{"id":"https://openalex.org/W2024615353","doi":"https://doi.org/10.1109/nems.2014.6908838","title":"Rare cells detection by selective enrichment with a novel multilayer concentric filter device","display_name":"Rare cells detection by selective enrichment with a novel multilayer concentric filter device","publication_year":2014,"publication_date":"2014-04-01","ids":{"openalex":"https://openalex.org/W2024615353","doi":"https://doi.org/10.1109/nems.2014.6908838","mag":"2024615353"},"language":"en","primary_location":{"id":"doi:10.1109/nems.2014.6908838","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2014.6908838","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082398310","display_name":"Chih\u2010Chung Chen","orcid":"https://orcid.org/0000-0003-3831-1413"},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Chih-Chung Chen","raw_affiliation_strings":["Institute of NanoEngineering and MicroSystems, National Tsing Hua University, Taiwan","Institute of NanoEngineering and MicroSystems National Tsing Hua University Hsinchu City 300, Taiwan, ROC"],"affiliations":[{"raw_affiliation_string":"Institute of NanoEngineering and MicroSystems, National Tsing Hua University, Taiwan","institution_ids":["https://openalex.org/I25846049"]},{"raw_affiliation_string":"Institute of NanoEngineering and MicroSystems National Tsing Hua University Hsinchu City 300, Taiwan, ROC","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100400911","display_name":"Yuan Chen","orcid":"https://orcid.org/0000-0002-5106-0658"},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-An Chen","raw_affiliation_strings":["Institute of NanoEngineering and MicroSystems, National Tsing Hua University, Taiwan","Institute of NanoEngineering and MicroSystems National Tsing Hua University Hsinchu City 300, Taiwan, ROC"],"affiliations":[{"raw_affiliation_string":"Institute of NanoEngineering and MicroSystems, National Tsing Hua University, Taiwan","institution_ids":["https://openalex.org/I25846049"]},{"raw_affiliation_string":"Institute of NanoEngineering and MicroSystems National Tsing Hua University Hsinchu City 300, Taiwan, ROC","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041931526","display_name":"Da\u2010Jeng Yao","orcid":"https://orcid.org/0000-0001-6631-780X"},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Da-Jeng Yao","raw_affiliation_strings":["Institute of NanoEngineering and MicroSystems, National Tsing Hua University, Taiwan","Institute of NanoEngineering and MicroSystems National Tsing Hua University Hsinchu City 300, Taiwan, ROC"],"affiliations":[{"raw_affiliation_string":"Institute of NanoEngineering and MicroSystems, National Tsing Hua University, Taiwan","institution_ids":["https://openalex.org/I25846049"]},{"raw_affiliation_string":"Institute of NanoEngineering and MicroSystems National Tsing Hua University Hsinchu City 300, Taiwan, ROC","institution_ids":["https://openalex.org/I25846049"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5082398310"],"corresponding_institution_ids":["https://openalex.org/I25846049"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08969483,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"407","last_page":"410"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/concentric","display_name":"Concentric","score":0.6275625228881836},{"id":"https://openalex.org/keywords/jurkat-cells","display_name":"Jurkat cells","score":0.596847414970398},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.5526911020278931},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5091156363487244},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.5080668926239014},{"id":"https://openalex.org/keywords/filter","display_name":"Filter (signal processing)","score":0.48519065976142883},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.42803773283958435},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.3475916087627411},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3254188001155853},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.2343142330646515},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.22770622372627258},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.1656348705291748},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.15880972146987915},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.153658926486969},{"id":"https://openalex.org/keywords/t-cell","display_name":"T cell","score":0.11953422427177429},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.06881678104400635},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.0633094310760498}],"concepts":[{"id":"https://openalex.org/C90296322","wikidata":"https://www.wikidata.org/wiki/Q619776","display_name":"Concentric","level":2,"score":0.6275625228881836},{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.596847414970398},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5526911020278931},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5091156363487244},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5080668926239014},{"id":"https://openalex.org/C106131492","wikidata":"https://www.wikidata.org/wiki/Q3072260","display_name":"Filter (signal processing)","level":2,"score":0.48519065976142883},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.42803773283958435},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3475916087627411},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3254188001155853},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2343142330646515},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.22770622372627258},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1656348705291748},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.15880972146987915},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.153658926486969},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.11953422427177429},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06881678104400635},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.0633094310760498},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/nems.2014.6908838","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2014.6908838","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1566131344","https://openalex.org/W2027765160","https://openalex.org/W2077346543","https://openalex.org/W2148438834","https://openalex.org/W4251243185"],"related_works":["https://openalex.org/W2218604244","https://openalex.org/W2382526585","https://openalex.org/W3012234454","https://openalex.org/W3004341553","https://openalex.org/W2347232560","https://openalex.org/W2374956551","https://openalex.org/W2415620897","https://openalex.org/W2381630051","https://openalex.org/W3024494504","https://openalex.org/W2057394305"],"abstract_inverted_index":{"We":[0],"develop":[1],"a":[2,22,106],"novel":[3],"multilayer":[4],"concentric":[5,67],"filter":[6,68],"device":[7,69,124],"conjugated":[8],"with":[9,94],"an":[10],"immune-binding":[11],"method":[12,43,71],"to":[13,44,78,90],"achieve":[14],"enrichment":[15,102],"and":[16,31,41,56,63,70,83,103,120],"detection":[17,104,135],"of":[18,36,52,117],"rare":[19,92,100],"cells":[20,101],"in":[21,73,136],"mass":[23,107],"cell":[24,54,62,93,108],"population":[25,109],"by":[26,87,113],"size":[27,58,81],"based":[28],"separation.":[29],"Filter":[30],"size-based":[32],"separation":[33,85],"is":[34,110],"one":[35],"the":[37,137],"most":[38],"efficient,":[39],"simple":[40,95],"inexpensive":[42],"isolate":[45],"cells,":[46],"but":[47],"it":[48],"encounters":[49],"main":[50],"disadvantages":[51],"clogs,":[53],"deformation":[55],"insignificant":[57],"difference":[59,82],"between":[60],"targeted":[61,118],"normal":[64],"cell.":[65,122],"The":[66,98,123],"used":[72],"this":[74],"research":[75],"were":[76],"designed":[77],"create":[79],"significant":[80],"better":[84],"efficiency":[86],"clogs":[88],"reducing":[89],"identify":[91],"lab":[96],"instrument.":[97],"target":[99],"from":[105],"successfully":[111],"demonstrated":[112],"mixing":[114],"1:100,000":[115],"ratio":[116],"MCF-7":[119],"Jurkat":[121],"can":[125],"be":[126],"potentially":[127],"applied":[128],"for":[129],"clinical":[130],"Circulating":[131],"Tumor":[132],"Cells":[133],"(CTCs)":[134],"future.":[138]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}