{"id":"https://openalex.org/W4411552817","doi":"https://doi.org/10.1109/saci66288.2025.11030160","title":"Radiocytogenetics in Multiple Myeloma: Predicting Cytogenetic Aberrations from WBCT Imaging Features","display_name":"Radiocytogenetics in Multiple Myeloma: Predicting Cytogenetic Aberrations from WBCT Imaging Features","publication_year":2025,"publication_date":"2025-05-19","ids":{"openalex":"https://openalex.org/W4411552817","doi":"https://doi.org/10.1109/saci66288.2025.11030160"},"language":"en","primary_location":{"id":"doi:10.1109/saci66288.2025.11030160","is_oa":false,"landing_page_url":"https://doi.org/10.1109/saci66288.2025.11030160","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 19th International Symposium on Applied Computational Intelligence and Informatics (SACI)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046083596","display_name":"Eleftherios Trivizakis","orcid":"https://orcid.org/0000-0003-3988-6809"},"institutions":[{"id":"https://openalex.org/I8901234","display_name":"Foundation for Research and Technology Hellas","ror":"https://ror.org/052rphn09","country_code":"GR","type":"facility","lineage":["https://openalex.org/I8901234"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Eleftherios Trivizakis","raw_affiliation_strings":["Foundation for Research and Technology,Computational BioMedicine Laboratory (CBML),Hellas, Heraklion,Greece"],"raw_orcid":"https://orcid.org/0000-0003-3988-6809","affiliations":[{"raw_affiliation_string":"Foundation for Research and Technology,Computational BioMedicine Laboratory (CBML),Hellas, Heraklion,Greece","institution_ids":["https://openalex.org/I8901234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056821356","display_name":"Emmanouil Koutoulakis","orcid":"https://orcid.org/0000-0002-2342-7934"},"institutions":[{"id":"https://openalex.org/I8901234","display_name":"Foundation for Research and Technology Hellas","ror":"https://ror.org/052rphn09","country_code":"GR","type":"facility","lineage":["https://openalex.org/I8901234"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Emmanouil Koutoulakis","raw_affiliation_strings":["Foundation for Research and Technology,Computational BioMedicine Laboratory (CBML),Hellas, Heraklion,Greece"],"raw_orcid":"https://orcid.org/0000-0002-2342-7934","affiliations":[{"raw_affiliation_string":"Foundation for Research and Technology,Computational BioMedicine Laboratory (CBML),Hellas, Heraklion,Greece","institution_ids":["https://openalex.org/I8901234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032994069","display_name":"Vassilis Koutoulidis","orcid":"https://orcid.org/0000-0001-6281-8586"},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Vassilis Koutoulidis","raw_affiliation_strings":["School of Medicine, Aretaieion Hospital, National Kapodistrian University of Athens,Department of Radiology,Athens,Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Aretaieion Hospital, National Kapodistrian University of Athens,Department of Radiology,Athens,Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041347954","display_name":"Lia A. Moulopoulos","orcid":"https://orcid.org/0000-0001-6009-1088"},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Lia A. Moulopoulos","raw_affiliation_strings":["School of Medicine, Aretaieion Hospital, National Kapodistrian University of Athens,Department of Radiology,Athens,Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Aretaieion Hospital, National Kapodistrian University of Athens,Department of Radiology,Athens,Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041407463","display_name":"Evangelos Terpos","orcid":"https://orcid.org/0000-0001-5133-1422"},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Evangelos Terpos","raw_affiliation_strings":["School of Medicine, National and Kapodistrian University of Athens,Department of Clinical Therapeutics,Athens,Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, National and Kapodistrian University of Athens,Department of Clinical Therapeutics,Athens,Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033282728","display_name":"Ioannis Ntanasis\u2010Stathopoulos","orcid":"https://orcid.org/0000-0002-6328-9783"},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Ioannis Ntanasis-Stathopoulos","raw_affiliation_strings":["School of Medicine, National and Kapodistrian University of Athens,Department of Clinical Therapeutics,Athens,Greece"],"raw_orcid":"https://orcid.org/0000-0002-6328-9783","affiliations":[{"raw_affiliation_string":"School of Medicine, National and Kapodistrian University of Athens,Department of Clinical Therapeutics,Athens,Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059359090","display_name":"Panagiotis Malandrakis","orcid":"https://orcid.org/0000-0002-4673-171X"},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Panagiotis Malandrakis","raw_affiliation_strings":["School of Medicine, National and Kapodistrian University of Athens,Department of Clinical Therapeutics,Athens,Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, National and Kapodistrian University of Athens,Department of Clinical Therapeutics,Athens,Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056752383","display_name":"Panagiotis Grigoropoulos","orcid":"https://orcid.org/0000-0002-0733-1377"},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Panagiotis Grigoropoulos","raw_affiliation_strings":["School of Medicine, Aretaieion Hospital, National Kapodistrian University of Athens,Department of Radiology,Athens,Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Aretaieion Hospital, National Kapodistrian University of Athens,Department of Radiology,Athens,Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036533432","display_name":"Panagiotis N. Papadopoulos","orcid":"https://orcid.org/0000-0001-7343-2590"},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Panagiotis Papadopoulos","raw_affiliation_strings":["School of Medicine, Aretaieion Hospital, National Kapodistrian University of Athens,Department of Radiology,Athens,Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Aretaieion Hospital, National Kapodistrian University of Athens,Department of Radiology,Athens,Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036083621","display_name":"Katerina Nikiforaki","orcid":"https://orcid.org/0000-0003-0792-9800"},"institutions":[{"id":"https://openalex.org/I8901234","display_name":"Foundation for Research and Technology Hellas","ror":"https://ror.org/052rphn09","country_code":"GR","type":"facility","lineage":["https://openalex.org/I8901234"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Katerina Nikiforaki","raw_affiliation_strings":["Foundation for Research and Technology,Computational BioMedicine Laboratory (CBML),Hellas, Heraklion,Greece"],"raw_orcid":"https://orcid.org/0000-0003-0792-9800","affiliations":[{"raw_affiliation_string":"Foundation for Research and Technology,Computational BioMedicine Laboratory (CBML),Hellas, Heraklion,Greece","institution_ids":["https://openalex.org/I8901234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103252738","display_name":"Nikolaos Papanikolaou","orcid":"https://orcid.org/0000-0002-1028-1016"},"institutions":[{"id":"https://openalex.org/I113358080","display_name":"Champalimaud Foundation","ror":"https://ror.org/03g001n57","country_code":"PT","type":"facility","lineage":["https://openalex.org/I113358080"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Nikolaos Papanikolaou","raw_affiliation_strings":["Champalimaud Foundation,Computational Clinical Imaging Group, Centre of the Unknown,Portugal"],"raw_orcid":"https://orcid.org/0000-0002-1028-1016","affiliations":[{"raw_affiliation_string":"Champalimaud Foundation,Computational Clinical Imaging Group, Centre of the Unknown,Portugal","institution_ids":["https://openalex.org/I113358080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037813012","display_name":"Dimitrios I. Fotiadis","orcid":"https://orcid.org/0000-0002-7362-5082"},"institutions":[{"id":"https://openalex.org/I8901234","display_name":"Foundation for Research and Technology Hellas","ror":"https://ror.org/052rphn09","country_code":"GR","type":"facility","lineage":["https://openalex.org/I8901234"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Dimitrios I. Fotiadis","raw_affiliation_strings":["Biomedical Research Institute (BRI), Foundation for Research and Technology, Hellas (FORTH),Ioannina,Greece"],"raw_orcid":"https://orcid.org/0000-0002-7362-5082","affiliations":[{"raw_affiliation_string":"Biomedical Research Institute (BRI), Foundation for Research and Technology, Hellas (FORTH),Ioannina,Greece","institution_ids":["https://openalex.org/I8901234"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014640458","display_name":"Kostas Marias","orcid":"https://orcid.org/0000-0003-3783-5223"},"institutions":[{"id":"https://openalex.org/I8901234","display_name":"Foundation for Research and Technology Hellas","ror":"https://ror.org/052rphn09","country_code":"GR","type":"facility","lineage":["https://openalex.org/I8901234"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Kostas Marias","raw_affiliation_strings":["Foundation for Research and Technology,Computational BioMedicine Laboratory,Hellas, Heraklion,Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foundation for Research and Technology,Computational BioMedicine Laboratory,Hellas, Heraklion,Greece","institution_ids":["https://openalex.org/I8901234"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"000231","last_page":"000236"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9846000075340271,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9836000204086304,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"Multiple myeloma","score":0.6322016716003418},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.35266539454460144},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.25926685333251953},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.12452128529548645}],"concepts":[{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.6322016716003418},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.35266539454460144},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25926685333251953},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12452128529548645}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/saci66288.2025.11030160","is_oa":false,"landing_page_url":"https://doi.org/10.1109/saci66288.2025.11030160","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 19th International Symposium on Applied Computational Intelligence and Informatics (SACI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4300000071525574,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W2040585723","https://openalex.org/W2148143831","https://openalex.org/W2169987170","https://openalex.org/W2783965560","https://openalex.org/W2912482553","https://openalex.org/W2953995767","https://openalex.org/W2961026219","https://openalex.org/W2975980063","https://openalex.org/W3088226914","https://openalex.org/W3120292872","https://openalex.org/W3126763003","https://openalex.org/W4200064073","https://openalex.org/W4281748479","https://openalex.org/W4380360883","https://openalex.org/W4389781629","https://openalex.org/W4391306872","https://openalex.org/W4391443328","https://openalex.org/W6881387143"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"Multiple":[0],"myeloma":[1,45],"is":[2,52,82,93],"a":[3,88,97],"plasma":[4,31],"cell":[5,32],"malignancy":[6,20],"with":[7,43,167],"an":[8,15,168],"underlying":[9,103],"genetic":[10],"complexity":[11],"that":[12,57],"develops":[13],"from":[14,127],"early":[16],"stage":[17],"prior":[18],"to":[19,47,95,101,124,139],"progression":[21],"because":[22],"of":[23,41,131,143,170],"recurrent":[24],"genomic":[25],"mutations.":[26],"The":[27,38,152],"disease":[28],"triggers":[29],"malignant":[30],"production":[33],"in":[34],"the":[35,48,79,102,128,141,148,164],"bone":[36,70,80,119],"marrow.":[37],"prognostic":[39],"stratification":[40],"patients":[42],"multiple":[44],"according":[46],"international":[49],"staging":[50],"systems":[51],"based":[53,157],"on":[54,158],"specific":[55],"criteria":[56],"incorporate":[58],"laboratory":[59],"examinations":[60],"and":[61,112,147,160],"chromosomal":[62,145],"aberrations.":[63],"Evaluating":[64],"these":[65],"cytogenetic":[66,104,150],"abnormalities":[67],"requires":[68],"invasive":[69],"marrow":[71,81,120],"aspiration,":[72],"which":[73],"might":[74],"be":[75],"unsuccessful,":[76],"especially":[77],"when":[78],"dry":[83],"tap.":[84],"In":[85],"this":[86],"study,":[87],"novel":[89],"machine":[90,134,154],"learning":[91,135,155],"model":[92],"used":[94,123],"match":[96],"robust":[98],"radiomic":[99],"signature":[100],"status,":[105],"including":[106],"del(13q),":[107],"<tex":[108,113,171],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[109,114,172],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$t(4;":[110],"14)$</tex>,":[111],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$\\operatorname{amp}(1":[115],"q":[116],"21)$</tex>.":[117],"Whole-body":[118],"masks":[121],"were":[122],"extract":[125],"radiomics":[126,162],"selected":[129],"groups":[130],"bones.":[132],"A":[133],"analysis":[136,156],"was":[137],"employed":[138],"predict":[140],"expression":[142],"key":[144],"alterations":[146],"subsequent":[149],"risk.":[151],"proposed":[153],"sacrum":[159],"pelvis":[161],"achieved":[163],"highest":[165],"performance":[166],"AUC":[169],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$0.76":[173],"\\pm":[174],"0.03$</tex>":[175],"among":[176],"other":[177],"radiocytogenetic":[178],"models.":[179]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}
