{"id":"https://openalex.org/W2946300968","doi":"https://doi.org/10.1109/ner.2019.8717052","title":"High frequency shift in Carotid Sinus Nerve and Sympathetic Nerve activity in Type 2 Diabetic Rat Model","display_name":"High frequency shift in Carotid Sinus Nerve and Sympathetic Nerve activity in Type 2 Diabetic Rat Model","publication_year":2019,"publication_date":"2019-03-01","ids":{"openalex":"https://openalex.org/W2946300968","doi":"https://doi.org/10.1109/ner.2019.8717052","mag":"2946300968"},"language":"en","primary_location":{"id":"doi:10.1109/ner.2019.8717052","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ner.2019.8717052","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 9th International IEEE/EMBS Conference on Neural Engineering (NER)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://infoscience.epfl.ch/record/267427","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077236926","display_name":"Marina Cracchiolo","orcid":"https://orcid.org/0000-0002-5108-7746"},"institutions":[{"id":"https://openalex.org/I162290304","display_name":"Scuola Superiore Sant'Anna","ror":"https://ror.org/025602r80","country_code":"IT","type":"education","lineage":["https://openalex.org/I162290304"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marina Cracchiolo","raw_affiliation_strings":["The BioRobotics Institute, Scuola Superiore Sant'Anna – Pontedera, Pisa, 56025, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The BioRobotics Institute, Scuola Superiore Sant'Anna – Pontedera, Pisa, 56025, Italy","institution_ids":["https://openalex.org/I162290304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005017089","display_name":"Joana F. Sacramento","orcid":"https://orcid.org/0000-0002-0853-4918"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joana F. Sacramento","raw_affiliation_strings":["CEDOC, Faculdade Ciências Médicas, Lisboa, 1150-082, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEDOC, Faculdade Ciências Médicas, Lisboa, 1150-082, Portugal","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034530138","display_name":"Alberto Mazzoni","orcid":"https://orcid.org/0000-0002-9632-1831"},"institutions":[{"id":"https://openalex.org/I162290304","display_name":"Scuola Superiore Sant'Anna","ror":"https://ror.org/025602r80","country_code":"IT","type":"education","lineage":["https://openalex.org/I162290304"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alberto Mazzoni","raw_affiliation_strings":["The BioRobotics Institute, Scuola Superiore Sant'Anna – Pontedera, Pisa, 56025, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The BioRobotics Institute, Scuola Superiore Sant'Anna – Pontedera, Pisa, 56025, Italy","institution_ids":["https://openalex.org/I162290304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007702330","display_name":"Alessandro Panarese","orcid":"https://orcid.org/0000-0002-4918-3069"},"institutions":[{"id":"https://openalex.org/I162290304","display_name":"Scuola Superiore Sant'Anna","ror":"https://ror.org/025602r80","country_code":"IT","type":"education","lineage":["https://openalex.org/I162290304"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Panarese","raw_affiliation_strings":["The BioRobotics Institute, Scuola Superiore Sant'Anna – Pontedera, Pisa, 56025, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The BioRobotics Institute, Scuola Superiore Sant'Anna – Pontedera, Pisa, 56025, Italy","institution_ids":["https://openalex.org/I162290304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107852094","display_name":"Jacopo Carpaneto","orcid":"https://orcid.org/0000-0001-5256-5087"},"institutions":[{"id":"https://openalex.org/I162290304","display_name":"Scuola Superiore Sant'Anna","ror":"https://ror.org/025602r80","country_code":"IT","type":"education","lineage":["https://openalex.org/I162290304"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Jacopo Carpaneto","raw_affiliation_strings":["The BioRobotics Institute, Scuola Superiore Sant'Anna – Pontedera, Pisa, 56025, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The BioRobotics Institute, Scuola Superiore Sant'Anna – Pontedera, Pisa, 56025, Italy","institution_ids":["https://openalex.org/I162290304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060251521","display_name":"S\u00edlvia V. Conde","orcid":"https://orcid.org/0000-0002-5920-5700"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Silvia V. Conde","raw_affiliation_strings":["CEDOC, Faculdade Ciências Médicas, Lisboa, 1150-082, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEDOC, Faculdade Ciências Médicas, Lisboa, 1150-082, Portugal","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080060929","display_name":"Silvestro Micera","orcid":"https://orcid.org/0000-0003-4396-8217"},"institutions":[{"id":"https://openalex.org/I162290304","display_name":"Scuola Superiore Sant'Anna","ror":"https://ror.org/025602r80","country_code":"IT","type":"education","lineage":["https://openalex.org/I162290304"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvestro Micera","raw_affiliation_strings":["The BioRobotics Institute, Scuola Superiore Sant'Anna – Pontedera, Pisa, 56025, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The BioRobotics Institute, Scuola Superiore Sant'Anna – Pontedera, Pisa, 56025, Italy","institution_ids":["https://openalex.org/I162290304"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1504,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.80497311,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"498","last_page":"501"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autonomic-nervous-system","display_name":"Autonomic nervous system","score":0.6938306093215942},{"id":"https://openalex.org/keywords/neuromodulation","display_name":"Neuromodulation","score":0.6614965200424194},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.6353298425674438},{"id":"https://openalex.org/keywords/sympathetic-nervous-system","display_name":"Sympathetic nervous system","score":0.6023825407028198},{"id":"https://openalex.org/keywords/nervous-system","display_name":"Nervous system","score":0.5386433601379395},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"Diabetes mellitus","score":0.522137463092804},{"id":"https://openalex.org/keywords/baroreflex","display_name":"Baroreflex","score":0.5009608268737793},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.500349760055542},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"Type 2 diabetes","score":0.478290855884552},{"id":"https://openalex.org/keywords/carotid-body","display_name":"Carotid body","score":0.4538222551345825},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"Insulin resistance","score":0.4512771666049957},{"id":"https://openalex.org/keywords/pathological","display_name":"Pathological","score":0.4435961842536926},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.4153522253036499},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.371646523475647},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.36552858352661133},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"Central nervous system","score":0.24040555953979492},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"Blood pressure","score":0.20869958400726318},{"id":"https://openalex.org/keywords/heart-rate","display_name":"Heart rate","score":0.19615361094474792},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.15500539541244507},{"id":"https://openalex.org/keywords/electrophysiology","display_name":"Electrophysiology","score":0.09804823994636536}],"concepts":[{"id":"https://openalex.org/C2777372248","wikidata":"https://www.wikidata.org/wiki/Q171064","display_name":"Autonomic nervous system","level":4,"score":0.6938306093215942},{"id":"https://openalex.org/C2780375056","wikidata":"https://www.wikidata.org/wiki/Q905905","display_name":"Neuromodulation","level":3,"score":0.6614965200424194},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6353298425674438},{"id":"https://openalex.org/C2776533406","wikidata":"https://www.wikidata.org/wiki/Q187215","display_name":"Sympathetic nervous system","level":3,"score":0.6023825407028198},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.5386433601379395},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.522137463092804},{"id":"https://openalex.org/C191237925","wikidata":"https://www.wikidata.org/wiki/Q808725","display_name":"Baroreflex","level":4,"score":0.5009608268737793},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.500349760055542},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.478290855884552},{"id":"https://openalex.org/C2778113364","wikidata":"https://www.wikidata.org/wiki/Q1532008","display_name":"Carotid body","level":3,"score":0.4538222551345825},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.4512771666049957},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.4435961842536926},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4153522253036499},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.371646523475647},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.36552858352661133},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.24040555953979492},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.20869958400726318},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.19615361094474792},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.15500539541244507},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.09804823994636536}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/ner.2019.8717052","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ner.2019.8717052","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 9th International IEEE/EMBS Conference on Neural Engineering (NER)","raw_type":"proceedings-article"},{"id":"pmh:oai:infoscience.epfl.ch:267427","is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/267427","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://infoscience.epfl.ch/record/267427","raw_type":"Text"},{"id":"pmh:oai:www.iris.sssup.it:11382/530702","is_oa":false,"landing_page_url":"http://hdl.handle.net/11382/530702","pdf_url":null,"source":{"id":"https://openalex.org/S4377196376","display_name":"CINECA IRIS Institutional Research Information System (Sant'Anna School of Advanced Studies)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I162290304","host_organization_name":"Scuola Superiore Sant'Anna","host_organization_lineage":["https://openalex.org/I162290304"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:infoscience.epfl.ch:267427","is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/267427","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://infoscience.epfl.ch/record/267427","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1971122483","https://openalex.org/W2066041574","https://openalex.org/W2122549480","https://openalex.org/W2125893767","https://openalex.org/W2166722928","https://openalex.org/W2189036932","https://openalex.org/W2312352372","https://openalex.org/W2508492660","https://openalex.org/W2524897358","https://openalex.org/W2531214807","https://openalex.org/W2783825054","https://openalex.org/W2801830100","https://openalex.org/W6687524610"],"related_works":["https://openalex.org/W2528841344","https://openalex.org/W2003195461","https://openalex.org/W2403869416","https://openalex.org/W2485040445","https://openalex.org/W2102837368","https://openalex.org/W4391033415","https://openalex.org/W2464916661","https://openalex.org/W2323647611","https://openalex.org/W2037707152","https://openalex.org/W2944031140"],"abstract_inverted_index":{"Overactivity":[0],"of":[1,35,73,186,190,200],"the":[2,36,43,71,81,165,170,181,187,198],"sympathetic":[3],"nervous":[4,83,172],"system":[5,84,173],"(SNS)":[6],"is":[7,68],"associated":[8],"to":[9,76,80,112],"several":[10],"cardiovascular":[11],"and":[12,18,24,48,52,62,85,106,149],"metabolic":[13,188],"dysfunctions,":[14],"such":[15],"as":[16],"hypertension":[17],"insulin":[19,87,150],"resistance.":[20],"Indirect":[21],"biochemical":[22],"measurements":[23],"surgical":[25],"manipulations":[26],"have":[27,55],"provided":[28],"preliminary":[29],"evidences":[30],"about":[31],"a":[32,99,193],"crucial":[33],"role":[34],"Carotid":[37],"Sinus":[38],"Nerve":[39],"(CSN)":[40],"in":[41,60,103,133,174],"generating":[42],"SNS":[44,49,107,140,147],"overactivity.":[45],"However,":[46],"CSN":[47,105,131,156],"neural":[50,108,121,167],"activities":[51,109],"their":[53],"interplay":[54],"not":[56],"been":[57],"yet":[58],"characterized":[59],"healthy":[61],"pathological":[63,166],"conditions.":[64],"Understanding":[65],"this":[66],"relationship":[67],"key":[69,194],"for":[70,183,197],"development":[72,199],"electroceutical":[74,201],"approaches":[75],"deliver":[77],"therapeutic":[78],"neuromodulation":[79],"autonomic":[82,171],"restore":[86],"sensitivity.":[88],"Here":[89],"we":[90,128],"show":[91,129],"that":[92,130,145],"early":[93,134],"type":[94,124,135,175],"2":[95,125,136,176],"diabetes":[96,137],"rats":[97,138],"present":[98],"high":[100,141],"frequency":[101,142],"shift":[102,143],"both":[104],"with":[110],"respect":[111],"control":[113],"animals.":[114],"This":[115],"feature":[116],"could":[117],"be":[118,153],"an":[119],"important":[120],"signature":[122],"characterizing":[123],"diabetes.":[126,177],"Moreover,":[127,178],"resection":[132],"abolishes":[139],"confirming":[144],"normal":[146],"activity":[148,157],"sensitivity":[151],"may":[152],"recovered":[154],"by":[155],"suppression.":[158],"These":[159],"findings":[160],"shed":[161],"new":[162],"light":[163],"on":[164],"changes":[168],"within":[169],"they":[179],"pave":[180],"way":[182],"electrical":[184],"monitoring":[185],"state":[189],"diabetic":[191],"patients,":[192],"first":[195],"step":[196],"therapies.":[202]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}