{"id":"https://openalex.org/W4377001555","doi":"https://doi.org/10.1109/tbcas.2023.3277398","title":"A Transcutaneous Carbon Dioxide Monitor Based on Time-Domain Dual Lifetime Referencing","display_name":"A Transcutaneous Carbon Dioxide Monitor Based on Time-Domain Dual Lifetime Referencing","publication_year":2023,"publication_date":"2023-05-17","ids":{"openalex":"https://openalex.org/W4377001555","doi":"https://doi.org/10.1109/tbcas.2023.3277398","pmid":"https://pubmed.ncbi.nlm.nih.gov/37195846"},"language":"en","primary_location":{"id":"doi:10.1109/tbcas.2023.3277398","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbcas.2023.3277398","pdf_url":null,"source":{"id":"https://openalex.org/S80299757","display_name":"IEEE Transactions on Biomedical Circuits and Systems","issn_l":"1932-4545","issn":["1932-4545","1940-9990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Circuits and Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059290570","display_name":"Tuna B. Tufan","orcid":"https://orcid.org/0000-0001-6905-1576"},"institutions":[{"id":"https://openalex.org/I107077323","display_name":"Worcester Polytechnic Institute","ror":"https://ror.org/05ejpqr48","country_code":"US","type":"education","lineage":["https://openalex.org/I107077323"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tuna B. Tufan","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Worcester Polytechnic Institute, Worcester, MA, USA"],"raw_orcid":"https://orcid.org/0000-0001-6905-1576","affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Worcester Polytechnic Institute, Worcester, MA, USA","institution_ids":["https://openalex.org/I107077323"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031435587","display_name":"\u00dclk\u00fchan G\u00fcler","orcid":"https://orcid.org/0000-0002-4723-4424"},"institutions":[{"id":"https://openalex.org/I107077323","display_name":"Worcester Polytechnic Institute","ror":"https://ror.org/05ejpqr48","country_code":"US","type":"education","lineage":["https://openalex.org/I107077323"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ulkuhan Guler","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Worcester Polytechnic Institute, Worcester, MA, USA"],"raw_orcid":"https://orcid.org/0000-0002-4723-4424","affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Worcester Polytechnic Institute, Worcester, MA, USA","institution_ids":["https://openalex.org/I107077323"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.8004,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.93760027,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"17","issue":"4","first_page":"795","last_page":"807"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11196","display_name":"Non-Invasive Vital Sign Monitoring","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carbon-dioxide","display_name":"Carbon dioxide","score":0.777703583240509},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.5785149335861206},{"id":"https://openalex.org/keywords/hyperventilation","display_name":"Hyperventilation","score":0.5272200107574463},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.4945327937602997},{"id":"https://openalex.org/keywords/carbon-dioxide-sensor","display_name":"Carbon dioxide sensor","score":0.48506560921669006},{"id":"https://openalex.org/keywords/partial-pressure","display_name":"Partial pressure","score":0.4803534746170044},{"id":"https://openalex.org/keywords/luminescence","display_name":"Luminescence","score":0.4491437077522278},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3414694666862488},{"id":"https://openalex.org/keywords/optoelectronics","display_name":"Optoelectronics","score":0.2708311080932617},{"id":"https://openalex.org/keywords/oxygen","display_name":"Oxygen","score":0.24781745672225952},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.1803480088710785},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1649300754070282},{"id":"https://openalex.org/keywords/anesthesia","display_name":"Anesthesia","score":0.1278410255908966}],"concepts":[{"id":"https://openalex.org/C530467964","wikidata":"https://www.wikidata.org/wiki/Q1997","display_name":"Carbon dioxide","level":2,"score":0.777703583240509},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5785149335861206},{"id":"https://openalex.org/C2777449187","wikidata":"https://www.wikidata.org/wiki/Q575168","display_name":"Hyperventilation","level":2,"score":0.5272200107574463},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4945327937602997},{"id":"https://openalex.org/C113803762","wikidata":"https://www.wikidata.org/wiki/Q5037960","display_name":"Carbon dioxide sensor","level":3,"score":0.48506560921669006},{"id":"https://openalex.org/C68463220","wikidata":"https://www.wikidata.org/wiki/Q27165","display_name":"Partial pressure","level":3,"score":0.4803534746170044},{"id":"https://openalex.org/C148869448","wikidata":"https://www.wikidata.org/wiki/Q184240","display_name":"Luminescence","level":2,"score":0.4491437077522278},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3414694666862488},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.2708311080932617},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.24781745672225952},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1803480088710785},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1649300754070282},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.1278410255908966},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001785","descriptor_name":"Blood Gas Monitoring, Transcutaneous","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D001785","descriptor_name":"Blood Gas Monitoring, Transcutaneous","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D001785","descriptor_name":"Blood Gas Monitoring, Transcutaneous","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tbcas.2023.3277398","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbcas.2023.3277398","pdf_url":null,"source":{"id":"https://openalex.org/S80299757","display_name":"IEEE Transactions on Biomedical Circuits and Systems","issn_l":"1932-4545","issn":["1932-4545","1940-9990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Circuits and Systems","raw_type":"journal-article"},{"id":"pmid:37195846","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37195846","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on biomedical circuits and systems","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3762462460","display_name":null,"funder_award_id":"EECS-2143898","funder_id":"https://openalex.org/F4320335353","funder_display_name":"National Science Foundation of Sri Lanka"}],"funders":[{"id":"https://openalex.org/F4320335353","display_name":"National Science Foundation of Sri Lanka","ror":"https://ror.org/010xaa060"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1521372868","https://openalex.org/W1602789896","https://openalex.org/W1964990013","https://openalex.org/W1982974441","https://openalex.org/W2000547075","https://openalex.org/W2001890557","https://openalex.org/W2016930478","https://openalex.org/W2019392760","https://openalex.org/W2044208422","https://openalex.org/W2053856970","https://openalex.org/W2071500083","https://openalex.org/W2081262105","https://openalex.org/W2112451691","https://openalex.org/W2196354034","https://openalex.org/W2223147105","https://openalex.org/W2491458126","https://openalex.org/W2585802439","https://openalex.org/W2620916556","https://openalex.org/W2771902180","https://openalex.org/W2775645691","https://openalex.org/W2791371985","https://openalex.org/W2795473041","https://openalex.org/W2943995087","https://openalex.org/W2952611328","https://openalex.org/W2987631307","https://openalex.org/W3033851921","https://openalex.org/W3082779101","https://openalex.org/W3091177011","https://openalex.org/W3097564282","https://openalex.org/W3122334817","https://openalex.org/W3163417018","https://openalex.org/W3175713954","https://openalex.org/W3181013774","https://openalex.org/W3202825965","https://openalex.org/W4200087685","https://openalex.org/W4200372773","https://openalex.org/W4210257803","https://openalex.org/W4280635619","https://openalex.org/W4294176545","https://openalex.org/W4309263354","https://openalex.org/W4309270032","https://openalex.org/W4323022471","https://openalex.org/W4389538395"],"related_works":["https://openalex.org/W1989715959","https://openalex.org/W2103576898","https://openalex.org/W2047018826","https://openalex.org/W4390993395","https://openalex.org/W2067448486","https://openalex.org/W2409053344","https://openalex.org/W4309263354","https://openalex.org/W2735601241","https://openalex.org/W4388892442","https://openalex.org/W2170958020"],"abstract_inverted_index":{"The":[0,203],"partial":[1,105],"pressure":[2,106],"of":[3,18,52,107,183,209,218],"arterial":[4,35,53],"carbon":[5,54,76,108,194],"dioxide":[6,77,109],"plays":[7],"a":[8,43,49,72,81,86,176,212],"critical":[9],"role":[10],"in":[11,66,103,136,151,187,192],"assessing":[12],"the":[13,19,96,104,111,117,121,140,158,181,184],"acid-base":[14],"and":[15,27,85,149,169],"respiratory":[16],"status":[17],"human":[20,177],"body.":[21],"Typically,":[22],"this":[23],"measurement":[24,131,173],"is":[25,38,42,59,127,211],"invasive":[26],"can":[28],"only":[29],"be":[30],"taken":[31],"momentarily":[32],"when":[33],"an":[34],"blood":[36],"sample":[37],"drawn.":[39],"Transcutaneous":[40],"monitoring":[41],"noninvasive":[44],"surrogate":[45],"method":[46,126,186],"that":[47,79],"provides":[48],"continuous":[50],"measure":[51],"dioxide.":[55],"Unfortunately,":[56],"current":[57],"technology":[58],"limited":[60],"to":[61,99,116,130,146,172],"bedside":[62],"instruments":[63],"mainly":[64],"used":[65],"intensive":[67],"care":[68],"units.":[69],"We":[70],"developed":[71],"first-of-its-kind":[73],"miniaturized":[74],"transcutaneous":[75,193],"monitor":[78],"utilizes":[80],"luminescence":[82,118],"sensing":[83,159],"film":[84,160],"time-domain":[87,122],"dual":[88,123],"lifetime":[89,124],"referencing":[90,125],"method.":[91],"Gas":[92],"cell":[93],"experiments":[94],"confirmed":[95],"monitor's":[97],"ability":[98],"accurately":[100],"identify":[101],"changes":[102,135,191],"within":[110],"clinically":[112],"significant":[113],"range.":[114],"Compared":[115],"intensity-based":[119],"technique,":[120],"less":[128],"prone":[129],"errors":[132],"caused":[133],"by":[134,161],"excitation":[137],"strength,":[138],"reducing":[139],"maximum":[141],"error":[142],"from":[143],"\u223c":[144,147,199],"40%":[145],"3%":[148],"resulting":[150],"more":[152],"reliable":[153],"readings.":[154],"Additionally,":[155],"we":[156],"analyzed":[157],"investigating":[162],"its":[163,170],"behavior":[164],"under":[165],"various":[166],"confounding":[167],"factors":[168],"susceptibility":[171],"drift.":[174],"Finally,":[175],"subject":[178],"test":[179],"demonstrated":[180],"effectiveness":[182],"applied":[185],"detecting":[188],"even":[189],"slight":[190],"dioxide,":[195],"as":[196,198],"small":[197],"0.7%,":[200],"during":[201],"hyperventilation.":[202],"prototype,":[204],"which":[205],"consumes":[206],"30.1":[207],"mW":[208],"power,":[210],"wearable":[213],"wristband":[214],"with":[215],"compact":[216],"dimensions":[217],"37":[219],"mm\u00d7":[220],"32":[221],"mm.":[222]},"counts_by_year":[{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":2}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}