{"id":"https://openalex.org/W2751258031","doi":"https://doi.org/10.1109/nems.2017.8017087","title":"Drug delivery nanovectors based on SPIONS for targeted therapy of hepatocellular carcinoma","display_name":"Drug delivery nanovectors based on SPIONS for targeted therapy of hepatocellular carcinoma","publication_year":2017,"publication_date":"2017-04-01","ids":{"openalex":"https://openalex.org/W2751258031","doi":"https://doi.org/10.1109/nems.2017.8017087","mag":"2751258031"},"language":"en","primary_location":{"id":"doi:10.1109/nems.2017.8017087","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2017.8017087","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE 12th International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025868627","display_name":"Nicoletta Depalo","orcid":"https://orcid.org/0000-0002-2107-2762"},"institutions":[{"id":"https://openalex.org/I4210154694","display_name":"Institute for Chemical and Physical Processes","ror":"https://ror.org/05patmk97","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210154694","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"N. Depalo","raw_affiliation_strings":["Istituto per i Processi Chimico-Fisici-CNR UOS Bari, Bari, Italy"],"affiliations":[{"raw_affiliation_string":"Istituto per i Processi Chimico-Fisici-CNR UOS Bari, Bari, Italy","institution_ids":["https://openalex.org/I4210154694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008977113","display_name":"Marinella Striccoli","orcid":"https://orcid.org/0000-0002-5366-691X"},"institutions":[{"id":"https://openalex.org/I4210131058","display_name":"Istituto Tumori Bari","ror":"https://ror.org/03jxkz251","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099368","https://openalex.org/I4210117053","https://openalex.org/I4210131058","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Striccoli","raw_affiliation_strings":["Dipartimento di Farmacia - Scienze del Farmaco, Universit\u00e0 degli Studi di Bari Aldo Moro, Bari, Italy","Istituto Tumori IRCCS Giovanni Paolo II, Bari, Italy"],"affiliations":[{"raw_affiliation_string":"Dipartimento di Farmacia - Scienze del Farmaco, Universit\u00e0 degli Studi di Bari Aldo Moro, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]},{"raw_affiliation_string":"Istituto Tumori IRCCS Giovanni Paolo II, Bari, Italy","institution_ids":["https://openalex.org/I4210131058","https://openalex.org/I4210153126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086616583","display_name":"Maria Lucia Curri","orcid":"https://orcid.org/0000-0002-0261-8379"},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. L. Curri","raw_affiliation_strings":["Dipartimento di Chimica, Universit\u00e0 degli Studi di Bari Aldo Moro, Bari, Italy"],"affiliations":[{"raw_affiliation_string":"Dipartimento di Chimica, Universit\u00e0 degli Studi di Bari Aldo Moro, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011081585","display_name":"Rosa Maria Iacobazzi","orcid":"https://orcid.org/0000-0002-0737-6591"},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"R. M. Iacobazzi","raw_affiliation_strings":["Dipartimento di Farmacia - Scienze del Farmaco, Universit\u00e0 degli Studi di Bari Aldo Moro, Bari, Italy"],"affiliations":[{"raw_affiliation_string":"Dipartimento di Farmacia - Scienze del Farmaco, Universit\u00e0 degli Studi di Bari Aldo Moro, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065585118","display_name":"Ilaria Arduino","orcid":"https://orcid.org/0000-0001-6881-7461"},"institutions":[{"id":"https://openalex.org/I4210154694","display_name":"Institute for Chemical and Physical Processes","ror":"https://ror.org/05patmk97","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210154694","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"I. Arduino","raw_affiliation_strings":["Istituto per i Processi Chimico-Fisici-CNR UOS Bari, Bari, Italy"],"affiliations":[{"raw_affiliation_string":"Istituto per i Processi Chimico-Fisici-CNR UOS Bari, Bari, Italy","institution_ids":["https://openalex.org/I4210154694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034343115","display_name":"Valentino Laquintana","orcid":"https://orcid.org/0000-0003-1266-638X"},"institutions":[{"id":"https://openalex.org/I4210154694","display_name":"Institute for Chemical and Physical Processes","ror":"https://ror.org/05patmk97","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210154694","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"V. Laquintana","raw_affiliation_strings":["Istituto per i Processi Chimico-Fisici-CNR UOS Bari, Bari, Italy"],"affiliations":[{"raw_affiliation_string":"Istituto per i Processi Chimico-Fisici-CNR UOS Bari, Bari, Italy","institution_ids":["https://openalex.org/I4210154694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059230325","display_name":"Annalisa Cutrignelli","orcid":"https://orcid.org/0000-0001-5197-9720"},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Cutrignelli","raw_affiliation_strings":["Dipartimento di Farmacia - Scienze del Farmaco, Universit\u00e0 degli Studi di Bari Aldo Moro, Bari, Italy"],"affiliations":[{"raw_affiliation_string":"Dipartimento di Farmacia - Scienze del Farmaco, Universit\u00e0 degli Studi di Bari Aldo Moro, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009793363","display_name":"Angela Lopedota","orcid":"https://orcid.org/0000-0003-4283-7063"},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Lopedota","raw_affiliation_strings":["Dipartimento di Chimica, Universit\u00e0 degli Studi di Bari Aldo Moro, Bari, Italy"],"affiliations":[{"raw_affiliation_string":"Dipartimento di Chimica, Universit\u00e0 degli Studi di Bari Aldo Moro, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012816356","display_name":"Marina Santiago Franco","orcid":"https://orcid.org/0000-0003-4610-1328"},"institutions":[{"id":"https://openalex.org/I4210154694","display_name":"Institute for Chemical and Physical Processes","ror":"https://ror.org/05patmk97","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210154694","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Franco","raw_affiliation_strings":["Istituto per i Processi Chimico-Fisici-CNR UOS Bari, Bari, Italy"],"affiliations":[{"raw_affiliation_string":"Istituto per i Processi Chimico-Fisici-CNR UOS Bari, Bari, Italy","institution_ids":["https://openalex.org/I4210154694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091296814","display_name":"Nunzio Denora","orcid":"https://orcid.org/0000-0002-7756-7828"},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"N. Denora","raw_affiliation_strings":["Dipartimento di Farmacia - Scienze del Farmaco, Universit\u00e0 degli Studi di Bari Aldo Moro, Bari, Italy"],"affiliations":[{"raw_affiliation_string":"Dipartimento di Farmacia - Scienze del Farmaco, Universit\u00e0 degli Studi di Bari Aldo Moro, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029535504","display_name":"Letizia Porcelli","orcid":"https://orcid.org/0000-0003-0175-9716"},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L. Porcelli","raw_affiliation_strings":["Dipartimento di Farmacia - Scienze del Farmaco, Universit\u00e0 degli Studi di Bari Aldo Moro, Bari, Italy"],"affiliations":[{"raw_affiliation_string":"Dipartimento di Farmacia - Scienze del Farmaco, Universit\u00e0 degli Studi di Bari Aldo Moro, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050514750","display_name":"Amalia Azzariti","orcid":"https://orcid.org/0000-0002-6149-5049"},"institutions":[{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210131058","display_name":"Istituto Tumori Bari","ror":"https://ror.org/03jxkz251","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099368","https://openalex.org/I4210117053","https://openalex.org/I4210131058","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Azzariti","raw_affiliation_strings":["Istituto Tumori IRCCS Giovanni Paolo II, Bari, Italy"],"affiliations":[{"raw_affiliation_string":"Istituto Tumori IRCCS Giovanni Paolo II, Bari, Italy","institution_ids":["https://openalex.org/I4210131058","https://openalex.org/I4210153126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038309768","display_name":"G. Valente","orcid":"https://orcid.org/0000-0002-6721-4180"},"institutions":[{"id":"https://openalex.org/I4210131058","display_name":"Istituto Tumori Bari","ror":"https://ror.org/03jxkz251","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099368","https://openalex.org/I4210117053","https://openalex.org/I4210131058","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. Valente","raw_affiliation_strings":["Istituto Tumori IRCCS Giovanni Paolo II, Bari, Italy"],"affiliations":[{"raw_affiliation_string":"Istituto Tumori IRCCS Giovanni Paolo II, Bari, Italy","institution_ids":["https://openalex.org/I4210131058","https://openalex.org/I4210153126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021199408","display_name":"Elisabetta Fanizza","orcid":"https://orcid.org/0000-0001-6293-9388"},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E. Fanizza","raw_affiliation_strings":["Dipartimento di Farmacia - Scienze del Farmaco, Universit\u00e0 degli Studi di Bari Aldo Moro, Bari, Italy"],"affiliations":[{"raw_affiliation_string":"Dipartimento di Farmacia - Scienze del Farmaco, Universit\u00e0 degli Studi di Bari Aldo Moro, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101461305","display_name":"Silvia Villa","orcid":"https://orcid.org/0000-0003-3913-4404"},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Villa","raw_affiliation_strings":["Dipartimento di Farmacia - Scienze del Farmaco, Universit\u00e0 degli Studi di Bari Aldo Moro, Bari, Italy"],"affiliations":[{"raw_affiliation_string":"Dipartimento di Farmacia - Scienze del Farmaco, Universit\u00e0 degli Studi di Bari Aldo Moro, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010614436","display_name":"F. Canepa","orcid":"https://orcid.org/0000-0003-2985-1258"},"institutions":[{"id":"https://openalex.org/I4210154694","display_name":"Institute for Chemical and Physical Processes","ror":"https://ror.org/05patmk97","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210154694","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Canepa","raw_affiliation_strings":["Istituto per i Processi Chimico-Fisici-CNR UOS Bari, Bari, Italy"],"affiliations":[{"raw_affiliation_string":"Istituto per i Processi Chimico-Fisici-CNR UOS Bari, Bari, Italy","institution_ids":["https://openalex.org/I4210154694"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":16,"corresponding_author_ids":["https://openalex.org/A5025868627"],"corresponding_institution_ids":["https://openalex.org/I4210154694"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.06135818,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"570","last_page":"573"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12405","display_name":"Characterization and Applications of Magnetic Nanoparticles","score":0.9930999875068665,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9904999732971191,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sorafenib","display_name":"Sorafenib","score":0.9269492626190186},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"Drug delivery","score":0.6639026403427124},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"Hepatocellular carcinoma","score":0.6433568596839905},{"id":"https://openalex.org/keywords/micelle","display_name":"Micelle","score":0.5497348308563232},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5440018773078918},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"Targeted drug delivery","score":0.511966347694397},{"id":"https://openalex.org/keywords/nanomedicine","display_name":"Nanomedicine","score":0.44826847314834595},{"id":"https://openalex.org/keywords/polyethylene-glycol","display_name":"Polyethylene glycol","score":0.4257635474205017},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.4160520136356354},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.4054443836212158},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.3892275094985962},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.355529248714447},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.35249823331832886},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.3042130470275879},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2180035412311554},{"id":"https://openalex.org/keywords/nanoparticle","display_name":"Nanoparticle","score":0.17468467354774475},{"id":"https://openalex.org/keywords/aqueous-solution","display_name":"Aqueous solution","score":0.09113892912864685},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.060340702533721924}],"concepts":[{"id":"https://openalex.org/C2778695046","wikidata":"https://www.wikidata.org/wiki/Q421136","display_name":"Sorafenib","level":3,"score":0.9269492626190186},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6639026403427124},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.6433568596839905},{"id":"https://openalex.org/C11268172","wikidata":"https://www.wikidata.org/wiki/Q421110","display_name":"Micelle","level":3,"score":0.5497348308563232},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5440018773078918},{"id":"https://openalex.org/C126511603","wikidata":"https://www.wikidata.org/wiki/Q1261145","display_name":"Targeted drug delivery","level":3,"score":0.511966347694397},{"id":"https://openalex.org/C15083742","wikidata":"https://www.wikidata.org/wiki/Q261659","display_name":"Nanomedicine","level":3,"score":0.44826847314834595},{"id":"https://openalex.org/C2776964284","wikidata":"https://www.wikidata.org/wiki/Q410083","display_name":"Polyethylene glycol","level":2,"score":0.4257635474205017},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4160520136356354},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4054443836212158},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3892275094985962},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.355529248714447},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35249823331832886},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3042130470275879},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2180035412311554},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.17468467354774475},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.09113892912864685},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.060340702533721924},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/nems.2017.8017087","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2017.8017087","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE 12th International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","raw_type":"proceedings-article"},{"id":"pmh:oai:ricerca.uniba.it:11586/212233","is_oa":false,"landing_page_url":"http://hdl.handle.net/11586/212233","pdf_url":null,"source":{"id":"https://openalex.org/S4377196296","display_name":"CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I5561750","host_organization_name":"University of Bari Aldo Moro","host_organization_lineage":["https://openalex.org/I5561750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1801840020","https://openalex.org/W1980122435","https://openalex.org/W2241596782","https://openalex.org/W2277587392","https://openalex.org/W2321660292"],"related_works":["https://openalex.org/W2415520711","https://openalex.org/W3014741021","https://openalex.org/W2256992551","https://openalex.org/W3118995675","https://openalex.org/W2342123427","https://openalex.org/W2083715308","https://openalex.org/W2328476987","https://openalex.org/W2793290090","https://openalex.org/W1553842589","https://openalex.org/W2973435978"],"abstract_inverted_index":{"Currently,":[0],"sorafenib":[1,202],"is":[2,171],"the":[3,10,14,26,49,52,119,130,136,152,158,168,175,190,198],"only":[4],"systemic":[5],"therapy":[6],"capable":[7],"to":[8,45,116,150,173],"increase":[9],"overall":[11],"survival":[12],"of":[13,54,89,157,192,201],"patient":[15],"affected":[16],"by":[17,87,125],"advanced":[18],"hepatocellular":[19,140],"carcinoma.":[20],"Unfortunately,":[21],"its":[22,205],"side":[23],"effects":[24],"limit":[25],"therapeutic":[27],"response.":[28],"Superparamagnetic":[29],"iron":[30],"oxide":[31],"nanoparticles":[32],"(SPIONs)":[33],"are":[34],"very":[35],"attractive":[36],"for":[37,189],"drug":[38,96,107,176],"delivery":[39,97,169],"as":[40,146],"they":[41],"can":[42,121,203],"be":[43,122],"targeted":[44],"specific":[46,193],"sites":[47],"in":[48,102,110,135,147],"body":[50],"through":[51],"application":[53],"a":[55],"magnetic":[56,127,184],"field,":[57],"thus":[58],"improving":[59],"intracellular":[60],"accumulation":[61],"and":[62,79,84,105,207],"reducing":[63],"adverse":[64],"effects.":[65],"Here,":[66],"nanoformulations":[67],"based":[68],"on":[69],"polyethylene":[70],"glycol":[71],"modified":[72],"phospholipid":[73],"micelles,":[74],"loaded":[75,161],"with":[76,99,162],"both":[77],"SPIONs":[78],"sorafenib,":[80],"were":[81,144],"successfully":[82],"prepared":[83],"thoroughly":[85],"investigated":[86],"means":[88],"complementary":[90],"techniques.":[91],"The":[92,164,182],"nanovectors":[93,185],"resulted":[94],"effective":[95],"systems":[98],"good":[100],"stability":[101],"aqueous":[103],"medium":[104],"controlled":[106],"loading.":[108],"An":[109],"vitro":[111,148],"system":[112,149],"was":[113],"specifically":[114],"designed":[115],"prove":[117],"that":[118,167],"SPION/Micelles":[120],"efficiently":[123],"held":[124],"using":[126],"field":[128],"under":[129],"flow":[131],"conditions":[132],"typically":[133],"found":[134],"human":[137],"liver.":[138],"Human":[139],"carcinoma":[141],"(HepG2)":[142],"cells":[143],"selected":[145],"evaluate":[151],"tumor":[153,195],"cell":[154],"targeting":[155,191],"efficacy":[156,206],"superparamagnetic":[159],"micelles":[160],"sorafenib.":[163],"experiments":[165],"demonstrated":[166],"platform":[170],"able":[172],"enhance":[174],"antitumor":[177],"effectiveness":[178],"when":[179],"magnetically":[180],"targeted.":[181],"presented":[183],"represent":[186],"promising":[187],"candidates":[188],"hepatic":[194],"sites,":[196],"where":[197],"selective":[199],"release":[200],"improve":[204],"safety":[208],"profile.":[209]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}