{"id":"https://openalex.org/W1991693391","doi":"https://doi.org/10.1109/nems.2013.6559940","title":"Physical modulation based cell manipulation in microfluidic devices","display_name":"Physical modulation based cell manipulation in microfluidic devices","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W1991693391","doi":"https://doi.org/10.1109/nems.2013.6559940","mag":"1991693391"},"language":"en","primary_location":{"id":"doi:10.1109/nems.2013.6559940","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2013.6559940","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The 8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074806342","display_name":"Jing Zhu","orcid":"https://orcid.org/0000-0002-0950-2512"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Zhu","raw_affiliation_strings":["Department of Mechanical Engineering, Columbia University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015783197","display_name":"Junyi Shang","orcid":"https://orcid.org/0000-0001-6048-3364"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junyi Shang","raw_affiliation_strings":["Department of Mechanical Engineering, Columbia University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yuan Jia","orcid":null},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuan Jia","raw_affiliation_strings":["Department of Mechanical Engineering, Columbia University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027612872","display_name":"Kun Liu","orcid":"https://orcid.org/0000-0003-2454-0653"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]},{"id":"https://openalex.org/I9224756","display_name":"Northeastern University","ror":"https://ror.org/03awzbc87","country_code":"CN","type":"education","lineage":["https://openalex.org/I9224756"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Kun Liu","raw_affiliation_strings":["Department of Mechanical Engineering, Columbia University, New York, NY, USA","School of Mechanical Engineering and Automation, Northeastern University, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"School of Mechanical Engineering and Automation, Northeastern University, Shenyang, China","institution_ids":["https://openalex.org/I9224756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048201953","display_name":"David J. Brenner","orcid":"https://orcid.org/0000-0002-0926-1210"},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Brenner","raw_affiliation_strings":["Department of Radiation Oncology and Center for Radiological Research, Columbia, Columbia University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology and Center for Radiological Research, Columbia, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104929121","display_name":"Qiao Lin","orcid":"https://orcid.org/0000-0002-7487-8428"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qiao Lin","raw_affiliation_strings":["Department of Mechanical Engineering, Columbia University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.07233751,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"23","issue":null,"first_page":"1226","last_page":"1229"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12224","display_name":"Nanofabrication and Lithography Techniques","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microfabrication","display_name":"Microfabrication","score":0.7233959436416626},{"id":"https://openalex.org/keywords/microfluidics","display_name":"Microfluidics","score":0.7224923968315125},{"id":"https://openalex.org/keywords/flexibility","display_name":"Flexibility (engineering)","score":0.6761382818222046},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.5935317277908325},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.5864298343658447},{"id":"https://openalex.org/keywords/aptamer","display_name":"Aptamer","score":0.5546379685401917},{"id":"https://openalex.org/keywords/trapping","display_name":"Trapping","score":0.4117722809314728},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.33080214262008667},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.07112893462181091}],"concepts":[{"id":"https://openalex.org/C527607","wikidata":"https://www.wikidata.org/wiki/Q175538","display_name":"Microfabrication","level":4,"score":0.7233959436416626},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.7224923968315125},{"id":"https://openalex.org/C2780598303","wikidata":"https://www.wikidata.org/wiki/Q65921492","display_name":"Flexibility (engineering)","level":2,"score":0.6761382818222046},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5935317277908325},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5864298343658447},{"id":"https://openalex.org/C128972844","wikidata":"https://www.wikidata.org/wiki/Q418722","display_name":"Aptamer","level":2,"score":0.5546379685401917},{"id":"https://openalex.org/C2777924906","wikidata":"https://www.wikidata.org/wiki/Q34168","display_name":"Trapping","level":2,"score":0.4117722809314728},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33080214262008667},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07112893462181091},{"id":"https://openalex.org/C136525101","wikidata":"https://www.wikidata.org/wiki/Q5428139","display_name":"Fabrication","level":3,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/nems.2013.6559940","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2013.6559940","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The 8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1971647685","https://openalex.org/W1979721854","https://openalex.org/W1995249314","https://openalex.org/W1996808217","https://openalex.org/W2008770843","https://openalex.org/W2010477093","https://openalex.org/W2063721824","https://openalex.org/W2124999157","https://openalex.org/W2139705669"],"related_works":["https://openalex.org/W2967136651","https://openalex.org/W2913646003","https://openalex.org/W2033684641","https://openalex.org/W599572244","https://openalex.org/W2377413176","https://openalex.org/W3002287269","https://openalex.org/W4286228843","https://openalex.org/W2078253688","https://openalex.org/W2162490895","https://openalex.org/W2024184971"],"abstract_inverted_index":{"Cell":[0],"manipulation":[1],"has":[2],"important":[3],"applications":[4,91],"in":[5],"biological":[6],"research":[7],"and":[8,20,28,43,50,87,100],"clinical":[9],"diagnostics.":[10],"We":[11,32,56],"integrate":[12],"microfabrication":[13],"with":[14],"physical":[15],"modulation":[16],"to":[17,45,64,77],"enable":[18,46],"selective":[19],"flexible":[21],"cell":[22,48],"manipulation,":[23],"such":[24],"as":[25,95,106,108],"isolation,":[26],"trapping":[27,110],"recovery":[29],"of":[30,38,53,62,68,82,103,111],"cells.":[31,55,83,113],"use":[33],"the":[34,59],"strong":[35],"temperature":[36],"dependence":[37],"affinity":[39],"binding":[40],"between":[41],"aptamers":[42],"cells":[44],"specific":[47,98],"capture":[49,78,99],"temperature-mediated":[51,101],"release":[52,102],"selected":[54],"also":[57],"exploit":[58],"large":[60],"compliance":[61],"elastomers":[63],"create":[65],"an":[66],"array":[67],"cell-trapping":[69],"microstructures,":[70],"whose":[71],"dimensions":[72],"can":[73,92],"be":[74,93],"mechanically":[75],"modulated":[76],"a":[79],"predetermined":[80],"number":[81],"Thus,":[84],"enhanced":[85],"utility":[86],"flexibility":[88],"for":[89],"practical":[90],"attained,":[94],"demonstrated":[96],"by":[97],"CCRF-CEM":[104],"cells,":[105],"well":[107],"tunable":[109],"MCF-7":[112]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}