{"id":"https://openalex.org/W2116562660","doi":"https://doi.org/10.1109/nems.2012.6196783","title":"Nanomechanical DNA origami devices as versatile molecular sensors","display_name":"Nanomechanical DNA origami devices as versatile molecular sensors","publication_year":2012,"publication_date":"2012-03-01","ids":{"openalex":"https://openalex.org/W2116562660","doi":"https://doi.org/10.1109/nems.2012.6196783","mag":"2116562660"},"language":"en","primary_location":{"id":"doi:10.1109/nems.2012.6196783","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2012.6196783","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 7th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039769062","display_name":"Akinori Kuzuya","orcid":"https://orcid.org/0000-0003-0003-2996"},"institutions":[{"id":"https://openalex.org/I56624758","display_name":"Kansai University","ror":"https://ror.org/03xg1f311","country_code":"JP","type":"education","lineage":["https://openalex.org/I56624758"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Akinori Kuzuya","raw_affiliation_strings":["Department of Chemistry and Materials Engineering, Kansai University, Japan","Department of Chemistry and Materials Engineering, Kansai University, JAPAN"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Materials Engineering, Kansai University, Japan","institution_ids":["https://openalex.org/I56624758"]},{"raw_affiliation_string":"Department of Chemistry and Materials Engineering, Kansai University, JAPAN","institution_ids":["https://openalex.org/I56624758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067979427","display_name":"Takahiro Yamazaki","orcid":"https://orcid.org/0000-0002-4193-2221"},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I56624758","display_name":"Kansai University","ror":"https://ror.org/03xg1f311","country_code":"JP","type":"education","lineage":["https://openalex.org/I56624758"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiro Yamazaki","raw_affiliation_strings":["Kansai Daigaku, Suita, Osaka, JP","The University of Tokyo, JAPAN"],"affiliations":[{"raw_affiliation_string":"Kansai Daigaku, Suita, Osaka, JP","institution_ids":["https://openalex.org/I56624758"]},{"raw_affiliation_string":"The University of Tokyo, JAPAN","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111348043","display_name":"Kohei Yasuda","orcid":null},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I56624758","display_name":"Kansai University","ror":"https://ror.org/03xg1f311","country_code":"JP","type":"education","lineage":["https://openalex.org/I56624758"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kohei Yasuda","raw_affiliation_strings":["Kansai Daigaku, Suita, Osaka, JP","The University of Tokyo, JAPAN"],"affiliations":[{"raw_affiliation_string":"Kansai Daigaku, Suita, Osaka, JP","institution_ids":["https://openalex.org/I56624758"]},{"raw_affiliation_string":"The University of Tokyo, JAPAN","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065457080","display_name":"Yusuke Sakai","orcid":"https://orcid.org/0000-0003-3285-0280"},"institutions":[{"id":"https://openalex.org/I56624758","display_name":"Kansai University","ror":"https://ror.org/03xg1f311","country_code":"JP","type":"education","lineage":["https://openalex.org/I56624758"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yusuke Sakai","raw_affiliation_strings":["Kansai Daigaku, Suita, Osaka, JP","The University of Tokyo, JAPAN"],"affiliations":[{"raw_affiliation_string":"Kansai Daigaku, Suita, Osaka, JP","institution_ids":["https://openalex.org/I56624758"]},{"raw_affiliation_string":"The University of Tokyo, JAPAN","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013182287","display_name":"Yusei Yamanaka","orcid":null},"institutions":[{"id":"https://openalex.org/I56624758","display_name":"Kansai University","ror":"https://ror.org/03xg1f311","country_code":"JP","type":"education","lineage":["https://openalex.org/I56624758"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yusei Yamanaka","raw_affiliation_strings":["Kansai Daigaku, Suita, Osaka, JP","Kansai University,Japan"],"affiliations":[{"raw_affiliation_string":"Kansai Daigaku, Suita, Osaka, JP","institution_ids":["https://openalex.org/I56624758"]},{"raw_affiliation_string":"Kansai University,Japan","institution_ids":["https://openalex.org/I56624758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027459729","display_name":"Yan Xu","orcid":"https://orcid.org/0000-0003-0379-8866"},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I56624758","display_name":"Kansai University","ror":"https://ror.org/03xg1f311","country_code":"JP","type":"education","lineage":["https://openalex.org/I56624758"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yan Xu","raw_affiliation_strings":["Kansai Daigaku, Suita, Osaka, JP","The University of Tokyo, JAPAN"],"affiliations":[{"raw_affiliation_string":"Kansai Daigaku, Suita, Osaka, JP","institution_ids":["https://openalex.org/I56624758"]},{"raw_affiliation_string":"The University of Tokyo, JAPAN","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087565134","display_name":"Yuichiro Aiba","orcid":"https://orcid.org/0000-0003-3994-7480"},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I56624758","display_name":"Kansai University","ror":"https://ror.org/03xg1f311","country_code":"JP","type":"education","lineage":["https://openalex.org/I56624758"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuichiro Aiba","raw_affiliation_strings":["Kansai Daigaku, Suita, Osaka, JP","The University of Tokyo, JAPAN"],"affiliations":[{"raw_affiliation_string":"Kansai Daigaku, Suita, Osaka, JP","institution_ids":["https://openalex.org/I56624758"]},{"raw_affiliation_string":"The University of Tokyo, JAPAN","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011399496","display_name":"Yuichi Ohya","orcid":"https://orcid.org/0000-0002-8862-850X"},"institutions":[{"id":"https://openalex.org/I56624758","display_name":"Kansai University","ror":"https://ror.org/03xg1f311","country_code":"JP","type":"education","lineage":["https://openalex.org/I56624758"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuichi Ohya","raw_affiliation_strings":["Kansai Daigaku, Suita, Osaka, JP","Kansai University,Japan"],"affiliations":[{"raw_affiliation_string":"Kansai Daigaku, Suita, Osaka, JP","institution_ids":["https://openalex.org/I56624758"]},{"raw_affiliation_string":"Kansai University,Japan","institution_ids":["https://openalex.org/I56624758"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080074020","display_name":"Makoto Komiyama","orcid":"https://orcid.org/0000-0002-9381-1018"},"institutions":[{"id":"https://openalex.org/I56624758","display_name":"Kansai University","ror":"https://ror.org/03xg1f311","country_code":"JP","type":"education","lineage":["https://openalex.org/I56624758"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Komiyama","raw_affiliation_strings":["Kansai Daigaku, Suita, Osaka, JP","The University of Tokyo, JAPAN"],"affiliations":[{"raw_affiliation_string":"Kansai Daigaku, Suita, Osaka, JP","institution_ids":["https://openalex.org/I56624758"]},{"raw_affiliation_string":"The University of Tokyo, JAPAN","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5039769062"],"corresponding_institution_ids":["https://openalex.org/I56624758"],"apc_list":null,"apc_paid":null,"fwci":0.1313,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.52426292,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"318","last_page":"321"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10295","display_name":"Plasmonic and Surface Plasmon Research","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molecular-beacon","display_name":"Molecular beacon","score":0.7580554485321045},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.6525576114654541},{"id":"https://openalex.org/keywords/dna-origami","display_name":"DNA origami","score":0.6310937404632568},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.4940260052680969},{"id":"https://openalex.org/keywords/nucleic-acid","display_name":"Nucleic acid","score":0.4667319059371948},{"id":"https://openalex.org/keywords/molecule","display_name":"Molecule","score":0.45585665106773376},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.45533958077430725},{"id":"https://openalex.org/keywords/molecular-biophysics","display_name":"Molecular biophysics","score":0.42219170928001404},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3047965168952942},{"id":"https://openalex.org/keywords/oligonucleotide","display_name":"Oligonucleotide","score":0.08344823122024536},{"id":"https://openalex.org/keywords/nanostructure","display_name":"Nanostructure","score":0.08110997080802917}],"concepts":[{"id":"https://openalex.org/C119203544","wikidata":"https://www.wikidata.org/wiki/Q425891","display_name":"Molecular beacon","level":4,"score":0.7580554485321045},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.6525576114654541},{"id":"https://openalex.org/C118630614","wikidata":"https://www.wikidata.org/wiki/Q1154606","display_name":"DNA origami","level":3,"score":0.6310937404632568},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4940260052680969},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.4667319059371948},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.45585665106773376},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.45533958077430725},{"id":"https://openalex.org/C70636015","wikidata":"https://www.wikidata.org/wiki/Q4300350","display_name":"Molecular biophysics","level":2,"score":0.42219170928001404},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3047965168952942},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.08344823122024536},{"id":"https://openalex.org/C186187911","wikidata":"https://www.wikidata.org/wiki/Q1093894","display_name":"Nanostructure","level":2,"score":0.08110997080802917},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/nems.2012.6196783","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2012.6196783","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 7th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1968903003","https://openalex.org/W1987682801","https://openalex.org/W1989172381","https://openalex.org/W2005055135","https://openalex.org/W2013563809","https://openalex.org/W2038125628","https://openalex.org/W2042042512","https://openalex.org/W2045825500","https://openalex.org/W2047786995","https://openalex.org/W2070046204","https://openalex.org/W2071836755","https://openalex.org/W2103409481","https://openalex.org/W2113834718","https://openalex.org/W2126961173","https://openalex.org/W2134751374","https://openalex.org/W2147007029","https://openalex.org/W4211177570","https://openalex.org/W4239232977"],"related_works":["https://openalex.org/W2592350013","https://openalex.org/W4225378520","https://openalex.org/W2072851996","https://openalex.org/W2036866027","https://openalex.org/W4283740642","https://openalex.org/W2010974451","https://openalex.org/W2312988278","https://openalex.org/W2755876272","https://openalex.org/W2086243558","https://openalex.org/W2116562660"],"abstract_inverted_index":{"We":[0,16],"propose":[1],"versatile":[2],"sensing":[3],"systems":[4],"for":[5],"a":[6,42,57,62,73],"variety":[7],"of":[8,33,61,76],"chemical":[9],"and":[10],"biological":[11],"targets":[12,47],"at":[13,41],"molecular":[14],"resolution.":[15],"have":[17],"designed":[18],"functional":[19],"nanomechanical":[20],"DNA":[21],"origami":[22,78],"devices":[23],"that":[24],"can":[25,66],"be":[26,67],"used":[27],"as":[28,54,56],"\u201csingle-molecule":[29],"beacons\u201d,":[30],"which":[31],"consist":[32],"two":[34],"levers":[35],"approximately":[36],"170":[37],"nm":[38],"long":[39],"connected":[40],"fulcrum.":[43],"Various":[44],"single-molecule":[45],"inorganic/organic":[46],"ranging":[48],"from":[49],"metal":[50],"ions":[51],"to":[52],"proteins":[53],"well":[55],"unique":[58],"binding":[59],"event":[60],"nucleic":[63],"acid":[64],"analogue":[65],"visually":[68],"detected":[69],"on":[70],"AFM":[71],"by":[72],"shape":[74],"transition":[75],"the":[77],"devices.":[79]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}