{"id":"https://openalex.org/W4417473161","doi":"https://doi.org/10.1109/sipaim67325.2025.11283316","title":"Does Covert Cerebral Small Vessel Disease Modulate Early Change in Glymphatic Flow from DTI-ALPS?","display_name":"Does Covert Cerebral Small Vessel Disease Modulate Early Change in Glymphatic Flow from DTI-ALPS?","publication_year":2025,"publication_date":"2025-11-18","ids":{"openalex":"https://openalex.org/W4417473161","doi":"https://doi.org/10.1109/sipaim67325.2025.11283316"},"language":null,"primary_location":{"id":"doi:10.1109/sipaim67325.2025.11283316","is_oa":false,"landing_page_url":"https://doi.org/10.1109/sipaim67325.2025.11283316","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 21st International Symposium on Biomedical Image Processing and Analysis (SIPAIM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Julia Chu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210090910","display_name":"O'Brien Institute","ror":"https://ror.org/00f0ppx79","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210090910"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Julia Chu","raw_affiliation_strings":["University of Calgary,O&#x2019;Brien Centre for Health Sciences,Calgary,Canada"],"affiliations":[{"raw_affiliation_string":"University of Calgary,O&#x2019;Brien Centre for Health Sciences,Calgary,Canada","institution_ids":["https://openalex.org/I4210090910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020991260","display_name":"Rachel Sharkey","orcid":"https://orcid.org/0000-0001-7555-222X"},"institutions":[{"id":"https://openalex.org/I2802418778","display_name":"Foothills Medical Centre","ror":"https://ror.org/020wfrz93","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2802418778"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Rachel J Sharkey","raw_affiliation_strings":["Foothills Medical Centre,Seaman Family MR Research Centre,Calgary,Canada"],"affiliations":[{"raw_affiliation_string":"Foothills Medical Centre,Seaman Family MR Research Centre,Calgary,Canada","institution_ids":["https://openalex.org/I2802418778"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000345576","display_name":"Cheryl R. McCreary","orcid":"https://orcid.org/0000-0003-1572-010X"},"institutions":[{"id":"https://openalex.org/I2802418778","display_name":"Foothills Medical Centre","ror":"https://ror.org/020wfrz93","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2802418778"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Cheryl R McCreary","raw_affiliation_strings":["Foothills Medical Centre,Seaman Family MR Research Centre,Calgary,Canada"],"affiliations":[{"raw_affiliation_string":"Foothills Medical Centre,Seaman Family MR Research Centre,Calgary,Canada","institution_ids":["https://openalex.org/I2802418778"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055393136","display_name":"Feryal Saad","orcid":"https://orcid.org/0000-0001-8038-8495"},"institutions":[{"id":"https://openalex.org/I1314596251","display_name":"Allen Institute for Brain Science","ror":"https://ror.org/00dcv1019","country_code":"US","type":"facility","lineage":["https://openalex.org/I1314596251","https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Feryal Saad","raw_affiliation_strings":["University of Calgary,Radiology and Clinical Neuroscience, Hotchkiss Brain Institute,Calgary,Canada"],"affiliations":[{"raw_affiliation_string":"University of Calgary,Radiology and Clinical Neuroscience, Hotchkiss Brain Institute,Calgary,Canada","institution_ids":["https://openalex.org/I168635309","https://openalex.org/I1314596251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015783013","display_name":"Eric E. Smith","orcid":"https://orcid.org/0000-0003-3956-1668"},"institutions":[{"id":"https://openalex.org/I1314596251","display_name":"Allen Institute for Brain Science","ror":"https://ror.org/00dcv1019","country_code":"US","type":"facility","lineage":["https://openalex.org/I1314596251","https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Eric E Smith","raw_affiliation_strings":["University of Calgary,Radiology and Clinical Neuroscience, Hotchkiss Brain Institute,Calgary,Canada"],"affiliations":[{"raw_affiliation_string":"University of Calgary,Radiology and Clinical Neuroscience, Hotchkiss Brain Institute,Calgary,Canada","institution_ids":["https://openalex.org/I168635309","https://openalex.org/I1314596251"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085398611","display_name":"Richard Frayne","orcid":"https://orcid.org/0000-0003-0358-1210"},"institutions":[{"id":"https://openalex.org/I2802418778","display_name":"Foothills Medical Centre","ror":"https://ror.org/020wfrz93","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2802418778"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Richard Frayne","raw_affiliation_strings":["Foothills Medical Centre,Seaman Family MR Research Centre,Calgary,Canada"],"affiliations":[{"raw_affiliation_string":"Foothills Medical Centre,Seaman Family MR Research Centre,Calgary,Canada","institution_ids":["https://openalex.org/I2802418778"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210090910"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.42396938,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11833","display_name":"Spinal Dysraphism and Malformations","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glymphatic-system","display_name":"Glymphatic system","score":0.6967999935150146},{"id":"https://openalex.org/keywords/perivascular-space","display_name":"Perivascular space","score":0.5436000227928162},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.5109000205993652},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4117000102996826},{"id":"https://openalex.org/keywords/cerebral-blood-flow","display_name":"Cerebral blood flow","score":0.38679999113082886},{"id":"https://openalex.org/keywords/analysis-of-variance","display_name":"Analysis of variance","score":0.37770000100135803},{"id":"https://openalex.org/keywords/linear-regression","display_name":"Linear regression","score":0.3237999975681305}],"concepts":[{"id":"https://openalex.org/C101054994","wikidata":"https://www.wikidata.org/wiki/Q15474254","display_name":"Glymphatic system","level":3,"score":0.6967999935150146},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5683000087738037},{"id":"https://openalex.org/C2777799939","wikidata":"https://www.wikidata.org/wiki/Q1711381","display_name":"Perivascular space","level":2,"score":0.5436000227928162},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5109000205993652},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5109000205993652},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4198000133037567},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4117000102996826},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40119999647140503},{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.38679999113082886},{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.37770000100135803},{"id":"https://openalex.org/C48921125","wikidata":"https://www.wikidata.org/wiki/Q10861030","display_name":"Linear regression","level":2,"score":0.3237999975681305},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.3176000118255615},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3050999939441681},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.301800012588501},{"id":"https://openalex.org/C2779338814","wikidata":"https://www.wikidata.org/wiki/Q5179285","display_name":"Covert","level":2,"score":0.29820001125335693},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.28769999742507935},{"id":"https://openalex.org/C3019152653","wikidata":"https://www.wikidata.org/wiki/Q186290","display_name":"Linear relationship","level":2,"score":0.2782999873161316},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.27390000224113464},{"id":"https://openalex.org/C171614378","wikidata":"https://www.wikidata.org/wiki/Q5064093","display_name":"Cerebral arteries","level":2,"score":0.2603999972343445},{"id":"https://openalex.org/C2779281540","wikidata":"https://www.wikidata.org/wiki/Q5062122","display_name":"Central nervous system disease","level":2,"score":0.25529998540878296}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/sipaim67325.2025.11283316","is_oa":false,"landing_page_url":"https://doi.org/10.1109/sipaim67325.2025.11283316","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 21st International Symposium on Biomedical Image Processing and Analysis (SIPAIM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308611","display_name":"Health Research","ror":"https://ror.org/059qgvg50"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W2091931051","https://openalex.org/W2150667092","https://openalex.org/W2157032372","https://openalex.org/W2158742097","https://openalex.org/W2200917453","https://openalex.org/W2588487507","https://openalex.org/W2742497781","https://openalex.org/W3049110726","https://openalex.org/W3165946599","https://openalex.org/W3170975817","https://openalex.org/W3185157623","https://openalex.org/W4224935308","https://openalex.org/W4281250460","https://openalex.org/W4283463194","https://openalex.org/W4309314340","https://openalex.org/W4327557666","https://openalex.org/W4362678287","https://openalex.org/W4365142767","https://openalex.org/W4377695790","https://openalex.org/W4383906895","https://openalex.org/W4384627174","https://openalex.org/W4390697668","https://openalex.org/W4390731436","https://openalex.org/W4392656389","https://openalex.org/W4394866019"],"related_works":[],"abstract_inverted_index":{"Diffusion":[0],"tensor":[1],"image":[2],"analysis":[3],"along":[4],"the":[5,30,98,164,227],"perivascular":[6,114],"space":[7],"(DTI-ALPS)":[8],"has":[9,26,39],"emerged":[10],"as":[11,94],"a":[12,80,95,131,175,217,242],"method":[13],"for":[14],"non-invasively":[15],"assessing":[16],"glymphatic":[17,220,239],"flow":[18,221,240],"from":[19,245],"magnetic":[20],"resonance":[21],"diffusion-weighted":[22],"images.":[23],"This":[24],"index":[25],"been":[27,40,55],"applied":[28],"to":[29,42,71,237],"study":[31],"of":[32,47,97,100,166,194,229],"neurodegenerative":[33,48],"and":[34,90,116,198],"other":[35,189],"brain":[36],"disorders.":[37],"It":[38],"found":[41,56,130],"decrease":[43,133],"in":[44,51,57,79,134,138,156,174,219,241],"most":[45],"studies":[46],"conditions.":[49],"Decreases":[50],"DTI-ALPS":[52,85,135,151],"also":[53],"have":[54,74],"healthy":[58,81,246],"adults":[59],"with":[60,136,154,213,222],"age.":[61,223],"Changes":[62],"by":[63,88],"sex":[64],"are":[65],"less":[66],"consistently":[67],"observed":[68],"but":[69,162],"seem":[70],"suggest":[72],"females":[73,139],"higher":[75],"indices.":[76],"We":[77],"explored":[78],"adult":[82],"cohort":[83],"whether":[84],"is":[86],"affected":[87],"age":[89,137,180,209],"sex,":[91,226],"or":[92,112,125,168,196],"serves":[93],"surrogate/biomarker":[96],"presence":[99,165,193,228],"early,":[101],"covert":[102],"small":[103],"vessel":[104],"disease":[105],"(SVD)":[106],"(white":[107],"matter":[108],"hyperintensities,":[109],"lacunes,":[110],"microbleeds":[111],"enlarged":[113],"spaces),":[115],"vascular":[117],"risk":[118],"factors":[119,191],"(VRFs)":[120],"like":[121],"diabetes,":[122],"hypertension,":[123],"hyperlipidemia,":[124],"smoking.":[126],"Separate":[127],"linear":[128,177],"regressions":[129],"slower":[132],"than":[140],"males":[141],"(-0.0034\u00b10.0013":[142],"units/year":[143],"vs":[144],"-0.0048":[145],"\u00b10.0011":[146],"units/year,":[147,184],"p<0.020":[148],"between":[149],"slopes).":[150],"was":[152,181,210],"associated":[153,212],"SVD":[155,195,231],"one-way":[157],"ANOVA":[158],"testing":[159],"(F=4.72,":[160],"p=0.032)":[161],"not":[163,203],"one":[167],"more":[169],"VRFs":[170,234],"(F=0.955,":[171],"p=0.330).":[172],"However,":[173,224],"multivariable":[176],"model":[178],"only":[179,207],"significant":[182],"(-0.0041":[183],"p":[185],"=":[186],"0.007).":[187],"The":[188],"examined":[190],"(sex,":[192],"VRF,":[197],"age\u00d7sex":[199],"interaction)":[200],"were":[201,235],"all":[202],"significant.":[204],"In":[205],"conclusion,":[206],"older":[208],"significantly":[211],"lower":[214],"DTI-ALPS,":[215],"suggesting":[216],"reduction":[218],"male":[225],"mild-to-moderate":[230],"pathology":[232],"nor":[233],"linked":[236],"decreased":[238],"sample":[243],"drawn":[244],"community-dwelling":[247],"adults.":[248]},"counts_by_year":[],"updated_date":"2026-04-17T18:11:37.981687","created_date":"2025-12-18T00:00:00"}