{"id":"https://openalex.org/W2019388307","doi":"https://doi.org/10.1109/nems.2013.6559687","title":"Microfluidic device for super-fast evaluation of membrane protein crystallization","display_name":"Microfluidic device for super-fast evaluation of membrane protein crystallization","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W2019388307","doi":"https://doi.org/10.1109/nems.2013.6559687","mag":"2019388307"},"language":"en","primary_location":{"id":"doi:10.1109/nems.2013.6559687","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2013.6559687","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The 8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102415776","display_name":"Hsin-Jui Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hsin-Jui Wu","raw_affiliation_strings":["University of Colorado, Boulder, CO, USA","University of Colorado  Boulder CO USA"],"affiliations":[{"raw_affiliation_string":"University of Colorado, Boulder, CO, USA","institution_ids":["https://openalex.org/I188538660"]},{"raw_affiliation_string":"University of Colorado  Boulder CO USA","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050515086","display_name":"Tamara Basta","orcid":"https://orcid.org/0000-0003-1944-7593"},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tamara Basta","raw_affiliation_strings":["University of Colorado, Boulder, CO, USA","University of Colorado  Boulder CO USA"],"affiliations":[{"raw_affiliation_string":"University of Colorado, Boulder, CO, USA","institution_ids":["https://openalex.org/I188538660"]},{"raw_affiliation_string":"University of Colorado  Boulder CO USA","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013067670","display_name":"Mary Morphew","orcid":null},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Morphew","raw_affiliation_strings":["University of Colorado, Boulder, CO, USA","University of Colorado  Boulder CO USA"],"affiliations":[{"raw_affiliation_string":"University of Colorado, Boulder, CO, USA","institution_ids":["https://openalex.org/I188538660"]},{"raw_affiliation_string":"University of Colorado  Boulder CO USA","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060946176","display_name":"Douglas C. Rees","orcid":"https://orcid.org/0000-0003-4073-1185"},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. C. Rees","raw_affiliation_strings":["California Institute of Technology, Pasadena, CA, USA","California Institute of Technology Pasadena CA USA"],"affiliations":[{"raw_affiliation_string":"California Institute of Technology, Pasadena, CA, USA","institution_ids":["https://openalex.org/I122411786"]},{"raw_affiliation_string":"California Institute of Technology Pasadena CA USA","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017196184","display_name":"Michael H. B. Stowell","orcid":"https://orcid.org/0000-0001-7250-1419"},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael H. B. Stowell","raw_affiliation_strings":["University of Colorado, Boulder, CO, USA","University of Colorado  Boulder CO USA"],"affiliations":[{"raw_affiliation_string":"University of Colorado, Boulder, CO, USA","institution_ids":["https://openalex.org/I188538660"]},{"raw_affiliation_string":"University of Colorado  Boulder CO USA","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037301533","display_name":"Y. C. Lee","orcid":null},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. C. Lee","raw_affiliation_strings":["University of Colorado, Boulder, CO, USA","University of Colorado  Boulder CO USA"],"affiliations":[{"raw_affiliation_string":"University of Colorado, Boulder, CO, USA","institution_ids":["https://openalex.org/I188538660"]},{"raw_affiliation_string":"University of Colorado  Boulder CO USA","institution_ids":["https://openalex.org/I188538660"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5102415776"],"corresponding_institution_ids":["https://openalex.org/I188538660"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09142084,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"160","issue":null,"first_page":"84","last_page":"87"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microfluidics","display_name":"Microfluidics","score":0.8090581893920898},{"id":"https://openalex.org/keywords/membrane","display_name":"Membrane","score":0.619940996170044},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.5296145677566528},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.5110701322555542},{"id":"https://openalex.org/keywords/protein-crystallization","display_name":"Protein crystallization","score":0.5076440572738647},{"id":"https://openalex.org/keywords/membrane-protein","display_name":"Membrane protein","score":0.5073227286338806},{"id":"https://openalex.org/keywords/nanoparticle","display_name":"Nanoparticle","score":0.501185417175293},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"Drug delivery","score":0.4973428547382355},{"id":"https://openalex.org/keywords/lipid-bilayer","display_name":"Lipid bilayer","score":0.48294657468795776},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3816225528717041},{"id":"https://openalex.org/keywords/crystallization","display_name":"Crystallization","score":0.2958422601222992},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.08140832185745239}],"concepts":[{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.8090581893920898},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.619940996170044},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5296145677566528},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5110701322555542},{"id":"https://openalex.org/C153064111","wikidata":"https://www.wikidata.org/wiki/Q1281033","display_name":"Protein crystallization","level":3,"score":0.5076440572738647},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.5073227286338806},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.501185417175293},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.4973428547382355},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.48294657468795776},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3816225528717041},{"id":"https://openalex.org/C203036418","wikidata":"https://www.wikidata.org/wiki/Q284256","display_name":"Crystallization","level":2,"score":0.2958422601222992},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08140832185745239},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/nems.2013.6559687","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2013.6559687","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The 8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems","raw_type":"proceedings-article"},{"id":"pmh:oai:authors.library.caltech.edu:73732","is_oa":false,"landing_page_url":"https://authors.library.caltech.edu/73732/","pdf_url":null,"source":{"id":"https://openalex.org/S4306402161","display_name":"CaltechAUTHORS (California Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Book Section"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/17","display_name":"Partnerships for the goals","score":0.4300000071525574}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320309398","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055"},{"id":"https://openalex.org/F4320332538","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1979859011","https://openalex.org/W2013052602","https://openalex.org/W2020438216","https://openalex.org/W2068934754","https://openalex.org/W2109015133","https://openalex.org/W2120764900","https://openalex.org/W2150697832","https://openalex.org/W4210960748"],"related_works":["https://openalex.org/W3103016203","https://openalex.org/W2106238498","https://openalex.org/W2463681241","https://openalex.org/W97203997","https://openalex.org/W161520385","https://openalex.org/W4200355601","https://openalex.org/W2302534651","https://openalex.org/W2085248918","https://openalex.org/W2011028086","https://openalex.org/W1493374012"],"abstract_inverted_index":{"Membrane":[0],"proteins":[1,29],"embedded":[2],"in":[3,50,81,126,168,176,182,256],"bi-layer":[4],"lipids":[5,67],"of":[6,23,45,63,78,161,202,258],"cell":[7],"membrane":[8,28,46,64,92,162,238],"have":[9,75,231],"unique":[10],"functions":[11],"including":[12],"inter-cell":[13],"communication,":[14],"ions/molecules":[15],"transport.":[16],"And":[17],"there":[18],"is":[19,68,196],"more":[20],"than":[21,205],"50%":[22],"drug":[24,82,85],"design":[25,86],"emphasizes":[26],"on":[27,32,94,103],"specifically":[30],"studying":[31],"their":[33],"structure":[34],"and":[35,42,66,84,117,128,141,242],"formation.":[36],"Recently":[37],"we":[38,145,230,243],"reported":[39],"the":[40,91,122,159],"structural":[41],"functional":[43],"studies":[44,101],"protein":[47,65,93,118,163,217,239],"lipid":[48,240],"nanoparticles":[49,74,241],"native":[51],"biological":[52],"membrane.":[53],"This":[54],"virus-like":[55],"nanoparticle":[56],"formed":[57],"by":[58,173],"a":[59,76,108,147,151,200,250],"self-assembly":[60],"crystallization":[61],"process":[62,111,167],"critical":[69],"to":[70,156,184,198,221,234,253,262],"pharmaceutical":[71],"industrial.":[72],"These":[73],"variety":[77,257],"potential":[79],"applications":[80,255],"delivery":[83],"that":[87,112],"can":[88,179,215],"carry":[89],"specific":[90],"aim":[95],"or":[96,224],"release":[97],"control.":[98],"The":[99,165,192],"previous":[100],"stay":[102],"an":[104,232],"inefficient":[105,207],"method":[106,247],"with":[107,150],"standard":[109],"dialysis":[110],"has":[113,134],"low-throughput,":[114],"time":[115],"consumption,":[116],"sample":[119,218],"waste.":[120],"However,":[121],"interdisciplinary":[123],"cooperation":[124],"between":[125],"biology":[127,261],"Micro":[129],"electro":[130],"mechanical":[131],"systems":[132],"(MEMS)":[133],"been":[135],"tremendous":[136],"developed":[137],"such":[138],"as":[139],"Bio-MEMS":[140],"Lab-on-a-chip":[142],"technologies.":[143],"Here":[144],"demonstrate":[146],"new":[148,246],"concept":[149],"high-throughput":[152],"membraneless":[153],"microfluidic":[154,177,213],"device":[155,214],"fast":[157],"produce":[158],"reconstitution":[160,166],"nanoparticles.":[164],"continuous":[169],"micro":[170],"flow":[171],"dominated":[172],"convection-diffusion":[174],"phenomena":[175],"channel":[178],"be":[180],"completed":[181],"seconds":[183],"form":[185,236],"protein/lipid":[186],"particles":[187],"under":[188],"multiple":[189],"conditions":[190,203],"applied.":[191],"controllable":[193],"syringe":[194],"pumps":[195],"used":[197],"test":[199],"combination":[201],"rather":[204],"using":[206,227],"hand":[208],"pipette.":[209],"Moreover":[210],"this":[211,228,245],"novel":[212],"save":[216],"consumption":[219],"down":[220],"only":[222],"nanoliter":[223],"picoliter.":[225],"By":[226],"device,":[229],"ability":[233],"rapidly":[235],"uniform":[237],"believe":[244],"will":[248],"make":[249],"transformative":[251],"impact":[252],"commercial":[254],"areas":[259],"from":[260],"pharmacology.":[263]},"counts_by_year":[],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}
