{"id":"https://openalex.org/W1993414942","doi":"https://doi.org/10.1109/scis-isis.2012.6505196","title":"Reconstructability analysis of genetic loci associated with Alzheimer disease","display_name":"Reconstructability analysis of genetic loci associated with Alzheimer disease","publication_year":2012,"publication_date":"2012-11-01","ids":{"openalex":"https://openalex.org/W1993414942","doi":"https://doi.org/10.1109/scis-isis.2012.6505196","mag":"1993414942"},"language":"en","primary_location":{"id":"doi:10.1109/scis-isis.2012.6505196","is_oa":false,"landing_page_url":"https://doi.org/10.1109/scis-isis.2012.6505196","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The 6th International Conference on Soft Computing and Intelligent Systems, and The 13th International Symposium on Advanced Intelligence Systems","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108987896","display_name":"Patricia Kramer","orcid":null},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia Kramer","raw_affiliation_strings":["Department of Neurology, Oregon Health and Sciences University, Portland, OR, USA","Department of Neurology Oregon Health and Sciences University Portland OR USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Oregon Health and Sciences University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Department of Neurology Oregon Health and Sciences University Portland OR USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084404581","display_name":"Shawn K. Westaway","orcid":null},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shawn K. Westaway","raw_affiliation_strings":["Department of Neurology, Oregon Health and Sciences University, Portland, OR, USA","Department of Neurology Oregon Health and Sciences University Portland OR USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Oregon Health and Sciences University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Department of Neurology Oregon Health and Sciences University Portland OR USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038714210","display_name":"Martin Zwick","orcid":"https://orcid.org/0000-0002-7247-6636"},"institutions":[{"id":"https://openalex.org/I126345244","display_name":"Portland State University","ror":"https://ror.org/00yn2fy02","country_code":"US","type":"education","lineage":["https://openalex.org/I126345244"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Zwick","raw_affiliation_strings":["Systems Science Department, Portland State University, Portland, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Science Department, Portland State University, Portland, OR, USA","institution_ids":["https://openalex.org/I126345244"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065157776","display_name":"Stephen Shervais","orcid":null},"institutions":[{"id":"https://openalex.org/I159107703","display_name":"Eastern Washington University","ror":"https://ror.org/002g57a93","country_code":"US","type":"education","lineage":["https://openalex.org/I159107703"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Shervais","raw_affiliation_strings":["College of Business and Public Administration, Eastern Washington University, Cheney, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Business and Public Administration, Eastern Washington University, Cheney, WA, USA","institution_ids":["https://openalex.org/I159107703"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4031,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.61163246,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"2104","last_page":"2110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9919000267982483,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9919000267982483,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9818000197410583,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9728000164031982,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"Apolipoprotein E","score":0.6641108989715576},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.6413733959197998},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.58006352186203},{"id":"https://openalex.org/keywords/alzheimers-disease","display_name":"Alzheimer's disease","score":0.4232890009880066},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4004056453704834},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.39401763677597046},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.344363808631897},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.22739526629447937},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2202741503715515},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.16422030329704285},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.0844169557094574}],"concepts":[{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.6641108989715576},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6413733959197998},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.58006352186203},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4232890009880066},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4004056453704834},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.39401763677597046},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.344363808631897},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22739526629447937},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2202741503715515},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.16422030329704285},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0844169557094574}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/scis-isis.2012.6505196","is_oa":false,"landing_page_url":"https://doi.org/10.1109/scis-isis.2012.6505196","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The 6th International Conference on Soft Computing and Intelligent Systems, and The 13th International Symposium on Advanced Intelligence Systems","raw_type":"proceedings-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.365.2661","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.365.2661","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.pdx.edu/sysc/sites/www.pdx.edu.sysc/files/Alzheimer2012Kobe288-1_0.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Quality Education","id":"https://metadata.un.org/sdg/4","score":0.8100000023841858}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W199129542","https://openalex.org/W608858759","https://openalex.org/W1539893433","https://openalex.org/W1545502161","https://openalex.org/W1606419771","https://openalex.org/W1964268922","https://openalex.org/W1967395566","https://openalex.org/W1986709161","https://openalex.org/W2009969871","https://openalex.org/W2011639175","https://openalex.org/W2012732645","https://openalex.org/W2018962858","https://openalex.org/W2039549451","https://openalex.org/W2040586898","https://openalex.org/W2046391671","https://openalex.org/W2074786675","https://openalex.org/W2081693136","https://openalex.org/W2084150578","https://openalex.org/W2085843402","https://openalex.org/W2086740067","https://openalex.org/W2112067091","https://openalex.org/W2127135920","https://openalex.org/W2131878646","https://openalex.org/W2131959994","https://openalex.org/W2140299844","https://openalex.org/W2140458856","https://openalex.org/W2142635246","https://openalex.org/W2157646585","https://openalex.org/W2161381121","https://openalex.org/W2161633633","https://openalex.org/W2168175751","https://openalex.org/W2169747954","https://openalex.org/W2327022120","https://openalex.org/W3087675653","https://openalex.org/W3149745985","https://openalex.org/W4211153813","https://openalex.org/W4232521193","https://openalex.org/W6632365238","https://openalex.org/W6653265940","https://openalex.org/W6660615926","https://openalex.org/W6783513180","https://openalex.org/W7074181722"],"related_works":["https://openalex.org/W3096251967","https://openalex.org/W2517337661","https://openalex.org/W2765880290","https://openalex.org/W1882000658","https://openalex.org/W2055507248","https://openalex.org/W2073589898","https://openalex.org/W1554075420","https://openalex.org/W2092065332","https://openalex.org/W4220910450","https://openalex.org/W2095013452"],"abstract_inverted_index":{"Reconstructability":[0],"Analysis":[1],"(RA)":[2],"is":[3],"an":[4],"information-":[5],"and":[6,26,55,61,67,99,104],"graph-theory-based":[7],"method":[8],"which":[9],"has":[10],"been":[11],"successfully":[12],"used":[13,115],"in":[14,35,65,70,116],"previous":[15],"genomic":[16,118],"studies.":[17,119],"Here":[18],"we":[19,102],"apply":[20],"it":[21],"to":[22,78,106],"genetic":[23],"(14":[24],"SNPs)":[25],"non-genetic":[27,58],"(Education,":[28],"Age,":[29],"Gender)":[30],"data":[31],"on":[32],"Alzheimer":[33],"disease":[34,74],"a":[36,50,80,93],"well-characterized":[37],"Case/Control":[38],"sample":[39],"of":[40,47,52,112],"424":[41],"individuals.":[42],"We":[43,90],"confirm":[44],"the":[45,53,68],"importance":[46],"APOE":[48],"as":[49,72],"predictor":[51],"disease,":[54],"identify":[56,92],"one":[57,64],"factor,":[59],"Education,":[60],"two":[62],"SNPs,":[63],"BINI":[66],"other":[69],"SORCS1,":[71],"likely":[73],"predictors.":[75],"SORCS1":[76],"appears":[77],"be":[79],"common":[81],"risk":[82],"factor":[83],"for":[84],"people":[85],"with":[86],"or":[87],"without":[88],"APOE.":[89],"also":[91],"possible":[94],"interaction":[95],"effect":[96],"between":[97],"Education":[98],"BINI.":[100],"Methodologically,":[101],"introduce":[103],"use":[105],"advantage":[107],"some":[108],"more":[109],"powerful":[110],"features":[111],"RA":[113],"not":[114],"prior":[117]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}