{"id":"https://openalex.org/W3169724401","doi":"https://doi.org/10.1109/ner49283.2021.9441261","title":"Human derived cortical excitatory neurospheroids showed spontaneous activity on micro electrodes array","display_name":"Human derived cortical excitatory neurospheroids showed spontaneous activity on micro electrodes array","publication_year":2021,"publication_date":"2021-05-04","ids":{"openalex":"https://openalex.org/W3169724401","doi":"https://doi.org/10.1109/ner49283.2021.9441261","mag":"3169724401"},"language":"en","primary_location":{"id":"doi:10.1109/ner49283.2021.9441261","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ner49283.2021.9441261","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 10th International IEEE/EMBS Conference on Neural Engineering (NER)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://research.utwente.nl/en/publications/37db865b-06e5-4da7-bc48-a2a3b26315c8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091471882","display_name":"Lorenzo Muzzi","orcid":"https://orcid.org/0000-0003-2893-6057"},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"L. Muzzi","raw_affiliation_strings":["University of Genova, Genova, Italy"],"affiliations":[{"raw_affiliation_string":"University of Genova, Genova, Italy","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032240248","display_name":"Matteo Falappa","orcid":"https://orcid.org/0000-0002-8168-5106"},"institutions":[{"id":"https://openalex.org/I4210120007","display_name":"3Brain (Switzerland)","ror":"https://ror.org/02phz7j25","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210120007"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"M. Falappa","raw_affiliation_strings":["3Brain AG, Switzerland"],"affiliations":[{"raw_affiliation_string":"3Brain AG, Switzerland","institution_ids":["https://openalex.org/I4210120007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028066463","display_name":"Alessandro Maccione","orcid":"https://orcid.org/0000-0002-5044-9899"},"institutions":[{"id":"https://openalex.org/I4210120007","display_name":"3Brain (Switzerland)","ror":"https://ror.org/02phz7j25","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210120007"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"A. Maccione","raw_affiliation_strings":["3Brain AG, Switzerland"],"affiliations":[{"raw_affiliation_string":"3Brain AG, Switzerland","institution_ids":["https://openalex.org/I4210120007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007309475","display_name":"Donatella Di Lisa","orcid":"https://orcid.org/0000-0002-4990-7653"},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"D. di Lisa","raw_affiliation_strings":["University of Genova, Genova, Italy"],"affiliations":[{"raw_affiliation_string":"University of Genova, Genova, Italy","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000602972","display_name":"Monica Frega","orcid":"https://orcid.org/0000-0002-9697-3282"},"institutions":[{"id":"https://openalex.org/I94624287","display_name":"University of Twente","ror":"https://ror.org/006hf6230","country_code":"NL","type":"education","lineage":["https://openalex.org/I94624287"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M. Frega","raw_affiliation_strings":["University of Twente, Enschede, the Netherlands"],"affiliations":[{"raw_affiliation_string":"University of Twente, Enschede, the Netherlands","institution_ids":["https://openalex.org/I94624287"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046747801","display_name":"S\u00e9rgio Martinoia","orcid":"https://orcid.org/0000-0002-0058-9519"},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Martinoia","raw_affiliation_strings":["University of Genova, Genova, Italy"],"affiliations":[{"raw_affiliation_string":"University of Genova, Genova, Italy","institution_ids":["https://openalex.org/I83816512"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5091471882"],"corresponding_institution_ids":["https://openalex.org/I83816512"],"apc_list":null,"apc_paid":null,"fwci":0.6145,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.60020472,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"119","issue":null,"first_page":"123","last_page":"127"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.7535213828086853},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cell","display_name":"Induced pluripotent stem cell","score":0.675716757774353},{"id":"https://openalex.org/keywords/excitatory-postsynaptic-potential","display_name":"Excitatory postsynaptic potential","score":0.6239250302314758},{"id":"https://openalex.org/keywords/transplantation","display_name":"Transplantation","score":0.551551342010498},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.5285386443138123},{"id":"https://openalex.org/keywords/electrophysiology","display_name":"Electrophysiology","score":0.5183252096176147},{"id":"https://openalex.org/keywords/human-brain","display_name":"Human brain","score":0.5091552138328552},{"id":"https://openalex.org/keywords/neural-stem-cell","display_name":"Neural stem cell","score":0.4763619899749756},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4725196957588196},{"id":"https://openalex.org/keywords/stem-cell","display_name":"Stem cell","score":0.31591302156448364},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.26911139488220215},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.19050568342208862},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.1607799530029297},{"id":"https://openalex.org/keywords/embryonic-stem-cell","display_name":"Embryonic stem cell","score":0.08313921093940735}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7535213828086853},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.675716757774353},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.6239250302314758},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.551551342010498},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5285386443138123},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.5183252096176147},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.5091552138328552},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.4763619899749756},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4725196957588196},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.31591302156448364},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26911139488220215},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.19050568342208862},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1607799530029297},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.08313921093940735},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.0},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1109/ner49283.2021.9441261","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ner49283.2021.9441261","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 10th International IEEE/EMBS Conference on Neural Engineering (NER)","raw_type":"proceedings-article"},{"id":"pmh:oai:ris.utwente.nl:openaire/37db865b-06e5-4da7-bc48-a2a3b26315c8","is_oa":true,"landing_page_url":"https://research.utwente.nl/en/publications/37db865b-06e5-4da7-bc48-a2a3b26315c8","pdf_url":null,"source":{"id":"https://openalex.org/S4406922991","display_name":"University of Twente Research Information","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Muzzi, L, Falappa, M, Maccione, A, di Lisa, D, Frega, M & Martinoia, S 2021, Human derived cortical excitatory neurospheroids showed spontaneous activity on micro electrodes array. in 2021 10th International IEEE/EMBS Conference on Neural Engineering, NER 2021., 9441261, International IEEE/EMBS Conference on Neural Engineering, NER, vol. 2021, IEEE, Piscataway, NJ, pp. 123-127, 10th International IEEE/EMBS Conference on Neural Engineering, NER 2021, Virtual, Online, Italy, 4/05/21. https://doi.org/10.1109/NER49283.2021.9441261","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:iris.unige.it:11567/1058619","is_oa":false,"landing_page_url":"http://hdl.handle.net/11567/1058619","pdf_url":null,"source":{"id":"https://openalex.org/S4377196291","display_name":"CINECA IRIS Institutial Research Information System (University of Genoa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I83816512","host_organization_name":"University of Genoa","host_organization_lineage":["https://openalex.org/I83816512"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"pmh:oai:ris.utwente.nl:publications/37db865b-06e5-4da7-bc48-a2a3b26315c8","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""}],"best_oa_location":{"id":"pmh:oai:ris.utwente.nl:openaire/37db865b-06e5-4da7-bc48-a2a3b26315c8","is_oa":true,"landing_page_url":"https://research.utwente.nl/en/publications/37db865b-06e5-4da7-bc48-a2a3b26315c8","pdf_url":null,"source":{"id":"https://openalex.org/S4406922991","display_name":"University of Twente Research Information","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Muzzi, L, Falappa, M, Maccione, A, di Lisa, D, Frega, M & Martinoia, S 2021, Human derived cortical excitatory neurospheroids showed spontaneous activity on micro electrodes array. in 2021 10th International IEEE/EMBS Conference on Neural Engineering, NER 2021., 9441261, International IEEE/EMBS Conference on Neural Engineering, NER, vol. 2021, IEEE, Piscataway, NJ, pp. 123-127, 10th International IEEE/EMBS Conference on Neural Engineering, NER 2021, Virtual, Online, Italy, 4/05/21. https://doi.org/10.1109/NER49283.2021.9441261","raw_type":"info:eu-repo/semantics/publishedVersion"},"sustainable_development_goals":[{"score":0.7900000214576721,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321015","display_name":"University of Twente","ror":"https://ror.org/006hf6230"},{"id":"https://openalex.org/F4320325847","display_name":"Istituto Italiano di Tecnologia","ror":"https://ror.org/042t93s57"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1492301850","https://openalex.org/W1977646448","https://openalex.org/W2019168090","https://openalex.org/W2033463239","https://openalex.org/W2040027262","https://openalex.org/W2059968966","https://openalex.org/W2067674700","https://openalex.org/W2072652550","https://openalex.org/W2086174087","https://openalex.org/W2568379729","https://openalex.org/W2607294442","https://openalex.org/W2763925266","https://openalex.org/W2801895273","https://openalex.org/W2803685378","https://openalex.org/W2967687737","https://openalex.org/W2982393021","https://openalex.org/W3029039883","https://openalex.org/W3044420893","https://openalex.org/W3088767096","https://openalex.org/W4206373712","https://openalex.org/W6731617174"],"related_works":["https://openalex.org/W4365454259","https://openalex.org/W2075483847","https://openalex.org/W3032525775","https://openalex.org/W2753973579","https://openalex.org/W2752743978","https://openalex.org/W3029981134","https://openalex.org/W2621499369","https://openalex.org/W2074844527","https://openalex.org/W4213286079","https://openalex.org/W2067807133"],"abstract_inverted_index":{"Human-induced":[0],"pluripotent":[1],"stem":[2],"cells":[3],"(hiPSCs)":[4],"with":[5],"their":[6],"differentiation":[7,102],"protocols,":[8],"constitute":[9],"a":[10,100],"potential":[11,89],"tool":[12],"to":[13,104],"investigate":[14],"the":[15,27,32,40,128],"various":[16],"biological":[17,43],"mechanisms":[18,44],"of":[19,26,34,42,45,110],"different":[20],"human":[21,76,111],"cells,":[22],"such":[23,35],"as":[24,70,88],"those":[25],"central":[28],"nervous":[29],"system.":[30],"With":[31],"advent":[33],"technique,":[36],"we":[37,98,118],"have":[38],"increased":[39],"knowledge":[41],"neural":[46,58],"diseases":[47],"and,":[48],"new":[49],"therapies":[50],"are":[51,67],"now":[52],"emerging.":[53],"In":[54,95],"particular,":[55],"three-dimensional":[56],"(3D)":[57],"cell":[59,78],"culture":[60],"models":[61],"including":[62],"brain":[63,77],"organoids":[64],"and":[65,80,86,126,144,155],"neurospheroids":[66,109],"increasingly":[68],"used":[69,119],"in":[71,83,141],"vitro":[72],"platforms":[73],"for":[74,91,127,152],"studying":[75],"biology":[79],"drug":[81,153],"screening,":[82],"genome":[84],"engineering":[85],"transplantation":[87],"treatment":[90],"some":[92],"neurodegenerative":[93],"diseases.":[94],"this":[96],"work,":[97],"exploited":[99],"particular":[101],"protocol":[103],"generate":[105],"engineered":[106],"excitatory":[107],"cortical":[108],"origin.":[112],"To":[113],"assess":[114],"functional":[115],"network":[116],"activity,":[117],"standard":[120],"Micro":[121],"Electrodes":[122],"Arrays":[123],"(60":[124],"channels)":[125],"first":[129,146],"time":[130],"CMOS":[131],"based":[132],"devices":[133],"(4096":[134],"channels).":[135],"Sample":[136],"cultures":[137],"showed":[138],"electrophysiological":[139],"activity":[140],"4":[142],"weeks":[143],"these":[145],"results":[147],"suggest":[148],"future":[149],"possible":[150],"applications":[151],"screening":[154],"transplantation.":[156]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}