{"id":"https://openalex.org/W4405490593","doi":"https://doi.org/10.1109/sensors60989.2024.10784609","title":"Electrical Impedance Spectroscopy Platform for Label-Free Characterization of Spheroid Viability","display_name":"Electrical Impedance Spectroscopy Platform for Label-Free Characterization of Spheroid Viability","publication_year":2024,"publication_date":"2024-10-20","ids":{"openalex":"https://openalex.org/W4405490593","doi":"https://doi.org/10.1109/sensors60989.2024.10784609"},"language":"en","primary_location":{"id":"doi:10.1109/sensors60989.2024.10784609","is_oa":false,"landing_page_url":"https://doi.org/10.1109/sensors60989.2024.10784609","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE SENSORS","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108913661","display_name":"Claudia Sampaio da Silva","orcid":null},"institutions":[{"id":"https://openalex.org/I135218257","display_name":"Swiss Center for Electronics and Microtechnology (Switzerland)","ror":"https://ror.org/05nrrsx06","country_code":"CH","type":"company","lineage":["https://openalex.org/I135218257"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Claudia Sampaio Da Silva","raw_affiliation_strings":["Centre Suisse d&#x0027;Electronique et de Microtechnique SA,Neuch&#x00E2;tel,Switzerland"],"affiliations":[{"raw_affiliation_string":"Centre Suisse d&#x0027;Electronique et de Microtechnique SA,Neuch&#x00E2;tel,Switzerland","institution_ids":["https://openalex.org/I135218257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008528822","display_name":"Julia Alicia Boos","orcid":"https://orcid.org/0000-0001-9490-9810"},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Julia Alicia Boos","raw_affiliation_strings":["ETH Zurich,Bio Engineering Laboratory,Department Biosystems Science and Engineering,Basel,Switzerland"],"affiliations":[{"raw_affiliation_string":"ETH Zurich,Bio Engineering Laboratory,Department Biosystems Science and Engineering,Basel,Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016349643","display_name":"Mario M. Modena","orcid":"https://orcid.org/0000-0002-4218-0404"},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Mario Modena","raw_affiliation_strings":["ETH Zurich,Bio Engineering Laboratory,Department Biosystems Science and Engineering,Basel,Switzerland"],"affiliations":[{"raw_affiliation_string":"ETH Zurich,Bio Engineering Laboratory,Department Biosystems Science and Engineering,Basel,Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073146371","display_name":"Sreedhar Kumar","orcid":null},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Sreedhar Kumar","raw_affiliation_strings":["ETH Zurich,Bio Engineering Laboratory,Department Biosystems Science and Engineering,Basel,Switzerland"],"affiliations":[{"raw_affiliation_string":"ETH Zurich,Bio Engineering Laboratory,Department Biosystems Science and Engineering,Basel,Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103105095","display_name":"Christian Beyer","orcid":"https://orcid.org/0000-0003-3209-8690"},"institutions":[{"id":"https://openalex.org/I135218257","display_name":"Swiss Center for Electronics and Microtechnology (Switzerland)","ror":"https://ror.org/05nrrsx06","country_code":"CH","type":"company","lineage":["https://openalex.org/I135218257"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Christian Beyer","raw_affiliation_strings":["Centre Suisse d&#x0027;Electronique et de Microtechnique SA,Neuch&#x00E2;tel,Switzerland"],"affiliations":[{"raw_affiliation_string":"Centre Suisse d&#x0027;Electronique et de Microtechnique SA,Neuch&#x00E2;tel,Switzerland","institution_ids":["https://openalex.org/I135218257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089797039","display_name":"Thomas Valentin","orcid":"https://orcid.org/0000-0001-5822-4881"},"institutions":[{"id":"https://openalex.org/I135218257","display_name":"Swiss Center for Electronics and Microtechnology (Switzerland)","ror":"https://ror.org/05nrrsx06","country_code":"CH","type":"company","lineage":["https://openalex.org/I135218257"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Thomas Valentin","raw_affiliation_strings":["Centre Suisse d&#x0027;Electronique et de Microtechnique SA,Neuch&#x00E2;tel,Switzerland"],"affiliations":[{"raw_affiliation_string":"Centre Suisse d&#x0027;Electronique et de Microtechnique SA,Neuch&#x00E2;tel,Switzerland","institution_ids":["https://openalex.org/I135218257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000470100","display_name":"Andreas Hierlemann","orcid":"https://orcid.org/0000-0002-3838-2468"},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Andreas Hierlemann","raw_affiliation_strings":["ETH Zurich,Bio Engineering Laboratory,Department Biosystems Science and Engineering,Basel,Switzerland"],"affiliations":[{"raw_affiliation_string":"ETH Zurich,Bio Engineering Laboratory,Department Biosystems Science and Engineering,Basel,Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011124600","display_name":"Vincent Revol","orcid":"https://orcid.org/0000-0002-0673-0683"},"institutions":[{"id":"https://openalex.org/I135218257","display_name":"Swiss Center for Electronics and Microtechnology (Switzerland)","ror":"https://ror.org/05nrrsx06","country_code":"CH","type":"company","lineage":["https://openalex.org/I135218257"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Vincent Revol","raw_affiliation_strings":["Centre Suisse d&#x0027;Electronique et de Microtechnique SA,Neuch&#x00E2;tel,Switzerland"],"affiliations":[{"raw_affiliation_string":"Centre Suisse d&#x0027;Electronique et de Microtechnique SA,Neuch&#x00E2;tel,Switzerland","institution_ids":["https://openalex.org/I135218257"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5108913661"],"corresponding_institution_ids":["https://openalex.org/I135218257"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21214829,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14117","display_name":"Integrated Circuits and Semiconductor Failure Analysis","score":0.5383999943733215,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T14117","display_name":"Integrated Circuits and Semiconductor Failure Analysis","score":0.5383999943733215,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12111","display_name":"Industrial Vision Systems and Defect Detection","score":0.5120000243186951,"subfield":{"id":"https://openalex.org/subfields/2209","display_name":"Industrial and Manufacturing Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11032","display_name":"VLSI and Analog Circuit Testing","score":0.4943000078201294,"subfield":{"id":"https://openalex.org/subfields/1708","display_name":"Hardware and Architecture"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dielectric-spectroscopy","display_name":"Dielectric spectroscopy","score":0.7921125292778015},{"id":"https://openalex.org/keywords/characterization","display_name":"Characterization (materials science)","score":0.7423978447914124},{"id":"https://openalex.org/keywords/spheroid","display_name":"Spheroid","score":0.6860568523406982},{"id":"https://openalex.org/keywords/electrical-impedance","display_name":"Electrical impedance","score":0.6292881369590759},{"id":"https://openalex.org/keywords/spectroscopy","display_name":"Spectroscopy","score":0.54188472032547},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.5091630816459656},{"id":"https://openalex.org/keywords/optoelectronics","display_name":"Optoelectronics","score":0.4214097261428833},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3925369381904602},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2759338319301605},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.262861430644989},{"id":"https://openalex.org/keywords/electrical-engineering","display_name":"Electrical engineering","score":0.2516496777534485},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.2316979169845581},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.20191138982772827},{"id":"https://openalex.org/keywords/electrode","display_name":"Electrode","score":0.1112934947013855},{"id":"https://openalex.org/keywords/electrochemistry","display_name":"Electrochemistry","score":0.07514414191246033},{"id":"https://openalex.org/keywords/physical-chemistry","display_name":"Physical chemistry","score":0.07439586520195007}],"concepts":[{"id":"https://openalex.org/C7040849","wikidata":"https://www.wikidata.org/wiki/Q899580","display_name":"Dielectric spectroscopy","level":4,"score":0.7921125292778015},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.7423978447914124},{"id":"https://openalex.org/C175369904","wikidata":"https://www.wikidata.org/wiki/Q208395","display_name":"Spheroid","level":3,"score":0.6860568523406982},{"id":"https://openalex.org/C17829176","wikidata":"https://www.wikidata.org/wiki/Q179043","display_name":"Electrical impedance","level":2,"score":0.6292881369590759},{"id":"https://openalex.org/C32891209","wikidata":"https://www.wikidata.org/wiki/Q483666","display_name":"Spectroscopy","level":2,"score":0.54188472032547},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5091630816459656},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.4214097261428833},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3925369381904602},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2759338319301605},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.262861430644989},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.2516496777534485},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.2316979169845581},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.20191138982772827},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.1112934947013855},{"id":"https://openalex.org/C52859227","wikidata":"https://www.wikidata.org/wiki/Q7877","display_name":"Electrochemistry","level":3,"score":0.07514414191246033},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.07439586520195007},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/sensors60989.2024.10784609","is_oa":false,"landing_page_url":"https://doi.org/10.1109/sensors60989.2024.10784609","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE SENSORS","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W2105017561","https://openalex.org/W2521918697","https://openalex.org/W2587788572","https://openalex.org/W3033444107","https://openalex.org/W3109712959","https://openalex.org/W3136976975","https://openalex.org/W3214730896","https://openalex.org/W4200022070","https://openalex.org/W4206337522","https://openalex.org/W4392645584","https://openalex.org/W4399134954"],"related_works":["https://openalex.org/W2050956753","https://openalex.org/W2184533732","https://openalex.org/W2034330200","https://openalex.org/W3045873720","https://openalex.org/W2906127908","https://openalex.org/W2408054456","https://openalex.org/W2068623945","https://openalex.org/W4243773385","https://openalex.org/W2050511751","https://openalex.org/W3209857138"],"abstract_inverted_index":{"Industrial":[0],"anti-cancer":[1],"drug":[2,12],"screening":[3],"processes":[4],"require":[5],"label-free":[6,48],"and":[7,67],"high-throughput":[8],"methods":[9,26],"to":[10,50,75,91],"characterize":[11],"effects":[13],"on":[14],"in":[15],"vitro":[16],"3D":[17],"cellular":[18],"models,":[19],"such":[20],"as":[21,46],"spheroids.":[22],"However,":[23],"conventional":[24,103],"characterization":[25],"are":[27],"either":[28],"invasive":[29],"or":[30],"have":[31],"limited":[32],"throughput.":[33],"In":[34],"this":[35],"study,":[36],"we":[37,82],"assessed":[38],"the":[39],"feasibility":[40],"of":[41,78],"using":[42],"electrical":[43],"impedance":[44,59,85],"spectroscopy":[45,86],"a":[47,79],"method":[49],"evaluate":[51],"spheroid":[52,93],"viability.":[53],"We":[54,98],"developed":[55],"an":[56],"easy-to-fabricate":[57],"flow-through":[58],"sensor":[60],"with":[61,95],"facing":[62],"electrodes":[63],"for":[64],"improved":[65],"sensitivity":[66],"simultaneous":[68],"imaging.":[69],"By":[70],"exposing":[71],"liver":[72],"cancer":[73],"spheroids":[74],"varying":[76],"concentrations":[77],"toxic":[80],"compound,":[81],"demonstrate":[83],"that":[84],"can":[87],"be":[88],"successfully":[89],"used":[90],"measure":[92],"viability":[94,104],"high":[96],"sensitivity.":[97],"benchmarked":[99],"our":[100],"results":[101],"against":[102],"assays,":[105],"including":[106],"ATP":[107],"assays.":[108]},"counts_by_year":[],"updated_date":"2025-12-27T23:08:20.325037","created_date":"2025-10-10T00:00:00"}
