{"id":"https://openalex.org/W1494189038","doi":"https://doi.org/10.1109/ner.2015.7146759","title":"Design of a novel closed-loop deep brain stimulation system for Parkinson's disease and obsessive-compulsive disorder","display_name":"Design of a novel closed-loop deep brain stimulation system for Parkinson's disease and obsessive-compulsive disorder","publication_year":2015,"publication_date":"2015-04-01","ids":{"openalex":"https://openalex.org/W1494189038","doi":"https://doi.org/10.1109/ner.2015.7146759","mag":"1494189038"},"language":"en","primary_location":{"id":"doi:10.1109/ner.2015.7146759","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ner.2015.7146759","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 7th International IEEE/EMBS Conference on Neural Engineering (NER)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026897702","display_name":"Sofia Karamintziou","orcid":null},"institutions":[{"id":"https://openalex.org/I174458059","display_name":"National Technical University of Athens","ror":"https://ror.org/03cx6bg69","country_code":"GR","type":"education","lineage":["https://openalex.org/I174458059"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"S D Karamintziou","raw_affiliation_strings":["National Technical University of Athens, Athens, Greece",", National Technical University of Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Technical University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I174458059"]},{"raw_affiliation_string":", National Technical University of Athens, Greece","institution_ids":["https://openalex.org/I174458059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027787279","display_name":"Brigitte Piallat","orcid":"https://orcid.org/0000-0001-9660-4850"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210151160","display_name":"Grenoble Institute of Neurosciences","ror":"https://ror.org/04as3rk94","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2738703131","https://openalex.org/I4210151160","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"B Piallat","raw_affiliation_strings":["Grenoble University and Grenoble Institute of Neurosciences (INSERM-U836), Grenoble, France","Grenoble University and Grenoble Institute of Neurosciences (INSERM-U836), France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grenoble University and Grenoble Institute of Neurosciences (INSERM-U836), Grenoble, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210151160","https://openalex.org/I899635006"]},{"raw_affiliation_string":"Grenoble University and Grenoble Institute of Neurosciences (INSERM-U836), France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087852701","display_name":"St\u00e9phan Chabard\u00e8s","orcid":"https://orcid.org/0000-0002-7930-1476"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2800555055","display_name":"Centre Hospitalier Universitaire de Grenoble","ror":"https://ror.org/041rhpw39","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I2800555055"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S Chabardes","raw_affiliation_strings":["INSERM-U836, University Hospital of Grenoble, Grenoble, France","INSERM-U836 and University Hospital of Grenoble, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM-U836, University Hospital of Grenoble, Grenoble, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I899635006"]},{"raw_affiliation_string":"INSERM-U836 and University Hospital of Grenoble, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024694534","display_name":"Mircea Polosan","orcid":"https://orcid.org/0009-0006-3849-3981"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2800555055","display_name":"Centre Hospitalier Universitaire de Grenoble","ror":"https://ror.org/041rhpw39","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I2800555055"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M Polosan","raw_affiliation_strings":["INSERM-U836, University Hospital of Grenoble, Grenoble, France","INSERM-U836 and University Hospital of Grenoble, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM-U836, University Hospital of Grenoble, Grenoble, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I899635006"]},{"raw_affiliation_string":"INSERM-U836 and University Hospital of Grenoble, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009848505","display_name":"Olivier David","orcid":"https://orcid.org/0000-0003-0776-0216"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210151160","display_name":"Grenoble Institute of Neurosciences","ror":"https://ror.org/04as3rk94","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2738703131","https://openalex.org/I4210151160","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"O David","raw_affiliation_strings":["Grenoble University and Grenoble Institute of Neurosciences (INSERM-U836), Grenoble, France","Grenoble University and Grenoble Institute of Neurosciences (INSERM-U836), France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grenoble University and Grenoble Institute of Neurosciences (INSERM-U836), Grenoble, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210151160","https://openalex.org/I899635006"]},{"raw_affiliation_string":"Grenoble University and Grenoble Institute of Neurosciences (INSERM-U836), France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076954584","display_name":"George L. Tsirogiannis","orcid":null},"institutions":[{"id":"https://openalex.org/I174458059","display_name":"National Technical University of Athens","ror":"https://ror.org/03cx6bg69","country_code":"GR","type":"education","lineage":["https://openalex.org/I174458059"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"G L Tsirogiannis","raw_affiliation_strings":["National Technical University of Athens, Athens, Greece",", National Technical University of Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Technical University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I174458059"]},{"raw_affiliation_string":", National Technical University of Athens, Greece","institution_ids":["https://openalex.org/I174458059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015598359","display_name":"Nick G Deligiannis","orcid":null},"institutions":[{"id":"https://openalex.org/I174458059","display_name":"National Technical University of Athens","ror":"https://ror.org/03cx6bg69","country_code":"GR","type":"education","lineage":["https://openalex.org/I174458059"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"N G Deligiannis","raw_affiliation_strings":["National Technical University of Athens, Athens, Greece",", National Technical University of Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Technical University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I174458059"]},{"raw_affiliation_string":", National Technical University of Athens, Greece","institution_ids":["https://openalex.org/I174458059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087105075","display_name":"Pantelis Stathis","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P G Stathis","raw_affiliation_strings":["Mediterraneo Hospital, Athens, Greece","Mediterraneo Hospital, Glyfada, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mediterraneo Hospital, Athens, Greece","institution_ids":[]},{"raw_affiliation_string":"Mediterraneo Hospital, Glyfada, Athens, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030390958","display_name":"G. Tagaris","orcid":null},"institutions":[{"id":"https://openalex.org/I4210105465","display_name":"General Hospital of Athens G. Genimatas","ror":"https://ror.org/00zq17821","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210105465"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"G A Tagaris","raw_affiliation_strings":["\u2018G. Gennimatas\u2019 General Hospital of Athens, Athens, Greece","\u2018G. Gennimatas\u2019 General Hospital of Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2018G. Gennimatas\u2019 General Hospital of Athens, Athens, Greece","institution_ids":["https://openalex.org/I4210105465"]},{"raw_affiliation_string":"\u2018G. Gennimatas\u2019 General Hospital of Athens, Greece","institution_ids":["https://openalex.org/I4210105465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050200813","display_name":"Efstathios Boviatsis","orcid":"https://orcid.org/0000-0002-8000-9739"},"institutions":[{"id":"https://openalex.org/I4210140282","display_name":"University General Hospital Attikon","ror":"https://ror.org/03gb7n667","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210140282"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"E J Boviatsis","raw_affiliation_strings":["Attikon University Hospital, Athens, Greece","\u2018Attikon\u2019 University Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Attikon University Hospital, Athens, Greece","institution_ids":["https://openalex.org/I4210140282"]},{"raw_affiliation_string":"\u2018Attikon\u2019 University Hospital, Athens, Greece","institution_ids":["https://openalex.org/I4210140282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108713136","display_name":"Damianos E. Sakas","orcid":null},"institutions":[{"id":"https://openalex.org/I4210166445","display_name":"Evangelismos Hospital","ror":"https://ror.org/05q4veh78","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210166445"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"D E Sakas","raw_affiliation_strings":["\u2018Evangelismos\u2019 General Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2018Evangelismos\u2019 General Hospital, Athens, Greece","institution_ids":["https://openalex.org/I4210166445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051469166","display_name":"Georgia E. Polychronaki","orcid":null},"institutions":[{"id":"https://openalex.org/I174458059","display_name":"National Technical University of Athens","ror":"https://ror.org/03cx6bg69","country_code":"GR","type":"education","lineage":["https://openalex.org/I174458059"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"G E Polychronaki","raw_affiliation_strings":["National Technical University of Athens, Athens, Greece",", National Technical University of Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Technical University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I174458059"]},{"raw_affiliation_string":", National Technical University of Athens, Greece","institution_ids":["https://openalex.org/I174458059"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082313849","display_name":"Konstantina S. Nikita","orcid":"https://orcid.org/0000-0001-8255-4354"},"institutions":[{"id":"https://openalex.org/I174458059","display_name":"National Technical University of Athens","ror":"https://ror.org/03cx6bg69","country_code":"GR","type":"education","lineage":["https://openalex.org/I174458059"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"K S Nikita","raw_affiliation_strings":["National Technical University of Athens, Athens, Greece",", National Technical University of Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Technical University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I174458059"]},{"raw_affiliation_string":", National Technical University of Athens, Greece","institution_ids":["https://openalex.org/I174458059"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"860","last_page":"863"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deep-brain-stimulation","display_name":"Deep brain stimulation","score":0.9238613843917847},{"id":"https://openalex.org/keywords/subthalamic-nucleus","display_name":"Subthalamic nucleus","score":0.8374672532081604},{"id":"https://openalex.org/keywords/parkinsons-disease","display_name":"Parkinson's disease","score":0.7084037065505981},{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.6106917858123779},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.5875170230865479},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.38164642453193665},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.3649771511554718},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.36301660537719727},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.35657379031181335},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.1498917043209076}],"concepts":[{"id":"https://openalex.org/C2778542668","wikidata":"https://www.wikidata.org/wiki/Q618076","display_name":"Deep brain stimulation","level":4,"score":0.9238613843917847},{"id":"https://openalex.org/C2777319143","wikidata":"https://www.wikidata.org/wiki/Q2270424","display_name":"Subthalamic nucleus","level":5,"score":0.8374672532081604},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.7084037065505981},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.6106917858123779},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5875170230865479},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38164642453193665},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3649771511554718},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.36301660537719727},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.35657379031181335},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1498917043209076}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/ner.2015.7146759","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ner.2015.7146759","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 7th International IEEE/EMBS Conference on Neural Engineering (NER)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Affordable and clean energy","score":0.8999999761581421,"id":"https://metadata.un.org/sdg/7"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W12794346","https://openalex.org/W111157985","https://openalex.org/W1503328619","https://openalex.org/W1909924204","https://openalex.org/W1975719341","https://openalex.org/W1998325841","https://openalex.org/W1998833946","https://openalex.org/W2001416448","https://openalex.org/W2011281843","https://openalex.org/W2037894949","https://openalex.org/W2079799462","https://openalex.org/W2080948124","https://openalex.org/W2090284100","https://openalex.org/W2103908673","https://openalex.org/W2109856309","https://openalex.org/W2122093158","https://openalex.org/W2143685192","https://openalex.org/W2170408241","https://openalex.org/W2171453145"],"related_works":["https://openalex.org/W2093780015","https://openalex.org/W4289755640","https://openalex.org/W4301179225","https://openalex.org/W2607326016","https://openalex.org/W1983965289","https://openalex.org/W22241804","https://openalex.org/W1564112868","https://openalex.org/W2771365127","https://openalex.org/W2390600672","https://openalex.org/W2884613167"],"abstract_inverted_index":{"We":[0],"present":[1],"a":[2,40,46,67],"novel":[3],"closed-loop":[4],"subthalamic":[5],"nucleus":[6],"(STN)":[7],"deep":[8],"brain":[9],"stimulation":[10,29,55],"(DBS)":[11],"scheme":[12],"for":[13,37,92],"Parkinson's":[14],"disease":[15],"(PD)":[16],"and":[17,71,87,94],"obsessive-compulsive":[18],"disorder":[19],"(OCD).":[20],"The":[21],"algorithm":[22],"is":[23],"designed":[24],"to":[25],"effectuate":[26],"real-time,":[27],"adaptive":[28],"employing":[30],"the":[31,34,49],"outcome":[32],"of":[33,45,54,66],"0-1":[35],"test":[36],"chaos":[38],"as":[39],"state-specific":[41],"biomarker.":[42],"In":[43],"case":[44],"null":[47],"outcome,":[48],"system":[50],"identifies":[51],"optimal":[52],"patterns":[53],"desynchronizing":[56],"pathologic":[57],"neuronal":[58],"activity":[59],"with":[60],"minimal":[61],"energy":[62],"consumption,":[63],"on":[64],"grounds":[65],"stochastic":[68],"dynamical":[69],"model":[70],"an":[72],"appropriately":[73],"formulated":[74],"cost":[75],"function.":[76],"Simulations":[77],"are":[78],"performed":[79],"utilizing":[80],"microelectrode":[81],"recordings":[82],"(MERs)":[83],"acquired":[84],"during":[85],"8":[86],"2":[88],"DBS":[89],"surgical":[90],"interventions":[91],"PD":[93],"OCD,":[95],"respectively.":[96]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}