{"id":"https://openalex.org/W4405490141","doi":"https://doi.org/10.1109/sensors60989.2024.10784712","title":"Electrochemical Biosensor Using Methylene Blue as an Electrochemical Mediator Coupling with DNA Aptamer","display_name":"Electrochemical Biosensor Using Methylene Blue as an Electrochemical Mediator Coupling with DNA Aptamer","publication_year":2024,"publication_date":"2024-10-20","ids":{"openalex":"https://openalex.org/W4405490141","doi":"https://doi.org/10.1109/sensors60989.2024.10784712"},"language":"en","primary_location":{"id":"doi:10.1109/sensors60989.2024.10784712","is_oa":false,"landing_page_url":"https://doi.org/10.1109/sensors60989.2024.10784712","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE SENSORS","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056431628","display_name":"Koji Yamashita","orcid":"https://orcid.org/0000-0002-7417-739X"},"institutions":[{"id":"https://openalex.org/I56624758","display_name":"Kansai University","ror":"https://ror.org/03xg1f311","country_code":"JP","type":"education","lineage":["https://openalex.org/I56624758"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koki Yamashita","raw_affiliation_strings":["Graduate School of Science and Engineering, Kansai University, Suita,Osaka,Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Science and Engineering, Kansai University, Suita,Osaka,Japan","institution_ids":["https://openalex.org/I56624758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101512433","display_name":"Tomohiro Shimizu","orcid":"https://orcid.org/0000-0002-5767-858X"},"institutions":[{"id":"https://openalex.org/I56624758","display_name":"Kansai University","ror":"https://ror.org/03xg1f311","country_code":"JP","type":"education","lineage":["https://openalex.org/I56624758"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomohiro Shimizu","raw_affiliation_strings":["Graduate School of Science and Engineering, Kansai University, Suita,Osaka,Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Science and Engineering, Kansai University, Suita,Osaka,Japan","institution_ids":["https://openalex.org/I56624758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067629492","display_name":"Shoso Shingubara","orcid":"https://orcid.org/0000-0003-2134-1691"},"institutions":[{"id":"https://openalex.org/I56624758","display_name":"Kansai University","ror":"https://ror.org/03xg1f311","country_code":"JP","type":"education","lineage":["https://openalex.org/I56624758"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shoso Shingubara","raw_affiliation_strings":["Graduate School of Science and Engineering, Kansai University, Suita,Osaka,Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Science and Engineering, Kansai University, Suita,Osaka,Japan","institution_ids":["https://openalex.org/I56624758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100781227","display_name":"Hitoshi Ishida","orcid":"https://orcid.org/0000-0002-6457-0083"},"institutions":[{"id":"https://openalex.org/I56624758","display_name":"Kansai University","ror":"https://ror.org/03xg1f311","country_code":"JP","type":"education","lineage":["https://openalex.org/I56624758"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hitoshi Ishida","raw_affiliation_strings":["Graduate School of Science and Engineering, Kansai University, Suita,Osaka,Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Science and Engineering, Kansai University, Suita,Osaka,Japan","institution_ids":["https://openalex.org/I56624758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039769062","display_name":"Akinori Kuzuya","orcid":"https://orcid.org/0000-0003-0003-2996"},"institutions":[{"id":"https://openalex.org/I56624758","display_name":"Kansai University","ror":"https://ror.org/03xg1f311","country_code":"JP","type":"education","lineage":["https://openalex.org/I56624758"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akinori Kuzuya","raw_affiliation_strings":["Graduate School of Science and Engineering, Kansai University, Suita,Osaka,Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Science and Engineering, Kansai University, Suita,Osaka,Japan","institution_ids":["https://openalex.org/I56624758"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5119809499","display_name":"Takeshi Ito","orcid":"https://orcid.org/0000-0001-7739-8705"},"institutions":[{"id":"https://openalex.org/I56624758","display_name":"Kansai University","ror":"https://ror.org/03xg1f311","country_code":"JP","type":"education","lineage":["https://openalex.org/I56624758"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Ito","raw_affiliation_strings":["Graduate School of Science and Engineering, Kansai University, Suita,Osaka,Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Science and Engineering, Kansai University, Suita,Osaka,Japan","institution_ids":["https://openalex.org/I56624758"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I56624758"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9670000076293945,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9670000076293945,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methylene-blue","display_name":"Methylene blue","score":0.803746223449707},{"id":"https://openalex.org/keywords/aptamer","display_name":"Aptamer","score":0.7541728019714355},{"id":"https://openalex.org/keywords/electrochemistry","display_name":"Electrochemistry","score":0.6829215884208679},{"id":"https://openalex.org/keywords/biosensor","display_name":"Biosensor","score":0.6336779594421387},{"id":"https://openalex.org/keywords/coupling","display_name":"Coupling (piping)","score":0.5356912612915039},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.5136955976486206},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3111255168914795},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.28911465406417847},{"id":"https://openalex.org/keywords/electrode","display_name":"Electrode","score":0.2140544056892395},{"id":"https://openalex.org/keywords/molecular-biology","display_name":"Molecular biology","score":0.08709290623664856},{"id":"https://openalex.org/keywords/composite-material","display_name":"Composite material","score":0.07353755831718445},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.07058516144752502},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.0561157763004303}],"concepts":[{"id":"https://openalex.org/C2779191827","wikidata":"https://www.wikidata.org/wiki/Q422134","display_name":"Methylene blue","level":4,"score":0.803746223449707},{"id":"https://openalex.org/C128972844","wikidata":"https://www.wikidata.org/wiki/Q418722","display_name":"Aptamer","level":2,"score":0.7541728019714355},{"id":"https://openalex.org/C52859227","wikidata":"https://www.wikidata.org/wiki/Q7877","display_name":"Electrochemistry","level":3,"score":0.6829215884208679},{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.6336779594421387},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.5356912612915039},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5136955976486206},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3111255168914795},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.28911465406417847},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.2140544056892395},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.08709290623664856},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.07353755831718445},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07058516144752502},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0561157763004303},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C65165184","wikidata":"https://www.wikidata.org/wiki/Q218831","display_name":"Photocatalysis","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/sensors60989.2024.10784712","is_oa":false,"landing_page_url":"https://doi.org/10.1109/sensors60989.2024.10784712","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE SENSORS","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/7","display_name":"Affordable and clean energy","score":0.5699999928474426}],"awards":[{"id":"https://openalex.org/G2811314389","display_name":"Development of peptide-linked supramolecular photocatalysts for Z-scheme artificial photosynthesis","funder_award_id":"23K04784","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1494633875","https://openalex.org/W1971793028","https://openalex.org/W1972027384","https://openalex.org/W1975728152","https://openalex.org/W2002479245","https://openalex.org/W2004901112","https://openalex.org/W2016437931","https://openalex.org/W2018188571","https://openalex.org/W2020866876","https://openalex.org/W2022745874","https://openalex.org/W2038351192","https://openalex.org/W2045451070","https://openalex.org/W2069066397","https://openalex.org/W2069751695","https://openalex.org/W2092576784","https://openalex.org/W2124654854","https://openalex.org/W2980319604","https://openalex.org/W3134094763","https://openalex.org/W4282944841"],"related_works":["https://openalex.org/W2913646003","https://openalex.org/W2033684641","https://openalex.org/W2967136651","https://openalex.org/W2081632393","https://openalex.org/W2147509954","https://openalex.org/W4389944751","https://openalex.org/W1970773045","https://openalex.org/W3092671456","https://openalex.org/W2566736735","https://openalex.org/W2378104911"],"abstract_inverted_index":{"Methylene":[0],"blue":[1],"(MB)":[2],"is":[3,97],"known":[4],"as":[5,9,11],"a":[6,12,26,30],"redox":[7,31],"mediator":[8,32],"well":[10],"DNA":[13,71],"intercalator.":[14],"We":[15,59,83],"evaluated":[16],"the":[17,22,49,85],"electrochemical":[18,64],"impedance":[19],"dependent":[20],"with":[21,25,47,74],"MB":[23,50,75],"concentration":[24,28],"fixed":[27],"of":[29,69,88,99,108,118],"<tex":[33,43],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[34,44],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$\\mathrm{K}_{4}[\\text{Fe}(\\text{CN})_{6}]/\\mathrm{K}_{3}[\\text{Fe}(\\text{CN})_{6}]$</tex>.":[35],"The":[36,102],"results":[37,103],"showed":[38,104],"that":[39,54,105],"charge":[40,55],"transfer":[41,56],"resistance":[42],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$(\\mathrm{R}_{\\text{ct}})$</tex>":[45],"decreased":[46],"increasing":[48],"concentration,":[51],"which":[52,96],"indicated":[53],"was":[57,76],"enhanced.":[58],"designed":[60],"to":[61,93],"develop":[62],"new":[63],"biosensor":[65],"using":[66],"above":[67],"characteristics":[68],"MB.":[70],"aptamer":[72],"coupling":[73],"synthesized":[77],"and":[78,120],"coated":[79],"on":[80],"Au":[81],"electrode.":[82],"demonstrated":[84],"sensing":[86,91],"property":[87],"this":[89],"newly":[90],"system":[92],"measure":[94],"thrombin,":[95],"one":[98],"serine":[100],"protease.":[101],"trace":[106],"amounts":[107],"thrombin":[109],"could":[110],"be":[111],"detected.":[112],"This":[113],"method":[114],"enables":[115],"early":[116],"detection":[117],"cancer":[119],"other":[121],"diseases.":[122]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}
