{"id":"https://openalex.org/W2775257480","doi":"https://doi.org/10.1109/tbcas.2017.2766210","title":"Pressure-Aware Control Layer Optimization for Flow-Based Microfluidic Biochips","display_name":"Pressure-Aware Control Layer Optimization for Flow-Based Microfluidic Biochips","publication_year":2017,"publication_date":"2017-11-30","ids":{"openalex":"https://openalex.org/W2775257480","doi":"https://doi.org/10.1109/tbcas.2017.2766210","mag":"2775257480","pmid":"https://pubmed.ncbi.nlm.nih.gov/29293429"},"language":"en","primary_location":{"id":"doi:10.1109/tbcas.2017.2766210","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbcas.2017.2766210","pdf_url":null,"source":{"id":"https://openalex.org/S80299757","display_name":"IEEE Transactions on Biomedical Circuits and Systems","issn_l":"1932-4545","issn":["1932-4545","1940-9990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Circuits and Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101498763","display_name":"Qin Wang","orcid":"https://orcid.org/0000-0003-2775-5502"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Qin Wang","raw_affiliation_strings":["Department of Computer Science and Technology, Tsinghua University, Taipei, Taiwan"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Technology, Tsinghua University, Taipei, Taiwan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101703225","display_name":"Yue Xu","orcid":"https://orcid.org/0000-0002-3786-6188"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yue Xu","raw_affiliation_strings":["Department of Computer Science and Technology, Tsinghua University, Taipei, Taiwan"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Technology, Tsinghua University, Taipei, Taiwan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021740993","display_name":"Shiliang Zuo","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shiliang Zuo","raw_affiliation_strings":["Department of Computer Science and Technology, Tsinghua University, Taipei, Taiwan"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Technology, Tsinghua University, Taipei, Taiwan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058812423","display_name":"Hailong Yao","orcid":"https://orcid.org/0000-0002-8750-3086"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hailong Yao","raw_affiliation_strings":["Department of Computer Science and Technology, Tsinghua University, Taipei, Taiwan"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Technology, Tsinghua University, Taipei, Taiwan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062800747","display_name":"Tsung-Yi Ho","orcid":"https://orcid.org/0000-0001-7348-5625"},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tsung-Yi Ho","raw_affiliation_strings":["Department of Computer Science, National Tsing Hua University, Hsinchu, Taiwan"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, National Tsing Hua University, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100451231","display_name":"Bing Li","orcid":"https://orcid.org/0000-0001-9752-7201"},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bing Li","raw_affiliation_strings":["Chair of Electronic Design Automation, Technical University of Munich, Munich, Germany"],"affiliations":[{"raw_affiliation_string":"Chair of Electronic Design Automation, Technical University of Munich, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017567485","display_name":"Ulf Schlichtmann","orcid":"https://orcid.org/0000-0003-4431-7619"},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ulf Schlichtmann","raw_affiliation_strings":["Chair of Electronic Design Automation, Technical University of Munich, Munich, Germany"],"affiliations":[{"raw_affiliation_string":"Chair of Electronic Design Automation, Technical University of Munich, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111983610","display_name":"Yici Cai","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yici Cai","raw_affiliation_strings":["Department of Computer Science and Technology, Tsinghua University, Taipei, Taiwan"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Technology, Tsinghua University, Taipei, Taiwan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5101498763"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4691,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.83592809,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"11","issue":"6","first_page":"1488","last_page":"1499"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12452","display_name":"Electrowetting and Microfluidic Technologies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12452","display_name":"Electrowetting and Microfluidic Technologies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiplexer","display_name":"Multiplexer","score":0.8017774820327759},{"id":"https://openalex.org/keywords/biochip","display_name":"Biochip","score":0.7505166530609131},{"id":"https://openalex.org/keywords/scalability","display_name":"Scalability","score":0.6670699119567871},{"id":"https://openalex.org/keywords/flow-control","display_name":"Flow control (data)","score":0.575696587562561},{"id":"https://openalex.org/keywords/microfluidics","display_name":"Microfluidics","score":0.5108218193054199},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.48079410195350647},{"id":"https://openalex.org/keywords/reliability","display_name":"Reliability (semiconductor)","score":0.46387943625450134},{"id":"https://openalex.org/keywords/electronic-engineering","display_name":"Electronic engineering","score":0.43169015645980835},{"id":"https://openalex.org/keywords/pressure-control","display_name":"Pressure control","score":0.4180828630924225},{"id":"https://openalex.org/keywords/layer","display_name":"Layer (electronics)","score":0.4157184064388275},{"id":"https://openalex.org/keywords/computer-hardware","display_name":"Computer hardware","score":0.3506026864051819},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.3474988341331482},{"id":"https://openalex.org/keywords/multiplexing","display_name":"Multiplexing","score":0.32174152135849},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.2500048875808716},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.17042401432991028},{"id":"https://openalex.org/keywords/computer-network","display_name":"Computer network","score":0.13452398777008057},{"id":"https://openalex.org/keywords/mechanical-engineering","display_name":"Mechanical engineering","score":0.1143137514591217}],"concepts":[{"id":"https://openalex.org/C70970002","wikidata":"https://www.wikidata.org/wiki/Q189434","display_name":"Multiplexer","level":3,"score":0.8017774820327759},{"id":"https://openalex.org/C87892846","wikidata":"https://www.wikidata.org/wiki/Q864256","display_name":"Biochip","level":2,"score":0.7505166530609131},{"id":"https://openalex.org/C48044578","wikidata":"https://www.wikidata.org/wiki/Q727490","display_name":"Scalability","level":2,"score":0.6670699119567871},{"id":"https://openalex.org/C186766456","wikidata":"https://www.wikidata.org/wiki/Q612457","display_name":"Flow control (data)","level":2,"score":0.575696587562561},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.5108218193054199},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48079410195350647},{"id":"https://openalex.org/C43214815","wikidata":"https://www.wikidata.org/wiki/Q7310987","display_name":"Reliability (semiconductor)","level":3,"score":0.46387943625450134},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.43169015645980835},{"id":"https://openalex.org/C2781153586","wikidata":"https://www.wikidata.org/wiki/Q7241717","display_name":"Pressure control","level":2,"score":0.4180828630924225},{"id":"https://openalex.org/C2779227376","wikidata":"https://www.wikidata.org/wiki/Q6505497","display_name":"Layer (electronics)","level":2,"score":0.4157184064388275},{"id":"https://openalex.org/C9390403","wikidata":"https://www.wikidata.org/wiki/Q3966","display_name":"Computer hardware","level":1,"score":0.3506026864051819},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.3474988341331482},{"id":"https://openalex.org/C19275194","wikidata":"https://www.wikidata.org/wiki/Q222903","display_name":"Multiplexing","level":2,"score":0.32174152135849},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2500048875808716},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.17042401432991028},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.13452398777008057},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.1143137514591217},{"id":"https://openalex.org/C163258240","wikidata":"https://www.wikidata.org/wiki/Q25342","display_name":"Power (physics)","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044085","descriptor_name":"Microfluidics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D044085","descriptor_name":"Microfluidics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D044085","descriptor_name":"Microfluidics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tbcas.2017.2766210","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbcas.2017.2766210","pdf_url":null,"source":{"id":"https://openalex.org/S80299757","display_name":"IEEE Transactions on Biomedical Circuits and Systems","issn_l":"1932-4545","issn":["1932-4545","1940-9990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Circuits and Systems","raw_type":"journal-article"},{"id":"pmid:29293429","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29293429","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on biomedical circuits and systems","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/7","score":0.7200000286102295,"display_name":"Affordable and clean energy"}],"awards":[{"id":"https://openalex.org/G265770845","display_name":null,"funder_award_id":"61774091","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8976140628","display_name":null,"funder_award_id":"MOST 105-2221-E-007-118-MY3","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G952536926","display_name":null,"funder_award_id":"104-2220-E-007-021","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322795","display_name":"Ministry of Science and Technology, Taiwan","ror":"https://ror.org/02kv4zf79"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1579034878","https://openalex.org/W1899927368","https://openalex.org/W1910126694","https://openalex.org/W1969845950","https://openalex.org/W1975920074","https://openalex.org/W1980073965","https://openalex.org/W1996296142","https://openalex.org/W1998450740","https://openalex.org/W2020438216","https://openalex.org/W2028712328","https://openalex.org/W2030819728","https://openalex.org/W2055565290","https://openalex.org/W2063127203","https://openalex.org/W2064053341","https://openalex.org/W2070855802","https://openalex.org/W2071311642","https://openalex.org/W2072910502","https://openalex.org/W2083068121","https://openalex.org/W2086187432","https://openalex.org/W2096710325","https://openalex.org/W2116208923","https://openalex.org/W2128427912","https://openalex.org/W2150515030","https://openalex.org/W2154347237","https://openalex.org/W2157486205","https://openalex.org/W2168482356","https://openalex.org/W2293017319","https://openalex.org/W2333296258","https://openalex.org/W2342204193","https://openalex.org/W2399948660","https://openalex.org/W2537391217","https://openalex.org/W2588907938","https://openalex.org/W2588979191","https://openalex.org/W2613742119","https://openalex.org/W2615909376","https://openalex.org/W2950837188","https://openalex.org/W3011891279","https://openalex.org/W6684605080","https://openalex.org/W6697385005","https://openalex.org/W6733850941","https://openalex.org/W6764266315"],"related_works":["https://openalex.org/W2364922518","https://openalex.org/W1995422305","https://openalex.org/W2039899645","https://openalex.org/W2371342700","https://openalex.org/W2327110311","https://openalex.org/W2363059241","https://openalex.org/W3215187042","https://openalex.org/W266342242","https://openalex.org/W2100439961","https://openalex.org/W4231117818"],"abstract_inverted_index":{"Flow-based":[0],"microfluidic":[1,16],"biochips":[2,17],"are":[3,86],"attracting":[4],"increasing":[5],"attention":[6],"with":[7,14,91,155],"successful":[8],"biomedical":[9],"applications.":[10],"One":[11],"critical":[12,59],"issue":[13,98],"flow-based":[15],"is":[18,54,67],"the":[19,31,64,72,81,92,96,101,107,113,120,131,139,147,152],"large":[20],"number":[21,73,82],"of":[22,44,50,74,80,83,151],"microvalves":[23,41,45],"that":[24],"require":[25,48],"peripheral":[26],"control":[27,37,51,62,75],"pins.":[28],"Even":[29],"using":[30],"broadcasting":[32],"addressing":[33],"scheme,":[34],"i.e.,":[35],"one":[36],"pin":[38],"controls":[39],"multiple":[40],"simultaneously,":[42],"thousands":[43],"would":[46],"still":[47],"hundreds":[49],"prins,":[52],"which":[53],"unrealistic.":[55],"To":[56],"address":[57],"this":[58],"challenge":[60],"in":[61,162,174],"scalability,":[63],"control-layer":[65,93],"multiplexer":[66],"introduced":[68],"to":[69],"effectively":[70],"reduce":[71],"pins":[76],"into":[77],"log":[78],"scale":[79],"microvalves.":[84],"There":[85],"two":[87,127],"practical":[88],"design":[89,128],"issues":[90,129],"multiplexer:":[94],"(1)":[95],"reliability":[97],"caused":[99,111],"by":[100,112,130],"frequent":[102],"control-valve":[103,114],"switching,":[104],"and":[105,138,149,167],"(2)":[106],"pressure":[108,117,121,141,164,175],"degradation":[109],"problem":[110],"switching":[115,134],"without":[116],"refreshing":[118,142,165],"from":[119],"source.":[122],"This":[123],"paper":[124],"addresses":[125],"these":[126],"proposed":[132,153],"Hamming-distance-based":[133],"sequence":[135],"optimization":[136],"method":[137],"XOR-based":[140],"method.":[143],"Simulation":[144],"results":[145],"demonstrate":[146],"effectiveness":[148],"efficiency":[150],"methods":[154],"an":[156,168],"average":[157,169],"77.2%":[158],"(maximum":[159,171],"89.6%)":[160],"improvement":[161,173],"total":[163],"cost,":[166],"88.5%":[170],"90.0%)":[172],"deviation.":[176]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":7}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
