{"id":"https://openalex.org/W2095493915","doi":"https://doi.org/10.1109/tbcas.2013.2288155","title":"A Newtonian Framework for Community Detection in Undirected Biological Networks","display_name":"A Newtonian Framework for Community Detection in Undirected Biological Networks","publication_year":2014,"publication_date":"2014-02-01","ids":{"openalex":"https://openalex.org/W2095493915","doi":"https://doi.org/10.1109/tbcas.2013.2288155","mag":"2095493915","pmid":"https://pubmed.ncbi.nlm.nih.gov/24681920"},"language":"en","primary_location":{"id":"doi:10.1109/tbcas.2013.2288155","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbcas.2013.2288155","pdf_url":null,"source":{"id":"https://openalex.org/S80299757","display_name":"IEEE Transactions on Biomedical Circuits and Systems","issn_l":"1932-4545","issn":["1932-4545","1940-9990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Circuits and Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109106772","display_name":"Tejaswini Narayanan","orcid":null},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tejaswini Narayanan","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA, USA","[Dept of Electr. & Comput. Eng., Univ. of California San Diego, La Jolla, CA, USA]"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"[Dept of Electr. & Comput. Eng., Univ. of California San Diego, La Jolla, CA, USA]","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063396453","display_name":"Shankar Subramaniam","orcid":"https://orcid.org/0000-0002-8059-4659"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shankar Subramaniam","raw_affiliation_strings":["Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA","Dept. ofBioengineering, Univ. of California, San Diego, La Jolla, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Dept. ofBioengineering, Univ. of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5109106772"],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":null,"apc_paid":null,"fwci":0.8366,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.72651232,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"8","issue":"1","first_page":"65","last_page":"73"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10064","display_name":"Complex Network Analysis Techniques","score":0.9929999709129333,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6779897212982178},{"id":"https://openalex.org/keywords/relevance","display_name":"Relevance (law)","score":0.6101082563400269},{"id":"https://openalex.org/keywords/ontology","display_name":"Ontology","score":0.5875282883644104},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.5494146943092346},{"id":"https://openalex.org/keywords/key","display_name":"Key (lock)","score":0.5251569151878357},{"id":"https://openalex.org/keywords/variety","display_name":"Variety (cybernetics)","score":0.48938220739364624},{"id":"https://openalex.org/keywords/domain","display_name":"Domain (mathematical analysis)","score":0.4804101288318634},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.44190865755081177},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.42268499732017517},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3985687494277954},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.39139822125434875},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.3616848587989807},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2097809612751007},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.15211105346679688},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1210145354270935}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6779897212982178},{"id":"https://openalex.org/C158154518","wikidata":"https://www.wikidata.org/wiki/Q7310970","display_name":"Relevance (law)","level":2,"score":0.6101082563400269},{"id":"https://openalex.org/C25810664","wikidata":"https://www.wikidata.org/wiki/Q44325","display_name":"Ontology","level":2,"score":0.5875282883644104},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.5494146943092346},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.5251569151878357},{"id":"https://openalex.org/C136197465","wikidata":"https://www.wikidata.org/wiki/Q1729295","display_name":"Variety (cybernetics)","level":2,"score":0.48938220739364624},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.4804101288318634},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.44190865755081177},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.42268499732017517},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3985687494277954},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.39139822125434875},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3616848587989807},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2097809612751007},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.15211105346679688},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1210145354270935},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tbcas.2013.2288155","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbcas.2013.2288155","pdf_url":null,"source":{"id":"https://openalex.org/S80299757","display_name":"IEEE Transactions on Biomedical Circuits and Systems","issn_l":"1932-4545","issn":["1932-4545","1940-9990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Circuits and Systems","raw_type":"journal-article"},{"id":"pmid:24681920","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24681920","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on biomedical circuits and systems","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7200000286102295,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W19224017","https://openalex.org/W199296758","https://openalex.org/W950821216","https://openalex.org/W1971421925","https://openalex.org/W1973377476","https://openalex.org/W1985625141","https://openalex.org/W1987299841","https://openalex.org/W1991098816","https://openalex.org/W1998767819","https://openalex.org/W2018045523","https://openalex.org/W2022980325","https://openalex.org/W2030961238","https://openalex.org/W2081607470","https://openalex.org/W2081931663","https://openalex.org/W2095293504","https://openalex.org/W2095965857","https://openalex.org/W2103017472","https://openalex.org/W2109463754","https://openalex.org/W2110175019","https://openalex.org/W2111002549","https://openalex.org/W2114227262","https://openalex.org/W2117412805","https://openalex.org/W2125179362","https://openalex.org/W2127048411","https://openalex.org/W2130687290","https://openalex.org/W2131717044","https://openalex.org/W2133465414","https://openalex.org/W2136850043","https://openalex.org/W2158217645","https://openalex.org/W2159482845","https://openalex.org/W2163485494","https://openalex.org/W2168316093","https://openalex.org/W2169499007","https://openalex.org/W2407765918","https://openalex.org/W3102641634","https://openalex.org/W3105855715","https://openalex.org/W4294216483","https://openalex.org/W6714208976"],"related_works":["https://openalex.org/W2032233321","https://openalex.org/W3121970507","https://openalex.org/W2110028391","https://openalex.org/W54497855","https://openalex.org/W217960748","https://openalex.org/W3125814499","https://openalex.org/W2090827041","https://openalex.org/W2094012830","https://openalex.org/W187246281","https://openalex.org/W2079194830"],"abstract_inverted_index":{"Community":[0,107],"detection":[1,39],"is":[2,41,76,183],"a":[3,14,34,44,50,53,138,149,166,175,194,215,234],"key":[4,235],"problem":[5,94],"of":[6,16,55,62,100,114,152,156],"interest":[7],"in":[8,13,129,191],"network":[9,23,51,173],"analysis,":[10],"with":[11,165,185],"applications":[12,241],"variety":[15],"domains":[17],"such":[18],"as":[19,52,174,233],"biological":[20,167,221],"networks,":[21],"social":[22],"modeling,":[24],"and":[25,58,81,120],"communication":[26],"pattern":[27],"analysis.":[28],"In":[29],"this":[30],"paper,":[31],"we":[32],"present":[33,148],"novel":[35],"framework":[36,75],"for":[37,92,143,197,238,246],"community":[38,63,144],"that":[40,88,126,203,209,225],"motivated":[42],"by":[43,65,103,160],"physical":[45],"system":[46,54],"analogy.":[47],"We":[48,96,123,146,223],"model":[49,86],"point":[56,72],"masses,":[57],"drive":[59],"the":[60,67,71,85,93,98,105,135,153,157,186,204,229],"process":[61],"detection,":[64],"leveraging":[66],"Newtonian":[68,106],"interactions":[69],"between":[70],"masses.":[73],"Our":[74],"designed":[77],"to":[78,84,131,193,231],"be":[79],"generic":[80],"extensible":[82],"relative":[83],"parameters":[87],"are":[89,127,210],"most":[90],"suited":[91],"domain.":[95],"illustrate":[97],"applicability":[99],"our":[101,161,226],"approach":[102],"applying":[104],"Detection":[108],"algorithm":[109,142,206,227],"on":[110],"protein-protein":[111],"interaction":[112],"networks":[113],"E.":[115,170],"coli":[116,171],",":[117],"C.":[118],"elegans,":[119],"S.":[121],"cerevisiae.":[122],"obtain":[124],"results":[125],"comparable":[128],"quality":[130],"those":[132],"obtained":[133],"from":[134,214],"Newman-Girvan":[136],"algorithm,":[137,163],"widely":[139],"employed":[140],"divisive":[141],"detection.":[145],"also":[147,219],"detailed":[150],"analysis":[151,196,201],"structural":[154],"properties":[155],"communities":[158,208],"produced":[159],"proposed":[162,205],"together":[164],"interpretation":[168],"using":[169],"protein":[172],"case":[176],"study.":[177],"A":[178],"functional":[179,189],"enrichment":[180],"heat":[181],"map":[182],"constructed":[184],"Gene":[187],"Ontology":[188],"mapping,":[190],"addition":[192],"pathway":[195],"each":[198],"community.":[199],"The":[200],"illustrates":[202],"elicits":[207],"not":[211],"only":[212],"meaningful":[213],"topological":[216],"standpoint,":[217],"but":[218],"possess":[220],"relevance.":[222],"believe":[224],"has":[228],"potential":[230],"serve":[232],"computational":[236],"tool":[237],"driving":[239],"therapeutic":[240],"involving":[242],"targeted":[243],"drug":[244],"development":[245],"personalized":[247],"care":[248],"delivery.":[249]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}