{"id":"https://openalex.org/W2104033605","doi":"https://doi.org/10.1109/nems.2015.7147419","title":"Flexible micro sensor for intravascular vulnerable plaque diagnostic with electrical impedance spectroscopy","display_name":"Flexible micro sensor for intravascular vulnerable plaque diagnostic with electrical impedance spectroscopy","publication_year":2015,"publication_date":"2015-04-01","ids":{"openalex":"https://openalex.org/W2104033605","doi":"https://doi.org/10.1109/nems.2015.7147419","mag":"2104033605"},"language":"en","primary_location":{"id":"doi:10.1109/nems.2015.7147419","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2015.7147419","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"10th IEEE International Conference on Nano/Micro Engineered and Molecular Systems","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100328174","display_name":"Xiaoxiao Zhang","orcid":"https://orcid.org/0000-0002-8566-2147"},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xiaoxiao Zhang","raw_affiliation_strings":["Caltech Micromachining Laboratory, California Institute of Technology, Pasadena, CA, USA","Caltech Micromachining Laboratory, California Institute of Technology, Pasadena, USA"],"affiliations":[{"raw_affiliation_string":"Caltech Micromachining Laboratory, California Institute of Technology, Pasadena, CA, USA","institution_ids":["https://openalex.org/I122411786"]},{"raw_affiliation_string":"Caltech Micromachining Laboratory, California Institute of Technology, Pasadena, USA","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100551246","display_name":"Lei Xu","orcid":null},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lei Xu","raw_affiliation_strings":["Caltech Micromachining Laboratory, California Institute of Technology, Pasadena, CA, USA","Caltech Micromachining Laboratory, California Institute of Technology, Pasadena, USA"],"affiliations":[{"raw_affiliation_string":"Caltech Micromachining Laboratory, California Institute of Technology, Pasadena, CA, USA","institution_ids":["https://openalex.org/I122411786"]},{"raw_affiliation_string":"Caltech Micromachining Laboratory, California Institute of Technology, Pasadena, USA","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100396180","display_name":"Juhyun Lee","orcid":null},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juhyun Lee","raw_affiliation_strings":["Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA","Department of Medicine, University of California, Los Angeles USA"],"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Medicine, University of California, Los Angeles USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005651627","display_name":"Rongsong Li","orcid":"https://orcid.org/0000-0002-8247-5258"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rongsong Li","raw_affiliation_strings":["Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA","Department of Medicine, University of California, Los Angeles USA"],"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Medicine, University of California, Los Angeles USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100355964","display_name":"Yang Liu","orcid":"https://orcid.org/0000-0002-6872-6815"},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yang Liu","raw_affiliation_strings":["Caltech Micromachining Laboratory, California Institute of Technology, Pasadena, CA, USA","Caltech Micromachining Laboratory, California Institute of Technology, Pasadena, USA"],"affiliations":[{"raw_affiliation_string":"Caltech Micromachining Laboratory, California Institute of Technology, Pasadena, CA, USA","institution_ids":["https://openalex.org/I122411786"]},{"raw_affiliation_string":"Caltech Micromachining Laboratory, California Institute of Technology, Pasadena, USA","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029892896","display_name":"Aubrey Shapero","orcid":null},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aubrey Shapero","raw_affiliation_strings":["Caltech Micromachining Laboratory, California Institute of Technology, Pasadena, CA, USA","Caltech Micromachining Laboratory, California Institute of Technology, Pasadena, USA"],"affiliations":[{"raw_affiliation_string":"Caltech Micromachining Laboratory, California Institute of Technology, Pasadena, CA, USA","institution_ids":["https://openalex.org/I122411786"]},{"raw_affiliation_string":"Caltech Micromachining Laboratory, California Institute of Technology, Pasadena, USA","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081322672","display_name":"Tzung K. Hsiai","orcid":"https://orcid.org/0000-0003-1734-0792"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tzung Hsiai","raw_affiliation_strings":["Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":null,"display_name":"Yu-Chong Tai","orcid":null},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu-Chong Tai","raw_affiliation_strings":["Caltech Micromachining Laboratory, California Institute of Technology, Pasadena, CA, USA","Caltech Micromachining Laboratory, California Institute of Technology, Pasadena, USA"],"affiliations":[{"raw_affiliation_string":"Caltech Micromachining Laboratory, California Institute of Technology, Pasadena, CA, USA","institution_ids":["https://openalex.org/I122411786"]},{"raw_affiliation_string":"Caltech Micromachining Laboratory, California Institute of Technology, Pasadena, USA","institution_ids":["https://openalex.org/I122411786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5100328174"],"corresponding_institution_ids":["https://openalex.org/I122411786"],"apc_list":null,"apc_paid":null,"fwci":0.3137,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.52868555,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"243","last_page":"247"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11434","display_name":"Electrochemical Analysis and Applications","score":0.9921000003814697,"subfield":{"id":"https://openalex.org/subfields/1603","display_name":"Electrochemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11434","display_name":"Electrochemical Analysis and Applications","score":0.9921000003814697,"subfield":{"id":"https://openalex.org/subfields/1603","display_name":"Electrochemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11472","display_name":"Analytical Chemistry and Sensors","score":0.9918000102043152,"subfield":{"id":"https://openalex.org/subfields/1502","display_name":"Bioengineering"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11778","display_name":"Electrical and Bioimpedance Tomography","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intravascular-ultrasound","display_name":"Intravascular ultrasound","score":0.7714097499847412},{"id":"https://openalex.org/keywords/ex-vivo","display_name":"Ex vivo","score":0.7445353865623474},{"id":"https://openalex.org/keywords/unstable-angina","display_name":"Unstable angina","score":0.6009291410446167},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5894408226013184},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"Myocardial infarction","score":0.5728826522827148},{"id":"https://openalex.org/keywords/lumen","display_name":"Lumen (anatomy)","score":0.5530208945274353},{"id":"https://openalex.org/keywords/thrombus","display_name":"Thrombus","score":0.5511554479598999},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.5019240379333496},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.4921797811985016},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"Coronary artery disease","score":0.4803648889064789},{"id":"https://openalex.org/keywords/fibrous-cap","display_name":"Fibrous cap","score":0.47952747344970703},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.47210565209388733},{"id":"https://openalex.org/keywords/vulnerable-plaque","display_name":"Vulnerable plaque","score":0.4364508092403412},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.4033260941505432},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.3658677041530609}],"concepts":[{"id":"https://openalex.org/C2776931568","wikidata":"https://www.wikidata.org/wiki/Q1671577","display_name":"Intravascular ultrasound","level":2,"score":0.7714097499847412},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.7445353865623474},{"id":"https://openalex.org/C2777785093","wikidata":"https://www.wikidata.org/wiki/Q2032041","display_name":"Unstable angina","level":3,"score":0.6009291410446167},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5894408226013184},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.5728826522827148},{"id":"https://openalex.org/C131631996","wikidata":"https://www.wikidata.org/wiki/Q1141325","display_name":"Lumen (anatomy)","level":2,"score":0.5530208945274353},{"id":"https://openalex.org/C2781362458","wikidata":"https://www.wikidata.org/wiki/Q1588755","display_name":"Thrombus","level":2,"score":0.5511554479598999},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5019240379333496},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4921797811985016},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.4803648889064789},{"id":"https://openalex.org/C2779179121","wikidata":"https://www.wikidata.org/wiki/Q559362","display_name":"Fibrous cap","level":2,"score":0.47952747344970703},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.47210565209388733},{"id":"https://openalex.org/C2778710248","wikidata":"https://www.wikidata.org/wiki/Q17154669","display_name":"Vulnerable plaque","level":2,"score":0.4364508092403412},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4033260941505432},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3658677041530609},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/nems.2015.7147419","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2015.7147419","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"10th IEEE International Conference on Nano/Micro Engineered and Molecular Systems","raw_type":"proceedings-article"},{"id":"pmh:oai:authors.library.caltech.edu:58976","is_oa":false,"landing_page_url":"https://authors.library.caltech.edu/58976/","pdf_url":null,"source":{"id":"https://openalex.org/S4306402161","display_name":"CaltechAUTHORS (California Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Book Section"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5899999737739563,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1969712210","https://openalex.org/W2011772934","https://openalex.org/W2034100644","https://openalex.org/W2090799954","https://openalex.org/W6658632940"],"related_works":["https://openalex.org/W1993638248","https://openalex.org/W2124944344","https://openalex.org/W2097290297","https://openalex.org/W2041294412","https://openalex.org/W2084762755","https://openalex.org/W2022622792","https://openalex.org/W2121179836","https://openalex.org/W2001233427","https://openalex.org/W2465801132","https://openalex.org/W1605683988"],"abstract_inverted_index":{"Studies":[0],"have":[1],"shown":[2],"emerging":[3],"evidence":[4],"that":[5,133],"rupture":[6],"of":[7,32,90,119,158,174],"coronary":[8,73],"plaque":[9,179,217],"containing":[10],"a":[11,159,214],"lipid-rich":[12],"core":[13],"with":[14,146,178],"subsequent":[15],"thrombus":[16],"formation":[17],"is":[18,48,89],"the":[19,28,46,107,117,120,155,165],"most":[20],"frequent":[21],"mechanism":[22],"by":[23],"which":[24],"atherosclerosis":[25],"leads":[26],"to":[27,71,78,94,99,142,171],"acute":[29,35],"ischaemic":[30],"syndromes":[31],"unstable":[33,216],"angina,":[34],"myocardial":[36],"infarction,":[37],"and":[38,64,101,164],"often":[39],"times,":[40],"sudden":[41],"cardiac":[42],"death.":[43],"However,":[44],"since":[45],"lumen":[47],"not":[49],"significantly":[50,112],"blocked":[51],"in":[52,61,123,130,152,200],"these":[53],"cases,":[54],"such":[55,80,103,147],"\u201cvulnerable\u201d":[56],"plaques":[57,83,145],"show":[58,129,188,210],"noncritical":[59],"stenosis":[60],"X-ray":[62],"angiography":[63],"Intravascular":[65],"Ultrasound":[66],"(IVUS),":[67],"tools":[68],"currently":[69],"available":[70],"diagnose":[72],"artery":[74],"disease.":[75],"The":[76,181,205],"ability":[77],"distinguish":[79,144],"rupture-prone":[81,104],"vulnerable":[82],"remains":[84],"largely":[85],"lacking.":[86],"Therefore":[87],"it":[88],"great":[91],"clinical":[92],"interest":[93],"find":[95],"improved":[96],"diagnostic":[97,218],"techniques":[98],"identify":[100],"localize":[102],"plaques.":[105],"On":[106],"other":[108],"hand,":[109],"lipid":[110,148],"has":[111],"lower":[113],"electrical":[114,134],"impedance":[115,135,182],"than":[116,195],"rest":[118],"vessel":[121],"components":[122],"certain":[124],"frequency":[125],"bands":[126],"[1].":[127],"We":[128,150],"this":[131,153],"paper":[132,154],"spectroscopy":[136],"(EIS)":[137],"technique":[138],"can":[139],"be":[140],"useful":[141],"effectively":[143],"cores.":[149],"include":[151],"design":[156],"rationale":[157],"four":[160],"electrode":[161],"EIS":[162,208,226],"sensor":[163],"measurement":[166],"results":[167,209],"between":[168],"1":[169],"Hz":[170],"300":[172],"KHz":[173,187],"ex-vivo":[175,207],"mouse":[176],"aortas":[177],"lesions.":[180],"modulus":[183],"over":[184],"200":[185],"Hz-100":[186],"consistent":[189],"elevated":[190],"values":[191],"2-5":[192],"times":[193],"higher":[194],"their":[196],"proximity":[197],"control":[198],"sites":[199],"all":[201],"three":[202],"individual":[203],"mice.":[204],"promising":[206,211],"potential":[212],"for":[213,220],"reliable":[215],"tool":[219],"in-vivo":[221],"catheter":[222],"integrated":[223],"intravascular":[224],"micro":[225],"sensors.":[227]},"counts_by_year":[{"year":2016,"cited_by_count":2}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}