{"id":"https://openalex.org/W3159291635","doi":"https://doi.org/10.1109/nems50311.2020.9419479","title":"Towards High-Throughput Single-Cell Proteomics Using Droplet Microfluidics","display_name":"Towards High-Throughput Single-Cell Proteomics Using Droplet Microfluidics","publication_year":2020,"publication_date":"2020-09-27","ids":{"openalex":"https://openalex.org/W3159291635","doi":"https://doi.org/10.1109/nems50311.2020.9419479","mag":"3159291635"},"language":"en","primary_location":{"id":"doi:10.1109/nems50311.2020.9419479","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems50311.2020.9419479","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 IEEE 15th International Conference on Nano/Micro Engineered and Molecular System (NEMS)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083714922","display_name":"Mohsen Paryavi","orcid":null},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mohsen Paryavi","raw_affiliation_strings":["Department of Electrical Engineering, University of Hawaii at Manoa, Honolulu, HI, USA"],"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering, University of Hawaii at Manoa, Honolulu, HI, USA","institution_ids":["https://openalex.org/I117965899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076759267","display_name":"Richie Chio","orcid":null},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richie Chio","raw_affiliation_strings":["Department of Electrical Engineering, University of Hawaii at Manoa, Honolulu, HI, USA"],"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering, University of Hawaii at Manoa, Honolulu, HI, USA","institution_ids":["https://openalex.org/I117965899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003595858","display_name":"Mizanur Rahman","orcid":"https://orcid.org/0000-0003-4259-1497"},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Rifur Rahman","raw_affiliation_strings":["Department of Electrical Engineering, University of Hawaii at Manoa, Honolulu, HI, USA"],"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering, University of Hawaii at Manoa, Honolulu, HI, USA","institution_ids":["https://openalex.org/I117965899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082802243","display_name":"Iain Macpherson","orcid":"https://orcid.org/0000-0003-0443-2073"},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Iain MacPherson","raw_affiliation_strings":["Department of Tropical Medicine, Medical Microbiology and Pharmacology, University of Hawaii at Manoa, Honolulu, HI, USA"],"affiliations":[{"raw_affiliation_string":"Department of Tropical Medicine, Medical Microbiology and Pharmacology, University of Hawaii at Manoa, Honolulu, HI, USA","institution_ids":["https://openalex.org/I117965899"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068511935","display_name":"Aaron T. Ohta","orcid":"https://orcid.org/0000-0003-3789-897X"},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron T. Ohta","raw_affiliation_strings":["Department of Electrical Engineering, University of Hawaii at Manoa, Honolulu, HI, USA"],"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering, University of Hawaii at Manoa, Honolulu, HI, USA","institution_ids":["https://openalex.org/I117965899"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5083714922"],"corresponding_institution_ids":["https://openalex.org/I117965899"],"apc_list":null,"apc_paid":null,"fwci":0.1717,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.48282626,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"329","last_page":"332"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12452","display_name":"Electrowetting and Microfluidic Technologies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microfluidics","display_name":"Microfluidics","score":0.8665070533752441},{"id":"https://openalex.org/keywords/barcode","display_name":"Barcode","score":0.7063732147216797},{"id":"https://openalex.org/keywords/coalescence","display_name":"Coalescence (physics)","score":0.5437707304954529},{"id":"https://openalex.org/keywords/microfluidic-chip","display_name":"Microfluidic chip","score":0.5224239230155945},{"id":"https://openalex.org/keywords/single-cell-analysis","display_name":"Single-cell analysis","score":0.5145849585533142},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.5112912654876709},{"id":"https://openalex.org/keywords/workflow","display_name":"Workflow","score":0.47721558809280396},{"id":"https://openalex.org/keywords/throughput","display_name":"Throughput","score":0.45183736085891724},{"id":"https://openalex.org/keywords/lab-on-a-chip","display_name":"Lab-on-a-chip","score":0.429992139339447},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.42944714426994324},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.42868903279304504},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.4183880090713501},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2662171721458435},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.07381170988082886}],"concepts":[{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.8665070533752441},{"id":"https://openalex.org/C2776841711","wikidata":"https://www.wikidata.org/wiki/Q856","display_name":"Barcode","level":2,"score":0.7063732147216797},{"id":"https://openalex.org/C149792144","wikidata":"https://www.wikidata.org/wiki/Q2071902","display_name":"Coalescence (physics)","level":2,"score":0.5437707304954529},{"id":"https://openalex.org/C2988198817","wikidata":"https://www.wikidata.org/wiki/Q633261","display_name":"Microfluidic chip","level":3,"score":0.5224239230155945},{"id":"https://openalex.org/C2776950831","wikidata":"https://www.wikidata.org/wiki/Q15635432","display_name":"Single-cell analysis","level":3,"score":0.5145849585533142},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5112912654876709},{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.47721558809280396},{"id":"https://openalex.org/C157764524","wikidata":"https://www.wikidata.org/wiki/Q1383412","display_name":"Throughput","level":3,"score":0.45183736085891724},{"id":"https://openalex.org/C138942068","wikidata":"https://www.wikidata.org/wiki/Q633261","display_name":"Lab-on-a-chip","level":3,"score":0.429992139339447},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.42944714426994324},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.42868903279304504},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4183880090713501},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2662171721458435},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07381170988082886},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/nems50311.2020.9419479","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems50311.2020.9419479","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 IEEE 15th International Conference on Nano/Micro Engineered and Molecular System (NEMS)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306371","display_name":"Hawaii Community Foundation","ror":"https://ror.org/03jwgbj27"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W91480292","https://openalex.org/W574197333","https://openalex.org/W1910197149","https://openalex.org/W1980221373","https://openalex.org/W1998857762","https://openalex.org/W2009434334","https://openalex.org/W2030718987","https://openalex.org/W2097455931","https://openalex.org/W2104612788","https://openalex.org/W2114528520","https://openalex.org/W2123303153","https://openalex.org/W2135461398","https://openalex.org/W2135937351","https://openalex.org/W2146488831","https://openalex.org/W2165786425","https://openalex.org/W2564176045","https://openalex.org/W2603592147","https://openalex.org/W2739492614","https://openalex.org/W2752426001","https://openalex.org/W2786402081","https://openalex.org/W2952613439","https://openalex.org/W4210280122"],"related_works":["https://openalex.org/W2709231633","https://openalex.org/W4387116029","https://openalex.org/W2463351222","https://openalex.org/W4312354843","https://openalex.org/W4299365654","https://openalex.org/W2615396203","https://openalex.org/W2351115691","https://openalex.org/W2936845415","https://openalex.org/W3098813295","https://openalex.org/W4251700743"],"abstract_inverted_index":{"Single-cell":[0],"proteomics":[1],"is":[2],"emerging":[3],"as":[4],"an":[5,59],"effective":[6],"method":[7],"to":[8,24],"characterize":[9],"cell":[10,26],"populations.":[11],"To":[12],"accommodate":[13],"alternative":[14],"protein":[15],"labeling":[16],"and":[17,28,43,64],"quantification":[18],"technologies,":[19],"it":[20],"may":[21],"be":[22],"beneficial":[23],"incorporate":[25],"encapsulation":[27],"droplet":[29,57,62,66],"coalescence":[30],"in":[31],"a":[32,38,55,65],"standard":[33],"workflow.":[34],"In":[35],"this":[36],"work,":[37],"microfluidic":[39,70],"device":[40,53],"was":[41,87],"designed":[42],"tested":[44],"towards":[45],"the":[46,79],"goal":[47],"of":[48,85],"high-throughput":[49],"single-cell":[50],"analysis.":[51],"The":[52,69],"incorporated":[54],"cell-encapsulated":[56],"generator,":[58],"on-chip":[60],"DNA-barcode":[61],"separator,":[63],"merging":[67,83],"module.":[68],"droplets":[71],"that":[72],"can":[73],"contain":[74],"cells":[75],"are":[76],"merged":[77],"with":[78],"barcode-containing":[80],"droplets.":[81],"A":[82],"efficiency":[84],"68%":[86],"achieved.":[88]},"counts_by_year":[{"year":2023,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}