{"id":"https://openalex.org/W3040054809","doi":"https://doi.org/10.1109/sose50414.2020.9130530","title":"Sensitivity and identifiability analysis of a third-order tumor growth model","display_name":"Sensitivity and identifiability analysis of a third-order tumor growth model","publication_year":2020,"publication_date":"2020-06-01","ids":{"openalex":"https://openalex.org/W3040054809","doi":"https://doi.org/10.1109/sose50414.2020.9130530","mag":"3040054809"},"language":"en","primary_location":{"id":"doi:10.1109/sose50414.2020.9130530","is_oa":false,"landing_page_url":"https://doi.org/10.1109/sose50414.2020.9130530","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 IEEE 15th International Conference of System of Systems Engineering (SoSE)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055832332","display_name":"M\u00e1t\u00e9 Siket","orcid":"https://orcid.org/0000-0002-4425-5588"},"institutions":[{"id":"https://openalex.org/I103356709","display_name":"Obuda University","ror":"https://ror.org/00ax71d21","country_code":"HU","type":"education","lineage":["https://openalex.org/I103356709"]}],"countries":["HU"],"is_corresponding":true,"raw_author_name":"Mate Siket","raw_affiliation_strings":["Physiological Controls Research Center within the Research, Innovation and Service Center of \u00d3buda University, Budapest, Hungary"],"affiliations":[{"raw_affiliation_string":"Physiological Controls Research Center within the Research, Innovation and Service Center of \u00d3buda University, Budapest, Hungary","institution_ids":["https://openalex.org/I103356709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077451025","display_name":"Gy\u00f6rgy Eigner","orcid":"https://orcid.org/0000-0001-8038-2210"},"institutions":[{"id":"https://openalex.org/I103356709","display_name":"Obuda University","ror":"https://ror.org/00ax71d21","country_code":"HU","type":"education","lineage":["https://openalex.org/I103356709"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Gyorgy Eigner","raw_affiliation_strings":["Physiological Controls Research Center within the Research, Innovation and Service Center of \u00d3buda University, Budapest, Hungary"],"affiliations":[{"raw_affiliation_string":"Physiological Controls Research Center within the Research, Innovation and Service Center of \u00d3buda University, Budapest, Hungary","institution_ids":["https://openalex.org/I103356709"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021051122","display_name":"Levente Kov\u00e1cs","orcid":"https://orcid.org/0000-0002-3188-0800"},"institutions":[{"id":"https://openalex.org/I103356709","display_name":"Obuda University","ror":"https://ror.org/00ax71d21","country_code":"HU","type":"education","lineage":["https://openalex.org/I103356709"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Levente Kovacs","raw_affiliation_strings":["Physiological Controls Research Center within the Research, Innovation and Service Center of \u00d3buda University, Budapest, Hungary"],"affiliations":[{"raw_affiliation_string":"Physiological Controls Research Center within the Research, Innovation and Service Center of \u00d3buda University, Budapest, Hungary","institution_ids":["https://openalex.org/I103356709"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5055832332"],"corresponding_institution_ids":["https://openalex.org/I103356709"],"apc_list":null,"apc_paid":null,"fwci":0.35,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.66784379,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":null,"issue":null,"first_page":"417","last_page":"422"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9869999885559082,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9710999727249146,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/identifiability","display_name":"Identifiability","score":0.9621037840843201},{"id":"https://openalex.org/keywords/sensitivity","display_name":"Sensitivity (control systems)","score":0.7573734521865845},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5293541550636292},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.4672683775424957},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.4449999928474426},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.34617018699645996},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.24116617441177368},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1108488142490387},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.10751646757125854}],"concepts":[{"id":"https://openalex.org/C122770356","wikidata":"https://www.wikidata.org/wiki/Q1656753","display_name":"Identifiability","level":2,"score":0.9621037840843201},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.7573734521865845},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5293541550636292},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.4672683775424957},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4449999928474426},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.34617018699645996},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.24116617441177368},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1108488142490387},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.10751646757125854},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/sose50414.2020.9130530","is_oa":false,"landing_page_url":"https://doi.org/10.1109/sose50414.2020.9130530","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 IEEE 15th International Conference of System of Systems Engineering (SoSE)","raw_type":"proceedings-article"},{"id":"pmh:oai:real.mtak.hu:121221","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306400081","display_name":"Repository of the Academy's Library (Library of the Hungarian Academy of Sciences)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210140733","host_organization_name":"Library and Information Centre of the Hungarian Academy of Sciences","host_organization_lineage":["https://openalex.org/I4210140733"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Conference or Workshop Item"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.699999988079071,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W139331474","https://openalex.org/W1964231254","https://openalex.org/W2008365461","https://openalex.org/W2101961850","https://openalex.org/W2122746292","https://openalex.org/W2472163094","https://openalex.org/W2561513855","https://openalex.org/W2582437320","https://openalex.org/W2733703420","https://openalex.org/W2791089002","https://openalex.org/W2991360384","https://openalex.org/W2998248873","https://openalex.org/W2998580544","https://openalex.org/W3000598214","https://openalex.org/W3033449782","https://openalex.org/W3040650072"],"related_works":["https://openalex.org/W2724847603","https://openalex.org/W2034041141","https://openalex.org/W2184661725","https://openalex.org/W2573470972","https://openalex.org/W112856298","https://openalex.org/W2105626102","https://openalex.org/W2131038454","https://openalex.org/W4240568257","https://openalex.org/W2900187352","https://openalex.org/W1996342314"],"abstract_inverted_index":{"The":[0,20,67,97],"growing":[1],"cancer":[2],"cases":[3],"attract":[4],"more":[5,7],"and":[6,10,18,49,65,72,94,111],"scientific":[8],"research":[9],"introductions":[11],"of":[12,27,37,69,84,103,114,126],"new":[13],"models,":[14],"applied":[15],"control":[16],"algorithms":[17],"methods.":[19],"models":[21,71],"are":[22,51],"fundamental":[23],"in":[24,119],"the":[25,35,38,46,61,70,112,115],"area":[26],"computer":[28],"generated":[29],"low-dose":[30],"metronomic":[31],"(LDM)":[32],"chemotherapy,":[33],"when":[34],"administration":[36],"drug":[39],"is":[40,57,75],"ought":[41],"to":[42,59],"be":[43,106],"optimized.":[44],"Generally":[45],"in-silico":[47],"tests":[48],"investigations":[50],"based":[52,90],"on":[53,91],"a":[54,85,101],"model,":[55],"which":[56],"hypothesized":[58],"describe":[60],"given":[62],"process":[63],"reliably":[64],"accurately.":[66],"analysis":[68,83,93],"its":[73],"parameters":[74,104],"crucial":[76],"for":[77],"therapy":[78],"generation.":[79],"We":[80],"performed":[81],"an":[82,120],"third-order":[86],"tumor":[87],"growth":[88],"model":[89],"sensitivity":[92],"identifiability":[95],"tests.":[96],"results":[98,118],"show":[99],"that":[100],"subset":[102],"can":[105],"fixed":[107],"as":[108],"population":[109],"values":[110],"rest":[113],"parameter":[116],"sets":[117],"identifiable":[121],"system":[122],"with":[123],"minor":[124],"loss":[125],"accuracy.":[127]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}