{"id":"https://openalex.org/W2336591923","doi":"https://doi.org/10.1109/tbcas.2016.2522402","title":"System-on-Chip Considerations for Heterogeneous Integration of CMOS and Fluidic Bio-Interfaces","display_name":"System-on-Chip Considerations for Heterogeneous Integration of CMOS and Fluidic Bio-Interfaces","publication_year":2016,"publication_date":"2016-04-21","ids":{"openalex":"https://openalex.org/W2336591923","doi":"https://doi.org/10.1109/tbcas.2016.2522402","mag":"2336591923","pmid":"https://pubmed.ncbi.nlm.nih.gov/28055826"},"language":"en","primary_location":{"id":"doi:10.1109/tbcas.2016.2522402","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbcas.2016.2522402","pdf_url":null,"source":{"id":"https://openalex.org/S80299757","display_name":"IEEE Transactions on Biomedical Circuits and Systems","issn_l":"1932-4545","issn":["1932-4545","1940-9990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Circuits and Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049061619","display_name":"Timir Datta","orcid":"https://orcid.org/0000-0001-7377-1939"},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Timir Datta-Chaudhuri","raw_affiliation_strings":["Department of Electrical and Computer Engineering, and the Institute for Systems Research, University of Maryland, College Park, MD, USA"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, and the Institute for Systems Research, University of Maryland, College Park, MD, USA","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088261669","display_name":"Elisabeth Smela","orcid":"https://orcid.org/0000-0003-3921-2265"},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elisabeth Smela","raw_affiliation_strings":["Department of Mechanical Engineering, and the Institute for Systems Research, University of Maryland, College Park, MD, USA"],"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, and the Institute for Systems Research, University of Maryland, College Park, MD, USA","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077161756","display_name":"Pamela Abshire","orcid":"https://orcid.org/0000-0001-9555-453X"},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pamela A. Abshire","raw_affiliation_strings":["Department of Electrical and Computer Engineering, and the Institute for Systems Research, University of Maryland, College Park, MD, USA"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, and the Institute for Systems Research, University of Maryland, College Park, MD, USA","institution_ids":["https://openalex.org/I66946132"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5049061619"],"corresponding_institution_ids":["https://openalex.org/I66946132"],"apc_list":null,"apc_paid":null,"fwci":2.4546,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.88237247,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"10","issue":"6","first_page":"1129","last_page":"1142"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cmos","display_name":"CMOS","score":0.7421369552612305},{"id":"https://openalex.org/keywords/interfacing","display_name":"Interfacing","score":0.7193934321403503},{"id":"https://openalex.org/keywords/fluidics","display_name":"Fluidics","score":0.5904939770698547},{"id":"https://openalex.org/keywords/electronic-engineering","display_name":"Electronic engineering","score":0.5287532210350037},{"id":"https://openalex.org/keywords/integrated-circuit","display_name":"Integrated circuit","score":0.508384644985199},{"id":"https://openalex.org/keywords/microsystem","display_name":"Microsystem","score":0.48624885082244873},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4725213646888733},{"id":"https://openalex.org/keywords/electronic-circuit","display_name":"Electronic circuit","score":0.4689685106277466},{"id":"https://openalex.org/keywords/lab-on-a-chip","display_name":"Lab-on-a-chip","score":0.46382275223731995},{"id":"https://openalex.org/keywords/mixed-signal-integrated-circuit","display_name":"Mixed-signal integrated circuit","score":0.4536137878894806},{"id":"https://openalex.org/keywords/microfabrication","display_name":"Microfabrication","score":0.4534856677055359},{"id":"https://openalex.org/keywords/microfluidics","display_name":"Microfluidics","score":0.4360368251800537},{"id":"https://openalex.org/keywords/signal-processing","display_name":"Signal processing","score":0.4219934940338135},{"id":"https://openalex.org/keywords/chip","display_name":"Chip","score":0.4168861508369446},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.3550873398780823},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.33659231662750244},{"id":"https://openalex.org/keywords/electrical-engineering","display_name":"Electrical engineering","score":0.28524479269981384},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.19362324476242065},{"id":"https://openalex.org/keywords/computer-hardware","display_name":"Computer hardware","score":0.15381136536598206},{"id":"https://openalex.org/keywords/digital-signal-processing","display_name":"Digital signal processing","score":0.10780072212219238}],"concepts":[{"id":"https://openalex.org/C46362747","wikidata":"https://www.wikidata.org/wiki/Q173431","display_name":"CMOS","level":2,"score":0.7421369552612305},{"id":"https://openalex.org/C2776303644","wikidata":"https://www.wikidata.org/wiki/Q1020499","display_name":"Interfacing","level":2,"score":0.7193934321403503},{"id":"https://openalex.org/C132651336","wikidata":"https://www.wikidata.org/wiki/Q185571","display_name":"Fluidics","level":2,"score":0.5904939770698547},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.5287532210350037},{"id":"https://openalex.org/C530198007","wikidata":"https://www.wikidata.org/wiki/Q80831","display_name":"Integrated circuit","level":2,"score":0.508384644985199},{"id":"https://openalex.org/C151054161","wikidata":"https://www.wikidata.org/wiki/Q379385","display_name":"Microsystem","level":2,"score":0.48624885082244873},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4725213646888733},{"id":"https://openalex.org/C134146338","wikidata":"https://www.wikidata.org/wiki/Q1815901","display_name":"Electronic circuit","level":2,"score":0.4689685106277466},{"id":"https://openalex.org/C138942068","wikidata":"https://www.wikidata.org/wiki/Q633261","display_name":"Lab-on-a-chip","level":3,"score":0.46382275223731995},{"id":"https://openalex.org/C62907940","wikidata":"https://www.wikidata.org/wiki/Q1541329","display_name":"Mixed-signal integrated circuit","level":3,"score":0.4536137878894806},{"id":"https://openalex.org/C527607","wikidata":"https://www.wikidata.org/wiki/Q175538","display_name":"Microfabrication","level":4,"score":0.4534856677055359},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.4360368251800537},{"id":"https://openalex.org/C104267543","wikidata":"https://www.wikidata.org/wiki/Q208163","display_name":"Signal processing","level":3,"score":0.4219934940338135},{"id":"https://openalex.org/C165005293","wikidata":"https://www.wikidata.org/wiki/Q1074500","display_name":"Chip","level":2,"score":0.4168861508369446},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.3550873398780823},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.33659231662750244},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.28524479269981384},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.19362324476242065},{"id":"https://openalex.org/C9390403","wikidata":"https://www.wikidata.org/wiki/Q3966","display_name":"Computer hardware","level":1,"score":0.15381136536598206},{"id":"https://openalex.org/C84462506","wikidata":"https://www.wikidata.org/wiki/Q173142","display_name":"Digital signal processing","level":2,"score":0.10780072212219238},{"id":"https://openalex.org/C136525101","wikidata":"https://www.wikidata.org/wiki/Q5428139","display_name":"Fabrication","level":3,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001639","descriptor_name":"Bicarbonates","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001639","descriptor_name":"Bicarbonates","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001639","descriptor_name":"Bicarbonates","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011984","descriptor_name":"Sensory Receptor Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D011984","descriptor_name":"Sensory Receptor Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D011984","descriptor_name":"Sensory Receptor Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D011984","descriptor_name":"Sensory Receptor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011984","descriptor_name":"Sensory Receptor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011984","descriptor_name":"Sensory Receptor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012666","descriptor_name":"Semiconductors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012666","descriptor_name":"Semiconductors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012666","descriptor_name":"Semiconductors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D056656","descriptor_name":"Lab-On-A-Chip Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056656","descriptor_name":"Lab-On-A-Chip Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056656","descriptor_name":"Lab-On-A-Chip Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1109/tbcas.2016.2522402","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbcas.2016.2522402","pdf_url":null,"source":{"id":"https://openalex.org/S80299757","display_name":"IEEE Transactions on Biomedical Circuits and Systems","issn_l":"1932-4545","issn":["1932-4545","1940-9990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Circuits and Systems","raw_type":"journal-article"},{"id":"pmid:28055826","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28055826","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on biomedical circuits and systems","raw_type":null},{"id":"pmh:oai:calhoun.nps.edu:10945/52401","is_oa":false,"landing_page_url":"http://hdl.handle.net/10945/52401","pdf_url":null,"source":{"id":"https://openalex.org/S4306400952","display_name":"Calhoun: The Naval Postgraduate School Institutional Archive (Naval Postgraduate School)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I35364215","host_organization_name":"Naval Postgraduate School","host_organization_lineage":["https://openalex.org/I35364215"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/9","score":0.4099999964237213,"display_name":"Industry, innovation and infrastructure"}],"awards":[{"id":"https://openalex.org/G1986058836","display_name":null,"funder_award_id":"0731090","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2361296660","display_name":null,"funder_award_id":"N002441110040","funder_id":"https://openalex.org/F4320337384","funder_display_name":"Naval Postgraduate School"},{"id":"https://openalex.org/G3541143091","display_name":null,"funder_award_id":"IIS0515873","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3919263431","display_name":null,"funder_award_id":"IIS0813773","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320337384","display_name":"Naval Postgraduate School","ror":"https://ror.org/033yfkj90"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":99,"referenced_works":["https://openalex.org/W29781625","https://openalex.org/W110250108","https://openalex.org/W589975765","https://openalex.org/W1484077497","https://openalex.org/W1508418921","https://openalex.org/W1530153479","https://openalex.org/W1533614470","https://openalex.org/W1539692606","https://openalex.org/W1548980110","https://openalex.org/W1562661071","https://openalex.org/W1581638574","https://openalex.org/W1602649238","https://openalex.org/W1842990947","https://openalex.org/W1863432867","https://openalex.org/W1887442275","https://openalex.org/W1969277140","https://openalex.org/W1970713994","https://openalex.org/W1978696561","https://openalex.org/W1980964944","https://openalex.org/W1982256640","https://openalex.org/W1982345515","https://openalex.org/W1983242608","https://openalex.org/W1984979136","https://openalex.org/W1986364032","https://openalex.org/W1987964430","https://openalex.org/W1989403232","https://openalex.org/W1993633645","https://openalex.org/W1995761359","https://openalex.org/W2002208658","https://openalex.org/W2009948709","https://openalex.org/W2016660234","https://openalex.org/W2026449889","https://openalex.org/W2028984123","https://openalex.org/W2034479251","https://openalex.org/W2036984726","https://openalex.org/W2050903747","https://openalex.org/W2051131629","https://openalex.org/W2052376548","https://openalex.org/W2053660789","https://openalex.org/W2053839707","https://openalex.org/W2057005089","https://openalex.org/W2059338946","https://openalex.org/W2061793163","https://openalex.org/W2064616746","https://openalex.org/W2069117732","https://openalex.org/W2069441503","https://openalex.org/W2079316730","https://openalex.org/W2080214472","https://openalex.org/W2080666629","https://openalex.org/W2081435823","https://openalex.org/W2086846249","https://openalex.org/W2092653614","https://openalex.org/W2095363155","https://openalex.org/W2098581338","https://openalex.org/W2103572224","https://openalex.org/W2104193637","https://openalex.org/W2107512323","https://openalex.org/W2108536243","https://openalex.org/W2112905131","https://openalex.org/W2113463561","https://openalex.org/W2119745832","https://openalex.org/W2120313229","https://openalex.org/W2121945344","https://openalex.org/W2123238616","https://openalex.org/W2126462474","https://openalex.org/W2126555345","https://openalex.org/W2131829381","https://openalex.org/W2134979084","https://openalex.org/W2135762586","https://openalex.org/W2139726710","https://openalex.org/W2140553508","https://openalex.org/W2141706223","https://openalex.org/W2142894335","https://openalex.org/W2147495308","https://openalex.org/W2148352592","https://openalex.org/W2148927531","https://openalex.org/W2150769312","https://openalex.org/W2152963787","https://openalex.org/W2155371790","https://openalex.org/W2158089865","https://openalex.org/W2159318368","https://openalex.org/W2163023636","https://openalex.org/W2164072701","https://openalex.org/W2164203530","https://openalex.org/W2166911092","https://openalex.org/W2167217284","https://openalex.org/W2167850060","https://openalex.org/W2171017780","https://openalex.org/W2171702041","https://openalex.org/W2174225487","https://openalex.org/W2180930892","https://openalex.org/W2324517905","https://openalex.org/W2487708677","https://openalex.org/W4244014322","https://openalex.org/W4247445392","https://openalex.org/W6601221807","https://openalex.org/W6674437191","https://openalex.org/W6682917267","https://openalex.org/W6825911994"],"related_works":["https://openalex.org/W2140296312","https://openalex.org/W4206869942","https://openalex.org/W2296243507","https://openalex.org/W2059180217","https://openalex.org/W2004263525","https://openalex.org/W4302328227","https://openalex.org/W4380784973","https://openalex.org/W2159755488","https://openalex.org/W2043672081","https://openalex.org/W169820967"],"abstract_inverted_index":{"CMOS":[0,22],"chips":[1,23],"are":[2,179],"increasingly":[3],"used":[4],"for":[5,24],"direct":[6],"sensing":[7,31,36],"and":[8,12,26,49,58,70,82,108,138,148,170,184,200,213],"interfacing":[9],"with":[10,29,37],"fluidic":[11,185],"biological":[13,100,183],"systems.":[14],"While":[15],"many":[16],"biosensing":[17],"systems":[18,33,66,88,212],"have":[19,217],"successfully":[20],"combined":[21],"readout":[25],"signal":[27,171],"processing":[28],"passive":[30],"arrays,":[32],"that":[34,74,178,216],"co-locate":[35],"active":[38],"circuits":[39,84],"on":[40,102],"a":[41,127],"single":[42],"chip":[43],"offer":[44],"significant":[45],"advantages":[46],"in":[47,162,210],"size":[48],"performance":[50],"but":[51,95],"increase":[52],"the":[53,77,97,103,106,117,143],"complexity":[54],"of":[55,64,80,99,105,120,159,197],"multi-domain":[56],"design":[57],"heterogeneous":[59,121],"integration.":[60,202],"This":[61],"emerging":[62],"class":[63],"lab-on-CMOS":[65,122,145,211],"also":[67,96],"poses":[68],"distinct":[69],"vexing":[71],"technical":[72],"challenges":[73,147,161,177],"arise":[75,209],"from":[76],"disparate":[78],"requirements":[79],"biosensors":[81],"integrated":[83],"(ICs).":[85],"Modeling":[86],"these":[87,205],"must":[89],"address":[90],"not":[91,115],"only":[92],"circuit":[93,132],"design,":[94],"behavior":[98],"components":[101],"surface":[104,193,198],"IC":[107],"any":[109],"physical":[110],"structures.":[111],"Existing":[112],"tools":[113],"do":[114],"support":[116],"cross-domain":[118],"simulation":[119,133],"systems,":[123],"so":[124],"we":[125],"recommend":[126],"two-step":[128],"modeling":[129],"approach:":[130],"using":[131],"to":[134,152,182],"inform":[135],"physics-based":[136],"simulation,":[137],"vice":[139],"versa.":[140],"We":[141,203],"review":[142],"primary":[144],"implementation":[146],"discuss":[149,214],"practical":[150],"approaches":[151],"overcome":[153],"them.":[154],"Issues":[155],"include":[156],"new":[157,176],"versions":[158],"classical":[160],"system-on-chip":[163],"integration,":[164],"such":[165,187],"as":[166,173,175,188,207],"thermal":[167],"effects,":[168,190],"floor-planning,":[169],"coupling,":[172],"well":[174],"specifically":[180],"attributable":[181],"domains,":[186],"electrochemical":[189],"non-standard":[191],"packaging,":[192],"treatments,":[194],"sterilization,":[195],"microfabrication":[196],"structures,":[199],"microfluidic":[201],"describe":[204],"concerns":[206],"they":[208],"solutions":[215],"been":[218],"experimentally":[219],"demonstrated.":[220]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}