{"id":"https://openalex.org/W2037854290","doi":"https://doi.org/10.1109/prni.2014.6858552","title":"Combining neuroanatomical and clinical data to improve individualized early diagnosis of schizophrenia in subjects at high familial risk","display_name":"Combining neuroanatomical and clinical data to improve individualized early diagnosis of schizophrenia in subjects at high familial risk","publication_year":2014,"publication_date":"2014-06-01","ids":{"openalex":"https://openalex.org/W2037854290","doi":"https://doi.org/10.1109/prni.2014.6858552","mag":"2037854290"},"language":"en","primary_location":{"id":"doi:10.1109/prni.2014.6858552","is_oa":false,"landing_page_url":"https://doi.org/10.1109/prni.2014.6858552","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 International Workshop on Pattern Recognition in Neuroimaging","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068159477","display_name":"Eleni Zarogianni","orcid":"https://orcid.org/0000-0002-0500-7784"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"E. Zarogianni","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111611876","display_name":"T. William J. Moorhead","orcid":null},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"T. W. Moorhead","raw_affiliation_strings":["University of Edinburgh, Edinburgh, United Kingdom"],"affiliations":[{"raw_affiliation_string":"University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083643852","display_name":"A. J. Starkey","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. J. Starkey","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5066795737","display_name":"Stephen M. Lawrie","orcid":"https://orcid.org/0000-0002-2444-5675"},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S. M. Lawrie","raw_affiliation_strings":["University of Edinburgh, Edinburgh, United Kingdom"],"affiliations":[{"raw_affiliation_string":"University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5068159477"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1242316,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.8066301941871643},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"Schizophrenia (object-oriented programming)","score":0.7965545654296875},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5891380310058594},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.5470909476280212},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.41089919209480286},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3661724328994751},{"id":"https://openalex.org/keywords/psychiatry","display_name":"Psychiatry","score":0.3205721974372864},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2792311906814575},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.15438500046730042}],"concepts":[{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.8066301941871643},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.7965545654296875},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5891380310058594},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5470909476280212},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.41089919209480286},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3661724328994751},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3205721974372864},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2792311906814575},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.15438500046730042}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/prni.2014.6858552","is_oa":false,"landing_page_url":"https://doi.org/10.1109/prni.2014.6858552","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 International Workshop on Pattern Recognition in Neuroimaging","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.44999998807907104}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1588725527","https://openalex.org/W1969959732","https://openalex.org/W1972369039","https://openalex.org/W2007483873","https://openalex.org/W2020206369","https://openalex.org/W2046829931","https://openalex.org/W2058046532","https://openalex.org/W2060080559","https://openalex.org/W2065131965","https://openalex.org/W2080951458","https://openalex.org/W2098650348","https://openalex.org/W2105037799","https://openalex.org/W2113870592","https://openalex.org/W2127679160","https://openalex.org/W2133502275","https://openalex.org/W2143426320","https://openalex.org/W2159722604"],"related_works":["https://openalex.org/W2327340211","https://openalex.org/W2027542625","https://openalex.org/W4292199793","https://openalex.org/W2282195379","https://openalex.org/W2089784006","https://openalex.org/W2295388821","https://openalex.org/W2102312026","https://openalex.org/W2885663991","https://openalex.org/W2071433170","https://openalex.org/W2003288100"],"abstract_inverted_index":{"To":[0],"date,":[1],"there":[2],"are":[3,18,26],"no":[4],"reliable":[5],"markers":[6],"for":[7,60],"making":[8],"an":[9,81,124,136],"early":[10,166],"diagnosis":[11],"of":[12,40,43,86,128,138,168],"schizophrenia":[13,52,79],"before":[14],"clinical":[15,46,70,133,162],"diagnostic":[16,38],"criteria":[17],"fully":[19],"met.":[20],"Neuroimaging":[21],"and":[22,45,69,80,83,132,161],"pattern":[23],"classification":[24],"techniques":[25],"promising":[27,156],"tools":[28],"towards":[29],"predicting":[30,49,141],"transition":[31,50,95],"to":[32,51,96,120,164],"schizophrenia.":[33,169],"Here,":[34],"we":[35],"investigated":[36],"the":[37,61,97,106],"performance":[39],"a":[41,94,115,155],"combination":[42],"neuroanatomical":[44,160],"data":[47,71,134],"in":[48,53,105,140,146,158],"subjects":[54,89,122,147],"at":[55,123,142,148],"high":[56],"familial":[57],"risk":[58],"(HR)":[59],"disorder.":[62],"Baseline":[63],"structural":[64,130],"magnetic":[65],"resonance":[66],"imaging":[67],"(MRI)":[68],"from":[72],"17":[73,87],"HR":[74,88],"subjects,":[75],"who":[76,90],"subsequently":[77],"developed":[78],"age":[82],"sex-matched":[84],"group":[85],"did":[91],"not":[92],"make":[93],"disease,":[98],"yet":[99],"had":[100],"psychotic":[101],"symptoms,":[102],"were":[103],"included":[104],"analysis.":[107],"We":[108],"employed":[109],"Support":[110],"Vector":[111],"Machine,":[112],"along":[113],"with":[114],"recursive":[116],"feature":[117],"selection":[118],"technique":[119],"classify":[121],"individual":[125],"level.":[126],"Combination":[127],"both":[129],"MRI":[131],"achieved":[135],"accuracy":[137],"94%":[139],"baseline":[143],"disease":[144],"conversion":[145],"genetic":[149],"HR.":[150],"Overall,":[151],"this":[152],"paper":[153],"presents":[154],"step":[157],"combining":[159],"information":[163],"improve":[165],"prediction":[167]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}