{"id":"https://openalex.org/W2991067142","doi":"https://doi.org/10.1109/nems.2019.8915667","title":"In Vitro Microfluidics-based Blood\u2013brain Barrier Model","display_name":"In Vitro Microfluidics-based Blood\u2013brain Barrier Model","publication_year":2019,"publication_date":"2019-04-01","ids":{"openalex":"https://openalex.org/W2991067142","doi":"https://doi.org/10.1109/nems.2019.8915667","mag":"2991067142"},"language":"en","primary_location":{"id":"doi:10.1109/nems.2019.8915667","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2019.8915667","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 IEEE 14th International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088011472","display_name":"Ya-Yu Chaing","orcid":null},"institutions":[{"id":"https://openalex.org/I162838928","display_name":"National Chung Hsing University","ror":"https://ror.org/05vn3ca78","country_code":"TW","type":"education","lineage":["https://openalex.org/I162838928"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Ya-Yu Chaing","raw_affiliation_strings":["Mechanical engineering, National Chung Hsing university, Taichung, Taiwan"],"affiliations":[{"raw_affiliation_string":"Mechanical engineering, National Chung Hsing university, Taichung, Taiwan","institution_ids":["https://openalex.org/I162838928"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026848654","display_name":"Kai-Hong Tu","orcid":null},"institutions":[{"id":"https://openalex.org/I162838928","display_name":"National Chung Hsing University","ror":"https://ror.org/05vn3ca78","country_code":"TW","type":"education","lineage":["https://openalex.org/I162838928"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kai-Hong Tu","raw_affiliation_strings":["Mechanical engineering, National Chung Hsing university, Taichung, Taiwan"],"affiliations":[{"raw_affiliation_string":"Mechanical engineering, National Chung Hsing university, Taichung, Taiwan","institution_ids":["https://openalex.org/I162838928"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5088011472"],"corresponding_institution_ids":["https://openalex.org/I162838928"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.13849981,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"351","last_page":"354"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.9926000237464905,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microchannel","display_name":"Microchannel","score":0.8346842527389526},{"id":"https://openalex.org/keywords/organ-on-a-chip","display_name":"Organ-on-a-chip","score":0.6931788921356201},{"id":"https://openalex.org/keywords/microfluidics","display_name":"Microfluidics","score":0.6177669167518616},{"id":"https://openalex.org/keywords/microelectromechanical-systems","display_name":"Microelectromechanical systems","score":0.6133683919906616},{"id":"https://openalex.org/keywords/wafer","display_name":"Wafer","score":0.5666918754577637},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.5621663928031921},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.5103023052215576},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.5015380382537842},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.5000100135803223},{"id":"https://openalex.org/keywords/blood\u2013brain-barrier","display_name":"Blood\u2013brain barrier","score":0.46800366044044495},{"id":"https://openalex.org/keywords/shear-stress","display_name":"Shear stress","score":0.45555174350738525},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"Tissue engineering","score":0.4213181436061859},{"id":"https://openalex.org/keywords/microfluidic-chip","display_name":"Microfluidic chip","score":0.4206653833389282},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.36527758836746216},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.23769983649253845},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.21144160628318787},{"id":"https://openalex.org/keywords/composite-material","display_name":"Composite material","score":0.13967964053153992},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"Central nervous system","score":0.12932494282722473},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.11062303185462952},{"id":"https://openalex.org/keywords/biotechnology","display_name":"Biotechnology","score":0.10476401448249817}],"concepts":[{"id":"https://openalex.org/C63662833","wikidata":"https://www.wikidata.org/wiki/Q6839341","display_name":"Microchannel","level":2,"score":0.8346842527389526},{"id":"https://openalex.org/C165932988","wikidata":"https://www.wikidata.org/wiki/Q7101746","display_name":"Organ-on-a-chip","level":3,"score":0.6931788921356201},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.6177669167518616},{"id":"https://openalex.org/C37977207","wikidata":"https://www.wikidata.org/wiki/Q175561","display_name":"Microelectromechanical systems","level":2,"score":0.6133683919906616},{"id":"https://openalex.org/C160671074","wikidata":"https://www.wikidata.org/wiki/Q267131","display_name":"Wafer","level":2,"score":0.5666918754577637},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5621663928031921},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5103023052215576},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5015380382537842},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5000100135803223},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.46800366044044495},{"id":"https://openalex.org/C21141959","wikidata":"https://www.wikidata.org/wiki/Q657936","display_name":"Shear stress","level":2,"score":0.45555174350738525},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.4213181436061859},{"id":"https://openalex.org/C2988198817","wikidata":"https://www.wikidata.org/wiki/Q633261","display_name":"Microfluidic chip","level":3,"score":0.4206653833389282},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.36527758836746216},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.23769983649253845},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.21144160628318787},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.13967964053153992},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.12932494282722473},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11062303185462952},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.10476401448249817}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/nems.2019.8915667","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2019.8915667","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 IEEE 14th International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W2082829054","https://openalex.org/W2101099825","https://openalex.org/W2117691576","https://openalex.org/W2139731074","https://openalex.org/W2154555351","https://openalex.org/W2740294724"],"related_works":["https://openalex.org/W2163143718","https://openalex.org/W2928699668","https://openalex.org/W3111440216","https://openalex.org/W2008985780","https://openalex.org/W4281999480","https://openalex.org/W4391564170","https://openalex.org/W4386016157","https://openalex.org/W2789898465","https://openalex.org/W2953365051","https://openalex.org/W2771036474"],"abstract_inverted_index":{"Organs-on-chips":[0],"in":[1,21],"vitro":[2],"model":[3,42],"is":[4,25],"a":[5,38],"micro":[6],"engineering":[7],"system":[8],"that":[9],"containing":[10],"the":[11,17,28,32,45,57,68,76,80,88,94,98,102,106],"microchannel":[12,69],"structure":[13],"and":[14,60,109],"could":[15,86],"replicate":[16],"tissue":[18,50],"living":[19],"condition":[20],"vivo.":[22],"Its":[23],"benefit":[24],"to":[26,97],"construct":[27],"user-friendly":[29],"platform":[30],"for":[31,51,67,79],"further":[33,52],"biological":[34],"experiment.":[35],"We":[36,100],"demonstrate":[37],"low-cost":[39],"2D":[40],"organ-on-chip":[41],"which":[43],"mimic":[44,87],"blood":[46],"brain":[47],"barrier":[48],"(BBB)":[49],"clinical":[53],"experiment,":[54],"such":[55],"as":[56,93],"drug":[58],"delivery":[59],"cytotoxicity":[61],"threat.":[62],"MEMS-fabricated":[63],"wafer":[64],"was":[65],"used":[66],"fabrication.":[70],"The":[71,82],"completely":[72],"transparent":[73],"material":[74],"offered":[75],"advanced":[77],"visibility":[78],"researchers.":[81],"continuous":[83],"medium":[84],"supplement":[85],"hydrodynamic":[89],"shear":[90,107],"stress":[91,108],"(SS)":[92],"physical":[95],"stimulus":[96],"cell.":[99],"described":[101],"positive":[103],"correlation":[104],"between":[105],"cell":[110],"growing":[111],"orientation.":[112]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-03-25T13:04:00.132906","created_date":"2025-10-10T00:00:00"}