{"id":"https://openalex.org/W1981444016","doi":"https://doi.org/10.1109/nems.2013.6559916","title":"Quantitative characterization of specific targeting of tumor cells by antibody-functionalized particles","display_name":"Quantitative characterization of specific targeting of tumor cells by antibody-functionalized particles","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W1981444016","doi":"https://doi.org/10.1109/nems.2013.6559916","mag":"1981444016"},"language":"en","primary_location":{"id":"doi:10.1109/nems.2013.6559916","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2013.6559916","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The 8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024541281","display_name":"Matthew T. Stamm","orcid":null},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M.T. Stamm","raw_affiliation_strings":["Department of Aerospace and Mechanical Engineering, University of Arizona, USA","Dept. of Aerosp. & Mech. Eng., Univ. of Arizona, Tucson, AZ, USA"],"affiliations":[{"raw_affiliation_string":"Department of Aerospace and Mechanical Engineering, University of Arizona, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Dept. of Aerosp. & Mech. Eng., Univ. of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031600480","display_name":"Andrew S. Trickey\u2010Glassman","orcid":null},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A.S. Trickey-Glassman","raw_affiliation_strings":["Department of Aerospace and Mechanical Engineering, University of Arizona, USA","Dept. of Aerosp. & Mech. Eng., Univ. of Arizona, Tucson, AZ, USA"],"affiliations":[{"raw_affiliation_string":"Department of Aerospace and Mechanical Engineering, University of Arizona, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Dept. of Aerosp. & Mech. Eng., Univ. of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043677467","display_name":"Linan Jiang","orcid":"https://orcid.org/0000-0003-4328-9003"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Jiang","raw_affiliation_strings":["Department of Aerospace and Mechanical Engineering, University of Arizona, USA","Dept. of Aerosp. & Mech. Eng., Univ. of Arizona, Tucson, AZ, USA"],"affiliations":[{"raw_affiliation_string":"Department of Aerospace and Mechanical Engineering, University of Arizona, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Dept. of Aerosp. & Mech. Eng., Univ. of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061740418","display_name":"Yitshak Zohar","orcid":"https://orcid.org/0000-0001-9276-0119"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. Zohar","raw_affiliation_strings":["Department of Aerospace and Mechanical Engineering, University of Arizona, USA","Dept. of Aerosp. & Mech. Eng., Univ. of Arizona, Tucson, AZ, USA"],"affiliations":[{"raw_affiliation_string":"Department of Aerospace and Mechanical Engineering, University of Arizona, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Dept. of Aerosp. & Mech. Eng., Univ. of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5024541281"],"corresponding_institution_ids":["https://openalex.org/I138006243"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.03957928,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"2","issue":null,"first_page":"1108","last_page":"1111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.992900013923645,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.582848846912384},{"id":"https://openalex.org/keywords/incubation","display_name":"Incubation","score":0.5596747994422913},{"id":"https://openalex.org/keywords/particle","display_name":"Particle (ecology)","score":0.5371392965316772},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.49359118938446045},{"id":"https://openalex.org/keywords/ligand","display_name":"Ligand (biochemistry)","score":0.4932836890220642},{"id":"https://openalex.org/keywords/antibody","display_name":"Antibody","score":0.46557873487472534},{"id":"https://openalex.org/keywords/cancer-cell","display_name":"Cancer cell","score":0.44757699966430664},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.43526121973991394},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.42429226636886597},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.17516669631004333},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.16907593607902527},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15200528502464294},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.11136925220489502}],"concepts":[{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.582848846912384},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.5596747994422913},{"id":"https://openalex.org/C2778517922","wikidata":"https://www.wikidata.org/wiki/Q7140482","display_name":"Particle (ecology)","level":2,"score":0.5371392965316772},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49359118938446045},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.4932836890220642},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.46557873487472534},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.44757699966430664},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.43526121973991394},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.42429226636886597},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.17516669631004333},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16907593607902527},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15200528502464294},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.11136925220489502},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/nems.2013.6559916","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2013.6559916","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The 8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7400000095367432}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1999187173","https://openalex.org/W2042110923","https://openalex.org/W2044703166","https://openalex.org/W2060222487","https://openalex.org/W2099374439","https://openalex.org/W2106513086","https://openalex.org/W6675083170"],"related_works":["https://openalex.org/W2728649671","https://openalex.org/W1979968480","https://openalex.org/W3023841466","https://openalex.org/W2289046032","https://openalex.org/W2807895903","https://openalex.org/W2126944494","https://openalex.org/W3041867244","https://openalex.org/W1970672327","https://openalex.org/W2183682716","https://openalex.org/W2950187185","https://openalex.org/W2914806940","https://openalex.org/W2035328561","https://openalex.org/W2997869844","https://openalex.org/W2535119751","https://openalex.org/W2108977657","https://openalex.org/W2954976320","https://openalex.org/W2017530321","https://openalex.org/W2288537663","https://openalex.org/W1986032553","https://openalex.org/W3083285127"],"abstract_inverted_index":{"Receptor-ligand":[0],"binding":[1,82,125],"has":[2],"been":[3],"one":[4],"of":[5,38,47,59,81,101,113],"the":[6,45,95,99],"more":[7],"popular":[8],"approaches":[9],"to":[10,51,64,87,104,123],"specifically":[11],"targeting":[12,18],"tumor":[13],"cells.":[14,35,106],"In":[15],"this":[16],"work,":[17],"efficiency":[19],"was":[20,62,92],"quantitatively":[21],"characterized":[22],"using":[23],"silica":[24],"particles":[25,49,61,102],"functionalized":[26,48],"with":[27,66,72],"EpCAM":[28],"antibodies":[29],"and":[30,41,78],"EpCAM-expressing":[31],"BT-20":[32],"breast":[33],"cancer":[34],"The":[36,57,107],"effects":[37],"incubation":[39,73],"time":[40,85],"particle":[42,67,76,116],"concentration":[43],"on":[44],"number":[46,58,100],"bound":[50,60,103,115],"target":[52,105],"cells":[53],"were":[54],"experimentally":[55],"investigated.":[56],"found":[63],"increase":[65],"concentration,":[68],"but":[69],"not":[70],"necessarily":[71],"time.":[74],"While":[75],"desorption":[77],"cellular":[79,124],"loss":[80],"affinity":[83],"in":[84],"seem":[86],"be":[88,121],"negligible,":[89],"cell-particle-cell":[90],"interaction":[91],"identified":[93],"as":[94],"limiting":[96],"mechanism":[97],"for":[98],"current":[108],"findings":[109],"suggest":[110],"that":[111],"separation":[112],"a":[114,118],"from":[117],"cell":[119],"may":[120],"detrimental":[122],"affinity.":[126]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
