{"id":"https://openalex.org/W4377089563","doi":"https://doi.org/10.1109/ner52421.2023.10123766","title":"Identification of Neural Biomarkers of Major Depressive Disorder Symptom Severity Using Computerized Linguistic Analysis","display_name":"Identification of Neural Biomarkers of Major Depressive Disorder Symptom Severity Using Computerized Linguistic Analysis","publication_year":2023,"publication_date":"2023-04-24","ids":{"openalex":"https://openalex.org/W4377089563","doi":"https://doi.org/10.1109/ner52421.2023.10123766"},"language":"en","primary_location":{"id":"doi:10.1109/ner52421.2023.10123766","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/ner52421.2023.10123766","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 11th International IEEE/EMBS Conference on Neural Engineering (NER)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044104551","display_name":"Daniela A. Astudillo Maya","orcid":"https://orcid.org/0000-0002-8965-6449"},"institutions":[{"id":"https://openalex.org/I76766440","display_name":"University of San Francisco","ror":"https://ror.org/029m7xn54","country_code":"US","type":"education","lineage":["https://openalex.org/I76766440"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniela A. Astudillo Maya","raw_affiliation_strings":["University of California, San Francisco,San Francisco,USA","University of California, San Francisco, San Francisco, USA"],"affiliations":[{"raw_affiliation_string":"University of California, San Francisco,San Francisco,USA","institution_ids":["https://openalex.org/I76766440"]},{"raw_affiliation_string":"University of California, San Francisco, San Francisco, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016875112","display_name":"Kristin K. Sellers","orcid":"https://orcid.org/0000-0002-0517-2296"},"institutions":[{"id":"https://openalex.org/I76766440","display_name":"University of San Francisco","ror":"https://ror.org/029m7xn54","country_code":"US","type":"education","lineage":["https://openalex.org/I76766440"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristin K. Sellers","raw_affiliation_strings":["University of California, San Francisco,San Francisco,USA","University of California, San Francisco, San Francisco, USA"],"affiliations":[{"raw_affiliation_string":"University of California, San Francisco,San Francisco,USA","institution_ids":["https://openalex.org/I76766440"]},{"raw_affiliation_string":"University of California, San Francisco, San Francisco, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063210793","display_name":"Noah Stapper","orcid":"https://orcid.org/0000-0002-1674-6718"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I76766440","display_name":"University of San Francisco","ror":"https://ror.org/029m7xn54","country_code":"US","type":"education","lineage":["https://openalex.org/I76766440"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noah Stapper","raw_affiliation_strings":["University of California, San Francisco,San Francisco,USA","University of California, San Francisco, San Francisco, USA"],"affiliations":[{"raw_affiliation_string":"University of California, San Francisco,San Francisco,USA","institution_ids":["https://openalex.org/I76766440"]},{"raw_affiliation_string":"University of California, San Francisco, San Francisco, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002171847","display_name":"Ankit N. Khambhati","orcid":"https://orcid.org/0000-0001-6182-4677"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I76766440","display_name":"University of San Francisco","ror":"https://ror.org/029m7xn54","country_code":"US","type":"education","lineage":["https://openalex.org/I76766440"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ankit N. Khambhati","raw_affiliation_strings":["University of California, San Francisco,San Francisco,USA","University of California, San Francisco, San Francisco, USA"],"affiliations":[{"raw_affiliation_string":"University of California, San Francisco,San Francisco,USA","institution_ids":["https://openalex.org/I76766440"]},{"raw_affiliation_string":"University of California, San Francisco, San Francisco, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040824510","display_name":"Catherine Henderson","orcid":"https://orcid.org/0000-0003-4340-4702"},"institutions":[{"id":"https://openalex.org/I76766440","display_name":"University of San Francisco","ror":"https://ror.org/029m7xn54","country_code":"US","type":"education","lineage":["https://openalex.org/I76766440"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine Henderson","raw_affiliation_strings":["University of California, San Francisco,San Francisco,USA","University of California, San Francisco, San Francisco, USA"],"affiliations":[{"raw_affiliation_string":"University of California, San Francisco,San Francisco,USA","institution_ids":["https://openalex.org/I76766440"]},{"raw_affiliation_string":"University of California, San Francisco, San Francisco, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009847906","display_name":"Joline M. Fan","orcid":"https://orcid.org/0000-0003-1099-8479"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I76766440","display_name":"University of San Francisco","ror":"https://ror.org/029m7xn54","country_code":"US","type":"education","lineage":["https://openalex.org/I76766440"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joline Fan","raw_affiliation_strings":["University of California, San Francisco,San Francisco,USA","University of California, San Francisco, San Francisco, USA"],"affiliations":[{"raw_affiliation_string":"University of California, San Francisco,San Francisco,USA","institution_ids":["https://openalex.org/I76766440"]},{"raw_affiliation_string":"University of California, San Francisco, San Francisco, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017216339","display_name":"Vikram R. Rao","orcid":"https://orcid.org/0000-0002-6389-2638"},"institutions":[{"id":"https://openalex.org/I76766440","display_name":"University of San Francisco","ror":"https://ror.org/029m7xn54","country_code":"US","type":"education","lineage":["https://openalex.org/I76766440"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vikram R. Rao","raw_affiliation_strings":["University of California, San Francisco,San Francisco,USA","University of California, San Francisco, San Francisco, USA"],"affiliations":[{"raw_affiliation_string":"University of California, San Francisco,San Francisco,USA","institution_ids":["https://openalex.org/I76766440"]},{"raw_affiliation_string":"University of California, San Francisco, San Francisco, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010623271","display_name":"Katherine W. Scangos","orcid":"https://orcid.org/0000-0001-7983-7767"},"institutions":[{"id":"https://openalex.org/I76766440","display_name":"University of San Francisco","ror":"https://ror.org/029m7xn54","country_code":"US","type":"education","lineage":["https://openalex.org/I76766440"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine W. Scangos","raw_affiliation_strings":["University of California, San Francisco,San Francisco,USA","University of California, San Francisco, San Francisco, USA"],"affiliations":[{"raw_affiliation_string":"University of California, San Francisco,San Francisco,USA","institution_ids":["https://openalex.org/I76766440"]},{"raw_affiliation_string":"University of California, San Francisco, San Francisco, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091099837","display_name":"Edward F. Chang","orcid":"https://orcid.org/0000-0003-2480-4700"},"institutions":[{"id":"https://openalex.org/I76766440","display_name":"University of San Francisco","ror":"https://ror.org/029m7xn54","country_code":"US","type":"education","lineage":["https://openalex.org/I76766440"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward F. Chang","raw_affiliation_strings":["University of California, San Francisco,San Francisco,USA","University of California, San Francisco, San Francisco, USA"],"affiliations":[{"raw_affiliation_string":"University of California, San Francisco,San Francisco,USA","institution_ids":["https://openalex.org/I76766440"]},{"raw_affiliation_string":"University of California, San Francisco, San Francisco, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042168269","display_name":"Andrew D. Krystal","orcid":"https://orcid.org/0000-0002-6702-781X"},"institutions":[{"id":"https://openalex.org/I76766440","display_name":"University of San Francisco","ror":"https://ror.org/029m7xn54","country_code":"US","type":"education","lineage":["https://openalex.org/I76766440"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew D. Krystal","raw_affiliation_strings":["University of California, San Francisco,San Francisco,USA","University of California, San Francisco, San Francisco, USA"],"affiliations":[{"raw_affiliation_string":"University of California, San Francisco,San Francisco,USA","institution_ids":["https://openalex.org/I76766440"]},{"raw_affiliation_string":"University of California, San Francisco, San Francisco, USA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5044104551"],"corresponding_institution_ids":["https://openalex.org/I180670191","https://openalex.org/I76766440"],"apc_list":null,"apc_paid":null,"fwci":0.3374,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.59531141,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12488","display_name":"Mental Health via Writing","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T12488","display_name":"Mental Health via Writing","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.9922999739646912,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9830999970436096,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/depression","display_name":"Depression (economics)","score":0.7549760341644287},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"Major depressive disorder","score":0.659608781337738},{"id":"https://openalex.org/keywords/depressive-symptoms","display_name":"Depressive symptoms","score":0.5469492077827454},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.4273584485054016},{"id":"https://openalex.org/keywords/clinical-psychology","display_name":"Clinical psychology","score":0.3628274202346802},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3397482633590698},{"id":"https://openalex.org/keywords/psychiatry","display_name":"Psychiatry","score":0.2772778272628784},{"id":"https://openalex.org/keywords/anxiety","display_name":"Anxiety","score":0.23491054773330688},{"id":"https://openalex.org/keywords/cognition","display_name":"Cognition","score":0.13369080424308777}],"concepts":[{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.7549760341644287},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.659608781337738},{"id":"https://openalex.org/C3019858935","wikidata":"https://www.wikidata.org/wiki/Q4340209","display_name":"Depressive symptoms","level":3,"score":0.5469492077827454},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4273584485054016},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.3628274202346802},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3397482633590698},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2772778272628784},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.23491054773330688},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.13369080424308777},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/ner52421.2023.10123766","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/ner52421.2023.10123766","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 11th International IEEE/EMBS Conference on Neural Engineering (NER)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5600000023841858,"id":"https://metadata.un.org/sdg/4","display_name":"Quality Education"}],"awards":[{"id":"https://openalex.org/G5920882000","display_name":null,"funder_award_id":"K23NS110962","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W26203047","https://openalex.org/W224720452","https://openalex.org/W2100772444","https://openalex.org/W2140910804","https://openalex.org/W2250553926","https://openalex.org/W2593668264","https://openalex.org/W2618843390","https://openalex.org/W2754588135","https://openalex.org/W2809637028","https://openalex.org/W2902570887","https://openalex.org/W2915177913","https://openalex.org/W3038317110","https://openalex.org/W3080768926","https://openalex.org/W3146268156","https://openalex.org/W3202708773"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W2931662336","https://openalex.org/W2077865380","https://openalex.org/W4401768695","https://openalex.org/W2765597752","https://openalex.org/W2134894512","https://openalex.org/W2516428577","https://openalex.org/W2013123873","https://openalex.org/W2013885389"],"abstract_inverted_index":{"Although":[0],"numerous":[1],"treatments":[2],"are":[3],"available":[4],"for":[5,32,157],"major":[6],"depressive":[7],"disorder":[8],"(MDD),":[9],"patients":[10],"can":[11,91],"be":[12,92,204],"refractory":[13],"to":[14,56,94,206,214],"sequential":[15],"treatment":[16,33,49,216],"regimens.":[17],"Experimental":[18],"studies":[19,69],"have":[20,84],"demonstrated":[21],"promising":[22],"results":[23],"implementing":[24],"deep":[25],"brain":[26],"stimulation":[27],"(DBS)":[28],"as":[29],"a":[30,77,116],"therapy":[31],"resistant":[34],"MDD.":[35],"However,":[36],"optimization":[37],"of":[38,44,48,63,76,102,111,114,130,164,210],"this":[39],"technique":[40],"requires":[41],"repeated":[42,87],"assessments":[43],"the":[45,54,59,71,109,139,171,194],"clinical":[46,155],"effects":[47],"in":[50,154],"each":[51],"patient":[52,153],"and":[53,61,73,96,142,174,200,212],"ability":[55],"reliably":[57],"capture":[58],"complexity":[60],"dynamics":[62],"depression":[64,165,187,211],"symptoms.":[65],"In":[66],"our":[67],"initial":[68],"evaluating":[70],"feasibility":[72],"preliminary":[74,190],"efficacy":[75],"novel":[78],"closed-loop":[79],"DBS":[80],"(CL-DBS)":[81],"approach,":[82],"we":[83,121,146],"observed":[85],"that":[86,167,193],"self-rated":[88,186],"MDD":[89,115],"metrics":[90],"burdensome":[93],"complete":[95],"may":[97],"not":[98],"provide":[99],"accurate":[100],"measures":[101],"symptom":[103,136,149,201],"severity":[104],"fluctuations":[105],"over":[106],"time,":[107],"making":[108],"identification":[110],"neural":[112,208],"biomarkers":[113,209],"challenge.":[117],"To":[118],"address":[119],"this,":[120],"evaluated":[122],"if":[123],"text":[124],"analysis":[125],"could":[126,203],"identify":[127],"linguistic":[128,162],"indicators":[129],"depression,":[131],"including":[132],"providing":[133],"insights":[134],"into":[135],"severity.":[137],"Using":[138],"Linguistic":[140],"Inquiry":[141],"Word":[143],"Count":[144],"software,":[145],"analyzed":[147],"written":[148],"reports":[150],"from":[151],"one":[152],"trial":[156],"CL-DBS.":[158],"We":[159],"found":[160,180],"significant":[161],"predictors":[163],"symptoms":[166,183],"were":[168],"associated":[169],"with":[170],"same":[172],"frequency-":[173],"region-":[175],"specific":[176],"spectral":[177],"power":[178],"correlates":[179],"when":[181],"assessing":[182],"captured":[184],"by":[185],"metrics.":[188],"These":[189],"findings":[191],"suggest":[192],"close":[195],"association":[196],"between":[197],"language":[198],"use":[199],"strength":[202],"utilized":[205],"detect":[207],"potentially":[213],"assess":[215],"outcome.":[217]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2025-12-23T23:11:35.936235","created_date":"2025-10-10T00:00:00"}
