{"id":"https://openalex.org/W4377089685","doi":"https://doi.org/10.1109/ner52421.2023.10123760","title":"Simulating The Effects of Low Intensity Focused Ultrasound in Parkinson's Disease","display_name":"Simulating The Effects of Low Intensity Focused Ultrasound in Parkinson's Disease","publication_year":2023,"publication_date":"2023-04-24","ids":{"openalex":"https://openalex.org/W4377089685","doi":"https://doi.org/10.1109/ner52421.2023.10123760"},"language":"en","primary_location":{"id":"doi:10.1109/ner52421.2023.10123760","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/ner52421.2023.10123760","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 11th International IEEE/EMBS Conference on Neural Engineering (NER)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060541634","display_name":"\u00cdtalo Karmann Aventurato","orcid":"https://orcid.org/0000-0001-9314-1109"},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"\u00cdtalo Karmann Aventurato","raw_affiliation_strings":["School of Medical Sciences University of Campinas,Department of Neurology,Campinas,SP,Brazil","Department of Neurology, School of Medical Sciences University of Campinas, Campinas, SP, Brazil"],"affiliations":[{"raw_affiliation_string":"School of Medical Sciences University of Campinas,Department of Neurology,Campinas,SP,Brazil","institution_ids":["https://openalex.org/I181391015"]},{"raw_affiliation_string":"Department of Neurology, School of Medical Sciences University of Campinas, Campinas, SP, Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044456256","display_name":"Marcelo Ramos Romano","orcid":"https://orcid.org/0000-0002-1882-5954"},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marcelo Ramos Romano","raw_affiliation_strings":["School of Electrical and Computer Engineering, University of Campinas,Dept. of Electronics and Biomedical Engineering,Campinas,SP,Brazil","Dept. of Electronics and Biomedical Engineering, School of Electrical and Computer Engineering, University of Campinas, Campinas, SP, Brazil","Neural Engineering Research Laboratory, Center for Biomedical Engineering, University of Campinas, Campinas, SP, Brazil"],"affiliations":[{"raw_affiliation_string":"School of Electrical and Computer Engineering, University of Campinas,Dept. of Electronics and Biomedical Engineering,Campinas,SP,Brazil","institution_ids":["https://openalex.org/I181391015"]},{"raw_affiliation_string":"Dept. of Electronics and Biomedical Engineering, School of Electrical and Computer Engineering, University of Campinas, Campinas, SP, Brazil","institution_ids":["https://openalex.org/I181391015"]},{"raw_affiliation_string":"Neural Engineering Research Laboratory, Center for Biomedical Engineering, University of Campinas, Campinas, SP, Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056603316","display_name":"Leonardo Abdala Elias","orcid":"https://orcid.org/0000-0003-4488-3063"},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Leonardo Abdala Elias","raw_affiliation_strings":["School of Electrical and Computer Engineering, University of Campinas,Dept. of Electronics and Biomedical Engineering,Campinas,SP,Brazil","Neural Engineering Research Laboratory, Center for Biomedical Engineering, University of Campinas, Campinas, SP, Brazil","Dept. of Electronics and Biomedical Engineering, School of Electrical and Computer Engineering, University of Campinas, Campinas, SP, Brazil"],"affiliations":[{"raw_affiliation_string":"School of Electrical and Computer Engineering, University of Campinas,Dept. of Electronics and Biomedical Engineering,Campinas,SP,Brazil","institution_ids":["https://openalex.org/I181391015"]},{"raw_affiliation_string":"Neural Engineering Research Laboratory, Center for Biomedical Engineering, University of Campinas, Campinas, SP, Brazil","institution_ids":["https://openalex.org/I181391015"]},{"raw_affiliation_string":"Dept. of Electronics and Biomedical Engineering, School of Electrical and Computer Engineering, University of Campinas, Campinas, SP, Brazil","institution_ids":["https://openalex.org/I181391015"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5060541634"],"corresponding_institution_ids":["https://openalex.org/I181391015"],"apc_list":null,"apc_paid":null,"fwci":0.1492,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.44716084,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"30","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subthalamic-nucleus","display_name":"Subthalamic nucleus","score":0.7600408792495728},{"id":"https://openalex.org/keywords/deep-brain-stimulation","display_name":"Deep brain stimulation","score":0.674490749835968},{"id":"https://openalex.org/keywords/neuromodulation","display_name":"Neuromodulation","score":0.6246117949485779},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.5961032509803772},{"id":"https://openalex.org/keywords/globus-pallidus","display_name":"Globus pallidus","score":0.5063885450363159},{"id":"https://openalex.org/keywords/stimulus","display_name":"Stimulus (psychology)","score":0.45175328850746155},{"id":"https://openalex.org/keywords/parkinsons-disease","display_name":"Parkinson's disease","score":0.44508054852485657},{"id":"https://openalex.org/keywords/efferent","display_name":"Efferent","score":0.42531266808509827},{"id":"https://openalex.org/keywords/basal-ganglia","display_name":"Basal ganglia","score":0.32713598012924194},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.31292951107025146},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3103134036064148},{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.28556591272354126},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.1929885745048523},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"Central nervous system","score":0.17911893129348755},{"id":"https://openalex.org/keywords/afferent","display_name":"Afferent","score":0.17567431926727295},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.13239139318466187}],"concepts":[{"id":"https://openalex.org/C2777319143","wikidata":"https://www.wikidata.org/wiki/Q2270424","display_name":"Subthalamic nucleus","level":5,"score":0.7600408792495728},{"id":"https://openalex.org/C2778542668","wikidata":"https://www.wikidata.org/wiki/Q618076","display_name":"Deep brain stimulation","level":4,"score":0.674490749835968},{"id":"https://openalex.org/C2780375056","wikidata":"https://www.wikidata.org/wiki/Q905905","display_name":"Neuromodulation","level":3,"score":0.6246117949485779},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5961032509803772},{"id":"https://openalex.org/C2780278869","wikidata":"https://www.wikidata.org/wiki/Q1759633","display_name":"Globus pallidus","level":4,"score":0.5063885450363159},{"id":"https://openalex.org/C2779918689","wikidata":"https://www.wikidata.org/wiki/Q3771842","display_name":"Stimulus (psychology)","level":2,"score":0.45175328850746155},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.44508054852485657},{"id":"https://openalex.org/C2776512019","wikidata":"https://www.wikidata.org/wiki/Q1816418","display_name":"Efferent","level":3,"score":0.42531266808509827},{"id":"https://openalex.org/C2778187257","wikidata":"https://www.wikidata.org/wiki/Q464210","display_name":"Basal ganglia","level":3,"score":0.32713598012924194},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.31292951107025146},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3103134036064148},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.28556591272354126},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1929885745048523},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.17911893129348755},{"id":"https://openalex.org/C2779263132","wikidata":"https://www.wikidata.org/wiki/Q2215671","display_name":"Afferent","level":2,"score":0.17567431926727295},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13239139318466187},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/ner52421.2023.10123760","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/ner52421.2023.10123760","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 11th International IEEE/EMBS Conference on Neural Engineering (NER)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7699999809265137,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1939064371","https://openalex.org/W1968335099","https://openalex.org/W1979872711","https://openalex.org/W2014671493","https://openalex.org/W2089845241","https://openalex.org/W2164653071","https://openalex.org/W2296941957","https://openalex.org/W2568559291","https://openalex.org/W2789348677","https://openalex.org/W2798091161","https://openalex.org/W2889286462","https://openalex.org/W2914999026","https://openalex.org/W2926474361","https://openalex.org/W2952076616","https://openalex.org/W3098173373","https://openalex.org/W4211123396"],"related_works":["https://openalex.org/W2060063293","https://openalex.org/W2093780015","https://openalex.org/W1972030906","https://openalex.org/W4289755640","https://openalex.org/W2913536894","https://openalex.org/W4301179225","https://openalex.org/W2607326016","https://openalex.org/W1983965289","https://openalex.org/W22241804","https://openalex.org/W4297540619"],"abstract_inverted_index":{"Invasiveness":[0],"limits":[1],"current":[2],"neuromodulation":[3,185],"approaches":[4],"for":[5],"treating":[6],"Parkinson's":[7],"disease":[8],"(PD).":[9],"Low-intensity":[10],"focused":[11],"ultrasound":[12,188],"(LIFUS)":[13],"is":[14,198],"a":[15,48,108,157],"viable":[16],"non-invasive":[17],"alternative":[18],"to":[19,36,43,114,117,136,141,151,161,200],"modulate":[20,162],"the":[21,38,44,53,65,75,88,118,124,138,145,172,176,194,202,205],"cortico-subcortical":[22,54],"networks":[23],"involved":[24,165],"in":[25,47,70,74,84,110,166,175,182,190,193],"PD.":[26],"In":[27,143],"this":[28],"study,":[29],"an":[30],"intramembrane":[31],"cavitation":[32,147],"model":[33,51,90,173],"was":[34,68,107],"used":[35,135],"simulate":[37],"effects":[39,186],"of":[40,52,82,87,123,187],"ultrasonic":[41,66],"stimulation":[42],"subthalamic":[45,76],"nucleus":[46,77],"simplified":[49],"validated":[50],"network.":[55],"Simulation":[56],"results":[57,203],"from":[58,204],"single":[59],"neuron":[60],"and":[61,94,103,214],"network":[62,89],"models":[63,213],"show":[64],"stimulus":[67,125],"effective":[69],"producing":[71],"neuronal":[72,163,191],"excitation":[73],"as":[78,80],"well":[79],"modulation":[81],"activities":[83],"other":[85,184],"nuclei":[86],"(e.g.,":[91],"globus":[92],"pallidus":[93],"thalamus).":[95],"Additionally,":[96],"depending":[97],"on":[98],"LIFUS":[99,154],"parameters":[100],"(i.e.,":[101],"amplitude":[102],"duty":[104],"cycle)":[105],"there":[106],"reduction":[109],"beta-band":[111],"parkinsonian":[112],"oscillations":[113],"values":[115],"close":[116],"healthy":[119],"condition.":[120],"Exploratory":[121],"tests":[122],"parametric":[126],"space":[127],"revealed":[128],"different":[129],"operating":[130],"ranges":[131],"that":[132,153],"could":[133],"be":[134,156,180],"optimize":[137],"therapeutic":[139,159],"response":[140],"LIFUS.":[142],"conclusion,":[144],"membrane":[146],"framework":[148],"provides":[149],"reasons":[150],"believe":[152],"would":[155,179],"potential":[158],"intervention":[160],"circuits":[164,192],"PD":[167],"without":[168],"surgical":[169],"procedures.":[170],"Also,":[171],"employed":[174],"present":[177],"study":[178],"helpful":[181],"exploring":[183],"waves":[189],"brain.":[195],"However,":[196],"it":[197],"important":[199],"validate":[201],"computer":[206],"simulations":[207],"using":[208],"both":[209],"experiments":[210],"with":[211,217],"animal":[212],"clinical":[215],"trials":[216],"humans.":[218]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-03-27T14:29:43.386196","created_date":"2025-10-10T00:00:00"}