{"id":"https://openalex.org/W2041347955","doi":"https://doi.org/10.1109/tbcas.2014.2343620","title":"Duplication and Divergence Effect on Network Motifs in Undirected Bio-Molecular Networks","display_name":"Duplication and Divergence Effect on Network Motifs in Undirected Bio-Molecular Networks","publication_year":2014,"publication_date":"2014-09-17","ids":{"openalex":"https://openalex.org/W2041347955","doi":"https://doi.org/10.1109/tbcas.2014.2343620","mag":"2041347955","pmid":"https://pubmed.ncbi.nlm.nih.gov/25203993"},"language":"en","primary_location":{"id":"doi:10.1109/tbcas.2014.2343620","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbcas.2014.2343620","pdf_url":null,"source":{"id":"https://openalex.org/S80299757","display_name":"IEEE Transactions on Biomedical Circuits and Systems","issn_l":"1932-4545","issn":["1932-4545","1940-9990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Circuits and Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/journal_contribution/Duplication_and_divergence_effect_on_network_motifs_in_undirected_bio-molecular_networks/27481512","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100462649","display_name":"Pei Wang","orcid":"https://orcid.org/0000-0002-8149-756X"},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]},{"id":"https://openalex.org/I82951845","display_name":"RMIT University","ror":"https://ror.org/04ttjf776","country_code":"AU","type":"education","lineage":["https://openalex.org/I82951845"]}],"countries":["AU","CN"],"is_corresponding":false,"raw_author_name":"Pei Wang","raw_affiliation_strings":["Henan University, School of Mathematics and Information Sciences, Kaifeng, China","RMIT University, School of Electrical and Computer Engineering, Melbourne, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henan University, School of Mathematics and Information Sciences, Kaifeng, China","institution_ids":["https://openalex.org/I173899330"]},{"raw_affiliation_string":"RMIT University, School of Electrical and Computer Engineering, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I82951845"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027725400","display_name":"Jinhu L\u00fc","orcid":"https://orcid.org/0000-0003-0275-8387"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinhu Lu","raw_affiliation_strings":["Chinese Academy of Sciences, Institute of Systems Science, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Sciences, Institute of Systems Science, Beijing, China","institution_ids":["https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070195520","display_name":"Xinghuo Yu","orcid":"https://orcid.org/0000-0001-8093-9787"},"institutions":[{"id":"https://openalex.org/I82951845","display_name":"RMIT University","ror":"https://ror.org/04ttjf776","country_code":"AU","type":"education","lineage":["https://openalex.org/I82951845"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Xinghuo Yu","raw_affiliation_strings":["RMIT University, School of Electrical and Computer Engineering, Melbourne, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RMIT University, School of Electrical and Computer Engineering, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I82951845"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112107398","display_name":"Zengrong Liu","orcid":null},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zengrong Liu","raw_affiliation_strings":["Shanghai University, Institute of Systems Biology, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai University, Institute of Systems Biology, Shanghai, China","institution_ids":["https://openalex.org/I113940042"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5356,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.82053858,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"9","issue":"3","first_page":"312","last_page":"320"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10064","display_name":"Complex Network Analysis Techniques","score":0.9776999950408936,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-duplication","display_name":"Gene duplication","score":0.7326487898826599},{"id":"https://openalex.org/keywords/network-motif","display_name":"Network motif","score":0.5781183838844299},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5641875863075256},{"id":"https://openalex.org/keywords/functional-divergence","display_name":"Functional divergence","score":0.5434617400169373},{"id":"https://openalex.org/keywords/divergence","display_name":"Divergence (linguistics)","score":0.536893904209137},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.5218559503555298},{"id":"https://openalex.org/keywords/molecular-evolution","display_name":"Molecular evolution","score":0.4740440845489502},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4699782431125641},{"id":"https://openalex.org/keywords/complex-network","display_name":"Complex network","score":0.45783379673957825},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.4567067325115204},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3454993963241577},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.3327765166759491},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.27401983737945557},{"id":"https://openalex.org/keywords/phylogenetic-tree","display_name":"Phylogenetic tree","score":0.16861602663993835},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.13264191150665283},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.12648865580558777},{"id":"https://openalex.org/keywords/gene-family","display_name":"Gene family","score":0.0970504879951477},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.0953710675239563}],"concepts":[{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.7326487898826599},{"id":"https://openalex.org/C60723933","wikidata":"https://www.wikidata.org/wiki/Q7001080","display_name":"Network motif","level":3,"score":0.5781183838844299},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5641875863075256},{"id":"https://openalex.org/C103077935","wikidata":"https://www.wikidata.org/wiki/Q5508811","display_name":"Functional divergence","level":5,"score":0.5434617400169373},{"id":"https://openalex.org/C207390915","wikidata":"https://www.wikidata.org/wiki/Q1230525","display_name":"Divergence (linguistics)","level":2,"score":0.536893904209137},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.5218559503555298},{"id":"https://openalex.org/C166393388","wikidata":"https://www.wikidata.org/wiki/Q856529","display_name":"Molecular evolution","level":4,"score":0.4740440845489502},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4699782431125641},{"id":"https://openalex.org/C34947359","wikidata":"https://www.wikidata.org/wiki/Q665189","display_name":"Complex network","level":2,"score":0.45783379673957825},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4567067325115204},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3454993963241577},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.3327765166759491},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27401983737945557},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.16861602663993835},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13264191150665283},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12648865580558777},{"id":"https://openalex.org/C5911399","wikidata":"https://www.wikidata.org/wiki/Q2278983","display_name":"Gene family","level":4,"score":0.0970504879951477},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0953710675239563},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020440","descriptor_name":"Gene Duplication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020440","descriptor_name":"Gene Duplication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020440","descriptor_name":"Gene Duplication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1109/tbcas.2014.2343620","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbcas.2014.2343620","pdf_url":null,"source":{"id":"https://openalex.org/S80299757","display_name":"IEEE Transactions on Biomedical Circuits and Systems","issn_l":"1932-4545","issn":["1932-4545","1940-9990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Circuits and Systems","raw_type":"journal-article"},{"id":"pmid:25203993","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25203993","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on biomedical circuits and systems","raw_type":null},{"id":"pmh:oai:alma61RMIT.INST:11247940820001341","is_oa":false,"landing_page_url":"https://researchrepository.rmit.edu.au/esploro/outputs/journalArticle/Duplication-and-divergence-effect-on-network/9921862861901341","pdf_url":null,"source":{"id":"https://openalex.org/S4306402074","display_name":"RMIT Research Repository (RMIT University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I82951845","host_organization_name":"RMIT University","host_organization_lineage":["https://openalex.org/I82951845"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},{"id":"pmh:oai:figshare.com:article/27481512","is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Duplication_and_divergence_effect_on_network_motifs_in_undirected_bio-molecular_networks/27481512","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/27481512","is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Duplication_and_divergence_effect_on_network_motifs_in_undirected_bio-molecular_networks/27481512","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1486817521","https://openalex.org/W1599969036","https://openalex.org/W1978245579","https://openalex.org/W1995863037","https://openalex.org/W1995907191","https://openalex.org/W1998732502","https://openalex.org/W2000367271","https://openalex.org/W2002728691","https://openalex.org/W2008620264","https://openalex.org/W2009660640","https://openalex.org/W2013900144","https://openalex.org/W2043308539","https://openalex.org/W2046363309","https://openalex.org/W2048451896","https://openalex.org/W2048596679","https://openalex.org/W2059044327","https://openalex.org/W2060977279","https://openalex.org/W2066235893","https://openalex.org/W2084668512","https://openalex.org/W2098045561","https://openalex.org/W2109110326","https://openalex.org/W2109248504","https://openalex.org/W2110553053","https://openalex.org/W2110699703","https://openalex.org/W2125210796","https://openalex.org/W2136931666","https://openalex.org/W2145100112","https://openalex.org/W2148606196","https://openalex.org/W2152495216","https://openalex.org/W2153624566","https://openalex.org/W2157145673","https://openalex.org/W2167680767","https://openalex.org/W2169526870","https://openalex.org/W2322934993","https://openalex.org/W2360926565","https://openalex.org/W4254977540","https://openalex.org/W6649328697"],"related_works":["https://openalex.org/W2796517744","https://openalex.org/W2008014943","https://openalex.org/W2807926763","https://openalex.org/W1939880835","https://openalex.org/W2951915565","https://openalex.org/W15348386","https://openalex.org/W2090574217","https://openalex.org/W3119507950","https://openalex.org/W2070704205","https://openalex.org/W2353485001"],"abstract_inverted_index":{"Duplication":[0],"and":[1,14,57,67,97,109,130,156,164],"divergence":[2,68,133],"are":[3,51],"two":[4,28],"basic":[5],"evolutionary":[6,147],"mechanisms":[7,148],"of":[8,33,41,64,77,106,114,139,149,166],"bio-molecular":[9,12,81,154],"networks.":[10,43,141],"Real-world":[11],"networks":[13,31,82,119,168],"their":[15],"statistical":[16],"characteristics":[17],"can":[18,101,134],"be":[19],"well":[20],"mimicked":[21],"by":[22],"artificial":[23,118],"algorithms":[24],"based":[25],"on":[26],"the":[27,62,73,78,86,90,98,104,117,123,127,137,140,145,161],"mechanisms.":[29],"Bio-molecular":[30],"consist":[32],"network":[34,49,150],"motifs,":[35,108],"which":[36],"act":[37],"as":[38,120],"building":[39],"blocks":[40],"large-scale":[42],"A":[44],"fundamental":[45],"question":[46],"is":[47],"how":[48],"motifs":[50,115,151],"evolved":[52],"from":[53],"long":[54],"time":[55],"evolution":[56],"natural":[58],"selection.":[59],"By":[60],"considering":[61],"effect":[63],"various":[65,107],"duplication":[66,75,95],"strategies,":[69],"we":[70],"find":[71],"that":[72,121],"underlying":[74],"scheme":[76],"real-world":[79,124,153],"undirected":[80],"would":[83],"rather":[84],"follow":[85],"anti-preference":[87,94,128],"strategy":[88],"than":[89],"random":[91],"one.":[92],"The":[93,142],"mechanism":[96,129],"dimerization":[99],"processes":[100],"lead":[102],"to":[103],"formation":[105],"robustly":[110,135],"conserve":[111],"proper":[112],"quantities":[113],"in":[116,122,152,160],"ones.":[125],"Furthermore,":[126],"edge":[131],"deletion":[132],"preserve":[136],"sparsity":[138],"investigations":[143],"reveal":[144],"possible":[146],"networks,":[155],"have":[157],"potential":[158],"implications":[159],"design,":[162],"synthesis":[163],"reengineering":[165],"biological":[167],"for":[169],"biomedical":[170],"purpose.":[171]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}