{"id":"https://openalex.org/W4404057194","doi":"https://doi.org/10.1109/sisy62279.2024.10737606","title":"Multi-Objective Chemotherapy Optimization Using NSGA-II and Epsilon-Constraint Method","display_name":"Multi-Objective Chemotherapy Optimization Using NSGA-II and Epsilon-Constraint Method","publication_year":2024,"publication_date":"2024-09-19","ids":{"openalex":"https://openalex.org/W4404057194","doi":"https://doi.org/10.1109/sisy62279.2024.10737606"},"language":"en","primary_location":{"id":"doi:10.1109/sisy62279.2024.10737606","is_oa":false,"landing_page_url":"https://doi.org/10.1109/sisy62279.2024.10737606","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE 22nd Jubilee International Symposium on Intelligent Systems and Informatics (SISY)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092276535","display_name":"Martin Ferenc D\u00f6m\u00e9ny","orcid":null},"institutions":[{"id":"https://openalex.org/I103356709","display_name":"Obuda University","ror":"https://ror.org/00ax71d21","country_code":"HU","type":"education","lineage":["https://openalex.org/I103356709"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Martin Ferenc D\u00f6m\u00e9ny","raw_affiliation_strings":["Physiological Controls Research Center, Research and Innovation Center of Obuda University, Obuda University,Budapest,Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiological Controls Research Center, Research and Innovation Center of Obuda University, Obuda University,Budapest,Hungary","institution_ids":["https://openalex.org/I103356709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051845260","display_name":"Mel\u00e1nia Pusk\u00e1s","orcid":"https://orcid.org/0009-0003-9694-6553"},"institutions":[{"id":"https://openalex.org/I103356709","display_name":"Obuda University","ror":"https://ror.org/00ax71d21","country_code":"HU","type":"education","lineage":["https://openalex.org/I103356709"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Mel\u00e1nia Pusk\u00e1s","raw_affiliation_strings":["Physiological Controls Research Center, Research and Innovation Center of Obuda University, Obuda University,Budapest,Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiological Controls Research Center, Research and Innovation Center of Obuda University, Obuda University,Budapest,Hungary","institution_ids":["https://openalex.org/I103356709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021051122","display_name":"Levente Kov\u00e1cs","orcid":"https://orcid.org/0000-0002-3188-0800"},"institutions":[{"id":"https://openalex.org/I103356709","display_name":"Obuda University","ror":"https://ror.org/00ax71d21","country_code":"HU","type":"education","lineage":["https://openalex.org/I103356709"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Levente Kov\u00e1cs","raw_affiliation_strings":["Physiological Controls Research Center, Research and Innovation Center of Obuda University, Obuda University,Budapest,Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiological Controls Research Center, Research and Innovation Center of Obuda University, Obuda University,Budapest,Hungary","institution_ids":["https://openalex.org/I103356709"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071491835","display_name":"D\u00e1niel Andr\u00e1s Drexler","orcid":"https://orcid.org/0000-0001-6655-4354"},"institutions":[{"id":"https://openalex.org/I103356709","display_name":"Obuda University","ror":"https://ror.org/00ax71d21","country_code":"HU","type":"education","lineage":["https://openalex.org/I103356709"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"D\u00e1niel Andr\u00e1s Drexler","raw_affiliation_strings":["Physiological Controls Research Center, Research and Innovation Center of Obuda University, Obuda University,Budapest,Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiological Controls Research Center, Research and Innovation Center of Obuda University, Obuda University,Budapest,Hungary","institution_ids":["https://openalex.org/I103356709"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I103356709"],"apc_list":null,"apc_paid":null,"fwci":1.5631,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.85349622,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"000179","last_page":"000184"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10848","display_name":"Advanced Multi-Objective Optimization Algorithms","score":0.8919000029563904,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10848","display_name":"Advanced Multi-Objective Optimization Algorithms","score":0.8919000029563904,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/constraint","display_name":"Constraint (computer-aided design)","score":0.5975069999694824},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5509037375450134},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.5162382125854492},{"id":"https://openalex.org/keywords/applied-mathematics","display_name":"Applied mathematics","score":0.3314115107059479},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.24899828433990479},{"id":"https://openalex.org/keywords/geometry","display_name":"Geometry","score":0.058631956577301025}],"concepts":[{"id":"https://openalex.org/C2776036281","wikidata":"https://www.wikidata.org/wiki/Q48769818","display_name":"Constraint (computer-aided design)","level":2,"score":0.5975069999694824},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5509037375450134},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.5162382125854492},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.3314115107059479},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.24899828433990479},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.058631956577301025}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/sisy62279.2024.10737606","is_oa":false,"landing_page_url":"https://doi.org/10.1109/sisy62279.2024.10737606","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE 22nd Jubilee International Symposium on Intelligent Systems and Informatics (SISY)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1817091417","https://openalex.org/W2066204710","https://openalex.org/W2098907614","https://openalex.org/W2117502083","https://openalex.org/W2126105956","https://openalex.org/W2147328441","https://openalex.org/W3000598214","https://openalex.org/W3046910774","https://openalex.org/W3083651542","https://openalex.org/W3154627449","https://openalex.org/W3155915728","https://openalex.org/W3208736444","https://openalex.org/W4242142581","https://openalex.org/W4280596964","https://openalex.org/W4288462067","https://openalex.org/W4309344239","https://openalex.org/W4310472797","https://openalex.org/W4312647239","https://openalex.org/W4366406433","https://openalex.org/W4382204541","https://openalex.org/W4382204882","https://openalex.org/W4382237614","https://openalex.org/W4386883086","https://openalex.org/W4388119736","https://openalex.org/W4391594566","https://openalex.org/W4391623607","https://openalex.org/W4392476271","https://openalex.org/W4392916887","https://openalex.org/W4401377568","https://openalex.org/W4401509237"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W2349580982"],"abstract_inverted_index":{"Chemotherapy":[0],"is":[1],"still":[2],"one":[3],"of":[4,10,29,98,110],"the":[5,26,30,43,48,81,88,107,111,124,135,139,143,145,166,169,173],"most":[6,174],"commonly":[7],"used":[8,78,130],"ways":[9],"treating":[11],"cancer.":[12],"While":[13],"being":[14],"very":[15],"effective,":[16],"this":[17,72,93],"method":[18,147],"has":[19],"serious":[20],"side":[21,54],"effects":[22],"which":[23,104],"can":[24,63],"harm":[25],"healthy":[27],"parts":[28],"body.":[31],"To":[32,118],"optimize":[33],"chemotherapy,":[34],"we":[35,74,122],"need":[36],"to":[37,51,91,115,142],"find":[38],"a":[39,67,162],"balance":[40],"between":[41],"minimizing":[42,47],"tumor":[44],"volume,":[45],"and":[46,87,138,176],"injected":[49],"doses,":[50],"reduce":[52],"harmful":[53],"effects.":[55],"By":[56],"leveraging":[57],"current":[58],"engineering":[59],"techniques,":[60,79],"these":[61,99],"objectives":[62],"be":[64],"implemented":[65],"in":[66,168,171],"multi-objective":[68],"optimization":[69,94],"process.":[70],"In":[71],"study,":[73],"implement":[75],"two":[76],"frequently":[77,129],"namely":[80],"NSGA-II":[82],"(non-dominated":[83],"sorting":[84],"genetic":[85],"algorithm)":[86],"Epsilon-constraint":[89,146],"method,":[90],"tackle":[92],"problem.":[95],"The":[96,156],"outputs":[97],"algorithms":[100],"are":[101,134],"Pareto":[102,126,150,158],"fronts,":[103],"contain":[105],"all":[106],"optimal":[108],"solutions":[109],"problem,":[112],"with":[113],"respect":[114],"each":[116],"objective.":[117],"determine":[119],"their":[120],"quality,":[121],"evaluate":[123],"generated":[125,157],"fronts":[127,151,159],"using":[128],"metrics.":[131,155],"These":[132],"metrics":[133],"Hypervolume":[136],"indicator":[137],"Epsilon-metric.":[140],"According":[141],"results,":[144],"provided":[148],"better":[149],"regarding":[152],"both":[153],"examined":[154],"could":[160],"provide":[161],"starting":[163],"point":[164],"for":[165],"decision-makers":[167],"future":[170],"determining":[172],"efficient":[175],"cost-effective":[177],"therapy.":[178]},"counts_by_year":[{"year":2025,"cited_by_count":5}],"updated_date":"2026-06-26T08:34:08.712188","created_date":"2025-10-10T00:00:00"}