{"id":"https://openalex.org/W4405489854","doi":"https://doi.org/10.1109/sensors60989.2024.10784972","title":"Highly Sensitive and Highly Specific Biomedical Sensing Device Development for Lung Cancer Tumor Marker","display_name":"Highly Sensitive and Highly Specific Biomedical Sensing Device Development for Lung Cancer Tumor Marker","publication_year":2024,"publication_date":"2024-10-20","ids":{"openalex":"https://openalex.org/W4405489854","doi":"https://doi.org/10.1109/sensors60989.2024.10784972"},"language":"en","primary_location":{"id":"doi:10.1109/sensors60989.2024.10784972","is_oa":false,"landing_page_url":"https://doi.org/10.1109/sensors60989.2024.10784972","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE SENSORS","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008170567","display_name":"Chia-Hsu Hsieh","orcid":"https://orcid.org/0000-0001-9492-1174"},"institutions":[{"id":"https://openalex.org/I142974352","display_name":"National Sun Yat-sen University","ror":"https://ror.org/00mjawt10","country_code":"TW","type":"education","lineage":["https://openalex.org/I142974352"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chia-Hsu Hsieh","raw_affiliation_strings":["College of Semiconductor and Advanced Technology, Research of National Sun Yat-sen University,Kaohsiung,Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Semiconductor and Advanced Technology, Research of National Sun Yat-sen University,Kaohsiung,Taiwan","institution_ids":["https://openalex.org/I142974352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110967146","display_name":"C. James Chou","orcid":null},"institutions":[{"id":"https://openalex.org/I142974352","display_name":"National Sun Yat-sen University","ror":"https://ror.org/00mjawt10","country_code":"TW","type":"education","lineage":["https://openalex.org/I142974352"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Cheng-Chuan Chou","raw_affiliation_strings":["College of Semiconductor and Advanced Technology, Research of National Sun Yat-sen University,Kaohsiung,Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Semiconductor and Advanced Technology, Research of National Sun Yat-sen University,Kaohsiung,Taiwan","institution_ids":["https://openalex.org/I142974352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003721468","display_name":"Guanhong Chen","orcid":"https://orcid.org/0009-0004-4517-5063"},"institutions":[{"id":"https://openalex.org/I142974352","display_name":"National Sun Yat-sen University","ror":"https://ror.org/00mjawt10","country_code":"TW","type":"education","lineage":["https://openalex.org/I142974352"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Guan-Hong Chen","raw_affiliation_strings":["Sun Yat-sen University,Department of Electrical Engineering of National,Kaohsiung,Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Yat-sen University,Department of Electrical Engineering of National,Kaohsiung,Taiwan","institution_ids":["https://openalex.org/I142974352"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113056292","display_name":"I\u2010Yu Huang","orcid":null},"institutions":[{"id":"https://openalex.org/I142974352","display_name":"National Sun Yat-sen University","ror":"https://ror.org/00mjawt10","country_code":"TW","type":"education","lineage":["https://openalex.org/I142974352"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"I-Yu Huang","raw_affiliation_strings":["College of Semiconductor and Advanced Technology, Research of National Sun Yat-sen University,Kaohsiung,Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Semiconductor and Advanced Technology, Research of National Sun Yat-sen University,Kaohsiung,Taiwan","institution_ids":["https://openalex.org/I142974352"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.19554972,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.9211999773979187,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.9211999773979187,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.6070825457572937},{"id":"https://openalex.org/keywords/tumor-marker","display_name":"Tumor marker","score":0.5387002825737},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4453316628932953},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4246494174003601},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.38171979784965515},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3399654030799866},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.32577815651893616},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.29617416858673096},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.26694977283477783},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.18827557563781738}],"concepts":[{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6070825457572937},{"id":"https://openalex.org/C2781447364","wikidata":"https://www.wikidata.org/wiki/Q584992","display_name":"Tumor marker","level":3,"score":0.5387002825737},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4453316628932953},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4246494174003601},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38171979784965515},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3399654030799866},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32577815651893616},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.29617416858673096},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26694977283477783},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18827557563781738}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/sensors60989.2024.10784972","is_oa":false,"landing_page_url":"https://doi.org/10.1109/sensors60989.2024.10784972","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE SENSORS","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7400000095367432}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W2059919138","https://openalex.org/W2098224798","https://openalex.org/W2130028915","https://openalex.org/W4319302919"],"related_works":["https://openalex.org/W2064573700","https://openalex.org/W2362665920","https://openalex.org/W2465690616","https://openalex.org/W3028981589","https://openalex.org/W2384443056","https://openalex.org/W2356609241","https://openalex.org/W2357263695","https://openalex.org/W2352564820","https://openalex.org/W2360867319","https://openalex.org/W3148573270"],"abstract_inverted_index":{"This":[0],"article":[1],"utilizes":[2],"the":[3,10,36,54,93,107,117],"Extended":[4],"Gate":[5],"Field-effect":[6],"Transistor":[7],"(EGFET)":[8],"as":[9,53],"sensing":[11,21,37,65,90,114,132],"element":[12],"for":[13,80,99,104,123,128,137],"detecting":[14,81],"lung":[15],"cancer":[16],"biomarkers":[17],"(NSE/CYFRA21-1).":[18],"The":[19,85],"EGFET":[20,55],"area":[22],"is":[23],"fabricated":[24],"with":[25],"a":[26],"conical":[27],"3D":[28],"structure":[29],"using":[30],"KOH":[31],"anisotropic":[32],"etching":[33],"to":[34,59],"increase":[35],"surface":[38],"area.":[39],"High":[40],"dielectric":[41,57,69],"constant":[42],"materials":[43],"HfO<inf":[44,108],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[45,47,49,87,109,111],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">2</inf>/TiO<inf":[46,110],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">2</inf>/ZrO<inf":[48],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">2</inf>":[50,88,112],"are":[51],"used":[52],"gate":[56,61,68,89,113],"layer":[58],"enhance":[60],"capacitance":[62],"and":[63,76,83,101,125,139],"improve":[64],"sensitivity.":[66],"Both":[67,130],"structures":[70],"exhibit":[71],"high":[72],"sensitivity,":[73],"linearity,":[74],"specificity,":[75],"low":[77],"detection":[78],"limits":[79],"NSE":[82,100,124],"CYFRA21-1.":[84,129],"ZrO<inf":[86],"chip":[91,115],"achieves":[92,116],"highest":[94,118],"sensitivity":[95,119],"of":[96,120],"0.051":[97],"V\u00b7(ng/ml)-1":[98,103,122,127],"0.210":[102],"CYFRA21-1,":[105],"while":[106],"0.061":[121],"0.243":[126],"NSE/CYFRA21-1":[131],"chips":[133],"demonstrate":[134],"excellent":[135],"specificity":[136],"CEA":[138],"CA15-3.":[140]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}