{"id":"https://openalex.org/W2441532972","doi":"https://doi.org/10.1109/syscon.2016.7490536","title":"Cellular automata simulation of signal transduction and calcium dynamics with healthy and faulty receptor trafficking","display_name":"Cellular automata simulation of signal transduction and calcium dynamics with healthy and faulty receptor trafficking","publication_year":2016,"publication_date":"2016-04-01","ids":{"openalex":"https://openalex.org/W2441532972","doi":"https://doi.org/10.1109/syscon.2016.7490536","mag":"2441532972"},"language":"en","primary_location":{"id":"doi:10.1109/syscon.2016.7490536","is_oa":false,"landing_page_url":"https://doi.org/10.1109/syscon.2016.7490536","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 Annual IEEE Systems Conference (SysCon)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076193064","display_name":"Chontita Rattanakul","orcid":"https://orcid.org/0000-0002-2362-5885"},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Chontita Rattanakul","raw_affiliation_strings":["Department of Mathematics, Mahidol University, Bangkok, Thailand"],"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Mahidol University, Bangkok, Thailand","institution_ids":["https://openalex.org/I25399158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081965928","display_name":"Yongwimon Lenbury","orcid":"https://orcid.org/0000-0002-8270-1980"},"institutions":[{"id":"https://openalex.org/I4210117768","display_name":"Centre of Excellence in Mathematics","ror":"https://ror.org/02df7gw66","country_code":"TH","type":"education","lineage":["https://openalex.org/I4210117768"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Yongwimon Lenbury","raw_affiliation_strings":["Centre of Excellence in Mathematics, Commission on Higher Education, Bangkok, Thailand"],"affiliations":[{"raw_affiliation_string":"Centre of Excellence in Mathematics, Commission on Higher Education, Bangkok, Thailand","institution_ids":["https://openalex.org/I4210117768"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5076193064"],"corresponding_institution_ids":["https://openalex.org/I25399158"],"apc_list":null,"apc_paid":null,"fwci":0.1667,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.62635849,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"63","issue":null,"first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13047","display_name":"Pharmacological Receptor Mechanisms and Effects","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9866999983787537,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/second-messenger-system","display_name":"Second messenger system","score":0.8026354312896729},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.6938048601150513},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"Calcium signaling","score":0.6573960185050964},{"id":"https://openalex.org/keywords/calcium","display_name":"Calcium","score":0.642202615737915},{"id":"https://openalex.org/keywords/calcium-in-biology","display_name":"Calcium in biology","score":0.575134813785553},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.53777015209198},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.5220599174499512},{"id":"https://openalex.org/keywords/cyclic-adenosine-monophosphate","display_name":"Cyclic adenosine monophosphate","score":0.5173508524894714},{"id":"https://openalex.org/keywords/intracellular","display_name":"Intracellular","score":0.5119343996047974},{"id":"https://openalex.org/keywords/cell-signaling","display_name":"Cell signaling","score":0.4574098587036133},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4245210289955139},{"id":"https://openalex.org/keywords/cytosol","display_name":"Cytosol","score":0.4241056740283966},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.3823033571243286},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3018421530723572},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2227853238582611},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.07701385021209717}],"concepts":[{"id":"https://openalex.org/C163235415","wikidata":"https://www.wikidata.org/wiki/Q899814","display_name":"Second messenger system","level":3,"score":0.8026354312896729},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.6938048601150513},{"id":"https://openalex.org/C201571599","wikidata":"https://www.wikidata.org/wiki/Q5018840","display_name":"Calcium signaling","level":3,"score":0.6573960185050964},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.642202615737915},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.575134813785553},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.53777015209198},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5220599174499512},{"id":"https://openalex.org/C2776668983","wikidata":"https://www.wikidata.org/wiki/Q210041","display_name":"Cyclic adenosine monophosphate","level":3,"score":0.5173508524894714},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5119343996047974},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.4574098587036133},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4245210289955139},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.4241056740283966},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3823033571243286},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3018421530723572},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2227853238582611},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07701385021209717},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/syscon.2016.7490536","is_oa":false,"landing_page_url":"https://doi.org/10.1109/syscon.2016.7490536","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 Annual IEEE Systems Conference (SysCon)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1496187814","https://openalex.org/W1596679547","https://openalex.org/W1868993678","https://openalex.org/W1973208670","https://openalex.org/W1979292005","https://openalex.org/W1984351623","https://openalex.org/W1986249076","https://openalex.org/W2007023896","https://openalex.org/W2008940139","https://openalex.org/W2016994976","https://openalex.org/W2022545708","https://openalex.org/W2052192720","https://openalex.org/W2063347367","https://openalex.org/W2066074704","https://openalex.org/W2070235828","https://openalex.org/W2078227548","https://openalex.org/W2079212311","https://openalex.org/W2090083628","https://openalex.org/W2113037104","https://openalex.org/W2113850105","https://openalex.org/W2151983621","https://openalex.org/W2152496846","https://openalex.org/W2612506596","https://openalex.org/W3104652402","https://openalex.org/W6629744594"],"related_works":["https://openalex.org/W4255451859","https://openalex.org/W2755915010","https://openalex.org/W1555347921","https://openalex.org/W2411241594","https://openalex.org/W2115894972","https://openalex.org/W2998168964","https://openalex.org/W4239582250","https://openalex.org/W596198965","https://openalex.org/W4210659176","https://openalex.org/W2496453176"],"abstract_inverted_index":{"The":[0],"signal":[1,10],"transduction":[2],"process":[3,62,77],"is":[4,11,38],"one":[5],"by":[6,13,120,133],"which":[7],"an":[8,39,84,121],"external":[9],"detected":[12],"the":[14,46,60,64,88,91,127],"cell":[15],"and":[16,43,52,97,117],"converted":[17],"into":[18],"cellular":[19,102],"responsive":[20],"actions":[21],"leading":[22],"to":[23,69,82,112],"changes":[24],"in":[25,55,59,87],"secondary":[26],"messengers,":[27],"such":[28],"as":[29],"cAMP":[30],"(cyclic":[31],"adenosine":[32],"monophosphate)":[33],"or":[34],"intracellular":[35,56],"calcium.":[36],"Calcium":[37],"important":[40,85],"second":[41],"messenger":[42],"has":[44,78],"been":[45,80],"subject":[47],"of":[48,72,90,109,126,129,137],"numerous":[49],"experimental":[50],"investigations":[51],"dynamic":[53],"studies":[54],"signaling.":[57],"Defects":[58],"signaling":[61],"involving":[63],"calcium-sensing":[65],"receptors":[66],"can":[67],"lead":[68],"faulty":[70],"re-adjustments":[71],"circulating":[73],"calcium":[74,132],"level.":[75],"Dimerization":[76],"also":[79],"proposed":[81],"play":[83],"role":[86],"efficiency":[89],"receptor":[92,114],"responses.":[93],"Here,":[94],"we":[95],"construct":[96],"simulate":[98],"a":[99,107,135],"Monte":[100],"Carlo":[101],"automata":[103],"model":[104,113],"coupled":[105],"with":[106],"system":[108,136],"difference":[110,138],"equations":[111],"binding,":[115],"trafficking,":[116],"dimerization":[118],"triggered":[119],"agonist,":[122],"while":[123],"keeping":[124],"track":[125],"concentration":[128],"cytosolic":[130],"free":[131],"using":[134],"equations.":[139]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}