{"id":"https://openalex.org/W2566877063","doi":"https://doi.org/10.1109/nems.2016.7758187","title":"A self-driven microfluidic chip through a rapid surface modification of PDMS and its application for digital loop-mediated amplification (LAMP)","display_name":"A self-driven microfluidic chip through a rapid surface modification of PDMS and its application for digital loop-mediated amplification (LAMP)","publication_year":2016,"publication_date":"2016-04-01","ids":{"openalex":"https://openalex.org/W2566877063","doi":"https://doi.org/10.1109/nems.2016.7758187","mag":"2566877063"},"language":"en","primary_location":{"id":"doi:10.1109/nems.2016.7758187","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2016.7758187","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086919612","display_name":"Yu-Dong Ma","orcid":null},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Dong Ma","raw_affiliation_strings":["Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100979148","display_name":"Wen-Hsin Chang","orcid":null},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wen-Hsin Chang","raw_affiliation_strings":["Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101502114","display_name":"Chih\u2010Hung Wang","orcid":"https://orcid.org/0000-0001-5058-4356"},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chih-Hung Wang","raw_affiliation_strings":["Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051922492","display_name":"Shih\u2010Yuan Liu","orcid":"https://orcid.org/0000-0003-3148-9147"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shih-Yuan Liu","raw_affiliation_strings":["Coretronic Corporation, Miaoli, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Coretronic Corporation, Miaoli, Taiwan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012093855","display_name":"Wen\u2010Hsiang Yen","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wen-Hsiang Yen","raw_affiliation_strings":["Coretronic Corporation, Miaoli, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Coretronic Corporation, Miaoli, Taiwan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101404382","display_name":"Kang Luo","orcid":"https://orcid.org/0000-0002-8884-8748"},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kang Luo","raw_affiliation_strings":["Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100865373","display_name":"Huey\u2010Ling You","orcid":null},"institutions":[{"id":"https://openalex.org/I4210093821","display_name":"Kaohsiung Chang Gung Memorial Hospital","ror":"https://ror.org/00k194y12","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210093821"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Huey-Ling You","raw_affiliation_strings":["Department of Laboratory Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan","institution_ids":["https://openalex.org/I4210093821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101034063","display_name":"Jiunn-Jong Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]},{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jiunn-Jong Wu","raw_affiliation_strings":["Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University, Tainan, Taiwan","School of Biomedical Science and Engineering, National Yang-Ming University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University, Tainan, Taiwan","institution_ids":["https://openalex.org/I91807558"]},{"raw_affiliation_string":"School of Biomedical Science and Engineering, National Yang-Ming University, Taipei, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008077323","display_name":"Mel S. Lee","orcid":"https://orcid.org/0000-0002-8736-6122"},"institutions":[{"id":"https://openalex.org/I4210093821","display_name":"Kaohsiung Chang Gung Memorial Hospital","ror":"https://ror.org/00k194y12","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210093821"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Mel S. Lee","raw_affiliation_strings":["Department of Orthopaedic Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan","institution_ids":["https://openalex.org/I4210093821"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007513075","display_name":"Gwo\u2010Bin Lee","orcid":"https://orcid.org/0000-0001-6910-9133"},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Gwo-Bin Lee","raw_affiliation_strings":["Institute of NanoEngineering and Microsystems, National Tsing Hua University, Hsinchu, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of NanoEngineering and Microsystems, National Tsing Hua University, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I25846049"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.175,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.60117097,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/loop-mediated-isothermal-amplification","display_name":"Loop-mediated isothermal amplification","score":0.9079827070236206},{"id":"https://openalex.org/keywords/polydimethylsiloxane","display_name":"Polydimethylsiloxane","score":0.8897486329078674},{"id":"https://openalex.org/keywords/microfluidics","display_name":"Microfluidics","score":0.8533300757408142},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.6891531944274902},{"id":"https://openalex.org/keywords/capillary-action","display_name":"Capillary action","score":0.6533785462379456},{"id":"https://openalex.org/keywords/lab-on-a-chip","display_name":"Lab-on-a-chip","score":0.5038053393363953},{"id":"https://openalex.org/keywords/chip","display_name":"Chip","score":0.4986252784729004},{"id":"https://openalex.org/keywords/surface-modification","display_name":"Surface modification","score":0.4939654469490051},{"id":"https://openalex.org/keywords/microfluidic-chip","display_name":"Microfluidic chip","score":0.48879382014274597},{"id":"https://openalex.org/keywords/contact-angle","display_name":"Contact angle","score":0.48742154240608215},{"id":"https://openalex.org/keywords/digital-microfluidics","display_name":"Digital microfluidics","score":0.4563572406768799},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.4516462981700897},{"id":"https://openalex.org/keywords/optoelectronics","display_name":"Optoelectronics","score":0.3808610439300537},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2263922393321991},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.18806681036949158},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.14882969856262207},{"id":"https://openalex.org/keywords/composite-material","display_name":"Composite material","score":0.10022562742233276},{"id":"https://openalex.org/keywords/electrowetting","display_name":"Electrowetting","score":0.07047095894813538}],"concepts":[{"id":"https://openalex.org/C60635243","wikidata":"https://www.wikidata.org/wiki/Q6675780","display_name":"Loop-mediated isothermal amplification","level":3,"score":0.9079827070236206},{"id":"https://openalex.org/C2779849746","wikidata":"https://www.wikidata.org/wiki/Q411955","display_name":"Polydimethylsiloxane","level":2,"score":0.8897486329078674},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.8533300757408142},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6891531944274902},{"id":"https://openalex.org/C196806460","wikidata":"https://www.wikidata.org/wiki/Q188603","display_name":"Capillary action","level":2,"score":0.6533785462379456},{"id":"https://openalex.org/C138942068","wikidata":"https://www.wikidata.org/wiki/Q633261","display_name":"Lab-on-a-chip","level":3,"score":0.5038053393363953},{"id":"https://openalex.org/C165005293","wikidata":"https://www.wikidata.org/wiki/Q1074500","display_name":"Chip","level":2,"score":0.4986252784729004},{"id":"https://openalex.org/C115537861","wikidata":"https://www.wikidata.org/wiki/Q7645993","display_name":"Surface modification","level":2,"score":0.4939654469490051},{"id":"https://openalex.org/C2988198817","wikidata":"https://www.wikidata.org/wiki/Q633261","display_name":"Microfluidic chip","level":3,"score":0.48879382014274597},{"id":"https://openalex.org/C6556556","wikidata":"https://www.wikidata.org/wiki/Q899239","display_name":"Contact angle","level":2,"score":0.48742154240608215},{"id":"https://openalex.org/C92444450","wikidata":"https://www.wikidata.org/wiki/Q5276112","display_name":"Digital microfluidics","level":4,"score":0.4563572406768799},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4516462981700897},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.3808610439300537},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2263922393321991},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.18806681036949158},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.14882969856262207},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.10022562742233276},{"id":"https://openalex.org/C2779673822","wikidata":"https://www.wikidata.org/wiki/Q907239","display_name":"Electrowetting","level":3,"score":0.07047095894813538},{"id":"https://openalex.org/C133386390","wikidata":"https://www.wikidata.org/wiki/Q184996","display_name":"Dielectric","level":2,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/nems.2016.7758187","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2016.7758187","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Clean water and sanitation","score":0.5,"id":"https://metadata.un.org/sdg/6"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1995927245","https://openalex.org/W1999331871","https://openalex.org/W2026908430","https://openalex.org/W2084419065","https://openalex.org/W2096847348"],"related_works":["https://openalex.org/W1038370629","https://openalex.org/W4379599538","https://openalex.org/W4292202565","https://openalex.org/W2282776549","https://openalex.org/W2747314403","https://openalex.org/W2482957293","https://openalex.org/W2109542958","https://openalex.org/W2709231633","https://openalex.org/W2784943883","https://openalex.org/W1995422305"],"abstract_inverted_index":{"Digital":[0],"loop-mediated":[1],"amplification":[2,9],"(LAMP)":[3],"is":[4,118],"an":[5,37],"isothermal,":[6],"quantitative":[7],"DNA":[8,27],"approach":[10],"which":[11,110,138],"has":[12,135],"high":[13],"sensitivity":[14],"and":[15,17,129,159],"specificity":[16],"could":[18,60,81,93,139],"be":[19,61,82,94,107,140],"used":[20,141],"to":[21,106],"analyze":[22],"extremely":[23],"low":[24],"amount":[25],"of":[26,32,99],"within":[28],"a":[29,47,123,153],"short":[30],"period":[31],"time.":[33],"In":[34],"this":[35],"study,":[36],"integrated":[38],"self-driven":[39,143],"microfluidic":[40,144],"chip":[41],"was":[42,104,111],"proposed":[43],"herein":[44],"for":[45,51,146,156],"performing":[46],"digital":[48,147],"LAMP":[49],"process":[50],"vancomycin-resistant":[52],"Enterococcus":[53],"(VRE)":[54],"diagnosis.":[55],"The":[56,96],"entire":[57],"bacterial":[58],"diagnosis":[59,158],"automatically":[62],"performed":[63],"by":[64,87],"capillary":[65],"forces":[66],"through":[67],"the":[68,100,112,119],"new":[69],"polydimethylsiloxane":[70],"(PDMS)":[71],"surface":[72,103,132],"treatment":[73],"without":[74],"using":[75],"external":[76],"pumps.":[77],"Moreover,":[78],"digitized":[79],"droplets":[80],"separated":[83],"from":[84],"each":[85],"other":[86],"normally-close":[88],"valves":[89],"such":[90],"that":[91,122],"it":[92],"quantitated.":[95],"contact":[97],"angle":[98],"treated":[101],"PDMS":[102,131],"measured":[105],"only":[108],"24\u00b0,":[109],"lowest":[113],"value":[114],"in":[115,142],"literatures.":[116],"This":[117,149],"first":[120],"time":[121],"rapid":[124],"(within":[125],"1":[126],"hour),":[127],"simple,":[128],"hydrophilic":[130],"modification":[133],"method":[134],"been":[136],"reported,":[137],"devices":[145],"LAMP.":[148],"device":[150],"may":[151],"become":[152],"promising":[154],"tool":[155],"clinical":[157],"point-of-care":[160],"applications.":[161]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
