{"id":"https://openalex.org/W2904961191","doi":"https://doi.org/10.1109/nems.2018.8556957","title":"Fluorescence Spectroscopic Detection and Measurement of Single Telomere Molecules","display_name":"Fluorescence Spectroscopic Detection and Measurement of Single Telomere Molecules","publication_year":2018,"publication_date":"2018-04-01","ids":{"openalex":"https://openalex.org/W2904961191","doi":"https://doi.org/10.1109/nems.2018.8556957","mag":"2904961191"},"language":"en","primary_location":{"id":"doi:10.1109/nems.2018.8556957","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2018.8556957","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE 13th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010053520","display_name":"Cyrus W. Beh","orcid":"https://orcid.org/0000-0002-8399-923X"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Cyrus W. Beh","raw_affiliation_strings":["Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100449358","display_name":"Ye Zhang","orcid":"https://orcid.org/0000-0003-3057-6759"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ye Zhang","raw_affiliation_strings":["Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027534599","display_name":"Yun\u2010Ling Zheng","orcid":"https://orcid.org/0000-0002-6564-8831"},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yun-Ling Zheng","raw_affiliation_strings":["Department of Oncology, Georgetown University Medical Center, Washington, DC"],"affiliations":[{"raw_affiliation_string":"Department of Oncology, Georgetown University Medical Center, Washington, DC","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011689931","display_name":"Bing Sun","orcid":"https://orcid.org/0000-0002-0350-5835"},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bing Sun","raw_affiliation_strings":["Department of Oncology, Georgetown University Medical Center, Washington, DC"],"affiliations":[{"raw_affiliation_string":"Department of Oncology, Georgetown University Medical Center, Washington, DC","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I184565670"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061361223","display_name":"Tza\u2010Huei Wang","orcid":"https://orcid.org/0000-0002-3540-9354"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tza-Huei Wang","raw_affiliation_strings":["Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD"],"affiliations":[{"raw_affiliation_string":"Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5010053520"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.19996407,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"28","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9610999822616577,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/telomere","display_name":"Telomere","score":0.8973139524459839},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.5266352295875549},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4437797963619232},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3745514154434204},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.25653940439224243}],"concepts":[{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.8973139524459839},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5266352295875549},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4437797963619232},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3745514154434204},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25653940439224243}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/nems.2018.8556957","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2018.8556957","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE 13th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.41999998688697815,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1971250886","https://openalex.org/W1995935464","https://openalex.org/W2014666122","https://openalex.org/W2029563560","https://openalex.org/W2142464898"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2082860237","https://openalex.org/W2096760656","https://openalex.org/W2119695867","https://openalex.org/W2045637853","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2005903392","https://openalex.org/W2046158694"],"abstract_inverted_index":{"Telomeres":[0],"are":[1,23,59],"the":[2,10,13,26,38,47],"end-caps":[3],"of":[4,12,28,49,56,68],"chromosomes":[5,76],"that":[6,84,135],"serve":[7,41],"to":[8,40,64,74,91,95,107,139],"protect":[9],"integrity":[11],"genome":[14],"and":[15,34,51,98,115],"which":[16],"shorten":[17],"during":[18],"normal":[19],"cell":[20,78],"division.":[21],"They":[22],"implicated":[24],"in":[25,46],"development":[27],"various":[29],"aging-associated":[30],"diseases":[31],"including":[32],"cancer":[33],"telomere":[35,57,70,141],"length":[36,142],"has":[37,104],"potential":[39],"as":[42],"a":[43,82,86,92,126],"useful":[44],"biomarker":[45],"field":[48],"aging":[50],"cancer.":[52],"However":[53],"existing":[54],"methods":[55],"measurement":[58,67],"either":[60],"too":[61],"laborious":[62],"unable":[63],"provide":[65],"absolute":[66],"individual":[69],"lengths":[71],"or":[72,77],"limited":[73],"certain":[75],"types.":[79],"We":[80],"developed":[81,106],"method":[83,129],"uses":[85],"confocal":[87],"spectroscopic":[88],"system":[89],"coupled":[90],"microfluidic":[93],"device":[94],"detect":[96],"nanoparticles":[97],"single":[99,111,132],"molecules.":[100],"Furthermore":[101],"an":[102],"model":[103],"been":[105],"distinguish":[108],"between":[109],"true":[110],"molecule":[112],"detection":[113],"events":[114],"spurious":[116],"peaks":[117],"arising":[118],"from":[119,144,148],"noise.":[120],"Combining":[121],"these":[122],"two":[123],"approaches":[124],"yields":[125],"flow":[127],"cytometry-like":[128],"for":[130],"characterizing":[131],"DNA":[133,146],"molecules":[134],"we":[136],"have":[137],"used":[138],"profile":[140],"distributions":[143],"genomic":[145],"extracted":[147],"cells.":[149]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}