{"id":"https://openalex.org/W4404739869","doi":"https://doi.org/10.1109/rtsi61910.2024.10761680","title":"Towards a Deep Learning Approach to Discriminate Hereditary Anemias","display_name":"Towards a Deep Learning Approach to Discriminate Hereditary Anemias","publication_year":2024,"publication_date":"2024-09-18","ids":{"openalex":"https://openalex.org/W4404739869","doi":"https://doi.org/10.1109/rtsi61910.2024.10761680"},"language":"en","primary_location":{"id":"doi:10.1109/rtsi61910.2024.10761680","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/rtsi61910.2024.10761680","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE 8th Forum on Research and Technologies for Society and Industry Innovation (RTSI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068143882","display_name":"Francesco Carlo Morabito","orcid":"https://orcid.org/0000-0003-0734-9136"},"institutions":[{"id":"https://openalex.org/I59725666","display_name":"University of Reggio Calabria","ror":"https://ror.org/041sz8d87","country_code":"IT","type":"education","lineage":["https://openalex.org/I59725666"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Francesco Carlo Morabito","raw_affiliation_strings":["DICEAM, Univ. Mediterranea of Reggio Calabria,Reggio Calabria,Italy"],"affiliations":[{"raw_affiliation_string":"DICEAM, Univ. Mediterranea of Reggio Calabria,Reggio Calabria,Italy","institution_ids":["https://openalex.org/I59725666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052687333","display_name":"Cosimo Ieracitano","orcid":"https://orcid.org/0000-0001-7890-2897"},"institutions":[{"id":"https://openalex.org/I59725666","display_name":"University of Reggio Calabria","ror":"https://ror.org/041sz8d87","country_code":"IT","type":"education","lineage":["https://openalex.org/I59725666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cosimo Ieracitano","raw_affiliation_strings":["DICEAM, Univ. Mediterranea of Reggio Calabria,Reggio Calabria,Italy"],"affiliations":[{"raw_affiliation_string":"DICEAM, Univ. Mediterranea of Reggio Calabria,Reggio Calabria,Italy","institution_ids":["https://openalex.org/I59725666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056605266","display_name":"Nadia Mammone","orcid":"https://orcid.org/0000-0003-4962-3500"},"institutions":[{"id":"https://openalex.org/I59725666","display_name":"University of Reggio Calabria","ror":"https://ror.org/041sz8d87","country_code":"IT","type":"education","lineage":["https://openalex.org/I59725666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nadia Mammone","raw_affiliation_strings":["DICEAM, Univ. Mediterranea of Reggio Calabria,Reggio Calabria,Italy"],"affiliations":[{"raw_affiliation_string":"DICEAM, Univ. Mediterranea of Reggio Calabria,Reggio Calabria,Italy","institution_ids":["https://openalex.org/I59725666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040700722","display_name":"Marika Valentino","orcid":"https://orcid.org/0000-0002-9148-7429"},"institutions":[{"id":"https://openalex.org/I4210091512","display_name":"Institute of Applied Science and Intelligent Systems","ror":"https://ror.org/00be3zh53","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210091512","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"funder","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marika Valentino","raw_affiliation_strings":["Inst. of App. Sciences and Int. Systems (ISASI), National Research Council of Italy (CNR),Dep. of Physical Science and Tech. of Matter,Pozzuoli (NA),Italy"],"affiliations":[{"raw_affiliation_string":"Inst. of App. Sciences and Int. Systems (ISASI), National Research Council of Italy (CNR),Dep. of Physical Science and Tech. of Matter,Pozzuoli (NA),Italy","institution_ids":["https://openalex.org/I4210091512","https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100407595","display_name":"Zhe Wang","orcid":"https://orcid.org/0000-0002-0593-0413"},"institutions":[{"id":"https://openalex.org/I4210091512","display_name":"Institute of Applied Science and Intelligent Systems","ror":"https://ror.org/00be3zh53","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210091512","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"funder","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Zhe Wang","raw_affiliation_strings":["Inst. of App. Sciences and Int. Systems (ISASI), National Research Council of Italy (CNR),Dep. of Physical Science and Tech. of Matter,Pozzuoli (NA),Italy"],"affiliations":[{"raw_affiliation_string":"Inst. of App. Sciences and Int. Systems (ISASI), National Research Council of Italy (CNR),Dep. of Physical Science and Tech. of Matter,Pozzuoli (NA),Italy","institution_ids":["https://openalex.org/I4210091512","https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092797250","display_name":"Michela Schiavo","orcid":null},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"funder","lineage":["https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210091512","display_name":"Institute of Applied Science and Intelligent Systems","ror":"https://ror.org/00be3zh53","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210091512","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michela Schiavo","raw_affiliation_strings":["Inst. of App. Sciences and Int. Systems (ISASI), National Research Council of Italy (CNR),Dep. of Physical Science and Tech. of Matter,Pozzuoli (NA),Italy"],"affiliations":[{"raw_affiliation_string":"Inst. of App. Sciences and Int. Systems (ISASI), National Research Council of Italy (CNR),Dep. of Physical Science and Tech. of Matter,Pozzuoli (NA),Italy","institution_ids":["https://openalex.org/I4210091512","https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072827553","display_name":"Vittorio Bianco","orcid":"https://orcid.org/0000-0003-1956-4976"},"institutions":[{"id":"https://openalex.org/I4210091512","display_name":"Institute of Applied Science and Intelligent Systems","ror":"https://ror.org/00be3zh53","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210091512","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"funder","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vittorio Bianco","raw_affiliation_strings":["Inst. of App. Sciences and Int. Systems (ISASI), National Research Council of Italy (CNR),Dep. of Physical Science and Tech. of Matter,Pozzuoli (NA),Italy"],"affiliations":[{"raw_affiliation_string":"Inst. of App. Sciences and Int. Systems (ISASI), National Research Council of Italy (CNR),Dep. of Physical Science and Tech. of Matter,Pozzuoli (NA),Italy","institution_ids":["https://openalex.org/I4210091512","https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109709597","display_name":"Anthony Iscaro","orcid":null},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]},{"id":"https://openalex.org/I4210128854","display_name":"Ceinge Biotecnologie Avanzate (Italy)","ror":"https://ror.org/033pa2k60","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210128854"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anthony Iscaro","raw_affiliation_strings":["DMMBM, University of Naples Federico II, CEINGE Biotecnologie Avanzate,Naples,Italy"],"affiliations":[{"raw_affiliation_string":"DMMBM, University of Naples Federico II, CEINGE Biotecnologie Avanzate,Naples,Italy","institution_ids":["https://openalex.org/I4210128854","https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002788306","display_name":"Antonella Nostroso","orcid":"https://orcid.org/0009-0007-3419-1641"},"institutions":[{"id":"https://openalex.org/I4210128854","display_name":"Ceinge Biotecnologie Avanzate (Italy)","ror":"https://ror.org/033pa2k60","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210128854"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonella Nostroso","raw_affiliation_strings":["DMMBM, University of Naples Federico II, CEINGE Biotecnologie Avanzate,Naples,Italy"],"affiliations":[{"raw_affiliation_string":"DMMBM, University of Naples Federico II, CEINGE Biotecnologie Avanzate,Naples,Italy","institution_ids":["https://openalex.org/I4210128854","https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043728055","display_name":"Immacolata Andolfo","orcid":"https://orcid.org/0000-0003-0493-812X"},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]},{"id":"https://openalex.org/I4210128854","display_name":"Ceinge Biotecnologie Avanzate (Italy)","ror":"https://ror.org/033pa2k60","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210128854"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Immacolata Andolfo","raw_affiliation_strings":["DMMBM, University of Naples Federico II, CEINGE Biotecnologie Avanzate,Naples,Italy"],"affiliations":[{"raw_affiliation_string":"DMMBM, University of Naples Federico II, CEINGE Biotecnologie Avanzate,Naples,Italy","institution_ids":["https://openalex.org/I4210128854","https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091406001","display_name":"Roberta Russo","orcid":"https://orcid.org/0000-0002-3624-7721"},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]},{"id":"https://openalex.org/I4210128854","display_name":"Ceinge Biotecnologie Avanzate (Italy)","ror":"https://ror.org/033pa2k60","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210128854"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberta Russo","raw_affiliation_strings":["DMMBM, University of Naples Federico II, CEINGE Biotecnologie Avanzate,Naples,Italy"],"affiliations":[{"raw_affiliation_string":"DMMBM, University of Naples Federico II, CEINGE Biotecnologie Avanzate,Naples,Italy","institution_ids":["https://openalex.org/I4210128854","https://openalex.org/I71267560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037659523","display_name":"Lisa Miccio","orcid":"https://orcid.org/0000-0001-9427-881X"},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"funder","lineage":["https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210091512","display_name":"Institute of Applied Science and Intelligent Systems","ror":"https://ror.org/00be3zh53","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210091512","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lisa Miccio","raw_affiliation_strings":["Inst. of App. Sciences and Int. Systems (ISASI), National Research Council of Italy (CNR),Dep. of Physical Science and Tech. of Matter,Pozzuoli (NA),Italy"],"affiliations":[{"raw_affiliation_string":"Inst. of App. Sciences and Int. Systems (ISASI), National Research Council of Italy (CNR),Dep. of Physical Science and Tech. of Matter,Pozzuoli (NA),Italy","institution_ids":["https://openalex.org/I4210091512","https://openalex.org/I4210155236"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5068143882"],"corresponding_institution_ids":["https://openalex.org/I59725666"],"apc_list":null,"apc_paid":null,"fwci":0.4827,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.70544022,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"339","last_page":"344"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.6680999994277954,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.6680999994277954,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.5698000192642212,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.5590000152587891,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6502760052680969},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4832044839859009}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6502760052680969},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4832044839859009}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/rtsi61910.2024.10761680","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/rtsi61910.2024.10761680","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE 8th Forum on Research and Technologies for Society and Industry Innovation (RTSI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities","score":0.8199999928474426}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1992550416","https://openalex.org/W2015913302","https://openalex.org/W2039252384","https://openalex.org/W2041512825","https://openalex.org/W2079825017","https://openalex.org/W2088297512","https://openalex.org/W2133736952","https://openalex.org/W2166395415","https://openalex.org/W2258981739","https://openalex.org/W2803379653","https://openalex.org/W2964355643","https://openalex.org/W3047047749","https://openalex.org/W3110114563","https://openalex.org/W3111817041","https://openalex.org/W3118078674","https://openalex.org/W4205702875","https://openalex.org/W4206291180","https://openalex.org/W4241300192","https://openalex.org/W4249023884","https://openalex.org/W4290603431","https://openalex.org/W4294214983","https://openalex.org/W4396925656"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"Anemia":[0],"affects":[1],"more":[2],"than":[3],"1.6":[4],"billion":[5],"people":[6],"globally;":[7],"about":[8],"10%":[9],"of":[10,18,39,64,102,116,146,159,172,189,193,203,208,220],"these":[11],"patients":[12],"are":[13,21,26],"affected":[14,195],"by":[15,28,196],"rare":[16],"anemias,":[17],"which":[19],"80%":[20],"hereditary.":[22],"Hereditary":[23],"anemias":[24],"(HA)":[25],"characterized":[27],"complex":[29],"genotype/phenotype":[30],"correlations":[31],"and":[32,51,59,67,77,81,94,154,192,232],"the":[33,65,70,100,106,114,127,141,152,156,160,163,170,181,206,217,221],"current":[34,222],"diagnostic":[35,89,223,230],"workflow":[36,224],"is":[37,108,167],"made":[38],"three":[40],"investigation":[41],"lines:":[42],"i)":[43],"clinical":[44,71],"tests":[45],"(familial":[46],"history,":[47],"complete":[48],"blood":[49,53],"count,":[50],"peripheral":[52],"smear);":[54],"ii)":[55],"specialized":[56],"biochemical":[57],"tests,":[58],"iii)":[60],"genetic":[61],"testing.":[62],"Because":[63],"diversity":[66],"overlapping":[68],"phenotypes":[69],"diagnosis":[72],"could":[73],"be":[74,214],"not":[75],"univocal":[76],"consequently":[78],"prevent":[79],"precise":[80],"correct":[82],"care.":[83],"The":[84],"present":[85],"study":[86],"proposes":[87],"a":[88,117,173],"step":[90],"combining":[91],"single-cell":[92],"imaging":[93],"Artificial":[95],"Intelligence":[96],"(AI)":[97],"to":[98,125,139,227],"identify":[99],"macro-class":[101],"hereditary":[103],"anemias.":[104],"Indeed,":[105],"method":[107],"based,":[109],"on":[110,113,151,155,162,169],"one":[111],"hand,":[112,165],"development":[115,171,207],"Digital":[118],"Holographic":[119],"(DH)":[120],"system":[121],"in":[122,132,225],"microscopy":[123],"configuration":[124],"image":[126],"Red":[128],"Blood":[129],"Cells":[130],"(RBC)":[131],"static":[133],"conditions.":[134],"Such":[135],"DH":[136],"approach":[137],"allows":[138],"retrieve":[140],"quantitative":[142,182],"phase":[143,183],"contrast":[144],"maps":[145],"RBC":[147,188],"that":[148,179,212],"contain":[149],"information":[150,184],"morphology":[153],"hemoglobin":[157],"content":[158],"sample;":[161],"other":[164],"it":[166],"based":[168],"custom":[174],"Convolutional":[175],"Neural":[176],"Network":[177],"(CNN)":[178],"exploits":[180],"for":[185],"classifying":[186],"single":[187],"healthy":[190],"subject":[191],"subjects":[194],"HA.":[197],"Experimental":[198],"results":[199,231],"(i.e.,":[200],"average":[201],"accuracy":[202],"93.6%)":[204],"encourage":[205],"an":[209],"effective":[210],"tool":[211],"would":[213],"integrated":[215],"into":[216],"second":[218],"line":[219],"order":[226],"speed":[228],"up":[229],"minimize":[233],"error.":[234]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-03-04T09:10:02.777135","created_date":"2025-10-10T00:00:00"}