{"id":"https://openalex.org/W3197821988","doi":"https://doi.org/10.1109/nems51815.2021.9451295","title":"A clogging rate prediction model based on porous microarray membranes for liquid biopsies","display_name":"A clogging rate prediction model based on porous microarray membranes for liquid biopsies","publication_year":2021,"publication_date":"2021-04-25","ids":{"openalex":"https://openalex.org/W3197821988","doi":"https://doi.org/10.1109/nems51815.2021.9451295","mag":"3197821988"},"language":"en","primary_location":{"id":"doi:10.1109/nems51815.2021.9451295","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems51815.2021.9451295","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE 16th International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102069097","display_name":"Yinghao He","orcid":"https://orcid.org/0009-0008-1999-0880"},"institutions":[{"id":"https://openalex.org/I4210128628","display_name":"Peking University Shenzhen Hospital","ror":"https://ror.org/03kkjyb15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128628"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yinghao He","raw_affiliation_strings":["Peking University ShenZhen Graduate School, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peking University ShenZhen Graduate School, Guangdong, China","institution_ids":["https://openalex.org/I4210128628"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106746026","display_name":"Yaoping Liu","orcid":"https://orcid.org/0000-0002-1194-0976"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210119392","display_name":"Institute of Microelectronics","ror":"https://ror.org/02s6gs133","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210119392"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaoping Liu","raw_affiliation_strings":["Institute of Microelectronics, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microelectronics, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210119392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100391983","display_name":"Wei Wang","orcid":"https://orcid.org/0000-0002-4628-1755"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210119392","display_name":"Institute of Microelectronics","ror":"https://ror.org/02s6gs133","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210119392"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Wang","raw_affiliation_strings":["Institute of Microelectronics, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microelectronics, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210119392"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104079377","display_name":"Yufeng Jin","orcid":"https://orcid.org/0009-0006-9750-4599"},"institutions":[{"id":"https://openalex.org/I4210128628","display_name":"Peking University Shenzhen Hospital","ror":"https://ror.org/03kkjyb15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128628"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yufeng Jin","raw_affiliation_strings":["Peking University ShenZhen Graduate School, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peking University ShenZhen Graduate School, Guangdong, China","institution_ids":["https://openalex.org/I4210128628"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":null,"first_page":"898","last_page":"901"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11751","display_name":"Lattice Boltzmann Simulation Studies","score":0.9811999797821045,"subfield":{"id":"https://openalex.org/subfields/2206","display_name":"Computational Mechanics"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9746999740600586,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clogging","display_name":"Clogging","score":0.9504673480987549},{"id":"https://openalex.org/keywords/filtration","display_name":"Filtration (mathematics)","score":0.7672218084335327},{"id":"https://openalex.org/keywords/membrane","display_name":"Membrane","score":0.7314542531967163},{"id":"https://openalex.org/keywords/microporous-material","display_name":"Microporous material","score":0.6125301718711853},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.5604351758956909},{"id":"https://openalex.org/keywords/filter","display_name":"Filter (signal processing)","score":0.5542659759521484},{"id":"https://openalex.org/keywords/reliability","display_name":"Reliability (semiconductor)","score":0.516293466091156},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.4613156318664551},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.44921329617500305},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.22422045469284058},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2222575545310974},{"id":"https://openalex.org/keywords/composite-material","display_name":"Composite material","score":0.21992838382720947},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.13655754923820496},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.10208505392074585}],"concepts":[{"id":"https://openalex.org/C2778152828","wikidata":"https://www.wikidata.org/wiki/Q488656","display_name":"Clogging","level":2,"score":0.9504673480987549},{"id":"https://openalex.org/C128489963","wikidata":"https://www.wikidata.org/wiki/Q1187724","display_name":"Filtration (mathematics)","level":2,"score":0.7672218084335327},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.7314542531967163},{"id":"https://openalex.org/C86381522","wikidata":"https://www.wikidata.org/wiki/Q2752988","display_name":"Microporous material","level":2,"score":0.6125301718711853},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5604351758956909},{"id":"https://openalex.org/C106131492","wikidata":"https://www.wikidata.org/wiki/Q3072260","display_name":"Filter (signal processing)","level":2,"score":0.5542659759521484},{"id":"https://openalex.org/C43214815","wikidata":"https://www.wikidata.org/wiki/Q7310987","display_name":"Reliability (semiconductor)","level":3,"score":0.516293466091156},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4613156318664551},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.44921329617500305},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.22422045469284058},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2222575545310974},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.21992838382720947},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13655754923820496},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.10208505392074585},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.0},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C163258240","wikidata":"https://www.wikidata.org/wiki/Q25342","display_name":"Power (physics)","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/nems51815.2021.9451295","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems51815.2021.9451295","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE 16th International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation","score":0.47999998927116394}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1489119370","https://openalex.org/W2005756410","https://openalex.org/W2532614625","https://openalex.org/W2808155111","https://openalex.org/W3003181374","https://openalex.org/W3036902841"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W1519163886","https://openalex.org/W2350847567","https://openalex.org/W2383005377","https://openalex.org/W1983727634","https://openalex.org/W3213247983","https://openalex.org/W1836039258","https://openalex.org/W2463868704","https://openalex.org/W1896264233","https://openalex.org/W2353769888"],"abstract_inverted_index":{"This":[0],"paper":[1,102],"presents":[2],"a":[3,162],"filter":[4,17,99,113],"clogging":[5,33,57,110,158],"model":[6,125],"for":[7,19,151],"the":[8,25,42,47,54,81,85,90,94,98,107,117,124,157,168],"screening":[9],"of":[10,41,46,49,56,68,89,97,109,123,170],"rare":[11],"tumour":[12,91,172],"cells":[13,79,92],"by":[14],"microporous":[15,36],"array":[16,37],"membranes":[18,38],"liquid":[20,50,142,175],"biopsies.":[21,176],"In":[22],"clinical":[23],"practice,":[24],"ability":[26],"to":[27,59,76,105,144,154],"achieve":[28],"high":[29],"throughput":[30],"and":[31,70,87,93,132,165,174],"low":[32],"rates":[34],"with":[35],"is":[39,160],"one":[40],"most":[43],"important":[44],"indicators":[45],"reliability":[48,122],"biopsy":[51],"technology.":[52],"However,":[53],"occurrence":[55],"due":[58],"various":[60],"complex":[61],"factors":[62],"such":[63],"as":[64],"pore":[65,95],"size,":[66],"number":[67,88],"pores":[69],"sample":[71,152],"concentration":[72],"makes":[73],"it":[74],"difficult":[75],"isolate":[77],"target":[78],"from":[80,116],"membrane.":[82],"By":[83],"considering":[84],"size":[86,96],"membrane,":[100],"this":[101],"allows":[103],"us":[104],"predict":[106],"trend":[108],"rate":[111,159],"after":[112],"membrane":[114],"filtration":[115,139],"change":[118],"in":[119],"concentration.":[120],"The":[121],"was":[126],"demonstrated":[127],"through":[128],"mathematical":[129],"validation":[130],"reasoning":[131],"experimental":[133],"results,":[134],"thus":[135],"helping":[136],"subsequent":[137],"extensive":[138],"experiments":[140],"on":[141],"biopsies":[143],"select":[145],"more":[146],"appropriate":[147],"blood":[148],"dilution":[149],"concentrations":[150],"pre-treatment":[153],"ensure":[155],"that":[156],"within":[161],"reasonable":[163],"range,":[164],"ultimately":[166],"improving":[167],"accuracy":[169],"capturing":[171],"markers":[173]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}