{"id":"https://openalex.org/W4311412970","doi":"https://doi.org/10.1109/sensors52175.2022.9967365","title":"Electro-Mechanical Measurement of Cardiomyocytes for Drug Toxicity Screening","display_name":"Electro-Mechanical Measurement of Cardiomyocytes for Drug Toxicity Screening","publication_year":2022,"publication_date":"2022-10-30","ids":{"openalex":"https://openalex.org/W4311412970","doi":"https://doi.org/10.1109/sensors52175.2022.9967365"},"language":"en","primary_location":{"id":"doi:10.1109/sensors52175.2022.9967365","is_oa":false,"landing_page_url":"https://doi.org/10.1109/sensors52175.2022.9967365","pdf_url":null,"source":{"id":"https://openalex.org/S4363604906","display_name":"2022 IEEE Sensors","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE Sensors","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026052075","display_name":"Pooja P. Kanade","orcid":"https://orcid.org/0000-0003-0249-8079"},"institutions":[{"id":"https://openalex.org/I111277659","display_name":"Chonnam National University","ror":"https://ror.org/05kzjxq56","country_code":"KR","type":"education","lineage":["https://openalex.org/I111277659"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Pooja P. Kanade","raw_affiliation_strings":["School of Mechanical Engineering, Chonnam National University,Gwangju,Republic of Korea","School of Mechanical Engineering, Chonnam National University, Gwangju, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mechanical Engineering, Chonnam National University,Gwangju,Republic of Korea","institution_ids":["https://openalex.org/I111277659"]},{"raw_affiliation_string":"School of Mechanical Engineering, Chonnam National University, Gwangju, Republic of Korea","institution_ids":["https://openalex.org/I111277659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013190285","display_name":"Nomin\u2010Erdene Oyunbaatar","orcid":null},"institutions":[{"id":"https://openalex.org/I111277659","display_name":"Chonnam National University","ror":"https://ror.org/05kzjxq56","country_code":"KR","type":"education","lineage":["https://openalex.org/I111277659"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Nomin-Erdene Oyunbaatar","raw_affiliation_strings":["School of Mechanical Engineering, Chonnam National University,Gwangju,Republic of Korea","School of Mechanical Engineering, Chonnam National University, Gwangju, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mechanical Engineering, Chonnam National University,Gwangju,Republic of Korea","institution_ids":["https://openalex.org/I111277659"]},{"raw_affiliation_string":"School of Mechanical Engineering, Chonnam National University, Gwangju, Republic of Korea","institution_ids":["https://openalex.org/I111277659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102722132","display_name":"Dong\u2010Su Kim","orcid":"https://orcid.org/0000-0003-0388-4633"},"institutions":[{"id":"https://openalex.org/I111277659","display_name":"Chonnam National University","ror":"https://ror.org/05kzjxq56","country_code":"KR","type":"education","lineage":["https://openalex.org/I111277659"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dong-Su Kim","raw_affiliation_strings":["School of Mechanical Engineering, Chonnam National University,Gwangju,Republic of Korea","School of Mechanical Engineering, Chonnam National University, Gwangju, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mechanical Engineering, Chonnam National University,Gwangju,Republic of Korea","institution_ids":["https://openalex.org/I111277659"]},{"raw_affiliation_string":"School of Mechanical Engineering, Chonnam National University, Gwangju, Republic of Korea","institution_ids":["https://openalex.org/I111277659"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101526466","display_name":"Dong\u2010Weon Lee","orcid":"https://orcid.org/0000-0002-0847-4505"},"institutions":[{"id":"https://openalex.org/I111277659","display_name":"Chonnam National University","ror":"https://ror.org/05kzjxq56","country_code":"KR","type":"education","lineage":["https://openalex.org/I111277659"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dong-Weon Lee","raw_affiliation_strings":["School of Mechanical Engineering, Chonnam National University,Gwangju,Republic of Korea","Advanced Medical Device Research Center for Cardiovascular Disease, Chonnam National University, Gwangju, Korea","Center for Next-Generation Sensor Research and Development, Chonnam National University, Gwangju, Republic of Korea","School of Mechanical Engineering, Chonnam National University, Gwangju, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mechanical Engineering, Chonnam National University,Gwangju,Republic of Korea","institution_ids":["https://openalex.org/I111277659"]},{"raw_affiliation_string":"Advanced Medical Device Research Center for Cardiovascular Disease, Chonnam National University, Gwangju, Korea","institution_ids":["https://openalex.org/I111277659"]},{"raw_affiliation_string":"Center for Next-Generation Sensor Research and Development, Chonnam National University, Gwangju, Republic of Korea","institution_ids":["https://openalex.org/I111277659"]},{"raw_affiliation_string":"School of Mechanical Engineering, Chonnam National University, Gwangju, Republic of Korea","institution_ids":["https://openalex.org/I111277659"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111277659"],"apc_list":null,"apc_paid":null,"fwci":0.7909,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.74532374,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9929999709129333,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11472","display_name":"Analytical Chemistry and Sensors","score":0.9851999878883362,"subfield":{"id":"https://openalex.org/subfields/1502","display_name":"Bioengineering"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cantilever","display_name":"Cantilever","score":0.7978432178497314},{"id":"https://openalex.org/keywords/microelectrode","display_name":"Microelectrode","score":0.7117831707000732},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.548899233341217},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"Cardiotoxicity","score":0.52944016456604},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.5287137627601624},{"id":"https://openalex.org/keywords/focused-impedance-measurement","display_name":"Focused Impedance Measurement","score":0.44439876079559326},{"id":"https://openalex.org/keywords/microelectromechanical-systems","display_name":"Microelectromechanical systems","score":0.43917226791381836},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"Drug toxicity","score":0.43315261602401733},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.3738809823989868},{"id":"https://openalex.org/keywords/electrical-impedance","display_name":"Electrical impedance","score":0.37114888429641724},{"id":"https://openalex.org/keywords/toxicity","display_name":"Toxicity","score":0.3665826618671417},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.3582592010498047},{"id":"https://openalex.org/keywords/optoelectronics","display_name":"Optoelectronics","score":0.3483697175979614},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.26975467801094055},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1684170365333557},{"id":"https://openalex.org/keywords/electrical-engineering","display_name":"Electrical engineering","score":0.16087105870246887},{"id":"https://openalex.org/keywords/composite-material","display_name":"Composite material","score":0.1567085087299347},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.14691779017448425},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.1320849359035492},{"id":"https://openalex.org/keywords/electrode","display_name":"Electrode","score":0.0845600962638855}],"concepts":[{"id":"https://openalex.org/C141354745","wikidata":"https://www.wikidata.org/wiki/Q17227","display_name":"Cantilever","level":2,"score":0.7978432178497314},{"id":"https://openalex.org/C111670793","wikidata":"https://www.wikidata.org/wiki/Q16979465","display_name":"Microelectrode","level":3,"score":0.7117831707000732},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.548899233341217},{"id":"https://openalex.org/C2778233292","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiotoxicity","level":3,"score":0.52944016456604},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5287137627601624},{"id":"https://openalex.org/C172066009","wikidata":"https://www.wikidata.org/wiki/Q5463955","display_name":"Focused Impedance Measurement","level":3,"score":0.44439876079559326},{"id":"https://openalex.org/C37977207","wikidata":"https://www.wikidata.org/wiki/Q175561","display_name":"Microelectromechanical systems","level":2,"score":0.43917226791381836},{"id":"https://openalex.org/C2992092908","wikidata":"https://www.wikidata.org/wiki/Q45959","display_name":"Drug toxicity","level":3,"score":0.43315261602401733},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3738809823989868},{"id":"https://openalex.org/C17829176","wikidata":"https://www.wikidata.org/wiki/Q179043","display_name":"Electrical impedance","level":2,"score":0.37114888429641724},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.3665826618671417},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3582592010498047},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.3483697175979614},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.26975467801094055},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1684170365333557},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.16087105870246887},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.1567085087299347},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.14691779017448425},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1320849359035492},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.0845600962638855},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/sensors52175.2022.9967365","is_oa":false,"landing_page_url":"https://doi.org/10.1109/sensors52175.2022.9967365","pdf_url":null,"source":{"id":"https://openalex.org/S4363604906","display_name":"2022 IEEE Sensors","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE Sensors","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.800000011920929,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1997349129","https://openalex.org/W2009768911","https://openalex.org/W2028163040","https://openalex.org/W2098952554","https://openalex.org/W2106379660","https://openalex.org/W2111643738","https://openalex.org/W2806250787","https://openalex.org/W2898059257","https://openalex.org/W3142761115","https://openalex.org/W3187716661","https://openalex.org/W4210301596"],"related_works":["https://openalex.org/W2160554962","https://openalex.org/W2107125189","https://openalex.org/W4253324731","https://openalex.org/W2809246414","https://openalex.org/W4387676337","https://openalex.org/W2137815833","https://openalex.org/W2760996480","https://openalex.org/W4324119913","https://openalex.org/W2145309571","https://openalex.org/W2901928456"],"abstract_inverted_index":{"This":[0],"work":[1],"demonstrates":[2],"a":[3,22,100,116],"dual":[4,106],"simultaneous":[5,79],"measurement":[6,107],"platform":[7,19,86,108],"that":[8,32],"can":[9,33],"be":[10,113],"used":[11,114],"for":[12,54,89,115],"drug":[13,93],"induced":[14],"cardiac":[15],"toxicity":[16,94],"screening.":[17],"The":[18,48,103],"consists":[20],"of":[21,40,62,67,119],"cantilever":[23,77],"with":[24],"strain":[25,69],"sensor":[26],"and":[27,37,65,78],"microelectrodes":[28,64],"patterned":[29],"on":[30,75],"them":[31],"measure":[34],"contraction":[35],"force":[36],"field":[38],"potential":[39,111],"the":[41,45,59,63,68,76,85],"cultured":[42,74],"cardiomyocytes":[43,72],"at":[44],"same":[46],"time.":[47],"fabricated":[49],"device":[50],"was":[51,87],"first":[52],"characterized":[53],"its":[55,90],"performance":[56],"by":[57,95],"measuring":[58],"base":[60],"impedance":[61],"sensitivity":[66],"sensor.":[70],"Thereafter,":[71],"were":[73,82],"electro-mechanical":[80],"measurements":[81],"performed.":[83],"Finally,":[84],"tested":[88],"response":[91],"to":[92,112],"adding":[96],"Blebbistatin":[97],"which":[98],"is":[99],"myosin":[101],"inhibitor.":[102],"proposed":[104],"cantilever-based":[105],"has":[109],"great":[110],"detailed":[117],"assessment":[118],"cardiotoxicity.":[120]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}