https://openalex.org/W4296580708","https://openalex.org/W4310456519","https://openalex.org/W4318624508","https://openalex.org/W4375955768","https://openalex.org/W4385330534","https://openalex.org/W4385564848"],"related_works":["https://openalex.org/W2378211422","https://openalex.org/W4321353415","https://openalex.org/W2745001401","https://openalex.org/W2130974462","https://openalex.org/W2028665553","https://openalex.org/W2086519370","https://openalex.org/W4246352526","https://openalex.org/W2121910908","https://openalex.org/W915438175","https://openalex.org/W4230315250"],"abstract_inverted_index":{"Accumulating":[0],"evidence":[1],"from":[2],"recent":[3],"research":[4,33],"reveals":[5],"that":[6,179],"circRNA":[7,26,66],"is":[8,110],"tightly":[9],"bound":[10],"to":[11,87,112],"human":[12],"complex":[13],"disease":[14,22,35,71,74],"and":[15,55,73,76,98,114,186],"plays":[16],"an":[17,137],"important":[18],"regulatory":[19],"role":[20,30],"in":[21,31,118,146],"progression.":[23],"Identifying":[24],"disease-associated":[25],"occupies":[27],"a":[28,42,142],"key":[29],"the":[32,62,79,90,104,119,126,131,161,173],"of":[34,82,93,122,139,144,160,166],"pathogenesis.":[36],"In":[37,125,149],"this":[38],"study,":[39],"we":[40,60],"propose":[41],"new":[43],"model":[44],"AMDECDA":[45,135,154,167,180],"for":[46,189],"predicting":[47],"circRNA-disease":[48],"association":[49],"(CDA)":[50],"by":[51,172],"combining":[52],"attention":[53,80],"mechanism":[54,81],"data":[56,133],"ensemble":[57,105],"strategy.":[58],"Firstly,":[59],"fuse":[61],"heterogeneous":[63],"information":[64,92],"including":[65],"Gaussian":[67],"interaction":[68],"profile":[69],"(GIP),":[70],"semantics":[72],"GIP,":[75],"then":[77],"use":[78],"Graph":[83],"Attention":[84],"Network":[85],"(GAT)":[86],"focus":[88],"on":[89,130],"critical":[91],"data,":[94],"reasonably":[95],"allocate":[96],"resources":[97],"extract":[99],"their":[100],"essential":[101],"features.":[102],"Finally,":[103],"deep":[106],"RVFL":[107],"network":[108],"(edRVFL)":[109],"utilized":[111],"quickly":[113],"accurately":[115],"predict":[116],"CDA":[117,185],"non-iterative":[120],"manner":[121],"closed-form":[123],"solutions.":[124],"five-fold":[127],"cross-validation":[128],"experiment":[129],"benchmark":[132],"set,":[134],"achieves":[136],"accuracy":[138],"93.10%":[140],"with":[141,151],"sensitivity":[143],"97.56%":[145],"0.9235":[147],"AUC.":[148],"comparison":[150],"previous":[152],"models,":[153],"exhibits":[155],"highly":[156],"competitiveness.":[157],"Furthermore,":[158],"26":[159],"top":[162],"30":[163],"unknown":[164],"CDAs":[165],"predicted":[168],"scores":[169],"are":[170],"proved":[171],"related":[174],"literature.":[175],"These":[176],"results":[177],"indicate":[178],"can":[181],"effectively":[182],"anticipate":[183],"latent":[184],"provide":[187],"help":[188],"further":[190],"biological":[191],"wet":[192],"experiments.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":27},{"year":2024,"cited_by_count":18}],"updated_date":"2026-07-16T13:24:37.021932","created_date":"2025-10-10T00:00:00"}