{"id":"https://openalex.org/W2925059790","doi":"https://doi.org/10.1109/tbcas.2019.2907074","title":"An Artificial Tissue Homeostasis Circuit Designed via Analog Circuit Techniques","display_name":"An Artificial Tissue Homeostasis Circuit Designed via Analog Circuit Techniques","publication_year":2019,"publication_date":"2019-03-25","ids":{"openalex":"https://openalex.org/W2925059790","doi":"https://doi.org/10.1109/tbcas.2019.2907074","mag":"2925059790","pmid":"https://pubmed.ncbi.nlm.nih.gov/30908238"},"language":"en","primary_location":{"id":"doi:10.1109/tbcas.2019.2907074","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tbcas.2019.2907074","pdf_url":"https://ieeexplore.ieee.org/ielx7/4156126/8721726/08673580.pdf","source":{"id":"https://openalex.org/S80299757","display_name":"IEEE Transactions on Biomedical Circuits and Systems","issn_l":"1932-4545","issn":["1932-4545","1940-9990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Circuits and Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ieeexplore.ieee.org/ielx7/4156126/8721726/08673580.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037593276","display_name":"Jonathan J. Y. Teo","orcid":"https://orcid.org/0000-0003-3702-499X"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jonathan J. Y. Teo","raw_affiliation_strings":["Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, MA, USA"],"affiliations":[{"raw_affiliation_string":"Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090030865","display_name":"Ron Weiss","orcid":null},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ron Weiss","raw_affiliation_strings":["Center for Synthetic Biology, Massachusetts Institute of Technology, Cambridge, MA, USA"],"affiliations":[{"raw_affiliation_string":"Center for Synthetic Biology, Massachusetts Institute of Technology, Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009252030","display_name":"Rahul Sarpeshkar","orcid":"https://orcid.org/0000-0002-5975-0004"},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rahul Sarpeshkar","raw_affiliation_strings":["Departments of Engineering, Microbiology & Immunology, Physics, and Molecular and Systems Biology, Dartmouth College, Hanover, NH, USA"],"affiliations":[{"raw_affiliation_string":"Departments of Engineering, Microbiology & Immunology, Physics, and Molecular and Systems Biology, Dartmouth College, Hanover, NH, USA","institution_ids":["https://openalex.org/I107672454"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5037593276"],"corresponding_institution_ids":["https://openalex.org/I63966007"],"apc_list":null,"apc_paid":null,"fwci":1.1051,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.77268212,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"13","issue":"3","first_page":"540","last_page":"553"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10323","display_name":"Analog and Mixed-Signal Circuit Design","score":0.9836000204086304,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9736999869346619,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.49548542499542236},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.4932367205619812},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.47496768832206726},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.3655130863189697},{"id":"https://openalex.org/keywords/electronic-engineering","display_name":"Electronic engineering","score":0.3435654044151306},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22556284070014954},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.11313378810882568}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.49548542499542236},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.4932367205619812},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.47496768832206726},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.3655130863189697},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.3435654044151306},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22556284070014954},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.11313378810882568},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1109/tbcas.2019.2907074","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tbcas.2019.2907074","pdf_url":"https://ieeexplore.ieee.org/ielx7/4156126/8721726/08673580.pdf","source":{"id":"https://openalex.org/S80299757","display_name":"IEEE Transactions on Biomedical Circuits and Systems","issn_l":"1932-4545","issn":["1932-4545","1940-9990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Circuits and Systems","raw_type":"journal-article"},{"id":"pmid:30908238","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30908238","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on biomedical circuits and systems","raw_type":null},{"id":"pmh:oai:dspace.mit.edu:1721.1/129772","is_oa":true,"landing_page_url":"https://hdl.handle.net/1721.1/129772","pdf_url":null,"source":{"id":"https://openalex.org/S4306400425","display_name":"DSpace@MIT (Massachusetts Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I63966007","host_organization_name":"Massachusetts Institute of Technology","host_organization_lineage":["https://openalex.org/I63966007"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"http://purl.org/eprint/type/JournalArticle"},{"id":"pmh:oai:pubmedcentral.nih.gov:6835118","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6835118","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans Biomed Circuits Syst","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1109/tbcas.2019.2907074","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tbcas.2019.2907074","pdf_url":"https://ieeexplore.ieee.org/ielx7/4156126/8721726/08673580.pdf","source":{"id":"https://openalex.org/S80299757","display_name":"IEEE Transactions on Biomedical Circuits and Systems","issn_l":"1932-4545","issn":["1932-4545","1940-9990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Circuits and Systems","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6299999952316284,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1523888516","display_name":null,"funder_award_id":"FA9550-","funder_id":"https://openalex.org/F4320338279","funder_display_name":"Air Force Office of Scientific Research"},{"id":"https://openalex.org/G5057084118","display_name":null,"funder_award_id":"GM123032","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5809100787","display_name":null,"funder_award_id":"FA9550","funder_id":"https://openalex.org/F4320338279","funder_display_name":"Air Force Office of Scientific Research"},{"id":"https://openalex.org/G8288036582","display_name":null,"funder_award_id":"NIH R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8302973806","display_name":null,"funder_award_id":"FA9550-18-1-0467","funder_id":"https://openalex.org/F4320338279","funder_display_name":"Air Force Office of Scientific Research"}],"funders":[{"id":"https://openalex.org/F4320310400","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22"},{"id":"https://openalex.org/F4320320696","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320338279","display_name":"Air Force Office of Scientific Research","ror":"https://ror.org/011e9bt93"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2925059790.pdf","grobid_xml":"https://content.openalex.org/works/W2925059790.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W808473155","https://openalex.org/W1482515349","https://openalex.org/W1645305843","https://openalex.org/W1668206751","https://openalex.org/W1669342238","https://openalex.org/W1967060514","https://openalex.org/W1974059924","https://openalex.org/W1986543208","https://openalex.org/W1986932941","https://openalex.org/W1988931767","https://openalex.org/W1989388426","https://openalex.org/W1993546274","https://openalex.org/W2022282748","https://openalex.org/W2030791386","https://openalex.org/W2032472678","https://openalex.org/W2037286164","https://openalex.org/W2045427414","https://openalex.org/W2050492893","https://openalex.org/W2065833295","https://openalex.org/W2071990853","https://openalex.org/W2075670261","https://openalex.org/W2090806860","https://openalex.org/W2106219965","https://openalex.org/W2112055300","https://openalex.org/W2114359573","https://openalex.org/W2120157258","https://openalex.org/W2126586267","https://openalex.org/W2127553277","https://openalex.org/W2132828256","https://openalex.org/W2148890861","https://openalex.org/W2157939115","https://openalex.org/W2511075493","https://openalex.org/W2525290462","https://openalex.org/W2950044372","https://openalex.org/W2953287058","https://openalex.org/W4206315045","https://openalex.org/W4234853498"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"Tissue":[0],"homeostasis":[1,36],"(feedback":[2],"control)":[3],"is":[4,127],"an":[5,94,171,212],"important":[6],"mechanism":[7],"that":[8,98,163],"regulates":[9],"the":[10,33,176,198,221],"population":[11],"of":[12,27,35,39,113,118,121,138,220],"different":[13],"cell":[14],"types":[15],"within":[16],"a":[17,58,104,119],"tissue.":[18],"In":[19],"type-1":[20],"diabetes,":[21],"auto-immune":[22],"attack":[23],"and":[24,37,81,87,110,147,189,201],"consequent":[25],"death":[26],"pancreatic":[28],"\u03b2":[29,62],"cells":[30,46],"result":[31],"in":[32,95,129,166,175,197,210],"failure":[34],"loss":[38],"organ":[40],"function.":[41],"Synthetically":[42],"engineered":[43],"adult":[44],"stem":[45,114],"with":[47,107],"homeostatic":[48,67,100],"control":[49,68,77,101],"based":[50],"on":[51],"digital":[52],"logic":[53],"have":[54,70,92],"been":[55,73],"proposed":[56,66],"as":[57,170],"solution":[59],"for":[60,144],"regenerating":[61],"cells.":[63,115],"Such":[64],"previously":[65],"circuits":[69,86,168],"thus":[71,202],"far":[72],"unable":[74],"to":[75,155,216],"reliably":[76],"both":[78,108],"stem-cell":[79,82],"proliferation":[80],"differentiation.":[83],"Using":[84],"analog":[85,130,167],"feedback":[88,122,199],"systems":[89,123],"analysis,":[90],"we":[91,161],"designed":[93],"silico":[96],"circuit":[97,131,178],"performs":[99],"by":[102],"utilizing":[103],"novel":[105],"scheme":[106,192],"symmetric":[109,188],"asymmetric":[111,190],"division":[112,191],"The":[116],"use":[117],"variety":[120],"analysis":[124,149],"techniques,":[125,135],"which":[126],"common":[128],"design,":[132],"including":[133],"root-locus":[134],"Bode":[136],"plots":[137],"feedback-loop":[139],"frequency":[140],"response,":[141],"compensation":[142,165],"techniques":[143],"improving":[145],"stability,":[146,180],"robustness":[148],"help":[150],"us":[151],"choose":[152],"design":[153,214],"parameters":[154],"meet":[156],"desirable":[157],"specifications.":[158],"For":[159],"example,":[160],"show":[162],"lead":[164],"instantiated":[169],"incoherent":[172],"feed-forward":[173],"loop":[174],"biological":[177,218],"improves":[179,194,203],"whereas":[181],"simultaneously":[182],"reducing":[183],"steady-state":[184],"tracking":[185],"error.":[186],"Our":[187],"also":[193],"phase":[195],"margin":[196],"loop,":[200],"robustness.":[204],"This":[205],"paper":[206],"could":[207],"be":[208],"useful":[209],"porting":[211],"analog-circuit":[213],"framework":[215],"synthetic":[217],"applications":[219],"future.":[222]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
