{"id":"https://openalex.org/W2824392129","doi":"https://doi.org/10.1109/siu.2018.8404805","title":"Automated cell segmentation and spot detection in fluorescence in situ hybridization staining to assess HER2 status in breast cancer","display_name":"Automated cell segmentation and spot detection in fluorescence in situ hybridization staining to assess HER2 status in breast cancer","publication_year":2018,"publication_date":"2018-05-01","ids":{"openalex":"https://openalex.org/W2824392129","doi":"https://doi.org/10.1109/siu.2018.8404805","mag":"2824392129"},"language":"en","primary_location":{"id":"doi:10.1109/siu.2018.8404805","is_oa":false,"landing_page_url":"https://doi.org/10.1109/siu.2018.8404805","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 26th Signal Processing and Communications Applications Conference (SIU)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070657196","display_name":"Sukru Burak Cetin","orcid":null},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sukru Burak Cetin","raw_affiliation_strings":["Virasoft, ARI 1 Teknokent, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virasoft, ARI 1 Teknokent, Istanbul, Turkey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019996623","display_name":"Fariba D. Khameneh","orcid":null},"institutions":[{"id":"https://openalex.org/I48912391","display_name":"Istanbul Technical University","ror":"https://ror.org/059636586","country_code":"TR","type":"education","lineage":["https://openalex.org/I48912391"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Fariba D. Khameneh","raw_affiliation_strings":["Istanbul Teknik Universitesi, Istanbul, TR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istanbul Teknik Universitesi, Istanbul, TR","institution_ids":["https://openalex.org/I48912391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070207013","display_name":"Ercan Alp Serteli","orcid":"https://orcid.org/0000-0002-4334-3068"},"institutions":[{"id":"https://openalex.org/I4210144623","display_name":"ODT\u00dc Teknokent (Turkey)","ror":"https://ror.org/04a197k40","country_code":"TR","type":"company","lineage":["https://openalex.org/I4210144623"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ercan Alp Serteli","raw_affiliation_strings":["Virasoft ARI 1 Teknokent, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virasoft ARI 1 Teknokent, Istanbul, Turkey","institution_ids":["https://openalex.org/I4210144623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032716191","display_name":"Sercan \u00c7ay\u0131r","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sercan Cayir","raw_affiliation_strings":["Virasoft, ARI 1 Teknokent, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virasoft, ARI 1 Teknokent, Istanbul, Turkey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032400019","display_name":"Gokhan Hatipoglu","orcid":"https://orcid.org/0000-0001-9048-3090"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gokhan Hatipoglu","raw_affiliation_strings":["Virasoft, ARI 1 Teknokent, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virasoft, ARI 1 Teknokent, Istanbul, Turkey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002812626","display_name":"Mustafa E. Kama\u015fak","orcid":"https://orcid.org/0000-0002-5050-3357"},"institutions":[{"id":"https://openalex.org/I48912391","display_name":"Istanbul Technical University","ror":"https://ror.org/059636586","country_code":"TR","type":"education","lineage":["https://openalex.org/I48912391"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mustafa Kamasak","raw_affiliation_strings":["Istanbul Teknik Universitesi, Istanbul, TR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istanbul Teknik Universitesi, Istanbul, TR","institution_ids":["https://openalex.org/I48912391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031731053","display_name":"Samet Ayalt\u0131","orcid":null},"institutions":[{"id":"https://openalex.org/I4210144623","display_name":"ODT\u00dc Teknokent (Turkey)","ror":"https://ror.org/04a197k40","country_code":"TR","type":"company","lineage":["https://openalex.org/I4210144623"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Samet Ayalti","raw_affiliation_strings":["Virasoft ARI 1 Teknokent, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virasoft ARI 1 Teknokent, Istanbul, Turkey","institution_ids":["https://openalex.org/I4210144623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028870698","display_name":"Salar Razavi","orcid":"https://orcid.org/0000-0003-2421-4524"},"institutions":[{"id":"https://openalex.org/I48912391","display_name":"Istanbul Technical University","ror":"https://ror.org/059636586","country_code":"TR","type":"education","lineage":["https://openalex.org/I48912391"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Salar Razavi","raw_affiliation_strings":["Istanbul Teknik Universitesi, Istanbul, TR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istanbul Teknik Universitesi, Istanbul, TR","institution_ids":["https://openalex.org/I48912391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026368937","display_name":"Yakup Budancamanak","orcid":null},"institutions":[{"id":"https://openalex.org/I4210144623","display_name":"ODT\u00dc Teknokent (Turkey)","ror":"https://ror.org/04a197k40","country_code":"TR","type":"company","lineage":["https://openalex.org/I4210144623"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Yakup Budancamanak","raw_affiliation_strings":["Virasoft ARI 1 Teknokent, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virasoft ARI 1 Teknokent, Istanbul, Turkey","institution_ids":["https://openalex.org/I4210144623"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090831642","display_name":"G\u00fcl\u015fah \u00d6zsoy","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gulsah Ozsoy","raw_affiliation_strings":["Virasoft, ARI 1 Teknokent, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virasoft, ARI 1 Teknokent, Istanbul, Turkey","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5070657196"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.257,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.74749013,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"10","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.7514654397964478},{"id":"https://openalex.org/keywords/fluorescence-in-situ-hybridization","display_name":"Fluorescence in situ hybridization","score":0.7002744674682617},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6104843020439148},{"id":"https://openalex.org/keywords/fish-actinopterygii","display_name":"Fish <Actinopterygii>","score":0.6031417846679688},{"id":"https://openalex.org/keywords/in-situ-hybridization","display_name":"In situ hybridization","score":0.5904418230056763},{"id":"https://openalex.org/keywords/in-situ","display_name":"In situ","score":0.5812508463859558},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5158347487449646},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.4701694846153259},{"id":"https://openalex.org/keywords/staining","display_name":"Staining","score":0.4594299793243408},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.43698474764823914},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.4310712218284607},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.41176027059555054},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3860814869403839},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.37401649355888367},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.3728552460670471},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.32426613569259644},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2647979259490967},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.186398446559906},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.16543027758598328},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.14838820695877075},{"id":"https://openalex.org/keywords/chromosome","display_name":"Chromosome","score":0.1296420693397522},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.09887170791625977},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.09673500061035156}],"concepts":[{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.7514654397964478},{"id":"https://openalex.org/C2777542201","wikidata":"https://www.wikidata.org/wiki/Q1336182","display_name":"Fluorescence in situ hybridization","level":4,"score":0.7002744674682617},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6104843020439148},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.6031417846679688},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.5904418230056763},{"id":"https://openalex.org/C2777822432","wikidata":"https://www.wikidata.org/wiki/Q216681","display_name":"In situ","level":2,"score":0.5812508463859558},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5158347487449646},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4701694846153259},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.4594299793243408},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.43698474764823914},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.4310712218284607},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.41176027059555054},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3860814869403839},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37401649355888367},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3728552460670471},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32426613569259644},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2647979259490967},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.186398446559906},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16543027758598328},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14838820695877075},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.1296420693397522},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09887170791625977},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.09673500061035156},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/siu.2018.8404805","is_oa":false,"landing_page_url":"https://doi.org/10.1109/siu.2018.8404805","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 26th Signal Processing and Communications Applications Conference (SIU)","raw_type":"proceedings-article"},{"id":"pmh:oai:polen.itu.edu.tr:11527/54563","is_oa":false,"landing_page_url":"https://hdl.handle.net/11527/54563","pdf_url":null,"source":{"id":"https://openalex.org/S4306400460","display_name":"Istanbul Technical University Academic Open Archive (Istanbul Technical University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I48912391","host_organization_name":"Istanbul Technical University","host_organization_lineage":["https://openalex.org/I48912391"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Life below water","id":"https://metadata.un.org/sdg/14","score":0.4300000071525574}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1976468890","https://openalex.org/W2016622085","https://openalex.org/W2078454159","https://openalex.org/W2109008952","https://openalex.org/W2111282668","https://openalex.org/W2136304620","https://openalex.org/W2137773299","https://openalex.org/W2167290035","https://openalex.org/W2325863768","https://openalex.org/W2727750196"],"related_works":["https://openalex.org/W2383463315","https://openalex.org/W2361625425","https://openalex.org/W1431904956","https://openalex.org/W2373675175","https://openalex.org/W1974583777","https://openalex.org/W2269144480","https://openalex.org/W3085510013","https://openalex.org/W2037370208","https://openalex.org/W1968072793","https://openalex.org/W2389590026"],"abstract_inverted_index":{"Fluorescence":[0],"in":[1,28,103,116,162,167],"situ":[2],"hybridization":[3],"(FISH)":[4],"approach":[5],"is":[6,36,56],"constituted":[7],"of":[8,11,26,32,50,121,138,176,179,191],"a":[9],"pair":[10],"complementary":[12],"techniques":[13],"for":[14,60],"precisely":[15],"detecting":[16],"gene":[17],"amplification":[18,43,177],"and":[19,48,58,75,101,151,158],"over-expression":[20],"which":[21,185],"are":[22,72,91,183],"regarded":[23],"as":[24,39,171,173],"signs":[25],"cancer":[27],"patients.":[29],"Signal":[30],"detection":[31,47,153],"FISH":[33,51,65,111,125],"whole":[34],"slides":[35,52,67],"extremely":[37],"significant":[38],"enables":[40],"to":[41,62,87,135,155,187],"detect":[42,156],"situation.":[44],"However,":[45],"nuclei":[46,149],"segmentation":[49,150],"through":[53],"microscopic":[54],"images":[55],"tedious":[57],"time-consuming":[59],"pathologists":[61],"evaluate.":[63],"Furthermore,":[64],"specimen":[66],"provided":[68],"at":[69],"pathological":[70],"laboratories":[71],"frequently":[73],"noisy":[74],"not":[76],"analyzable":[77],"entirely.":[78],"Therefore,":[79],"traditional":[80],"visual":[81,169,189],"methods":[82],"require":[83,98],"more":[84,99],"time":[85,100],"due":[86,134],"fact":[88],"that":[89],"they":[90,130],"exceedingly":[92],"reliant":[93],"on":[94],"human":[95],"view.":[96],"They":[97],"attention":[102],"the":[104,136,168,174,180,188],"evaluation":[105],"process":[106],"by":[107],"pathologists.":[108,192],"Nowadays,":[109],"computer-aided":[110,124],"solutions":[112,126],"bring":[113],"radical":[114],"remedies":[115],"this":[117,142],"particular":[118],"problematic":[119],"area":[120],"pathology.":[122],"Although":[123],"have":[127,131],"many":[128],"advantages,":[129],"some":[132],"drawbacks":[133],"variability":[137],"staining":[139],"images.":[140],"In":[141],"study,":[143],"we":[144],"present":[145],"an":[146],"accurate":[147],"cell":[148],"signal":[152],"methodology":[154],"red":[157],"green":[159],"spots":[160],"localized":[161],"segmented":[163],"cells.":[164],"The":[165],"problems":[166],"experiments":[170],"well":[172],"assessment":[175],"state":[178],"evaluated":[181],"cases":[182],"presented,":[184],"corresponds":[186],"scoring":[190]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-05-05T08:41:31.759640","created_date":"2025-10-10T00:00:00"}
