{"id":"https://openalex.org/W4408235725","doi":"https://doi.org/10.1109/robio64047.2024.10907311","title":"A Robotic Blind Patch-Clamp System Based on Cranial Opening Localization and Micropipette Guidance","display_name":"A Robotic Blind Patch-Clamp System Based on Cranial Opening Localization and Micropipette Guidance","publication_year":2024,"publication_date":"2024-12-10","ids":{"openalex":"https://openalex.org/W4408235725","doi":"https://doi.org/10.1109/robio64047.2024.10907311"},"language":"en","primary_location":{"id":"doi:10.1109/robio64047.2024.10907311","is_oa":false,"landing_page_url":"https://doi.org/10.1109/robio64047.2024.10907311","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Robotics and Biomimetics (ROBIO)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049331166","display_name":"Zijian Guo","orcid":"https://orcid.org/0000-0003-4986-9308"},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zijian Guo","raw_affiliation_strings":["Institute of Robotics and Automatic Information System (IRAIS), Nankai University,Tianjin,China,300350"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Robotics and Automatic Information System (IRAIS), Nankai University,Tianjin,China,300350","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019317339","display_name":"Ruimin Li","orcid":"https://orcid.org/0000-0003-1610-2864"},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruimin Li","raw_affiliation_strings":["Institute of Robotics and Automatic Information System (IRAIS), Nankai University,Tianjin,China,300350"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Robotics and Automatic Information System (IRAIS), Nankai University,Tianjin,China,300350","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039219507","display_name":"Jinyu Qiu","orcid":"https://orcid.org/0000-0001-8480-744X"},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinyu Qiu","raw_affiliation_strings":["Institute of Robotics and Automatic Information System (IRAIS), Nankai University,Tianjin,China,300350"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Robotics and Automatic Information System (IRAIS), Nankai University,Tianjin,China,300350","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101923674","display_name":"Mingzhu Sun","orcid":"https://orcid.org/0000-0003-0562-7665"},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingzhu Sun","raw_affiliation_strings":["Institute of Robotics and Automatic Information System (IRAIS), Nankai University,Tianjin,China,300350"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Robotics and Automatic Information System (IRAIS), Nankai University,Tianjin,China,300350","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034713347","display_name":"Xin Zhao","orcid":"https://orcid.org/0000-0003-0631-4628"},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Zhao","raw_affiliation_strings":["Institute of Robotics and Automatic Information System (IRAIS), Nankai University,Tianjin,China,300350"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Robotics and Automatic Information System (IRAIS), Nankai University,Tianjin,China,300350","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090578099","display_name":"Qili Zhao","orcid":"https://orcid.org/0000-0002-9517-7460"},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qili Zhao","raw_affiliation_strings":["Institute of Robotics and Automatic Information System (IRAIS), Nankai University,Tianjin,China,300350"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Robotics and Automatic Information System (IRAIS), Nankai University,Tianjin,China,300350","institution_ids":["https://openalex.org/I205237279"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1628,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.49616516,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"571","last_page":"576"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10868","display_name":"Soft Robotics and Applications","score":0.9879000186920166,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10868","display_name":"Soft Robotics and Applications","score":0.9879000186920166,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13382","display_name":"Robotics and Automated Systems","score":0.9631999731063843,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10191","display_name":"Robotics and Sensor-Based Localization","score":0.9476000070571899,"subfield":{"id":"https://openalex.org/subfields/2202","display_name":"Aerospace Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pipette","display_name":"Pipette","score":0.7996479272842407},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5387287139892578},{"id":"https://openalex.org/keywords/clamp","display_name":"Clamp","score":0.5083112120628357},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.36472320556640625},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.35024797916412354},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.33894628286361694},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.2827404737472534},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.11243399977684021}],"concepts":[{"id":"https://openalex.org/C151552171","wikidata":"https://www.wikidata.org/wiki/Q163373","display_name":"Pipette","level":2,"score":0.7996479272842407},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5387287139892578},{"id":"https://openalex.org/C2776161997","wikidata":"https://www.wikidata.org/wiki/Q846600","display_name":"Clamp","level":3,"score":0.5083112120628357},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.36472320556640625},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.35024797916412354},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.33894628286361694},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.2827404737472534},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.11243399977684021},{"id":"https://openalex.org/C84111939","wikidata":"https://www.wikidata.org/wiki/Q5125465","display_name":"Clamping","level":2,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/robio64047.2024.10907311","is_oa":false,"landing_page_url":"https://doi.org/10.1109/robio64047.2024.10907311","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Robotics and Biomimetics (ROBIO)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4007014212","display_name":null,"funder_award_id":"62273186,62027812","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6232818662","display_name":null,"funder_award_id":"2024A1515011171","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321921","display_name":"Natural Science Foundation of Guangdong Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W189697432","https://openalex.org/W2011525418","https://openalex.org/W2019085618","https://openalex.org/W2200926199","https://openalex.org/W2621494960","https://openalex.org/W2751742913","https://openalex.org/W2753735661","https://openalex.org/W2782146525","https://openalex.org/W2963162614","https://openalex.org/W3128273553","https://openalex.org/W3129822347","https://openalex.org/W3184911172","https://openalex.org/W4200355095","https://openalex.org/W4323275449","https://openalex.org/W4327694466"],"related_works":["https://openalex.org/W2772917594","https://openalex.org/W2036807459","https://openalex.org/W2058170566","https://openalex.org/W2755342338","https://openalex.org/W2166024367","https://openalex.org/W3116076068","https://openalex.org/W2229312674","https://openalex.org/W2951359407","https://openalex.org/W2079911747","https://openalex.org/W1969923398"],"abstract_inverted_index":{"The":[0,75],"blind":[1,34,117],"patch-clamp":[2,35,50],"is":[3,145],"a":[4,109,115,123,129,168],"powerful":[5],"technique":[6],"for":[7],"studying":[8],"ion":[9],"channel":[10],"function,":[11],"offering":[12],"crucial":[13],"insights":[14],"into":[15],"the":[16,23,54,58,62,69,79,84,87,92,139,151],"mechanisms":[17],"underlying":[18],"brain":[19],"neural":[20],"circuits":[21],"and":[22,73,101,114,128],"factors":[24],"contributing":[25],"to":[26,61,98,149,172],"neurological":[27],"disorders":[28],"of":[29,57,68,78,86,142,174],"alive":[30],"animals.":[31],"However,":[32],"existing":[33],"systems":[36],"usually":[37],"lack":[38],"an":[39],"effective":[40],"animal":[41],"head":[42,112],"fixation":[43],"mechanism":[44],"compatible":[45],"with":[46],"conventional":[47],"in":[48,155],"vitro":[49],"system":[51],"setup.":[52],"Additionally,":[53],"random":[55],"location":[56],"craniotomy":[59],"relative":[60],"exposed":[63],"skull":[64,94],"makes":[65],"manual":[66,176],"positioning":[67,127],"cranial":[70,80,125],"opening":[71,81,126],"time-consuming":[72],"labor-intensive.":[74],"small":[76],"size":[77],"further":[82],"increases":[83],"risk":[85],"micropipette":[88,131,143],"tip":[89,99,144],"scraping":[90],"against":[91],"adjacent":[93],"during":[95],"operation,":[96],"leading":[97],"breakage":[100],"experimental":[102],"failure.":[103],"In":[104,136],"this":[105,137],"paper,":[106],"we":[107],"present":[108],"universal":[110],"mouse":[111],"fixer":[113],"robotic":[116,124],"patch":[118],"clamp":[119],"operation":[120,154,163],"process,":[121,138],"including":[122],"fast":[130],"approaching":[132],"trajectory":[133],"generation":[134],"method.":[135],"resistance":[140],"value":[141],"used":[146],"as":[147],"feedback":[148],"guide":[150],"its":[152],"step-by-step":[153],"vivo.":[156],"This":[157],"method":[158],"not":[159],"only":[160],"achieves":[161],"faster":[162],"speed,":[164],"but":[165],"also":[166],"guarantees":[167],"success":[169],"rate":[170],"comparable":[171],"that":[173],"professional":[175],"operation.":[177]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}