{"id":"https://openalex.org/W3193480802","doi":"https://doi.org/10.1109/tbcas.2021.3107805","title":"Microscope-FTIR Spectrometry Based Sensor for Neurotransmitters Detection","display_name":"Microscope-FTIR Spectrometry Based Sensor for Neurotransmitters Detection","publication_year":2021,"publication_date":"2021-08-25","ids":{"openalex":"https://openalex.org/W3193480802","doi":"https://doi.org/10.1109/tbcas.2021.3107805","mag":"3193480802","pmid":"https://pubmed.ncbi.nlm.nih.gov/34432634"},"language":"en","primary_location":{"id":"doi:10.1109/tbcas.2021.3107805","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbcas.2021.3107805","pdf_url":null,"source":{"id":"https://openalex.org/S80299757","display_name":"IEEE Transactions on Biomedical Circuits and Systems","issn_l":"1932-4545","issn":["1932-4545","1940-9990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Circuits and Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061885085","display_name":"Hamza Landari","orcid":"https://orcid.org/0000-0002-0154-9789"},"institutions":[{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Hamza Landari","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Laval University, Quebec City, Canada","Department of Physics, Engineering Physics and Optics, Center for Optics, Photonics and Lasers (COPL), Quebec City, Canada","LABioTRON Bio-Engineering Research Laboratory, Research Centre for Advanced Materials (CERMA), Quebec City, Canada"],"raw_orcid":"https://orcid.org/0000-0002-0154-9789","affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Laval University, Quebec City, Canada","institution_ids":["https://openalex.org/I43406934"]},{"raw_affiliation_string":"Department of Physics, Engineering Physics and Optics, Center for Optics, Photonics and Lasers (COPL), Quebec City, Canada","institution_ids":[]},{"raw_affiliation_string":"LABioTRON Bio-Engineering Research Laboratory, Research Centre for Advanced Materials (CERMA), Quebec City, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080759731","display_name":"Youn\u00e8s Messaddeq","orcid":"https://orcid.org/0000-0002-0868-2726"},"institutions":[{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Younes Messaddeq","raw_affiliation_strings":["Department of Physics, Engineering Physics and Optics, Laval University, Quebec City, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, Engineering Physics and Optics, Laval University, Quebec City, Canada","institution_ids":["https://openalex.org/I43406934"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053817761","display_name":"Amine Miled","orcid":"https://orcid.org/0000-0002-1766-7528"},"institutions":[{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Amine Miled","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Laval University, Quebec City, Canada","Research Centre for Advanced Materials (CERMA), Quebec City, Canada"],"raw_orcid":"https://orcid.org/0000-0002-1766-7528","affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Laval University, Quebec City, Canada","institution_ids":["https://openalex.org/I43406934"]},{"raw_affiliation_string":"Research Centre for Advanced Materials (CERMA), Quebec City, Canada","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2419,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.84801332,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"15","issue":"5","first_page":"938","last_page":"948"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11472","display_name":"Analytical Chemistry and Sensors","score":0.9927999973297119,"subfield":{"id":"https://openalex.org/subfields/1502","display_name":"Bioengineering"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fourier-transform-infrared-spectroscopy","display_name":"Fourier transform infrared spectroscopy","score":0.6882959604263306},{"id":"https://openalex.org/keywords/analytical-chemistry","display_name":"Analytical Chemistry (journal)","score":0.6192864775657654},{"id":"https://openalex.org/keywords/ascorbic-acid","display_name":"Ascorbic acid","score":0.6125178933143616},{"id":"https://openalex.org/keywords/microscope","display_name":"Microscope","score":0.5643666982650757},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5416020154953003},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.4589885175228119},{"id":"https://openalex.org/keywords/aqueous-solution","display_name":"Aqueous solution","score":0.44907668232917786},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3694048523902893},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.14267215132713318},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.12809908390045166}],"concepts":[{"id":"https://openalex.org/C160892712","wikidata":"https://www.wikidata.org/wiki/Q901559","display_name":"Fourier transform infrared spectroscopy","level":2,"score":0.6882959604263306},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.6192864775657654},{"id":"https://openalex.org/C2986274086","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Ascorbic acid","level":2,"score":0.6125178933143616},{"id":"https://openalex.org/C67649825","wikidata":"https://www.wikidata.org/wiki/Q196538","display_name":"Microscope","level":2,"score":0.5643666982650757},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5416020154953003},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4589885175228119},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.44907668232917786},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3694048523902893},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.14267215132713318},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.12809908390045166},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017550","descriptor_name":"Spectroscopy, Fourier Transform Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017550","descriptor_name":"Spectroscopy, Fourier Transform Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017550","descriptor_name":"Spectroscopy, Fourier Transform Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tbcas.2021.3107805","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbcas.2021.3107805","pdf_url":null,"source":{"id":"https://openalex.org/S80299757","display_name":"IEEE Transactions on Biomedical Circuits and Systems","issn_l":"1932-4545","issn":["1932-4545","1940-9990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Circuits and Systems","raw_type":"journal-article"},{"id":"pmid:34432634","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34432634","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on biomedical circuits and systems","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Clean water and sanitation","score":0.5299999713897705,"id":"https://metadata.un.org/sdg/6"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1529899878","https://openalex.org/W1624473174","https://openalex.org/W2017437986","https://openalex.org/W2107387895","https://openalex.org/W2156866094","https://openalex.org/W2157425349","https://openalex.org/W2159928621","https://openalex.org/W2170281990","https://openalex.org/W2171176699","https://openalex.org/W2332411379","https://openalex.org/W2483924485","https://openalex.org/W2520790663","https://openalex.org/W2522119026","https://openalex.org/W2602745533","https://openalex.org/W2638987837","https://openalex.org/W2775477995","https://openalex.org/W2780450343","https://openalex.org/W2890695728","https://openalex.org/W2897687447","https://openalex.org/W2922344389","https://openalex.org/W2954096078","https://openalex.org/W2987309209","https://openalex.org/W2989922051","https://openalex.org/W3001326673","https://openalex.org/W3002486440","https://openalex.org/W3164625222","https://openalex.org/W4256487088","https://openalex.org/W4300621778","https://openalex.org/W6634627481"],"related_works":["https://openalex.org/W2085044184","https://openalex.org/W4290258708","https://openalex.org/W2239919633","https://openalex.org/W2410155092","https://openalex.org/W1491785374","https://openalex.org/W1992943367","https://openalex.org/W2385551767","https://openalex.org/W2130767824","https://openalex.org/W2394979372","https://openalex.org/W2265489283"],"abstract_inverted_index":{"In":[0,75],"this":[1,24],"work,":[2],"we":[3],"present":[4],"a":[5,28,39,43,54,71,85,120],"new":[6,29,86,164],"sensing":[7],"approach":[8],"for":[9,19,33,47,184,188,192,196,199,203],"aqueous":[10],"samples":[11],"based":[12,37,68,100,155],"on":[13,38,70,101,107,156],"the":[14,34,93,102,114,157,163,166],"microscope-FTIR":[15,35,115],"spectrometer":[16,36,116],"and":[17,50,53,99,130,149,174,201],"applied":[18],"neurotransmitters.":[20],"Our":[21],"contribution":[22,81],"in":[23,128,172],"work":[25],"consists":[26,82],"of":[27,79,83,92,104,182],"sample":[30,51,59,63],"handling":[31,64],"system":[32,56,65],"total":[40,72],"reflective":[41,73],"mirror,":[42],"heated":[44],"hydrophobic":[45],"layer":[46],"solvent":[48],"removal/evaporation":[49],"confinement":[52],"microfluidic":[55],"that":[57],"handles":[58],"injection":[60],"unlike":[61],"standard":[62],"which":[66],"was":[67,117],"only":[69],"mirror.":[74],"addition,":[76],"another":[77],"part":[78],"our":[80],"proposing":[84],"algorithm":[87,123,158],"to":[88,124],"extract":[89],"molecular":[90],"composition":[91],"solution":[94],"with":[95,133,177],"high":[96,134],"estimation":[97,179],"ratios":[98],"analysis":[103],"detected":[105],"peaks":[106],"IR":[108],"spectra.":[109],"The":[110,152],"data":[111],"acquired":[112],"from":[113],"analyzed":[118],"by":[119],"newly":[121],"developed":[122,159],"identify":[125],"each":[126],"neurotransmitter":[127,139],"homogeneous":[129,173],"non-homogeneous":[131],"solutions":[132,176],"selectivity.":[135],"We":[136],"used":[137],"six":[138,167],"molecules":[140],"(Dopamine":[141],"hydrochloride,":[142,186],"L-Ascorbic":[143,189],"acid,":[144,190],"Acetylcholine":[145,193],"chloride,":[146,194],"y-Aminobutyric,":[147],"Glycine":[148],"L-Glutamic":[150],"acid).":[151],"results":[153],"obtained":[154],"showed":[160],"that,":[161],"using":[162],"system,":[165],"neurotransmitters":[168],"can":[169],"be":[170],"identified":[171],"mixture":[175],"an":[178],"ratio":[180],"range":[181],"88.8%-100%":[183],"Dopamine":[185],"80%-100%":[187],"75%-100%":[191,195,202],"L-Glutamic,":[197],"77.7%-100%":[198],"y-Aminobutyric":[200],"Glycine.":[204]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}