{"id":"https://openalex.org/W4405304279","doi":"https://doi.org/10.1109/sipaim62974.2024.10783615","title":"Longitudinal Multi-Site Modeling of Brain Atrophy Trajectories Associated with Amyloid and Tau","display_name":"Longitudinal Multi-Site Modeling of Brain Atrophy Trajectories Associated with Amyloid and Tau","publication_year":2024,"publication_date":"2024-11-13","ids":{"openalex":"https://openalex.org/W4405304279","doi":"https://doi.org/10.1109/sipaim62974.2024.10783615"},"language":"en","primary_location":{"id":"doi:10.1109/sipaim62974.2024.10783615","is_oa":false,"landing_page_url":"https://doi.org/10.1109/sipaim62974.2024.10783615","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 20th International Symposium on Medical Information Processing and Analysis (SIPAIM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093064010","display_name":"Sunanda Somu","orcid":null},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sunanda Somu","raw_affiliation_strings":["Keck School of Medicine of USC, University of Southern California,Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute,Marina del Rey,CA"],"affiliations":[{"raw_affiliation_string":"Keck School of Medicine of USC, University of Southern California,Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute,Marina del Rey,CA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066345371","display_name":"Alyssa H. Zhu","orcid":"https://orcid.org/0000-0003-0083-5107"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alyssa H. Zhu","raw_affiliation_strings":["Keck School of Medicine of USC, University of Southern California,Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute,Marina del Rey,CA"],"affiliations":[{"raw_affiliation_string":"Keck School of Medicine of USC, University of Southern California,Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute,Marina del Rey,CA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010125964","display_name":"Siddharth Narula","orcid":"https://orcid.org/0000-0003-2918-2883"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Siddharth Narula","raw_affiliation_strings":["Keck School of Medicine of USC, University of Southern California,Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute,Marina del Rey,CA"],"affiliations":[{"raw_affiliation_string":"Keck School of Medicine of USC, University of Southern California,Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute,Marina del Rey,CA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019781190","display_name":"Neda Jahanshad","orcid":"https://orcid.org/0000-0003-4401-8950"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neda Jahanshad","raw_affiliation_strings":["Keck School of Medicine of USC, University of Southern California,Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute,Marina del Rey,CA"],"affiliations":[{"raw_affiliation_string":"Keck School of Medicine of USC, University of Southern California,Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute,Marina del Rey,CA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076060041","display_name":"Talia M. Nir","orcid":"https://orcid.org/0000-0002-7106-7443"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Talia M. Nir","raw_affiliation_strings":["Keck School of Medicine of USC, University of Southern California,Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute,Marina del Rey,CA"],"affiliations":[{"raw_affiliation_string":"Keck School of Medicine of USC, University of Southern California,Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute,Marina del Rey,CA","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5093064010"],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.237618,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.8483999967575073,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.8483999967575073,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8141999840736389,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.7989000082015991,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atrophy","display_name":"Atrophy","score":0.5277974009513855},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.5010993480682373},{"id":"https://openalex.org/keywords/amyloid","display_name":"Amyloid (mycology)","score":0.49203822016716003},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4516068398952484},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2954995036125183},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.2379138171672821},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.21724185347557068}],"concepts":[{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.5277974009513855},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5010993480682373},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.49203822016716003},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4516068398952484},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2954995036125183},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2379138171672821},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.21724185347557068}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/sipaim62974.2024.10783615","is_oa":false,"landing_page_url":"https://doi.org/10.1109/sipaim62974.2024.10783615","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 20th International Symposium on Medical Information Processing and Analysis (SIPAIM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4089392682","display_name":null,"funder_award_id":"AARG-23-1149996,R01AG059874,R01AG058854,S10OD032285","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1899329334","https://openalex.org/W1915842929","https://openalex.org/W1993571512","https://openalex.org/W2000501114","https://openalex.org/W2028655791","https://openalex.org/W2040016992","https://openalex.org/W2070949043","https://openalex.org/W2136573752","https://openalex.org/W2139886607","https://openalex.org/W2168570536","https://openalex.org/W2560584411","https://openalex.org/W2774486220","https://openalex.org/W2912461714","https://openalex.org/W2946021986","https://openalex.org/W2954332791","https://openalex.org/W2962851149","https://openalex.org/W2968446587","https://openalex.org/W2996482231","https://openalex.org/W2997283194","https://openalex.org/W3030476832","https://openalex.org/W3048865760","https://openalex.org/W3080256062","https://openalex.org/W4235770099","https://openalex.org/W4307873068","https://openalex.org/W4386137660","https://openalex.org/W4394688419","https://openalex.org/W6772352366"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"Amyloid":[0,21],"and":[1,10,31,33,62,65,92,104,111,120,138],"tau":[2,29,63,105,112,139],"pathogenesis":[3],"are":[4],"hallmarks":[5],"of":[6,39,79,95,102,151],"Alzheimer's":[7],"disease":[8],"(AD)":[9],"occur":[11,26],"before":[12,28],"observable":[13],"volumetric":[14],"changes":[15],"in":[16,99,124],"a":[17],"brain":[18,41,66,128],"MRI":[19,49],"scan.":[20],"beta":[22,61],"plaque":[23],"deposition":[24],"can":[25],"years":[27],"accumulation":[30],"neurodegeneration,":[32],"may":[34],"be":[35],"an":[36],"important":[37],"predictor":[38],"subsequent":[40],"atrophy.":[42],"In":[43],"this":[44],"study,":[45],"we":[46,83,134],"evaluated":[47],"T1-weighted":[48],"data":[50],"from":[51],"four":[52],"longitudinal":[53],"AD":[54],"datasets":[55],"to":[56],"assess":[57],"associations":[58],"between":[59,89],"amyloid":[60,103,110,137],"biomarkers":[64],"atrophy":[67,80,96,119,122,153,159],"patterns":[68],"using":[69],"tensor":[70],"based":[71],"morphometry.":[72],"To":[73],"account":[74],"for":[75],"potential":[76],"non-linear":[77],"effects":[78],"over":[81],"time,":[82],"modeled":[84],"age":[85,156],"effects,":[86],"time":[87],"interval":[88],"subject":[90],"visits,":[91],"the":[93,100,149],"acceleration":[94,145],"with":[97,117,131,143,155],"aging":[98],"context":[101],"positivity.":[106],"We":[107],"found":[108,135],"that":[109,136,148],"positivity":[113,140],"were":[114,141],"both":[115],"associated":[116,130,142],"greater":[118,121],"rates":[123,160],"medial":[125],"temporal":[126],"lobe":[127],"regions":[129],"AD.":[132],"Furthermore,":[133],"different":[144],"patterns,":[146],"namely":[147],"rate":[150],"amyloid-related":[152],"decelerated":[154],"while":[157],"tau-related":[158],"accelerated.":[161]},"counts_by_year":[],"updated_date":"2025-12-27T23:08:20.325037","created_date":"2025-10-10T00:00:00"}
