{"id":"https://openalex.org/W2757330072","doi":"https://doi.org/10.1109/tbcas.2017.2742548","title":"Droplet Size-Aware and Error-Correcting Sample Preparation Using Micro-Electrode-Dot-Array Digital Microfluidic Biochips","display_name":"Droplet Size-Aware and Error-Correcting Sample Preparation Using Micro-Electrode-Dot-Array Digital Microfluidic Biochips","publication_year":2017,"publication_date":"2017-09-29","ids":{"openalex":"https://openalex.org/W2757330072","doi":"https://doi.org/10.1109/tbcas.2017.2742548","mag":"2757330072","pmid":"https://pubmed.ncbi.nlm.nih.gov/28976321"},"language":"en","primary_location":{"id":"doi:10.1109/tbcas.2017.2742548","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbcas.2017.2742548","pdf_url":null,"source":{"id":"https://openalex.org/S80299757","display_name":"IEEE Transactions on Biomedical Circuits and Systems","issn_l":"1932-4545","issn":["1932-4545","1940-9990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Circuits and Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045626406","display_name":"Zipeng Li","orcid":"https://orcid.org/0000-0001-5896-2542"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zipeng Li","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Duke University, Durham, NC, USA"],"raw_orcid":"https://orcid.org/0000-0001-5896-2542","affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Duke University, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042846142","display_name":"Kelvin Yi-Tse Lai","orcid":null},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kelvin Yi-Tse Lai","raw_affiliation_strings":["Department of Electronics Engineering, National Chiao Tung University, Hsinchu, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electronics Engineering, National Chiao Tung University, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033880864","display_name":"Krishnendu Chakrabarty","orcid":"https://orcid.org/0000-0003-4475-6435"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krishnendu Chakrabarty","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Duke University, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Duke University, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062800747","display_name":"Tsung-Yi Ho","orcid":"https://orcid.org/0000-0001-7348-5625"},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tsung-Yi Ho","raw_affiliation_strings":["Department of Computer Science, National Tsing Hua University, Hsinchu, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, National Tsing Hua University, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101838014","display_name":"Chen\u2010Yi Lee","orcid":"https://orcid.org/0000-0002-6795-0874"},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chen-Yi Lee","raw_affiliation_strings":["Department of Electronics Engineering, National Chiao Tung University, Hsinchu, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electronics Engineering, National Chiao Tung University, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5703,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.83407449,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"11","issue":"6","first_page":"1380","last_page":"1391"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12452","display_name":"Electrowetting and Microfluidic Technologies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12452","display_name":"Electrowetting and Microfluidic Technologies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.9873999953269958,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biochip","display_name":"Biochip","score":0.9892978668212891},{"id":"https://openalex.org/keywords/microfluidics","display_name":"Microfluidics","score":0.9106979370117188},{"id":"https://openalex.org/keywords/digital-microfluidics","display_name":"Digital microfluidics","score":0.8862991333007812},{"id":"https://openalex.org/keywords/fluidics","display_name":"Fluidics","score":0.6710000038146973},{"id":"https://openalex.org/keywords/sample","display_name":"Sample (material)","score":0.6469360589981079},{"id":"https://openalex.org/keywords/sample-preparation","display_name":"Sample preparation","score":0.5567448735237122},{"id":"https://openalex.org/keywords/lab-on-a-chip","display_name":"Lab-on-a-chip","score":0.5251747965812683},{"id":"https://openalex.org/keywords/chip","display_name":"Chip","score":0.43230095505714417},{"id":"https://openalex.org/keywords/electrode-array","display_name":"Electrode array","score":0.41973063349723816},{"id":"https://openalex.org/keywords/electronic-engineering","display_name":"Electronic engineering","score":0.4148007035255432},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4091629385948181},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3960321545600891},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.39267659187316895},{"id":"https://openalex.org/keywords/computer-hardware","display_name":"Computer hardware","score":0.38346540927886963},{"id":"https://openalex.org/keywords/electrowetting","display_name":"Electrowetting","score":0.23457765579223633},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.213807612657547},{"id":"https://openalex.org/keywords/optoelectronics","display_name":"Optoelectronics","score":0.1839691698551178},{"id":"https://openalex.org/keywords/voltage","display_name":"Voltage","score":0.14333575963974},{"id":"https://openalex.org/keywords/electrical-engineering","display_name":"Electrical engineering","score":0.1313541829586029},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.11992239952087402},{"id":"https://openalex.org/keywords/telecommunications","display_name":"Telecommunications","score":0.07723227143287659},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.07519569993019104}],"concepts":[{"id":"https://openalex.org/C87892846","wikidata":"https://www.wikidata.org/wiki/Q864256","display_name":"Biochip","level":2,"score":0.9892978668212891},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.9106979370117188},{"id":"https://openalex.org/C92444450","wikidata":"https://www.wikidata.org/wiki/Q5276112","display_name":"Digital microfluidics","level":4,"score":0.8862991333007812},{"id":"https://openalex.org/C132651336","wikidata":"https://www.wikidata.org/wiki/Q185571","display_name":"Fluidics","level":2,"score":0.6710000038146973},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.6469360589981079},{"id":"https://openalex.org/C2778576202","wikidata":"https://www.wikidata.org/wiki/Q2540164","display_name":"Sample preparation","level":2,"score":0.5567448735237122},{"id":"https://openalex.org/C138942068","wikidata":"https://www.wikidata.org/wiki/Q633261","display_name":"Lab-on-a-chip","level":3,"score":0.5251747965812683},{"id":"https://openalex.org/C165005293","wikidata":"https://www.wikidata.org/wiki/Q1074500","display_name":"Chip","level":2,"score":0.43230095505714417},{"id":"https://openalex.org/C97562148","wikidata":"https://www.wikidata.org/wiki/Q5357989","display_name":"Electrode array","level":3,"score":0.41973063349723816},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.4148007035255432},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4091629385948181},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3960321545600891},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.39267659187316895},{"id":"https://openalex.org/C9390403","wikidata":"https://www.wikidata.org/wiki/Q3966","display_name":"Computer hardware","level":1,"score":0.38346540927886963},{"id":"https://openalex.org/C2779673822","wikidata":"https://www.wikidata.org/wiki/Q907239","display_name":"Electrowetting","level":3,"score":0.23457765579223633},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.213807612657547},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.1839691698551178},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.14333575963974},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.1313541829586029},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.11992239952087402},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.07723227143287659},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.07519569993019104},{"id":"https://openalex.org/C133386390","wikidata":"https://www.wikidata.org/wiki/Q184996","display_name":"Dielectric","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004566","descriptor_name":"Electrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004566","descriptor_name":"Electrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004566","descriptor_name":"Electrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044085","descriptor_name":"Microfluidics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D044085","descriptor_name":"Microfluidics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D044085","descriptor_name":"Microfluidics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tbcas.2017.2742548","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbcas.2017.2742548","pdf_url":null,"source":{"id":"https://openalex.org/S80299757","display_name":"IEEE Transactions on Biomedical Circuits and Systems","issn_l":"1932-4545","issn":["1932-4545","1940-9990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Circuits and Systems","raw_type":"journal-article"},{"id":"pmid:28976321","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28976321","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on biomedical circuits and systems","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1516293512","display_name":null,"funder_award_id":"291763","funder_id":"https://openalex.org/F4320333065","funder_display_name":"Seventh Framework Programme"},{"id":"https://openalex.org/G4385614252","display_name":null,"funder_award_id":"MOST 103-2221-E-009-191","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G4468363586","display_name":"Synthesis and Optimization for Large-Scale Microfluidic Biochips( II )","funder_award_id":"MOST104-2220-E007-021","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G6751327566","display_name":"Research on Design Automation Technology for Continuous-Flow Microfluidic Biochips","funder_award_id":"MOST105-2221-E007-118-MY3","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G7945569121","display_name":"Fundamental Technologies for Multi-Bio-Medical Signal Detection Modules and Packages( III )","funder_award_id":"MOST104-2218-E009-007","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"}],"funders":[{"id":"https://openalex.org/F4320322795","display_name":"Ministry of Science and Technology, Taiwan","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320333065","display_name":"Seventh Framework Programme","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W830146919","https://openalex.org/W1536801036","https://openalex.org/W1717854081","https://openalex.org/W1896965749","https://openalex.org/W1987214109","https://openalex.org/W1993190122","https://openalex.org/W2010357805","https://openalex.org/W2013907841","https://openalex.org/W2029481052","https://openalex.org/W2032239903","https://openalex.org/W2036702954","https://openalex.org/W2052580805","https://openalex.org/W2063968553","https://openalex.org/W2076958395","https://openalex.org/W2098665512","https://openalex.org/W2104622925","https://openalex.org/W2109834102","https://openalex.org/W2111267412","https://openalex.org/W2168567259","https://openalex.org/W2168987465","https://openalex.org/W2185340920","https://openalex.org/W2243464227","https://openalex.org/W2335928809","https://openalex.org/W2395906706","https://openalex.org/W2488722193","https://openalex.org/W2510233378","https://openalex.org/W2510328378","https://openalex.org/W2538785073","https://openalex.org/W2543059994","https://openalex.org/W2571542050","https://openalex.org/W2599588613","https://openalex.org/W4232534952","https://openalex.org/W4240583845","https://openalex.org/W4252528336","https://openalex.org/W6637490550","https://openalex.org/W6639325977","https://openalex.org/W6659869445"],"related_works":["https://openalex.org/W2593620286","https://openalex.org/W2029481052","https://openalex.org/W4235248979","https://openalex.org/W2074654211","https://openalex.org/W2332939083","https://openalex.org/W1995422305","https://openalex.org/W2071803082","https://openalex.org/W2182486668","https://openalex.org/W2903853891","https://openalex.org/W2945007116"],"abstract_inverted_index":{"Sample":[0],"preparation":[1,43,95],"in":[2,61],"digital":[3,21],"microfluidics":[4],"refers":[5],"to":[6,58,110],"the":[7,62,88,119,125,149,152],"generation":[8,106],"of":[9,64,76,128,131,151],"droplets":[10],"with":[11,41],"target":[12],"concentrations":[13],"for":[14,31,68,90,114],"on-chip":[15],"biochemical":[16],"applications.":[17],"In":[18],"recent":[19],"years,":[20],"microfluidic":[22],"biochips":[23],"(DMFBs)":[24],"have":[25],"been":[26],"adopted":[27],"as":[28,85,111],"a":[29,45,50,73,82,86,104,141],"platform":[30],"sample":[32,42,69,94,115],"preparation.":[33,70,116],"However,":[34],"there":[35],"remain":[36],"two":[37],"major":[38],"problems":[39],"associated":[40],"on":[44,81],"conventional":[46,83],"DMFB.":[47],"First,":[48],"only":[49,72],"(1:1)":[51],"mixing/splitting":[52],"model":[53],"can":[54,78],"be":[55,79],"used,":[56],"leading":[57],"an":[59],"increase":[60],"number":[63,75],"fluidic":[65],"operations":[66],"required":[67],"Second,":[71],"limited":[74],"sensors":[77],"integrated":[80],"DMFB;":[84],"result,":[87],"latency":[89],"error":[91],"detection":[92],"during":[93],"is":[96],"significant.":[97],"To":[98],"overcome":[99],"these":[100],"drawbacks,":[101],"we":[102],"adopt":[103],"next":[105],"DMFB":[107],"platform,":[108],"referred":[109],"micro-electrode-dot-array":[112],"(MEDA),":[113],"We":[117],"propose":[118],"first":[120],"sample-preparation":[121,154],"method":[122],"that":[123],"exploits":[124],"MEDA-specific":[126],"advantages":[127],"fine-grained":[129],"control":[130],"droplet":[132,136],"sizes":[133],"and":[134,145],"real-time":[135],"sensing.":[137],"Experimental":[138],"demonstration":[139],"using":[140],"fabricated":[142],"MEDA":[143],"biochip":[144],"simulation":[146],"results":[147],"highlight":[148],"effectiveness":[150],"proposed":[153],"method.":[155]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5}],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2025-10-10T00:00:00"}
