{"id":"https://openalex.org/W4377089431","doi":"https://doi.org/10.1109/ner52421.2023.10123737","title":"On the in vitro long-term stability of thin-film stimulation contacts in polyimide-based neural interfaces","display_name":"On the in vitro long-term stability of thin-film stimulation contacts in polyimide-based neural interfaces","publication_year":2023,"publication_date":"2023-04-24","ids":{"openalex":"https://openalex.org/W4377089431","doi":"https://doi.org/10.1109/ner52421.2023.10123737"},"language":"en","primary_location":{"id":"doi:10.1109/ner52421.2023.10123737","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/ner52421.2023.10123737","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 11th International IEEE/EMBS Conference on Neural Engineering (NER)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057740989","display_name":"Paul \u010cvan\u010dara","orcid":"https://orcid.org/0000-0003-2189-4413"},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Paul \u010cvan\u010dara","raw_affiliation_strings":["IMTEK, IMBIT, University of Freiburg,Laboratory for Biomedical Microtechnology // NeuroProbes BrainLinks-BrainTools Cluster of Excellence,Department of Microsystems Engineering -,Freiburg,Germany","Department of Microsystems Engineering -, Laboratory for Biomedical Microtechnology // NeuroProbes BrainLinks-BrainTools Cluster of Excellence, IMTEK, IMBIT, University of Freiburg, Freiburg, Germany"],"affiliations":[{"raw_affiliation_string":"IMTEK, IMBIT, University of Freiburg,Laboratory for Biomedical Microtechnology // NeuroProbes BrainLinks-BrainTools Cluster of Excellence,Department of Microsystems Engineering -,Freiburg,Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Department of Microsystems Engineering -, Laboratory for Biomedical Microtechnology // NeuroProbes BrainLinks-BrainTools Cluster of Excellence, IMTEK, IMBIT, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109607321","display_name":"Inga Bartels","orcid":null},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Inga Bartels","raw_affiliation_strings":["IMTEK, IMBIT, University of Freiburg,Laboratory for Biomedical Microtechnology // NeuroProbes BrainLinks-BrainTools Cluster of Excellence,Department of Microsystems Engineering -,Freiburg,Germany","Department of Microsystems Engineering -, Laboratory for Biomedical Microtechnology // NeuroProbes BrainLinks-BrainTools Cluster of Excellence, IMTEK, IMBIT, University of Freiburg, Freiburg, Germany"],"affiliations":[{"raw_affiliation_string":"IMTEK, IMBIT, University of Freiburg,Laboratory for Biomedical Microtechnology // NeuroProbes BrainLinks-BrainTools Cluster of Excellence,Department of Microsystems Engineering -,Freiburg,Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Department of Microsystems Engineering -, Laboratory for Biomedical Microtechnology // NeuroProbes BrainLinks-BrainTools Cluster of Excellence, IMTEK, IMBIT, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058067206","display_name":"Thomas Stieglitz","orcid":"https://orcid.org/0000-0002-7349-4254"},"institutions":[{"id":"https://openalex.org/I4210098324","display_name":"Bernstein Center for Computational Neuroscience Freiburg","ror":"https://ror.org/010p50m34","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210092532","https://openalex.org/I4210098324"]},{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Stieglitz","raw_affiliation_strings":["IMTEK, IMBIT, University of Freiburg,Laboratory for Biomedical Microtechnology // NeuroProbes BrainLinks-BrainTools Cluster of Excellence, Bernstein Center Freiburg,Department of Microsystems Engineering,Freiburg,Germany","Department of Microsystems Engineering, Laboratory for Biomedical Microtechnology // NeuroProbes BrainLinks-BrainTools Cluster of Excellence, Bernstein Center Freiburg, IMTEK, IMBIT, University of Freiburg, Freiburg, Germany"],"affiliations":[{"raw_affiliation_string":"IMTEK, IMBIT, University of Freiburg,Laboratory for Biomedical Microtechnology // NeuroProbes BrainLinks-BrainTools Cluster of Excellence, Bernstein Center Freiburg,Department of Microsystems Engineering,Freiburg,Germany","institution_ids":["https://openalex.org/I4210098324"]},{"raw_affiliation_string":"Department of Microsystems Engineering, Laboratory for Biomedical Microtechnology // NeuroProbes BrainLinks-BrainTools Cluster of Excellence, Bernstein Center Freiburg, IMTEK, IMBIT, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I4210098324","https://openalex.org/I161046081"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5057740989"],"corresponding_institution_ids":["https://openalex.org/I161046081"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11193286,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10784","display_name":"Muscle activation and electromyography studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.7096589803695679},{"id":"https://openalex.org/keywords/thin-film","display_name":"Thin film","score":0.5459501147270203},{"id":"https://openalex.org/keywords/polyimide","display_name":"Polyimide","score":0.4763255715370178},{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.47073352336883545},{"id":"https://openalex.org/keywords/delamination","display_name":"Delamination (geology)","score":0.45504534244537354},{"id":"https://openalex.org/keywords/micrometer","display_name":"Micrometer","score":0.45132628083229065},{"id":"https://openalex.org/keywords/composite-material","display_name":"Composite material","score":0.4466373026371002},{"id":"https://openalex.org/keywords/microelectrode","display_name":"Microelectrode","score":0.41785016655921936},{"id":"https://openalex.org/keywords/oxide","display_name":"Oxide","score":0.412431925535202},{"id":"https://openalex.org/keywords/optoelectronics","display_name":"Optoelectronics","score":0.41030073165893555},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.34600764513015747},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.3358697295188904},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.2663121819496155},{"id":"https://openalex.org/keywords/electrode","display_name":"Electrode","score":0.25213366746902466},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.20645061135292053},{"id":"https://openalex.org/keywords/layer","display_name":"Layer (electronics)","score":0.18727907538414001},{"id":"https://openalex.org/keywords/metallurgy","display_name":"Metallurgy","score":0.14606019854545593}],"concepts":[{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.7096589803695679},{"id":"https://openalex.org/C19067145","wikidata":"https://www.wikidata.org/wiki/Q1137203","display_name":"Thin film","level":2,"score":0.5459501147270203},{"id":"https://openalex.org/C2780965675","wikidata":"https://www.wikidata.org/wiki/Q145958","display_name":"Polyimide","level":3,"score":0.4763255715370178},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.47073352336883545},{"id":"https://openalex.org/C30239060","wikidata":"https://www.wikidata.org/wiki/Q5253111","display_name":"Delamination (geology)","level":4,"score":0.45504534244537354},{"id":"https://openalex.org/C171635847","wikidata":"https://www.wikidata.org/wiki/Q406983","display_name":"Micrometer","level":2,"score":0.45132628083229065},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.4466373026371002},{"id":"https://openalex.org/C111670793","wikidata":"https://www.wikidata.org/wiki/Q16979465","display_name":"Microelectrode","level":3,"score":0.41785016655921936},{"id":"https://openalex.org/C2779851234","wikidata":"https://www.wikidata.org/wiki/Q50690","display_name":"Oxide","level":2,"score":0.412431925535202},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.41030073165893555},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.34600764513015747},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3358697295188904},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.2663121819496155},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.25213366746902466},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.20645061135292053},{"id":"https://openalex.org/C2779227376","wikidata":"https://www.wikidata.org/wiki/Q6505497","display_name":"Layer (electronics)","level":2,"score":0.18727907538414001},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.14606019854545593},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C58097730","wikidata":"https://www.wikidata.org/wiki/Q176318","display_name":"Subduction","level":3,"score":0.0},{"id":"https://openalex.org/C77928131","wikidata":"https://www.wikidata.org/wiki/Q193343","display_name":"Tectonics","level":2,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/ner52421.2023.10123737","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/ner52421.2023.10123737","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 11th International IEEE/EMBS Conference on Neural Engineering (NER)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7300000190734863,"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1582625486","https://openalex.org/W1975092334","https://openalex.org/W1975506063","https://openalex.org/W2006071157","https://openalex.org/W2012853348","https://openalex.org/W2022483102","https://openalex.org/W2049483283","https://openalex.org/W2076038000","https://openalex.org/W2127964476","https://openalex.org/W2134500330","https://openalex.org/W2204802825","https://openalex.org/W2902344618","https://openalex.org/W2972339980","https://openalex.org/W2977579781","https://openalex.org/W3092717999","https://openalex.org/W4308744879"],"related_works":["https://openalex.org/W2071100647","https://openalex.org/W4214695150","https://openalex.org/W2916874140","https://openalex.org/W1970751963","https://openalex.org/W2162543021","https://openalex.org/W2070855277","https://openalex.org/W2061896995","https://openalex.org/W2017123568","https://openalex.org/W1970327753","https://openalex.org/W2059736020"],"abstract_inverted_index":{"Micro-machined":[0],"peripheral":[1],"nerve":[2],"interfaces":[3],"have":[4],"entered":[5],"translational":[6,211],"research":[7],"successfully.":[8],"Polyimide-based":[9],"interface":[10,24],"substrates":[11],"showed":[12],"chemical":[13,68],"inertness,":[14],"mechanical":[15],"flexibility":[16],"and":[17,100,135,150],"low":[18],"water":[19],"uptake.":[20],"They":[21],"allow":[22],"neural":[23],"with":[25,141,180,187,205],"a":[26,57,95,113,142,181],"thicknesses":[27,41],"of":[28,34,56,75,104,174,193],"ten":[29],"micrometer":[30],"reducing":[31],"the":[32,54,105,116,194],"probability":[33],"severe":[35],"inflammatory":[36],"reactions.":[37],"To":[38],"realize":[39],"device":[40],"in":[42,53,72,97,115,128,139,176,203],"this":[43],"range,":[44],"photolithographic":[45],"processes":[46],"are":[47],"used":[48,124],"to":[49,63,161],"deposit":[50],"thin-film":[51],"metallization":[52],"range":[55],"few":[58],"hundred":[59],"nanometers.":[60],"In":[61],"order":[62],"prove":[64],"long-term":[65,195],"stability":[66,198],"within":[67],"safe":[69],"stimulation":[70,74,80,159,175,189,196,201],"limits,":[71],"vitro":[73],"sputtered":[76],"iridium":[77],"oxide":[78],"film":[79],"contact":[81,121,156],"sites":[82,122,157],"was":[83,165,169],"performed.":[84],"After":[85],"4.5":[86],"billion":[87,163],"pulses,":[88],"first":[89,210],"electrochemical":[90],"changes":[91],"occurred":[92],"indicated":[93,112],"by":[94],"decrease":[96],"impedance":[98],"magnitude":[99],"simultaneously":[101],"an":[102,126],"increase":[103],"cathodic":[106],"charge":[107],"storage":[108],"capacity.":[109],"Both":[110],"scenarios":[111],"change":[114],"effective":[117],"surface":[118],"area.":[119],"These":[120],"were":[123],"for":[125,153,199,209],"optical":[127],"depth":[129],"analysis":[130],"using":[131],"white":[132],"light":[133],"interferometry":[134],"scanning":[136],"electron":[137],"microscopy":[138],"combination":[140],"focused":[143],"ion":[144],"beam,":[145],"which":[146],"confirmed":[147],"crack":[148],"formation":[149],"delamination.":[151],"However,":[152],"all":[154],"other":[155],"further":[158],"up":[160],"6.5":[162],"pulses":[164],"applied.":[166],"This":[167],"amount":[168],"estimated":[170],"about":[171],"6.6":[172],"years":[173],"chronic":[177,200],"human":[178],"application":[179],"conservative":[182],"approach":[183],"assuming":[184],"daily":[185],"work":[186],"each":[188],"contact.":[190],"The":[191],"outcome":[192],"indicates":[197],"studies":[202,212],"humans":[204],"life-times":[206],"reasonably":[207],"long":[208],"on":[213],"larger":[214],"subject":[215],"cohorts.":[216]},"counts_by_year":[],"updated_date":"2025-12-19T19:40:27.379048","created_date":"2025-10-10T00:00:00"}