{"id":"https://openalex.org/W4411552497","doi":"https://doi.org/10.1109/saci66288.2025.11030097","title":"Label-Free Machine Learning-Based Segmentation of Whole-Body Bone Marrow Imaging in Multiple Myeloma","display_name":"Label-Free Machine Learning-Based Segmentation of Whole-Body Bone Marrow Imaging in Multiple Myeloma","publication_year":2025,"publication_date":"2025-05-19","ids":{"openalex":"https://openalex.org/W4411552497","doi":"https://doi.org/10.1109/saci66288.2025.11030097"},"language":"en","primary_location":{"id":"doi:10.1109/saci66288.2025.11030097","is_oa":false,"landing_page_url":"https://doi.org/10.1109/saci66288.2025.11030097","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 19th International Symposium on Applied Computational Intelligence and Informatics (SACI)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056821356","display_name":"Emmanouil Koutoulakis","orcid":"https://orcid.org/0000-0002-2342-7934"},"institutions":[{"id":"https://openalex.org/I8901234","display_name":"Foundation for Research and Technology Hellas","ror":"https://ror.org/052rphn09","country_code":"GR","type":"facility","lineage":["https://openalex.org/I8901234"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Emmanouil Koutoulakis","raw_affiliation_strings":["Foundation for Research and Technology,Computational BioMedicine Laboratory (CBML),Hellas,Heraklion,Greece"],"raw_orcid":"https://orcid.org/0000-0002-2342-7934","affiliations":[{"raw_affiliation_string":"Foundation for Research and Technology,Computational BioMedicine Laboratory (CBML),Hellas,Heraklion,Greece","institution_ids":["https://openalex.org/I8901234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046083596","display_name":"Eleftherios Trivizakis","orcid":"https://orcid.org/0000-0003-3988-6809"},"institutions":[{"id":"https://openalex.org/I8901234","display_name":"Foundation for Research and Technology Hellas","ror":"https://ror.org/052rphn09","country_code":"GR","type":"facility","lineage":["https://openalex.org/I8901234"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Eleftherios Trivizakis","raw_affiliation_strings":["Foundation for Research and Technology,Computational BioMedicine Laboratory (CBML),Hellas,Heraklion,Greece"],"raw_orcid":"https://orcid.org/0000-0003-3988-6809","affiliations":[{"raw_affiliation_string":"Foundation for Research and Technology,Computational BioMedicine Laboratory (CBML),Hellas,Heraklion,Greece","institution_ids":["https://openalex.org/I8901234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032994069","display_name":"Vassilis Koutoulidis","orcid":"https://orcid.org/0000-0001-6281-8586"},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Vassilis Koutoulidis","raw_affiliation_strings":["School of Medicine, Aretaieion Hospital, National Kapodistrian University of Athens,1st Department of Radiology,Athens,Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Aretaieion Hospital, National Kapodistrian University of Athens,1st Department of Radiology,Athens,Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041347954","display_name":"Lia A. Moulopoulos","orcid":"https://orcid.org/0000-0001-6009-1088"},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Lia A. Moulopoulos","raw_affiliation_strings":["School of Medicine, Aretaieion Hospital, National Kapodistrian University of Athens,1st Department of Radiology,Athens,Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Aretaieion Hospital, National Kapodistrian University of Athens,1st Department of Radiology,Athens,Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041407463","display_name":"Evangelos Terpos","orcid":"https://orcid.org/0000-0001-5133-1422"},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Evangelos Terpos","raw_affiliation_strings":["School of Medicine, National and Kapodistrian University of Athens,Department of Clinical Therapeutics,Athens,Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, National and Kapodistrian University of Athens,Department of Clinical Therapeutics,Athens,Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033282728","display_name":"Ioannis Ntanasis\u2010Stathopoulos","orcid":"https://orcid.org/0000-0002-6328-9783"},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Ioannis Ntanasis-Stathopoulos","raw_affiliation_strings":["School of Medicine, National and Kapodistrian University of Athens,Department of Clinical Therapeutics,Athens,Greece"],"raw_orcid":"https://orcid.org/0000-0002-6328-9783","affiliations":[{"raw_affiliation_string":"School of Medicine, National and Kapodistrian University of Athens,Department of Clinical Therapeutics,Athens,Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059359090","display_name":"Panagiotis Malandrakis","orcid":"https://orcid.org/0000-0002-4673-171X"},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Panagiotis Malandrakis","raw_affiliation_strings":["School of Medicine, National and Kapodistrian University of Athens,Department of Clinical Therapeutics,Athens,Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, National and Kapodistrian University of Athens,Department of Clinical Therapeutics,Athens,Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056752383","display_name":"Panagiotis Grigoropoulos","orcid":"https://orcid.org/0000-0002-0733-1377"},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Panagiotis Grigoropoulos","raw_affiliation_strings":["School of Medicine, Aretaieion Hospital, National Kapodistrian University of Athens,1st Department of Radiology,Athens,Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Aretaieion Hospital, National Kapodistrian University of Athens,1st Department of Radiology,Athens,Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101458833","display_name":"Panagiotis Papadopoulos","orcid":"https://orcid.org/0000-0001-9913-9771"},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Panagiotis Papadopoulos","raw_affiliation_strings":["School of Medicine, Aretaieion Hospital, National Kapodistrian University of Athens,1st Department of Radiology,Athens,Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Aretaieion Hospital, National Kapodistrian University of Athens,1st Department of Radiology,Athens,Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036083621","display_name":"Katerina Nikiforaki","orcid":"https://orcid.org/0000-0003-0792-9800"},"institutions":[{"id":"https://openalex.org/I8901234","display_name":"Foundation for Research and Technology Hellas","ror":"https://ror.org/052rphn09","country_code":"GR","type":"facility","lineage":["https://openalex.org/I8901234"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Katerina Nikiforaki","raw_affiliation_strings":["Foundation for Research and Technology,Computational BioMedicine Laboratory (CBML),Hellas,Heraklion,Greece"],"raw_orcid":"https://orcid.org/0000-0003-0792-9800","affiliations":[{"raw_affiliation_string":"Foundation for Research and Technology,Computational BioMedicine Laboratory (CBML),Hellas,Heraklion,Greece","institution_ids":["https://openalex.org/I8901234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103252738","display_name":"Nikolaos Papanikolaou","orcid":"https://orcid.org/0000-0002-1028-1016"},"institutions":[{"id":"https://openalex.org/I113358080","display_name":"Champalimaud Foundation","ror":"https://ror.org/03g001n57","country_code":"PT","type":"facility","lineage":["https://openalex.org/I113358080"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Nikolaos Papanikolaou","raw_affiliation_strings":["Computational Clinical Imaging Group,Centre of the Unknown, Champalimaud Foundation,Portugal"],"raw_orcid":"https://orcid.org/0000-0002-1028-1016","affiliations":[{"raw_affiliation_string":"Computational Clinical Imaging Group,Centre of the Unknown, Champalimaud Foundation,Portugal","institution_ids":["https://openalex.org/I113358080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037813012","display_name":"Dimitrios I. Fotiadis","orcid":"https://orcid.org/0000-0002-7362-5082"},"institutions":[{"id":"https://openalex.org/I8901234","display_name":"Foundation for Research and Technology Hellas","ror":"https://ror.org/052rphn09","country_code":"GR","type":"facility","lineage":["https://openalex.org/I8901234"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Dimitrios I. Fotiadis","raw_affiliation_strings":["Biomedical Research Institute (BRI), Foundation for Research and Technology, Hellas (FORTH),Ioannina,Greece"],"raw_orcid":"https://orcid.org/0000-0002-7362-5082","affiliations":[{"raw_affiliation_string":"Biomedical Research Institute (BRI), Foundation for Research and Technology, Hellas (FORTH),Ioannina,Greece","institution_ids":["https://openalex.org/I8901234"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014640458","display_name":"Kostas Marias","orcid":"https://orcid.org/0000-0003-3783-5223"},"institutions":[{"id":"https://openalex.org/I8901234","display_name":"Foundation for Research and Technology Hellas","ror":"https://ror.org/052rphn09","country_code":"GR","type":"facility","lineage":["https://openalex.org/I8901234"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Kostas Marias","raw_affiliation_strings":["Foundation for Research and Technology,Computational BioMedicine Laboratory,Hellas,Heraklion,Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foundation for Research and Technology,Computational BioMedicine Laboratory,Hellas,Heraklion,Greece","institution_ids":["https://openalex.org/I8901234"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12874","display_name":"Digital Imaging for Blood Diseases","score":0.9642999768257141,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12874","display_name":"Digital Imaging for Blood Diseases","score":0.9642999768257141,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"Multiple myeloma","score":0.6798020005226135},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.6640843152999878},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6192772388458252},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"Bone marrow","score":0.563413143157959},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.4521234333515167},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.38703739643096924},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.3339933156967163},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.32062476873397827},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.20939674973487854},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.13850903511047363}],"concepts":[{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.6798020005226135},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.6640843152999878},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6192772388458252},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.563413143157959},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.4521234333515167},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.38703739643096924},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3339933156967163},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32062476873397827},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.20939674973487854},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13850903511047363}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/saci66288.2025.11030097","is_oa":false,"landing_page_url":"https://doi.org/10.1109/saci66288.2025.11030097","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 19th International Symposium on Applied Computational Intelligence and Informatics (SACI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.5099999904632568}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W2040585723","https://openalex.org/W2104307326","https://openalex.org/W2169987170","https://openalex.org/W2777404548","https://openalex.org/W2783965560","https://openalex.org/W2901462650","https://openalex.org/W2912482553","https://openalex.org/W2961026219","https://openalex.org/W2963037989","https://openalex.org/W2975980063","https://openalex.org/W3088226914","https://openalex.org/W3120292872","https://openalex.org/W3126763003","https://openalex.org/W3201546913","https://openalex.org/W3212911004","https://openalex.org/W4225638482","https://openalex.org/W4281731607","https://openalex.org/W4281748479","https://openalex.org/W4292180745","https://openalex.org/W4391306713","https://openalex.org/W4391306872","https://openalex.org/W4391443328","https://openalex.org/W6680300913"],"related_works":["https://openalex.org/W2013771509","https://openalex.org/W2810456981","https://openalex.org/W125438382","https://openalex.org/W2366743523","https://openalex.org/W2354239783","https://openalex.org/W4253070239","https://openalex.org/W1973936169","https://openalex.org/W2079153642","https://openalex.org/W2424707511","https://openalex.org/W1522196789"],"abstract_inverted_index":{"Multiple":[0,39],"myeloma":[1,34,40,164],"is":[2,41,81],"a":[3,42],"plasma":[4,22],"cell":[5,23],"neoplasm":[6,43],"with":[7,179],"genetic":[8],"complexity":[9],"that":[10,44],"originates":[11],"in":[12,27,83,97,162],"pre-malignant":[13],"stages":[14],"due":[15],"to":[16,20,92,99,121,132],"genomic":[17],"alterations,":[18],"leading":[19],"malignant":[21],"proliferation.":[24],"Monitoring":[25],"alterations":[26],"bone":[28,78,114,124,159,181],"marrow":[29,79,125,160],"during":[30,55],"treatment":[31],"for":[32,76],"multiple":[33,163],"may":[35],"optimize":[36],"patient":[37],"outcomes.":[38],"can":[45],"distort":[46],"bones,":[47],"compromising":[48],"the":[49,56,94,110,113,123,134,157,176],"efficacy":[50],"of":[51,58,67,103,156,169],"conventional":[52],"segmentation":[53,80,135,149],"methodologies":[54],"evaluation":[57],"whole":[59],"body":[60],"low":[61],"dose":[62],"computed":[63],"tomography.":[64],"A":[65,116],"combination":[66],"pre-trained":[68,87],"deep":[69],"learning":[70],"and":[71,105,112,127,153],"traditional":[72],"image":[73],"analysis":[74,139],"techniques":[75],"wholebody":[77],"explored":[82],"this":[84],"study.":[85],"The":[86,137,147],"TotalSegmentator":[88],"model":[89],"was":[90,119],"used":[91],"segment":[93],"entire":[95],"skeleton":[96],"order":[98],"isolate":[100],"key":[101],"regions":[102],"interest":[104],"reduce":[106],"pixel":[107],"imbalances":[108],"between":[109],"background":[111],"pixels.":[115],"clustering":[117],"technique":[118],"adapted":[120],"identify":[122],"pixels":[126],"morphological":[128],"operations":[129],"were":[130],"employed":[131],"refine":[133],"mask.":[136],"qualitative":[138],"performed":[140],"by":[141],"experienced":[142],"radiologists":[143],"shows":[144],"promising":[145],"results.":[146],"proposed":[148],"pipeline":[150],"allows":[151],"accurate":[152],"fast":[154],"annotation":[155],"whole-body":[158],"imaging":[161],"patients,":[165],"achieving":[166],"an":[167],"IoU":[168],"<tex":[170],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[171],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$0.79":[172],"\\pm":[173],"0.05$</tex>":[174],"on":[175],"available":[177],"cohort":[178],"femur":[180],"annotations.":[182]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}
